SHP1 and SHP2 inhibition enhances the pro-differentiative effect of phorbol esters: an alternative approach against acute myeloid leukemia by Alejandro Pérez-Fernández, Guillermo López-Ruano, Rodrigo Prieto-Bermejo, Carla Ijurko, María Díez-Campelo, Fermín Sánchez-Guijo, Ángel Hernández-Hernández

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Jiyuan Oridonin A Overcomes Differentiation Blockade in Acute Myeloid Leukemia Cells With MLL Rearrangements via Multiple Signaling Pathways by Mei Qu, Mei Qu, Yu Duan, Yu Duan, Min Zhao, Min Zhao, Zhanju Wang, Mengjie Zhao, Mengjie Zhao, Yao Zhao, Haihua Wang, Yu Ke, Ying Liu, Hong-Min Liu, Liuya Wei, Liuya Wei, Zhenbo Hu

Subjects: “…differentiation therapy…”
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Omics Technologies to Decipher Regulatory Networks in Granulocytic Cell Differentiation by Svetlana Novikova, Olga Tikhonova, Leonid Kurbatov, Tatiana Farafonova, Igor Vakhrushev, Alexey Lupatov, Konstantin Yarygin, Victor Zgoda

“…Induced granulocytic differentiation of human leukemic cells under all-<i>trans</i>-retinoid acid (ATRA) treatment underlies differentiation therapy of acute myeloid leukemia. Knowing the regulation of this process it is possible to identify potential targets for antileukemic drugs and develop novel approaches to differentiation therapy. …”
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Vitamin D Derivatives in Acute Myeloid Leukemia: The Matter of Selecting the Right Targets by Ewa Marcinkowska

“…A very attractive way to treat myeloid leukemia, called “differentiation therapy”, was proposed when in vitro studies showed that some compounds are capable of inducing differentiation of AML cell lines. …”
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Two cases of differentiation syndrome with ocular manifestations in patients with acute promyelocytic leukaemia treated with all-trans retinoic acid and arsenic trioxide by A.R. Newman, B. Leung, A. Richards, T.G. Campbell, J. Wellwood, F.R. Imrie

“…Both patients reported bilateral reduction in visual acuity at days fourteen and ten respectively following initiation of differentiation therapy in addition to developing other systemic manifestations of differentiation syndrome. …”
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Nuclear GRP75 binds retinoic acid receptors to promote neuronal differentiation of neuroblastoma. by Yu-Yin Shih, Hsinyu Lee, Akira Nakagawara, Hseuh-Fen Juan, Yung-Ming Jeng, Yeou-Guang Tsay, Dong-Tsamn Lin, Fon-Jou Hsieh, Chien-Yuan Pan, Wen-Ming Hsu, Yung-Feng Liao

“…Retinoic acid (RA) has been approved for the differentiation therapy of neuroblastoma (NB). Previous work revealed a correlation between glucose-regulated protein 75 (GRP75) and the RA-elicited neuronal differentiation of NB cells. …”
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Cytarabine-induced differentiation of AML cells depends on Chk1 activation and shares the mechanism with inhibitors of DHODH and pyrimidine synthesis by Barbara Tomic, Tomislav Smoljo, Hrvoje Lalic, Vilma Dembitz, Josip Batinic, Drago Batinic, Antonio Bedalov, Dora Visnjic

“…Abstract Acute myeloid leukemia (AML) is characterized by arrested differentiation making differentiation therapy a promising treatment strategy. Recent success of inhibitors of mutated isocitrate dehydrogenase (IDH) invigorated interest in differentiation therapy of AML so that several new drugs have been proposed, including inhibitors of dihydroorotate dehydrogenase (DHODH), an enzyme in pyrimidine synthesis. …”
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Retinoic Acid affects Lung Adenocarcinoma growth by inducing differentiation via GATA6 activation and EGFR and Wnt inhibition by Giovanni Zito, Flores Naselli, Laura Saieva, Stefania Raimondo, Giovanna Calabrese, Claudio Guzzardo, Stefano Forte, Christian Rolfo, Rosalba Parenti, Riccardo Alessandro

“…All together, these findings prove that differentiation therapy might be feasible in TKI resistant NSCLCs, and shed light on new targets to define new pharmacological therapies.…”
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Parbendazole as a promising drug for inducing differentiation of acute myeloid leukemia cells with various subtypes by Hidemasa Matsuo, Aina Inagami, Yuri Ito, Nana Ito, Shinju Iyoda, Yutarou Harata, Moe Higashitani, Kota Shoji, Miu Tanaka, Mina Noura, Takashi Mikami, Itaru Kato, Junko Takita, Tatsutoshi Nakahata, Souichi Adachi

“…Abstract Acute myeloid leukemia (AML) is a malignancy characterized by differentiation arrest of hematopoietic precursor cells. Differentiation therapy is effective for patients with acute promyelocytic leukemia; however, only a few effective differentiation therapies have been established for patients with other AML subtypes. …”
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Excellent treatment outcomes in children younger than 18 months with stage 4 nonamplified neuroblastoma by Chiwoo Kim, Young Bae Choi, Ji Won Lee, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo

