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Cytokines, reverse genetics and anti-cytokine therapy
Published 2019-05-01“…Many aspects of inflammation, autoimmune diseases and neoplasia are associated with cytokine signaling through specific receptors. The establishment of new physiological functions of “old” cytokines and understanding the molecular and cellular mechanisms of their involvement in disease pathogenesis, as well as the search for new therapeutic targets and development of innovative approaches to anti-cytokine therapy, present a fundamental problem. …”
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Anti-cytokines and cytokines in the treatment of rheumatoid arthritis.
Published 2003“…Other pro-inflammatory cytokines representing potential therapeutic targets include interferon-beta, interferon-alpha, IL-6, IL-15, IL-17 and IL-18. …”
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Relationship of cytokines and cytokine signaling to immunodeficiency disorders in the mouse
Published 1998-01-01“…Some studies have indicated an etiologic role for type 2 cytokines, while others have emphasized the importance of type 1 cytokines. …”
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Mnk kinases in cytokine signaling and regulation of cytokine responses
Published 2015-03-01Get full text
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Compartmentalisation of cytokines and cytokine inhibitors in ventilator-associated pneumonia.
Published 2004“…RESULTS: Plasma concentrations of the measured cytokines and cytokine inhibitors did not change significantly in any patients. …”
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Cytokines and anti-cytokine biologicals in autoimmunity: present and future.
Published 2002“…The future developments of anti-TNFalpha and anti-cytokine therapy in general will be interesting.…”
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Cytokines in autoimmunity.
Published 1992“…It is now generally accepted that many cytokines are involved in the pathogenesis of autoimmune disease, either directly by causing tissue destruction or indirectly through the activation of autoreactive and inflammatory cells. …”
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Cytokines in autoimmunity.
Published 1996“…The past few years have witnessed exciting developments regarding the role of cytokines in autoimmune diseases, particularly in rheumatoid arthritis and Crohn's disease, with the demonstration that anti-TNF alpha therapy is clinically beneficial and provides reproducible results. …”
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Cytokines in infection
Published 1993“…However, it appears that cytokines may also have detrimental effects in infections by actually enhancing microbial growth. …”
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Navigating the Cytokine Seas: Targeting Cytokine Signaling Pathways in Cancer Therapy
Published 2024-01-01Subjects: “…cytokine signaling…”
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Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines
Published 2020-09-01“…We address various changes in cellular components of the immune response corroborating with changes in cytokine levels while discussing cytokine sources and biological functions. …”
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Cytokines Involved in the Pathogenesis of SSc and Problems in the Development of Anti-Cytokine Therapy
Published 2021-05-01“…Therapeutic methods to control these cytokines have been proposed; however, which cytokines have a dominant role in SSc might differ depending on the extent of visceral lesions and the stage of disease progression. …”
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Cytokine Profile in Lung Cancer Patients: Anti-Tumor and Oncogenic Cytokines
Published 2023-11-01Subjects: Get full text
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Th17 cytokines regulate profibrotic cytokines release by human eosinophils
Published 2012-11-01Article