The concept of hemostasis disorders in severe leptospirosis by D. L. Moisova, V. N. Gorodin

“…Relative risk (RR) was calculated with a 95% confidence interval (CI).Results: the use of early diagnosis of coagulopathy variants and the use of a differentiated therapy regimen in the choice of the variant of hemostasis disorder led to a decrease of mortality from 16.45% to 11.5% and decrease in the consumption of platelet concentrate and fresh frozen plasma.Conclusion: patients with severe leptospirosis develop a multivariate hemostatic pathology: isolated thrombocytopenia (38%) with thrombotic microangiopathy (20,5%), disseminated intravascular coagulopathy (37,1%), uremic coagulopathy (4,9%), hepatic coagulopathy (3,4%). …”
Get full text

Media Use and Physical Activity Behaviour of Adolescent Participants in Obesity Therapy: Impact Analysis of Selected Socio-Demographic Factors by Hagen Wulff, Petra Wagner

“…Girls were found to use mobile phones for longer (2.49 vs. 1.90; p Conclusion: Compared to current recommendations, the sample shows reduced physical activity and increased media use, which vary between the groups. Hence, differentiated therapy approaches appear recommendable. Future research needs to evaluate, how media (despite its risks) can facilitate therapy, training and aftercare concepts.…”
Get full text

CYTOKINES IN THE DIAGNOSIS OF THE SEVERITY OF THE ACTIVE PHASE OF CHRONIC PYELONEPHRITIS by D. G. Korenkov, A. L. Pavlov

“…Determination of proinflammatory cytokines in the diagnosis of the severity of pyelonephritis flow has a large diagnostic and differential diagnostic significance that will allow for differentiated therapy depending on the severity of the inflammatory process and improve the results of treatment.…”
Get full text

Analytical review of 664 cases of penetrating buttock trauma by Schulte Klaus-Martin, Lunevicius Raimundas

“…Sharp differences in injury pattern endorse an algorithm for differential therapy of penetrating buttock trauma. In conclusion, penetrating buttock trauma should be regarded as a life-threatening injury with impact beyond the pelvis until proven otherwise.…”
Get full text

Relationship between anal symptoms and anal findings by Hans Georg Kuehn, Ole Gebbensleben, York Hilger, Henning Rohde

“…</p> <p><b>Conclusions: </b>The knee-chest position may allow for the accumulation of more detailed information about BAD than the left lateral Sims' position, thus enabling physicians to make more reliable anal diagnoses and provide better differentiated therapies.</p>…”
Get full text

Structure based design and synthesis of peptide inhibitor of human LOX-12: in vitro and in vivo analysis of a novel therapeutic agent for breast cancer. by Abhay Kumar Singh, Ratnakar Singh, Farhat Naz, Shyam Singh Chauhan, Amit Dinda, Abhay Anand Shukla, Kamaldeep Gill, Vaishali Kapoor, Sharmistha Dey

“…This peptide can be used as a lead compound and complement for ongoing efforts to develop differentiation therapies for breast cancer.…”
Get full text

Central Hemodynamics and Intracranial and Cerebral Perfusion Pressures in Acute Cerebral Circulatory Disorders by K. V. Lukashev, A. Z. Valiakhmedov, Yu. A., Churlyaev, L. Yu. Redkokasha, T. I. Borshchikova, P. G. Sitnikov, T. P. Aikina

“…Objective: to study the central hemodynamics (CH) and intracranial and cerebral perfusion pressures (ICP and CPP) in acute cerebral circulatory disorders (ACCD) and their possible relationships for further development of intensive differential therapy for the detected disorders. Material and methods. …”
Get full text

Characterising early human lympho-myeloid haematopoietic progenitors and their relationship with acute myeloid leukaemia stem cells by Aboukhalil, Z

“…Firstly, a more thorough understanding of the process of normal lympho-myeloid differentiation may aid the development of differentiation therapies. Secondly, by identifying functionally relevant markers of the leukaemia stem cell, treatments targeting the apex of the leukaemic hierarchy may be developed. …”

Modulation of redox-sensitive transcription factors with polyphenols as pathogenetically grounded approach in therapy of systemic inflammatory response by Vitalii Kostenko, Oleh Akimov, Oleksandr Gutnik, Heorhii Kostenko, Viktoriia Kostenko, Tamara Romantseva, Yevhen Morhun, Svitlana Nazarenko, Olena Taran

“…The leading role in this process is played by the Systemic Inflammatory Response that is accompanied by the production of pro- and anti-inflammatory cytokines, acute phase proteins, and reactive oxygen and nitrogen species.The purpose of this review that highlights both the recent reports and the results of the authors' own research is to encourage scientists to develop new approaches to the differentiated therapy of various SIR manifestations (low- and high-grade systemic inflammatory response phenotypes) by modulating redox-sensitive transcription factors with polyphenols and to evaluate the saturation of the pharmaceutical market with appropriate dosage forms tailored for targeted delivery of these compounds.Redox-sensitive transcription factors such as NFκB, STAT3, AP1 and Nrf2 have a leading role in mechanisms of the formation of low- and high-grade systemic inflammatory phenotypes as variants of SIR. …”
Get full text

