Age-related decline in function of ON and OFF visual pathways. by Amithavikram R Hathibelagal, Vishal Prajapati, Indrani Jayagopi, Subhadra Jalali, Shonraj Ballae Ganeshrao

“…<h4>Conclusions</h4>This normative database will be useful to quantify disease-specific defects. More importantly, the ON pathway function can potentially serve as a surrogate for rod photoreceptor function.…”
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Dilemma of t-tests: Retaining or discarding choice and solutions by WenJun Zhang

“…In terms of significance test, the t-test has the general defects of statistical significance tests, coupled with the inherent fallacies of confidence intervals, and the peculiar uncertainty problems of t-intervals, make the t-test methodology obviously insufficient. …”
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Measuring F-actin properties in dendritic spines by Mikko eKoskinen, Pirta eHotulainen

“…Synaptic stimulation rapidly changes the actin dynamics and many actin regulators have been shown to play roles in neuron functionality. Accordingly, defects in the regulation of the actin cytoskeleton in neurons have been implicated in memory disorders. …”
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Manifestation of glucose-6-phosphate dehydrogenase deficiency in the wake of new-onset type 1 diabetes mellitus: a case report by Sandhya Govindarajan, Imran Zamir, Sunil Bagewadi, Emily Moore

“…Abstract Background Diabetes mellitus is the most common metabolic disease globally, while glucose-6-phosphate dehydrogenase deficiency, an X-linked inherited disorder, is the most common erythrocyte enzyme defect. The association between the two in children has been infrequently reported. …”
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Analysis, Modeling and Simulation of Mechatronic Systems using the Bond Graph Method by A. Alabakhshizadeh, Y. Iskandarani, G. Hovland, O. M. Midtgård

“…The Bond Graph is the proper choice of physical system used for: (i) Modeling which can be applied to systems combining multidisciplinary energy domains, (ii) Analysis to provide a great value proposition for finding the algebraic loops within the system enabling the process of troubleshooting and eliminating the defects by using the proper component(s) to fix the causality conflict even without being acquainted in the proper system, and (iii) Simulation facilitated through derived state space equations from the Bond Graph model is solved using industrial simulation software, such as 20-Sim. …”
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36-year Follow-up on Scalp Reconstruction Using Free Latissimus Dorsi Muscle Flap, Skin Grafting, and Scalp Expansion by Nourollah B. Ghorbani, MD

“…Then, scalp tissue surrounding the defect and forehead skin were expanded and used to restore the scalp to its original shape. …”
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Do Enamelin, Lactotransferrin, and Amelogenin-X Polymorphisms Predispose Dental Caries Susceptibility in Egyptian Children? A Cross-Sectional Study by Hassan Mossad Hassan Negm

“…These particular polymorphisms exhibited a noteworthy presence or occurrence rate in individuals who were more prone to developing dental caries.Conclusion ENAM rs3796703, AMELX rs946252 were frequently detected in the caries-susceptible group, suggesting the possible correlation between the defect in these proteins and the incidence of developing dental caries. …”
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A rare case of dysferlinopathy with paternal isodisomy for chromosome 2 determined by exome sequencing by Huan Li, Liang Wang, Cheng Zhang

“…Abstract Background Dysferlinopathies are autosomal recessive muscular dystrophies resulting from defects in DYSF (MIM: 603009), which is located on chromosome 2p13 and encodes the dysferlin protein. …”
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A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair. by Alexander F Bruns, Nadira Yuldasheva, Antony M Latham, Leyuan Bao, Caroline Pellet-Many, Paul Frankel, Sam L Stephen, Gareth J Howell, Stephen B Wheatcroft, Mark T Kearney, Ian C Zachary, Sreenivasan Ponnambalam

“…Depletion of either HSP70 or HSP90 caused defects in blood vessel formation in a transgenic zebrafish model. …”
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Seroprevalence of high incidence congenital infections among pregnant women in Coatepeque, Guatemala and surrounding areas, 2017-2018. by Victoria J Hicks, César Sánchez, María Reneé López, Anna Gottschlich, Laura M Grajeda, Amanda Balish, Ana Gómez, Nevis Nuñez, Julio Juárez, Beatriz López, Mariangeli Freitas-Ning, Celia Cordón-Rosales, Manuel Sagastume, John P McCracken, Andrés Espinosa-Bode, Loren Cadena, Terrence Q Lo

