Beyond Genetics—Stratified and Personalised Medicines Using Multiple Parameters by Richard Peck, Patrick Smith

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Adjusting perioperative methadone dose for elderly and fragile hip fracture patients (MetaHip-trial) – A statistical analysis plan for an adaptive dose-finding trial by Andreas Kristian Pedersen, Kevin Heebøll Nygaard, Sofie Ronja Petersen, Kirsten Specht, Thomas Strøm, Caroline Margaret Moos, Helene Skjøt-Arkil, Jesper Ougaard Schønnemann

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The effective doses of remimazolam besylate in the procedural sedation of endoscopic retrograde cholangiopancreatography by Dan‐Dan Tan, Jin Gu, Juan Li, Wan‐Qiu Yu, De‐Xing Liu, Li‐Jin Zhao, Guo‐Hua Zhu, Xin‐Xin Yang, Jin Tian, Qi Tian, Zhao‐Qiong Zhu

Subjects: “…dose finding…”
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Efficacy and Safety of Cathine (Nor-Pseudoephedrine) in the Treatment of Obesity: A Randomized Dose-Finding Study by Hans Hauner, Ljiljana Hastreiter, Dieter Werdier, Annette Chen-Stute, Jürgen Scholze, Matthias Blüher

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Interval design to identify the optimal biological dose for immunotherapy by Yeonhee Park

Subjects: “…Dose-finding…”
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Activity and Safety of NAB-FOLFIRI and NAB-FOLFOX as First-Line Treatment for metastatic Pancreatic Cancer (NabucCO Study) by Elisa Giommoni, Evaristo Maiello, Vanja Vaccaro, Ermanno Rondini, Caterina Vivaldi, Giampaolo Tortora, Laura Toppo, Guido Giordano, Tiziana Pia Latiano, Cinzia Lamperini, Serena Pillozzi, Luca Boni, Lorenzo Antonuzzo, Francesco Di Costanzo

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Is more better? An analysis of toxicity and response outcomes from dose-finding clinical trials in cancer by Kristian Brock, Victoria Homer, Gurjinder Soul, Claire Potter, Cody Chiuzan, Shing Lee

Subjects: “…Dose finding…”
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Effective concentration (EC50) of sevoflurane for intraocular pressure measurement in anaesthetised children with glaucoma: A dose-finding study by Elayavel Ravichandran, Nitika Goel, Babita Ghai, Vikas Saini, Sushmita Kaushik

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Efficacy and safety of ascending dosages of albendazole against Trichuris trichiura in preschool-aged children, school-aged children and adults: A multi-cohort randomized controlle... by Chandni Patel, Jean T. Coulibaly, Jessica D. Schulz, Yves N'Gbesso, Jan Hattendorf, Jennifer Keiser

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TRAFIC: statistical design and analysis plan for a pragmatic early phase 1/2 Bayesian adaptive dose escalation trial in rheumatoid arthritis by M. Cole, C. Yap, C. Buckley, W. F. Ng, I. McInnes, A. Filer, S. Siebert, A. Pratt, J. D. Isaacs, D. D. Stocken

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A dose-finding design for phase I clinical trials based on Bayesian stochastic approximation by Jin Xu, Dapeng Zhang, Rongji Mu

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Once weekly paclitaxel associated with a fixed dose of oral metronomic cyclophosphamide: a dose-finding phase 1 trial by Diane Pannier, Antoine Adenis, Emilie Bogart, Eric Dansin, Stéphanie Clisant-Delaine, Emilie Decoupigny, Anne Lesoin, Eric Amela, Sandrine Ducornet, Jean-Pierre Meurant, Marie-Cécile Le Deley, Nicolas Penel

Subjects: “…Dose-finding phase 1 trial…”
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Bayesian optimization for estimating the maximum tolerated dose in Phase I clinical trials by Ami Takahashi, Taiji Suzuki

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Assessing the reporting quality of early phase dose-finding trial protocols: a methodological reviewResearch in context by Guillermo Villacampa, Dhrusti Patel, Haiyan Zheng, Jessica McAleese, Jan Rekowski, Olga Solovyeva, Zhulin Yin, Christina Yap

Subjects: “…Dose-finding…”
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Development of consensus-driven SPIRIT and CONSORT extensions for early phase dose-finding trials: the DEFINE study by Olga Solovyeva, Munyaradzi Dimairo, Christopher J. Weir, Siew Wan Hee, Aude Espinasse, Moreno Ursino, Dhrusti Patel, Andrew Kightley, Sarah Hughes, Thomas Jaki, Adrian Mander, Thomas R. Jeffry Evans, Shing Lee, Sally Hopewell, Khadija Rerhou Rantell, An-Wen Chan, Alun Bedding, Richard Stephens, Dawn Richards, Lesley Roberts, John Kirkpatrick, Johann de Bono, Christina Yap

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Concurrent dose-finding of a novel cancer drug with and without a second agent by Nolan A. Wages, Ramy R. Saleh, Thomas M. Braun

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Implementing the EffTox dose-finding design in the Matchpoint trial by Kristian Brock, Lucinda Billingham, Mhairi Copland, Shamyla Siddique, Mirjana Sirovica, Christina Yap

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Impact of dose feasibility on the conduct of phase I trials of adoptive cell therapy by Evan M. Bagley, Nolan A. Wages

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Statistical methods and data visualisation of patient-reported outcomes in early phase dose-finding oncology trials: a methodological reviewResearch in context by Emily Alger, Anna Minchom, Olalekan Lee Aiyegbusi, Matthew Schipper, Christina Yap

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Optimal biological dose: a systematic review in cancer phase I clinical trials by J. Fraisse, D. Dinart, D. Tosi, C. Bellera, C. Mollevi

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