Fbxw7-associated drug resistance is reversed by induction of terminal differentiation in murine intestinal organoid culture by Federica Lorenzi, Roya Babaei-Jadidi, Jonathan Sheard, Bradley Spencer-Dene, Abdolrahman S Nateri

“…Our results support the hypothesis that a differentiating therapy successfully targets FBXW7-mutated CRC cells.…”
Get full text

Improving diagnosis and treatment for endometrial polyp by L. Yu. Bagdasaryan, V. V. Ponomarev, G. A. Penghoyan

“…Immunohistochemical estimators can be used for differentiating therapy, which allowed a 70.3% pregnancy success rate.…”
Get full text

Possibilities of colecalciferol therapy for tension type headache combined with hypovitaminosis D by A. A. Koloskova, O. V. Vorob’eva

“…The patients received differentiated therapy for 16 weeks: group 1 – colecalciferol, group 2 – amitriptyline, group 3 – a combination of these medicines. …”
Get full text

Clinical and electroencephalographic characteristics of chronic tic disorders in children and adolescents by N. A. Ermolenko, E. I. Zakharova, I. A. Buchneva

“…The investigation consisted of two steps: 1) clinical, laboratory, and neurophysiologic  examination; 2) differentiated therapy. The Yaele Global Tic Severity Scale (YGTSS) was used. …”
Get full text

<i>miR-7</i> Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation by Lavanya Adusumilli, Nicola Facchinello, Cathleen Teh, Giorgia Busolin, Minh TN Le, Henry Yang, Giorgia Beffagna, Stefano Campanaro, Wai Leong Tam, Francesco Argenton, Bing Lim, Vladimir Korzh, Natascia Tiso

“…Being mediated by a microRNA, this mechanism represents a promising target in cell differentiation therapies for Parkinson&#8217;s disease.…”
Get full text

Results of differential treatment of children with juvenile myelomonocytic leukemia with 13-cis retinoic acid and low dose cytosine-arabinoside by L. A. Khachatrian, M. A. Maschan, Ye. V. Samochatova, M. M. Schneider, D. D. Baidildina, G. G. Solopova, Ye. V. Suntzova, L. I. Zjarikova, U. N. Petrova, V. V. Sinitsina, G. A. Novichkova, A. A. Maschan

“…Prognosis of patients with juvenile myelomonocytic leukemia not undergoing allogeneic hematopoietic cells transplantation (SCT) is dismal and not affected by any cytotoxic chemotherapy. Differentiating therapy is an attractive approach in JMML, due to ability of JMML cells to differentiate and die under influence of treatment with various agents in vitro. …”
Get full text

CHRONIC ENDOMETRITIS: CURRENT ASPECTS by V. E. RADZINSKY, Yu. A. PETROV, M. L. PОLINA

“…The study of signalling chain markers of control over proliferative cascades at the endometrial level in comparison with the response to the introduction of a pathogenic infection and morphological transformations promotes the expansion of the concept of pathogenetic CE variants, and therefore, the choice of differentiated therapy for the purpose of restoring the fertile potential after reproductive losses.…”
Get full text

Peculiarities of the influence of antihypertensive therapy on endothelial function, oxidative stress and immune activation in obese patients by T. V. Ashcheulova, N. N. Gerasimchuk

“…Thus, the improvement of endothelial function, a significant decrease in autoimmune activation due to lower tension of oxidative stress in the examined patients optimizes use of a combination of bisoprolol and indapamid for differentiated therapy in hypertensive patients with obesity.…”
Get full text

The accuracy of initial diagnoses in coma: an observational study in 835 patients with non-traumatic disorder of consciousness by Maximilian Lutz, Martin Möckel, Tobias Lindner, Christoph J. Ploner, Mischa Braun, Wolf Ulrich Schmidt

“…CUE is associated with a high mortality and a wide variety of pathologies that require differential therapies. A suspected diagnosis issued by pre-hospital emergency care providers often drives the first approach to these patients. …”
Get full text

Factors of lumbosacral radiculopathy chronicity by L. A. Dziak, O. O. Shulha, V. M. Suk

“…Assessment of the factors that determine the chronicity of the course in the acute period of the disease allows to prescribe complex differential therapy at the early stage of the disease.…”
Get full text

Single-center, observational study of AML/MDS-EB with IDH1/2 mutations: genetic profile, immunophenotypes, mutational kinetics and outcomes by Vasiliki Papadopoulou, Jacqueline Schoumans, Valentin Basset, Françoise Solly, Jérôme Pasquier, Sabine Blum, Olivier Spertini

“…NPM1-IDH1/2 mutated AML has a mature phenotype possibly amenable to differentiation therapies. IDH1/2 and SRSF2 mutations probably arise at the same developmental stage of the disease, as their allele burdens covariate. …”
Get full text