Dextropropoxyphene hydrochloride by 982 SIRIM

Subjects: “…Dextropropoxyphene hydrochloride…”

Dextropropoxyphene induced hepatotoxicity: a report of nine cases. by Rosenberg, WM, Ryley, N, Trowell, J, McGee, J, Chapman, R

“…Nine patients are described with jaundice, upper abdominal pain and malaise attributable to dextropropoxyphene hepatotoxicity. In each case the history was suggestive of large bile duct obstruction. …”

Study of sociodemographic correlates, anxiety, and depression among opioid dependents admitted in treatment centres in Sikkim, India by Bishnu Sharma, Samrat Singh Bhandari, Sanjiba Dutta, Geeta Soohinda

Subjects: “…Rehabilitation. Mania. Dextropropoxyphene. Codeine. Sikkim.…”
Get full text

Intravenous buprenorphine does not impair psychomotor and cognitive functioning in opioid-dependent patients using oral dextropropoxyphene: A randomized, double-blind, crossover study by Shri Gopal Goyal, Atul Ambekar, Raka Jain, Manju Mehta, Ashwani Kumar Mishra

Subjects: Get full text

Co-proxamol and suicide: preventing the continuing toll of overdose deaths. by Simkin, S, Hawton, K, Sutton, L, Gunnell, D, Bennewith, O, Kapur, N

“…The problem of self-poisoning with the prescription-only drug co-proxamol (dextropropoxyphene plus paracetamol) has received attention in several countries. …”

Musculoskeletal pain: prescription of NSAID and weak opioid by primary health care physicians in Sweden 2004–2008 – a retrospective patient record review by Metha Brattwall, Ibrahim Turan, Jan Jakobsson

“…The impact on gastrointestinal and cardiovascular adverse effects associated with the extensive prescription of NSAIDS for musculoskeletal pain warrants further analysis.Keywords: nonsteroidal anti-inflammatory drugs, tramadol, codeine, dextropropoxyphene, primary care, pattern of use, pharmacoepidemiology…”
Get full text

A conservative method of testing whether combination analgesics produce additive or synergistic effects using evidence from acute pain and migraine. by Moore, R, Derry, C, Derry, S, Straube, S, McQuay, H

“…This was true for combinations of paracetamol plus ibuprofen and paracetamol plus opioids in acute pain, and naproxen plus sumatriptan in migraine, but not where efficacy was very low or very high, nor combinations of paracetamol plus dextropropoxyphene. There was no evidence of synergy, defined as supra-additive effects.…”

A conservative method of testing whether combination analgesics produce additive or synergistic effects using evidence from acute pain and migraine. by Moore, R, Derry, C, Derry, S, Straube, S, McQuay, H

“…This was true for combinations of paracetamol plus ibuprofen and paracetamol plus opioids in acute pain, and naproxen plus sumatriptan in migraine, but not where efficacy was very low or very high, nor combinations of paracetamol plus dextropropoxyphene. There was no evidence of synergy, defined as supra-additive effects.…”

Potentially inappropriate medication use: the Beers' Criteria used among older adults with depressive symptoms by Lee D, Martini N, Moyes S, Hayman K, Zolezzi M, Kerse N

“…The most commonly prescribed potentially inappropriate medications were amitriptyline, dextropropoxyphene, quinine and benzodiazepines. Almost half (49%) of the participants were prescribed at least one potentially inappropriate medication; 29% were considered to suffer significant depressive symptoms (Geriatric Depression Scale ≥5) and no differences were found in the number of inappropriate medications used between those with and without significant depressive symptoms (Chi-square 0.005 p=0.54). …”
Get full text

Pharmaceutical services in a Mexican pain relief and palliative care institute by Escutia Gutierrez R, Cortéz Alvarez CR, Álvarez Alvarez RM, Flores Hernandez JL, Gutiérrez Godinez J, López y Lopez JG

“…The frequently used drugs were morphine sulfate (62%), amitriptyline (6.4%), and dextropropoxyphene (5.8%). The Drug Information Service answered 114 consultations, mainly asked by a physician (71%) concerned with adverse drug reactions and contraindications (21%). …”
Get full text

Use of analgesics in intentional drug overdose presentations to hospital before and after the withdrawal of distalgesic from the Irish market. by Corcoran, P, Reulbach, U, Keeley, H, Perry, I, Hawton, K, Arensman, E

“… BACKGROUND: Distalgesic, the prescription-only analgesic compound of paracetamol (325 mg) and dextropropoxyphene (32.5 mg) known as co-proxamol in the UK, was withdrawn from the Irish market as of January 2006. …”

Relative toxicity of analgesics commonly used for intentional self-poisoning: a study of case fatality based on fatal and non-fatal overdoses by Hawton, K, Ferrey, A, Casey, D, Wells, C, Fuller, A, Bankhead, C, Clements, C, Ness, J, Gunnell, D, Kapur, N, Geulayov, G

“…<br/><br/> <strong>Methods</strong> Using data for 2005–2012 we investigated case fatality (number of suicides relative to number of non-fatal self-poisonings) of paracetamol, aspirin, codeine, dihydrocodeine, tramadol, paracetamol with codeine (co-codamol), paracetamol with dihydrocodeine (co-dydramol), ibuprofen and co-proxamol (paracetamol plus dextropropoxyphene; withdrawn in the UK in 2008 due to high toxicity). …”

