Analysis of Powassan Virus Genome Sequences from Human Cases Reveals Substantial Genetic Diversity with Implications for Molecular Assay Development by Erik H. Klontz, Navid Chowdhury, Nolan Holbrook, Isaac H. Solomon, Sam R. Telford, Matthew T. Aliota, Chantal B. F. Vogels, Nathan D. Grubaugh, Jeffrey Helgager, Holly R. Hughes, Jason Velez, Anne Piantadosi, Charles Y. Chiu, Jacob Lemieux, John A. Branda

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Sharing the Ride: Ixodes scapularis Symbionts and Their Interactions by Philip E. Stewart, Marshall E. Bloom

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Ecology of Powassan Virus in the United States by Erin M. Hassett, Saravanan Thangamani

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Comparative Pathogenesis of Two Lineages of Powassan Virus Reveals Distinct Clinical Outcome, Neuropathology, and Inflammation by Erin S. Reynolds, Charles E. Hart, Jacob T. Nelson, Brandon J. Marzullo, Allen T. Esterly, Dakota N. Paine, Jessica Crooker, Paul T. Massa, Saravanan Thangamani

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Development and Validation of a Serologic Test Panel for Detection of Powassan Virus Infection in U.S. Patients Residing in Regions Where Lyme Disease Is Endemic by Angela M. Thomm, Anna M. Schotthoefer, Alan P. Dupuis, Laura D. Kramer, Holly M. Frost, Thomas R. Fritsche, Yvette A. Harrington, Konstance K. Knox, Sue C. Kehl

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Potential Role of Deer Tick Virus in Powassan Encephalitis Cases in Lyme Disease–endemic Areas of New York, USA by Marc Y. El Khoury, Jose F. Camargo, Jennifer L. White, Bryon P. Backenson, Alan P. Dupuis, Kay L. Escuyer, Laura Kramer, Kirsten St. George, Debarati Chatterjee, Melissa Prusinski, Gary P. Wormser, Susan J. Wong

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Powassan Virus—A New Reemerging Tick-Borne Disease by Syed Soheb Fatmi, Rija Zehra, David O. Carpenter

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Identification and characterization of novel lineage 1 Powassan virus strains in New York State by Rachel E. Lange, Alan P. Dupuis II, Melissa A. Prusinski, Joseph G. Maffei, Cheri A. Koetzner, Kiet Ngo, Bryon Backenson, JoAnne Oliver, Chantal B.F. Vogels, Nathan D. Grubaugh, Laura D. Kramer, Alexander T. Ciota

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Of Murines and Humans: Modeling Persistent Powassan Disease in C57BL/6 Mice by Stacey L. P. Scroggs, Danielle K. Offerdahl, Philip E. Stewart, Carl Shaia, Amanda J. Griffin, Marshall E. Bloom

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Direct Evidence of Powassan Virus Vertical Transmission in <i>Ixodes scapularis</i> in Nature by Rachel E. Lange, Melissa A. Prusinski, Alan P. Dupuis, Alexander T. Ciota

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Differences in Genetic Diversity of Mammalian Tick-Borne Flaviviruses by Kassandra L. Carpio, Jill K. Thompson, Steven G. Widen, Jennifer K. Smith, Terry L. Juelich, David E. Clements, Alexander N. Freiberg, Alan D. T. Barrett

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Serologic Evidence of Powassan Virus Infection in Patients with Suspected Lyme Disease by Holly M. Frost, Anna M. Schotthoefer, Angela M. Thomm, Alan P. Dupuis, Sue C. Kehl, Laura D. Kramer, Thomas R. Fritsche, Yvette A. Harrington, Konstance K. Knox

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Characterization of Live-Attenuated Powassan Virus Vaccine Candidates Identifies an Efficacious Prime-Boost Strategy for Mitigating Powassan Virus Disease in a Murine Model by Andrew M. Cheung, Elaine Z. Yip, Alison W. Ashbrook, Niluka Goonawardane, Corrine Quirk, Charles M. Rice, Margaret R. MacDonald, Hans-Heinrich Hoffmann

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