“…Maternal infections during pregnancy can potentially cause birth defects and severe adverse effects in infants. From 2017 to 2018, we investigated the seroprevalence of five antibodies among 436 mother-infant pairs enrolled in a pregnancy cohort study in Coatepeque, Guatemala. …”
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Whole transcriptome RNA-seq reveals key regulatory factors involved in type 2 diabetes pathology in peripheral fat of Asian Indians by Aditya Saxena, Nitish Mathur, Pradeep Tiwari, Sandeep Kumar Mathur

“…In conclusions, this RNS-Seq study finds that peripheral subcutaneous adipose tissue among Asian Indians show pathology characterized by altered lipid, glucose and protein metabolism, adipogenesis defect and inflammation. A network of regulatory transcription factors, protein kinases and microRNAs have been imputed which converge on the process of adipogenesis. …”
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VISUAL EVOKED POTENTIALS OF SICK INFANTS WITH EPILEPSY by V. P. Zykov, I. M. Mosin, D. L. Safronov, E. B. Izumova, I. L. Stepanishev, O. A. Voronenko

“…The first group consisted of 19 sick infants with symptomatic epilepsy, the second – 10 infants with motor defect without epilepsy, the third – 10 healthy infants. …”
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The Drosophila melanogaster Y-linked gene, WDY, is required for sperm to swim in the female reproductive tract by Yassi Hafezi, Arsen Omurzakov, Jolie A. Carlisle, Ian V. Caldas, Mariana F. Wolfner, Andrew G. Clark

“…Finally, we show that mutants for another Y-linked gene, PRY, also show a sperm storage defect that may explain their subfertility. Overall, we provide direct evidence for the long-held presumption that protein-coding genes on the Drosophila Y regulate sperm motility.…”
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Surgical Repair of Symptomatic Chronic Achilles Tendon Rupture Using Synthetic Graft Augmentation by Ahmed Shoaib MBBS, MRCS, Viren Mishra MS Orth, MSc Orth Engineering, FRCS(Orth)

“…Category: Other Introduction/Purpose: Surgical repair of symptomatic chronic Achilles tendon (TA) rupture is a challenging problem due to the presence of large defect between tendon edges. We report the results of surgical repair of symptomatic chronic TA rupture by synthetic graft augmentation. …”
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Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells. by Lisa Yu, Andres Lopez, Abderrahmane Anaflous, Brahim El Bali, Abdellah Hamal, Elke Ericson, Lawrence E Heisler, Angus McQuibban, Guri Giaever, Corey Nislow, Charles Boone, Grant W Brown, Mohammed Bellaoui

“…Using validated chemogenomic assays in Saccharomyces cerevisiae, we discovered that two closely related compounds, an imidazo[1,2-a]pyridine and -pyrimidine that differ by a single atom, have distinctly different mechanisms of action in vivo. 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine was toxic to yeast strains with defects in electron transport and mitochondrial functions and caused mitochondrial fragmentation, suggesting that compound 13 acts by disrupting mitochondria. …”
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Gene expression in a Drosophila model of mitochondrial disease. by Daniel J M Fernández-Ayala, Shanjun Chen, Esko Kemppainen, Kevin M C O'Dell, Howard T Jacobs

“…<h4>Background</h4>A point mutation in the Drosophila gene technical knockout (tko), encoding mitoribosomal protein S12, was previously shown to cause a phenotype of respiratory chain deficiency, developmental delay, and neurological abnormalities similar to those presented in many human mitochondrial disorders, as well as defective courtship behavior.<h4>Methodology/principal findings</h4>Here, we describe a transcriptome-wide analysis of gene expression in tko(25t) mutant flies that revealed systematic and compensatory changes in the expression of genes connected with metabolism, including up-regulation of lactate dehydrogenase and of many genes involved in the catabolism of fats and proteins, and various anaplerotic pathways. …”
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Prestige, manipulation, and coercion : elite power struggles and the fate of three revolutions by Torigian, Joseph (Joseph P.)

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How to improve M&A loans in China : a comparison and risk management angle by Liu, Xiaohua, S.M. Sloan School of Management

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Optimizing chemical-vapor-deposition diamond for nitrogen-vacancy center ensemble magnetometry by Alsid, Scott T

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Smoothing silver nanowires for optoelectronic applications by Swartwout, Richard Michael Steuben

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