Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance by David Mavor, Kyle A. Barlow, Daniel Asarnow, Yuliya Birman, Derek Britain, Weilin Chen, Evan M. Green, Lillian R. Kenner, Bruk Mensa, Leanna S. Morinishi, Charlotte A. Nelson, Erin M. Poss, Pooja Suresh, Ruilin Tian, Taylor Arhar, Beatrice E. Ary, David P. Bauer, Ian D. Bergman, Rachel M. Brunetti, Cynthia M. Chio, Shizhong A. Dai, Miles S. Dickinson, Susanna K. Elledge, Cole V. M. Helsell, Nathan L. Hendel, Emily Kang, Nadja Kern, Matvei S. Khoroshkin, Lisa L. Kirkemo, Greyson R. Lewis, Kevin Lou, Wesley M. Marin, Alison M. Maxwell, Peter F. McTigue, Douglas Myers-Turnbull, Tamas L. Nagy, Andrew M. Natale, Keely Oltion, Sergei Pourmal, Gabriel K. Reder, Nicholas J. Rettko, Peter J. Rohweder, Daniel M. C Schwarz, Sophia K. Tan, Paul V. Thomas, Ryan W. Tibble, Jason P. Town, Mary K. Tsai, Fatima S. Ugur, Douglas R. Wassarman, Alexander M. Wolff, Taia S. Wu, Derek Bogdanoff, Jennifer Li, Kurt S. Thorn, Shane O'Conchúir, Danielle L. Swaney, Eric D. Chow, Hiten D. Madhani, Sy Redding, Daniel N. Bolon, Tanja Kortemme, Joseph L. DeRisi, Martin Kampmann, James S. Fraser

Subjects: “…Deep mutational scanning…”
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Deep mutational scanning and machine learning reveal structural and molecular rules governing allosteric hotspots in homologous proteins by Megan Leander, Zhuang Liu, Qiang Cui, Srivatsan Raman

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Uncovering the basis of protein-protein interaction specificity with a combinatorially complete library by Thuy-Lan V Lite, Robert A Grant, Isabel Nocedal, Megan L Littlehale, Monica S Guo, Michael T Laub

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Deep mutational scanning quantifies DNA binding and predicts clinical outcomes of PAX6 variants by Alexander F McDonnell, Marcin Plech, Benjamin J Livesey, Lukas Gerasimavicius, Liusaidh J Owen, Hildegard Nikki Hall, David R FitzPatrick, Joseph A Marsh, Grzegorz Kudla

Subjects: “…Deep Mutational Scanning…”
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A comprehensive map of human glucokinase variant activity by Sarah Gersing, Matteo Cagiada, Marinella Gebbia, Anette P. Gjesing, Atina G. Coté, Gireesh Seesankar, Roujia Li, Daniel Tabet, Jochen Weile, Amelie Stein, Anna L. Gloyn, Torben Hansen, Frederick P. Roth, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen

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Identification of HIV-1 Envelope Mutations that Enhance Entry Using Macaque CD4 and CCR5 by Jeremy I. Roop, Noah A. Cassidy, Adam S. Dingens, Jesse D. Bloom, Julie Overbaugh

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Accurate Measurement of the Effects of All Amino-Acid Mutations on Influenza Hemagglutinin by Michael B. Doud, Jesse D. Bloom

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Elucidating the Molecular Determinants of Aβ Aggregation with Deep Mutational Scanning by Vanessa E. Gray, Katherine Sitko, Floriane Z. Ngako Kameni, Miriam Williamson, Jason J. Stephany, Nicholas Hasle, Douglas M. Fowler

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Deep Mutational Scanning to Predict Escape from Bebtelovimab in SARS-CoV-2 Omicron Subvariants by Mellissa C. Alcantara, Yusuke Higuchi, Yuhei Kirita, Satoaki Matoba, Atsushi Hoshino

Subjects: “…deep mutational scanning…”
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Deep mutational scanning of influenza A virus neuraminidase facilitates the identification of drug resistance mutations in vivo by Sihan Wang, Tian-hao Zhang, Menglong Hu, Kejun Tang, Li Sheng, Mengying Hong, Dongdong Chen, Liubo Chen, Yuan Shi, Jun Feng, Jing Qian, Lifeng Sun, Kefeng Ding, Ren Sun, Yushen Du

Subjects: “…deep mutational scanning…”
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Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain by Gabriella O Estevam, Edmond M Linossi, Christian B Macdonald, Carla A Espinoza, Jennifer M Michaud, Willow Coyote-Maestas, Eric A Collisson, Natalia Jura, James S Fraser

Subjects: “…deep mutational scanning…”
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Applications of Deep Mutational Scanning in Virology by Thomas D. Burton, Nicholas S. Eyre

Subjects: “…deep mutational scanning…”
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MoCHI: neural networks to fit interpretable models and quantify energies, energetic couplings, epistasis, and allostery from deep mutational scanning data by Andre J. Faure, Ben Lehner

Subjects: “…Deep mutational scanning…”
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Globally Defining the Effects of Amino Acid Mutations across a Picornavirus Capsid by Florian Mattenberger, Ron Geller

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Unsupervised modeling of mutational landscapes of adeno-associated viruses viability by Matteo De Leonardis, Jorge Fernandez-de-Cossio-Diaz, Guido Uguzzoni, Andrea Pagnani

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Systematic genetic characterization of the human PKR kinase domain highlights its functional malleability to escape a poxvirus substrate mimic by Michael James Chambers, Sophia B Scobell, Meru J Sadhu

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Comprehensive fitness maps of Hsp90 show widespread environmental dependence by Julia M Flynn, Ammeret Rossouw, Pamela Cote-Hammarlof, Inês Fragata, David Mavor, Carl Hollins III, Claudia Bank, Daniel NA Bolon

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The inherent mutational tolerance and antigenic evolvability of influenza hemagglutinin by Bargavi Thyagarajan, Jesse D Bloom

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A framework for exhaustively mapping functional missense variants by Jochen Weile, Song Sun, Atina G Cote, Jennifer Knapp, Marta Verby, Joseph C Mellor, Yingzhou Wu, Carles Pons, Cassandra Wong, Natascha van Lieshout, Fan Yang, Murat Tasan, Guihong Tan, Shan Yang, Douglas M Fowler, Robert Nussbaum, Jesse D Bloom, Marc Vidal, David E Hill, Patrick Aloy, Frederick P Roth

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High Throughput Analyses of Budding Yeast ARSs Reveal New DNA Elements Capable of Conferring Centromere-Independent Plasmid Propagation by Timothy Hoggard, Ivan Liachko, Cassaundra Burt, Troy Meikle, Katherine Jiang, Gheorghe Craciun, Maitreya J. Dunham, Catherine A. Fox

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