Dextropropoxyphene hydrochloride by 982 SIRIM

Subjects: “…Dextropropoxyphene hydrochloride…”

Dextropropoxyphene induced hepatotoxicity: a report of nine cases. by Rosenberg, WM, Ryley, N, Trowell, J, McGee, J, Chapman, R

“…Nine patients are described with jaundice, upper abdominal pain and malaise attributable to dextropropoxyphene hepatotoxicity. In each case the history was suggestive of large bile duct obstruction. …”

Co-proxamol and suicide: preventing the continuing toll of overdose deaths. by Simkin, S, Hawton, K, Sutton, L, Gunnell, D, Bennewith, O, Kapur, N

“…The problem of self-poisoning with the prescription-only drug co-proxamol (dextropropoxyphene plus paracetamol) has received attention in several countries. …”

A conservative method of testing whether combination analgesics produce additive or synergistic effects using evidence from acute pain and migraine. by Moore, R, Derry, C, Derry, S, Straube, S, McQuay, H

“…This was true for combinations of paracetamol plus ibuprofen and paracetamol plus opioids in acute pain, and naproxen plus sumatriptan in migraine, but not where efficacy was very low or very high, nor combinations of paracetamol plus dextropropoxyphene. There was no evidence of synergy, defined as supra-additive effects.…”

A conservative method of testing whether combination analgesics produce additive or synergistic effects using evidence from acute pain and migraine. by Moore, R, Derry, C, Derry, S, Straube, S, McQuay, H

“…This was true for combinations of paracetamol plus ibuprofen and paracetamol plus opioids in acute pain, and naproxen plus sumatriptan in migraine, but not where efficacy was very low or very high, nor combinations of paracetamol plus dextropropoxyphene. There was no evidence of synergy, defined as supra-additive effects.…”

Use of analgesics in intentional drug overdose presentations to hospital before and after the withdrawal of distalgesic from the Irish market. by Corcoran, P, Reulbach, U, Keeley, H, Perry, I, Hawton, K, Arensman, E

“… BACKGROUND: Distalgesic, the prescription-only analgesic compound of paracetamol (325 mg) and dextropropoxyphene (32.5 mg) known as co-proxamol in the UK, was withdrawn from the Irish market as of January 2006. …”

Relative toxicity of analgesics commonly used for intentional self-poisoning: a study of case fatality based on fatal and non-fatal overdoses by Hawton, K, Ferrey, A, Casey, D, Wells, C, Fuller, A, Bankhead, C, Clements, C, Ness, J, Gunnell, D, Kapur, N, Geulayov, G

“…<br/><br/> <strong>Methods</strong> Using data for 2005–2012 we investigated case fatality (number of suicides relative to number of non-fatal self-poisonings) of paracetamol, aspirin, codeine, dihydrocodeine, tramadol, paracetamol with codeine (co-codamol), paracetamol with dihydrocodeine (co-dydramol), ibuprofen and co-proxamol (paracetamol plus dextropropoxyphene; withdrawn in the UK in 2008 due to high toxicity). …”

Six-year follow-up of impact of co-proxamol withdrawal in England and Wales on prescribing and deaths: time-series study. by Hawton, K, Bergen, H, Simkin, S, Wells, C, Kapur, N, Gunnell, D

“…BACKGROUND: The analgesic co-proxamol (paracetamol/dextropropoxyphene combination) has been widely involved in fatal poisoning. …”

Trends of dispensed opioids in Catalonia, Spain, 2007–19: a population-based cohort study of over 5 million individuals by Xie, J, Strauss, VY, Collins, GS, Khalid, S, Delmestri, A, Turkiewicz, A, Englund, M, Tadrous, M, Reyes, C, Prieto-Alhambra, D

“…<br><strong> Main exposure and outcomes: </strong>The exposures were all commercialized opioids and their combinations (ATC-codes): codeine, tramadol, oxycodone, tapentadol, fentanyl, morphine, and other opioids (dihydrocodeine, hydromorphone, dextropropoxyphene, buprenorphine, pethidine, pentazocine). …”

Single dose oral analgesics for acute postoperative pain in adults. by Moore, R, Derry, S, McQuay, H, Wiffen, P

“…Inadequate amounts of data were available for dexibuprofen, dextropropoxyphene 130 mg, diflunisal 125 mg, etoricoxib 60 mg, fenbufen, and indometacin. …”

Single dose oral analgesics for acute postoperative pain in adults. by Moore, R, Derry, S, McQuay, H, Wiffen, P

“…Inadequate amounts of data were available for dexibuprofen, dextropropoxyphene 130 mg, diflunisal 125 mg, etoricoxib 60 mg, fenbufen, and indometacin. …”