Cellular hierarchy insights reveal leukemic stem-like cells and early death risk in acute promyelocytic leukemia by Wen Jin, Yuting Dai, Li Chen, Honghu Zhu, Fangyi Dong, Hongming Zhu, Guoyu Meng, Junmin Li, Saijuan Chen, Zhu Chen, Hai Fang, Kankan Wang

“…Abstract Acute promyelocytic leukemia (APL) represents a paradigm for targeted differentiation therapy, with a minority of patients experiencing treatment failure and even early death. …”
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Androgen promotes squamous differentiation of atypical cells in cervical intraepithelial neoplasia via an ELF3‐dependent pathway by Takeo Matsumoto, Takuma Suzuki, Mitsuhiro Nakamura, Megumi Yamamoto, Takashi Iizuka, Masanori Ono, Kyosuke Kagami, Haruki Kasama, Tatsuhito Kanda, Yuya Sakai, Junpei Iwadare, Ayumi Matsuoka, Kayo Kayahashi, Kousho Wakae, Masamichi Muramatsu, Satoru Kyo, Yasuhiko Yamamoto, Yasunari Mizumoto, Takiko Daikoku, Hiroshi Fujiwara

“…Conclusion Androgen is a novel factor that regulates squamous differentiation in the early stage of CIN, providing a new strategy for nonsurgical and hormone‐induced differentiation therapy against CIN1 and CIN2.…”
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Dual inhibition of EZH2 and G9A/GLP histone methyltransferases by HKMTI-1-005 promotes differentiation of acute myeloid leukemia cells by Y. Sbirkov, Y. Sbirkov, Y. Sbirkov, T. Schenk, T. Schenk, T. Schenk, C. Kwok, S. Stengel, S. Stengel, R. Brown, G. Brown, L. Chesler, A. Zelent, A. Zelent, M. J. Fuchter, K. Petrie, K. Petrie

“…All-trans-retinoic acid (ATRA)-based differentiation therapy of acute promyelocytic leukemia (APL) represents one of the most clinically effective examples of precision medicine and the first example of targeted oncoprotein degradation. …”
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Differential regulation of H3K9/H3K14 acetylation by small molecules drives neuron-fate-induction of glioma cell by Xincheng Liu, Cui Guo, Tiandong Leng, Zhen Fan, Jialuo Mai, Jiehong Chen, Jinhai Xu, Qianyi Li, Bin Jiang, Ke Sai, Wenzhuo Yang, Jiayu Gu, Jingyi Wang, Shuxin Sun, Zhijie Chen, Yingqian Zhong, Xuanming Liang, Chaoxin Chen, Jing Cai, Yuan Lin, Jiankai Liang, Jun Hu, Guangmei Yan, Wenbo Zhu, Wei Yin

“…Abstract Differentiation therapy using small molecules is a promising strategy for improving the prognosis of glioblastoma (GBM). …”
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The Anti-Warburg Effect Elicited by the cAMP-PGC1α Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes by Fan Xing, Yizhao Luan, Jing Cai, Sihan Wu, Jialuo Mai, Jiayu Gu, Haipeng Zhang, Kai Li, Yuan Lin, Xiao Xiao, Jiankai Liang, Yuan Li, Wenli Chen, Yaqian Tan, Longxiang Sheng, Bingzheng Lu, Wanjun Lu, Mingshi Gao, Pengxin Qiu, Xingwen Su, Wei Yin, Jun Hu, Zhongping Chen, Ke Sai, Jing Wang, Furong Chen, Yinsheng Chen, Shida Zhu, Dongbing Liu, Shiyuan Cheng, Zhi Xie, Wenbo Zhu, Guangmei Yan

“…Summary: Glioblastoma multiforme (GBM) is among the most aggressive of human cancers. Although differentiation therapy has been proposed as a potential approach to treat GBM, the mechanisms of induced differentiation remain poorly defined. …”
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Differential approach to treatment of primary nocturnal enuresis in children by Nesterenko O.V., Goremykin V.I., Koroleva I.V., Elizarova S.U., Sidorovich O.V.