“…Three years after chemotherapy completion, none of the patients had experienced grade ≥3 late adverse effects.ConclusionPatients younger than 18 months with stage 4 MYCN nonamplified neuroblastoma showed excellent outcomes, without significant late adverse effects, when treated with alternating cycles of CEDC and ICE, followed by surgery and differentiation therapy.…”
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Disruption of β-catenin-mediated negative feedback reinforces cAMP-induced neuronal differentiation in glioma stem cells by Zhijie Chen, Yingqian Zhong, Jiehong Chen, Shuxin Sun, Wenfeng Liu, Yu Han, Xincheng Liu, Cui Guo, Depei Li, Wanming Hu, Peiyu Zhang, Zhuopeng Chen, Zhongping Chen, Yonggao Mou, Guangmei Yan, Wenbo Zhu, Wei Yin, Ke Sai

“…Overall, our findings identified a negative feedback mechanism for cAMP-induced differentiation in GSCs and provided potential targets for the reinforcement of differentiation therapy for GBM.…”
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Characterization and therapeutic perspectives of differentiation-inducing therapy in malignant tumors by Kangwei Zhu, Yuren Xia, Xindi Tian, Yuchao He, Jun Zhou, Ruyu Han, Hua Guo, Tianqiang Song, Lu Chen, Xiangdong Tian

“…For example, differentiation therapy has become the first choice for acute promyelocytic leukemia, with the cure rate of more than 90%. …”
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The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on EMT-Related Proteins in Breast Cancer: Minireview by Pavel Bobal, Marketa Lastovickova, Janette Bobalova

“…The success of all-<i>trans</i> retinoic acid (ATRA) differentiation therapy in acute promyelocytic leukemia has stimulated studies in the treatment of other tumors with ATRA. …”
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CYTOPROTECTIVE AND NEUROTROPHIC THERAPY FOR CEREBRAL STROKE by M. Yu. Martynov, A. N. Yasamanova, I. A. Shchukin, T. I. Kolesnikova, V. I. Chubykin

“…<p>The paper gives the data of Russian and foreign studies on the pathophysiological mechanisms of brain injury in ischemic and hemorrhagic<br />stroke, the specific features of brain plasticity and its activation after cerebral stroke, and main directions for basic and differentiation therapy for acute cerebrovascular pathology. …”
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CYTOPROTECTIVE AND NEUROTROPHIC THERAPY FOR CEREBRAL STROKE by M. Yu. Martynov, A. N. Yasamanova, I. A. Shchukin, T. I. Kolesnikova, V. I. Chubykin

“…The paper gives the data of Russian and foreign studies on the pathophysiological mechanisms of brain injury in ischemic and hemorrhagicstroke, the specific features of brain plasticity and its activation after cerebral stroke, and main directions for basic and differentiation therapy for acute cerebrovascular pathology. …”
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Multi-Omics Investigation to on the Effect of Replication Stress on Leukemia Cells by Vermeulen, Sidney

“…Differentiation therapy has the potential to treat cancers like acute myeloid leukemia. …”
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cFos mediates cAMP-dependent generation of ROS and rescue of maturation program in retinoid-resistant acute promyelocytic leukemia cell line NB4-LR1. by Jean-Luc Carrier, Pasha Javadi, Emilie Bourrier, Céline Camus, Evelyne Ségal-Bendirdjian, Aïda Karniguian

“…A determining role has been assigned to cAMP in the signaling pathways that relieve resistance to anti-leukemia differentiation therapy. However, the underlying mechanisms have not been elucidated yet. …”
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Analysis of the management of hypertension complications in patients during emergency care by A R Alpysova, Yu V Subbota, A K Adambekova, N T Telembetov, M Maratkyzy

“…When emergency care was rendered, differentiation therapy for hypertension complications was not always withstood; the use of drugs was noted to be unwarranted and contrary to the data of evidence-based medicine. …”
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RHEUMATOID ARTHRITIS: THE PROBLEMS OF REMISSION AND THERAPY RESISTANCE by E. L. Nasonov, Yu. A. Olyunin, A. M. Lila

“…Further investigations are needed to study the nature of heterogeneity of pathogenetic mechanisms of RA and approaches to early diagnosis, to improve methods for monitoring disease activity and biomarkers for the efficiency of and resistance to therapy and, finally, to develop differentiation therapy, including those related to a search for new therapeutic targets.…”
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Prediction of neuroblastoma cell response to treatment with natural or synthetic retinoids using selected protein biomarkers. by Viera Dobrotkova, Petr Chlapek, Marta Jezova, Katerina Adamkova, Pavel Mazanek, Jaroslav Sterba, Renata Veselska

“…Our study focused on the comparative analysis of the expression of five genes and corresponding proteins (DDX39A, HMGA1, HMGA2, HOXC9 and PBX1) that have recently been discussed as possible predictive biomarkers of clinical response to retinoid differentiation therapy. Expression of these five candidate biomarkers was evaluated at both the mRNA and protein level in the same subset of 8 neuroblastoma cell lines after treatment with natural or synthetic retinoids. …”
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