Six-year follow-up of impact of co-proxamol withdrawal in England and Wales on prescribing and deaths: time-series study. by Keith Hawton, Helen Bergen, Sue Simkin, Claudia Wells, Navneet Kapur, David Gunnell

“…The analgesic co-proxamol (paracetamol/dextropropoxyphene combination) has been widely involved in fatal poisoning. …”
Get full text

Six-year follow-up of impact of co-proxamol withdrawal in England and Wales on prescribing and deaths: time-series study. by Hawton, K, Bergen, H, Simkin, S, Wells, C, Kapur, N, Gunnell, D

“…BACKGROUND: The analgesic co-proxamol (paracetamol/dextropropoxyphene combination) has been widely involved in fatal poisoning. …”

Trends of dispensed opioids in Catalonia, Spain, 2007–19: a population-based cohort study of over 5 million individuals by Xie, J, Strauss, VY, Collins, GS, Khalid, S, Delmestri, A, Turkiewicz, A, Englund, M, Tadrous, M, Reyes, C, Prieto-Alhambra, D

“…<br><strong> Main exposure and outcomes: </strong>The exposures were all commercialized opioids and their combinations (ATC-codes): codeine, tramadol, oxycodone, tapentadol, fentanyl, morphine, and other opioids (dihydrocodeine, hydromorphone, dextropropoxyphene, buprenorphine, pethidine, pentazocine). …”

Understanding the association between injecting and sexual risk behaviors of injecting drug users in Manipur and Nagaland, India by Suohu Khrieketou, Humtsoe Chumben, Saggurti Niranjan, Sabarwal Shrutika, Mahapatra Bidhubhusan, Kermode Michelle

“…In Nagaland, where Spasmoproxyvon (SP, a synthetic opioid analgesic that contains dextropropoxyphene, dicyclomine hydrochloride and paracetamol) is most common, regular injectors as compared to occasional injectors were more likely to report multiple sex partners (67% vs. 42%, AOR: 2.7, CI: 1.8-4.1) and sex with paid partners (13% vs. 3%, AOR: 6.0, CI: 3.0-12.1). …”
Get full text

Postoperative analgesia and vomiting, with special reference to day-case surgery: a systematic review. by McQuay, Moore

“…RESULTS-ANALGESIA, INTERVENTIONS OF PROVEN VALUE: These include a number of oral analgesics including (at standard doses): (1) dextropropoxyphene; (2) tramadol; (3) paracetamol; (4) ibuprofen; (5) diclofenac. …”
Get full text

Trends of Dispensed Opioids in Catalonia, Spain, 2007–19: A Population-Based Cohort Study of Over 5 Million Individuals by Junqing Xie, Victoria Y. Strauss, Gary S. Collins, Gary S. Collins, Sara Khalid, Antonella Delmestri, Aleksandra Turkiewicz, Martin Englund, Mina Tadrous, Carlen Reyes, Carlen Reyes, Daniel Prieto-Alhambra

“…Objective: To characterize the trend of opioid use (number of users, dispensations and oral morphine milligram equivalents) in Catalonia (Spain).Design, setting, and participants: This population-based cohort study included all individuals aged 18 years or older, registered in the Information System for Research in Primary Care (SIDIAP), which covers &gt;75% of the population in Catalonia, Spain, from 1 January 2007, to 31 December 2019.Main exposure and outcomes: The exposures were all commercialized opioids and their combinations (ATC-codes): codeine, tramadol, oxycodone, tapentadol, fentanyl, morphine, and other opioids (dihydrocodeine, hydromorphone, dextropropoxyphene, buprenorphine, pethidine, pentazocine). …”
Get full text

Dataset of the first report of pharmacogenomics profiling in an outpatient spine setting by Ethan Cottrill, Zach Pennington, Chun Wan Jeffrey Lai, Jeff Ehresman, Bowen Jiang, A. Karim Ahmed, Alex Zhu, Alexander Perdomo-Pantoja, Daniel M. Sciubba, Timothy Witham, Chun Hin Lee, Kevin MacDonald, Nicholas Theodore

“…These medications included both non-opioid analgesics (i.e., aspirin, diclofenac, nabumetone, indomethacin, meloxicam, piroxicam, tenoxicam, lornoxicam, celecoxib, ibuprofen, flurbiprofen, ketoprofen, fenoprofen, naproxen, and mefenamic acid) and opioid analgesics (i.e., morphine, codeine, dihydrocodeine, ethylmorphine, hydrocodone, hydromorphone, oxycodone, oxymorphone, alfentanil, fentanyl, sufentanil, meperidine, ketobemidone, dextropropoxyphene, levacetylmethadol, loperamide, methadone, buprenorphine, dextromethorphan, tramadol, tapentadol, and tilidine). …”
Get full text

Single dose oral analgesics for acute postoperative pain in adults. by Moore, R, Derry, S, McQuay, H, Wiffen, P

“…Inadequate amounts of data were available for dexibuprofen, dextropropoxyphene 130 mg, diflunisal 125 mg, etoricoxib 60 mg, fenbufen, and indometacin. …”