“…The aim of the work is to develop an algorithm of differentiated therapy in children with PNE. 234 children aged 5-15 years were studied. …”
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Differentiated treatment of patients with acne and concomitant candida infection by Yaakubi Randa

“…Aim of the research was to study the effect of the recommended differentiated therapy on the pathogenetic disorders in patients with acne and concomitant Candida infection. …”
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CLASSIFICATION AND DIAGNOSTICS OF ANEMIA IN CHILDREN by A. G. Rumyantsev

“…Diagnostics makes accent on laboratory analysis; they are the basis of differential diagnosis and differential therapy of anemia in children.…”
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Eosinophils as a non-invasive marker to assess inflammatory activities in those suffering from chronic obstructive pulmonary disease by M. A. Kаrnаushkinа, R. S. Dаnilov

“…The article presents the review of latest studies devoted to assessment of the eosinophilic inflammation in chronic obstructive pulmonary disease (COPD) and opportunities for differential therapy of stable COPD and COPD therapy during exacerbation. …”
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CLASSIFICATION AND DIAGNOSTICS OF ANEMIA IN CHILDREN by A. G. Rumyantsev

“…Diagnostics makes accent on laboratory analysis; they are the basis of differential diagnosis and differential therapy of anemia in children.<br /><br />…”
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A phenotypic screen identifies a compound series that induces differentiation of acute myeloid leukemia cells in vitro and shows antitumor effects in vivo by Josa-Culleré, L, Madden, KS, Cogswell, TJ, Jackson, TR, Carter, TS, Zhang, D, Trevitt, G, Davies, SG, Vyas, P, Wynne, GM, Milne, TA, Russell, AJ

“…However, current differentiation therapies are effective only to specific patient populations. …”

Pharmacological methods of therapy in Parkinson’s disease by Y. N. Bykov, T. B. Bender

“…The article considers main features, assessment methods and targets of the differentiated therapy, presents benefits and drawbacks of each drug, and describes the problem of generics. …”
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Rheumatoid arthritis: achievements and unresolved issues by E L Nasonov, A M Lila

“…Further research is needed which should be directed to investigation of a heterogeneity of RA pathogenetic mechanisms and to elaboration of approaches to its early diagnosis as well as to improving methods for monitoring a disease activity, biomarkers of efficacy and resistance to therapy, and finally, to developing of a differentiated therapy, including a search for new “therapeutic” targets.…”
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From genomics to targeted treatment in haematological malignancies: a focus on acute myeloid leukaemia by Jakobsen, N, Vyas, P

“…Multiple novel drug classes are now on the horizon, including agents that target overactive signalling pathways, differentiation therapies and immunotherapies. By combining molecular diagnostics with targeted therapy, the management of these diseases is set to change radically over the coming years.…”

Biomarkers in spinal cord compression by A. St. Iencean, A. Tascu, St. M. Iencean

“…Diagnosis, prognosis, and treatment guidance based on biomarker used as a predictive indicator can determine ethical difficulties by differentiated therapies in patients with spinal cord compression. …”
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Mechanisms in the pathogenesis of poststroke spasticity by E. A. Katushkina, O. E. Zinovyeva, B. S. Shenkman, N. N. Yakhno

“…The time course of the changes suggests that there is partial reversibility in the central nervous system and skeletal muscle, which allows elaboration of approaches to differentiated therapy for the above conditions.…”
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Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition by Shalini Singh, Danielle Howell, Niraj Trivedi, Ketty Kessler, Taren Ong, Pedro Rosmaninho, Alexandre ASF Raposo, Giles Robinson, Martine F Roussel, Diogo S Castro, David J Solecki

“…Restored polarity signaling promotes differentiation and rescues GZ exit, suggesting a model for future differentiative therapies. These results reveal unexpected parallels between neuronal differentiation and mesenchymal-to-epithelial transition and suggest that active polarity inhibition contributes to altered GZ exit in pediatric brain cancers.…”
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Sleep disorders in Parkinson’s disease: approaches to treatment and prevention by M. R. Nodel, G. V. Kovrov

“…Emphasis is focused on the basic principles of differentiated therapy for sleep disorders in PD in relation to the degree of nocturnal motor symptoms of the disease. …”
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Chronic heart failure: syndrome or disease? by V. V. Kalyuzhin, A. T. Teplyakov, G. E. Chernogoryuk, E. V. Kalyuzhina, I. D. Bespalova, N. N. Terentyeva, I. K. Livshits, V. L. Ostanko, O. F. Sibireva, N. Yu. Chasovskikh

“…Since the identification of the underlying cause of heart failure is crucial for therapeutic reasons, the only correct view is that of CHF as a syndrome, the detailed description of which in clinical diagnosis is an important intranosological characteristic that allows building the most effective differentiated therapy and accurately determining the prognosis of the disease.…”
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Growth and differentiation factor 3 induces expression of genes related to differentiation in a model of cancer stem cells and protects them from retinoic acid-induced apoptosis. by Karolina Tykwinska, Roland Lauster, Petra Knaus, Mark Rosowski

“…Our study implies that blocking of GDF3 combined with retinoic acid-treatment of solid cancers is a compelling direction for further investigations, which can lead to re-design of cancer differentiation therapies.…”
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