Facile One-Pot Preparation of Self-Assembled Hyaluronate/Doxorubicin Nanoaggregates for Cancer Therapy by Yong Geun Lim, Hyung Geun Park, Kyeongsoon Park

“…To resolve these issues, we developed a facile one-pot method to prepare self-assembled sodium hyaluronate/doxorubicin (HA/DOX) nanoaggregates by mixing HA and DOX. The self-assembled HA/DOX nanoaggregates were formed via cation–π interactions between the aromatic moiety of DOX and Na⁺ ions in HA as well as electrostatic interactions between HA and DOX. …”
Get full text

The attenuation effect of low piperine Piper nigrum extract on doxorubicin-induced toxicity of blood chemical and immunological properties in mammary tumour rats by Jirakrit Saetang, Aman Tedasen, Surasak Sangkhathat, Natnaree Sangkaew, Sirinapa Dokduang, Napat Prompat, Siriporn Taraporn, Potchanapond Graidist

“…Objective To evaluate the effect of PFPE in attenuating the side effects of Dox. Materials and methods Tumour-bearing Sprague Dawley rats were divided into five groups including normal, vehicle, 100 mg/kg BW of PFPE plus 2 mg/kg BW of Dox (P100 + Dox), 100 mg/kg BW of PFPE plus 2 mg/kg BW of Dox (P200 + Dox) and Dox. …”
Get full text

Downregulation of carbonic anhydrase IX expression in mouse xenograft nasopharyngeal carcinoma model via doxorubicin nanobubble combined with ultrasound by Li Rong, Lu Liugui, Huang Zhaoxi, Gao Yong

“…The cumulative release of DOX in the DOX-NB + DUS group was significantly higher compared with that of the DOX-NB group (p < 0.05). …”
Get full text

Selective Cellular Uptake and Druggability Efficacy through Functionalized Chitosan-Conjugated Polyamidoamine (PAMAM) Dendrimers by Ye Hu, Jian Chen, Wenyan Hu

“…Specifically, doxorubicin (DOX) was initially loaded into PAMAM dendrimers to form DOX-loaded PAMAM (DOX@PAMAM) complexes via intermolecular forces. …”
Get full text

Comparison of conventional chemotherapy, stealth liposomes and temperature-sensitive liposomes in a mathematical model. by Astrid Gasselhuber, Matthew R Dreher, Frank Rattay, Bradford J Wood, Dieter Haemmerich

“…We developed a mathematical model to compare different liposome formulations of doxorubicin (DOX): conventional chemotherapy (Free-DOX), Stealth liposomes (Stealth-DOX), temperature sensitive liposomes (TSL) with intra-vascular triggered release (TSL-i), and TSL with extra-vascular triggered release (TSL-e). …”
Get full text

Prolonged Endurance Exercise Adaptations Counteract Doxorubicin Chemotherapy-Induced Myotoxicity in Mice by Insu Kwon, Gwang-Woong Go, Youngil Lee, Jong-Hee Kim

“…Doxorubicin (DOX) is a potent chemotherapeutic agent widely used for various types of cancer; however, its accumulation causes myotoxicity and muscle atrophy. …”
Get full text

Pyridoxamine Attenuates Doxorubicin-Induced Cardiomyopathy without Affecting Its Antitumor Effect on Rat Mammary Tumor Cells by Sibren Haesen, Eline Verghote, Ellen Heeren, Esther Wolfs, Dorien Deluyker, Virginie Bito

“…This study investigated the effect of PM on DOX cardiotoxicity and DOX antitumor effectiveness. …”
Get full text

Potentiation of Doxorubicin Cytotoxicity Utilizing Clarithromycin Loaded-PEGylated Liposomes by Islam Alfreahat MS, Hamdi Nsairat PhD, Ibrahim Deeb Aldeeb PhD, Ali Al-Samydai PhD, Walhan Alshaer PhD

“…Clarithromycin (CAM), a macrolide antibiotic, inhibits multiple metabolic pathways including CYP3A and P-gp, potentially countering DOX resistance. Objective This study aimed to evaluate the potentiation of DOX and its effectiveness against the MCF-7 breast cancer cell line by encapsulating both DOX and CAM in PEGylated liposomes. …”
Get full text

Macrophage membrane-camouflaged pH-sensitive nanoparticles for targeted therapy of oral squamous cell carcinoma by Lin Yang, Hongjiao Li, Aihua Luo, Yao Zhang, Hong Chen, Li Zhu, Deqin Yang

“…The boronate ester bonds between PBA and DOX responded to the low pH value in the tumor microenvironment, selectively releasing the loaded DOX. …”
Get full text

Novel Worm-like Micelles for Hydrochloride Doxorubicin Delivery: Preparation, Characterization, and In Vitro Evaluation by Ya-Ni Yang, Chen Ge, Jun He, Wei-Gen Lu

“…This study aimed to explore a novel acitretin-based surfactant (ACMeNa) with good solid stability to encapsulate DOX to form micelles (ACM-DOX). In this work, ACM-DOX micelles were prepared by a microfluidic method free of organic solvents. …”
Get full text

Protective Effect of Galantamine against Doxorubicin-Induced Neurotoxicity by Rawan S. Alsikhan, Maha A. Aldubayan, Ibtesam S. Almami, Ahmad H. Alhowail

“…Background and aims: Doxorubicin (DOX) causes cognitive impairment (chemobrain) in patients with cancer. …”
Get full text

Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial. by Ute Klarmann-Schulz, Sabine Specht, Alexander Yaw Debrah, Linda Batsa, Nana Kwame Ayisi-Boateng, Jubin Osei-Mensah, Yusif Mubarik, Peter Konadu, Arcangelo Ricchiuto, Rolf Fimmers, Sandra Arriens, Bettina Dubben, Louise Ford, Mark Taylor, Achim Hoerauf

“…The search for new macrofilaricidal drugs against onchocerciasis that can be administered in shorter regimens than required for doxycycline (DOX, 200mg/d given for 4-6 weeks), identified minocycline (MIN) with superior efficacy to DOX. …”
Get full text

Deletion of LOX-1 Protects against Heart Failure Induced by Doxorubicin. by Chiharu Yokoyama, Takuma Aoyama, Takahiro Ido, Akemi Kakino, Takeru Shiraki, Toshiki Tanaka, Kazuhiko Nishigaki, Aiko Hasegawa, Yoshiko Fujita, Tatsuya Sawamura, Shinya Minatoguchi

“…Therefore, we examined whether or not LOX-1 contributes to the pathogenesis of DOX-induced cardiomyopathy. Cardiomyopathy was induced by a single intraperitoneal injection of DOX into wild-type (WT) mice and LOX-1 knockout (KO) mice. …”
Get full text

In vivo evaluation of anticancer efficacy of drug loaded cockle shell‐derived aragonite nanoparticles by Fu, Wenliang, P Rameli, Mohd Adha, Tengku Ibrahim, Tengku Azmi, Mohd Noor, Mohd Hezmee, Mohamad Yusof, Loqman, Abu Bakar @ Zakaria, Md Zuki

“…The anticancer efficacy study included five groups: normal control group, OS model group, free DOX group (2 mg/kg), DOX‐ANPs 1 group (2 mg of equivalent DOX/kg) and DOX‐ANPs 2 group (1.5 mg of equivalent DOX/kg). …”
Get full text

[(WR)₈WKβA]-Doxorubicin Conjugate: A Delivery System to Overcome Multi-Drug Resistance against Doxorubicin by Khalid Zoghebi, Hamidreza Montazeri Aliabadi, Rakesh Kumar Tiwari, Keykavous Parang

“…Doxorubicin (Dox) is an anthracycline chemotherapeutic agent used to treat breast, leukemia, and lymphoma malignancies. …”
Get full text

Enhanced Cytotoxic Effect of Doxorubicin Conjugated to Glutathione-Stabilized Gold Nanoparticles in Canine Osteosarcoma—In Vitro Studies by Anna Małek, Bartłomiej Taciak, Katarzyna Sobczak, Agnieszka Grzelak, Michał Wójcik, Józef Mieczkowski, Roman Lechowski, Katarzyna A. Zabielska-Koczywąs

“…Previous studies have revealed that Dox conjugated with 4 nm glutathione-stabilized gold nanoparticles (Au-GSH-Dox) enhanced the anti-tumor activity and cytotoxicity of Dox in Dox-resistant feline fibrosarcoma cell lines exhibiting high P-glycoprotein (P-gp) activity. …”
Get full text

Histological and safety evaluation of cockle shell-derived CaCO₃ nanoparticle loaded with doxorubicin in dogs by Abubakar, Danmaigoro

“…CS-CaCO3NP-DOX increased half-life and area under the curve, with lower clearance rate as compared to free DOX. …”
Get full text

Low-Dose Radiation Reduces Doxorubicin-Induced Myocardial Injury Through Mitochondrial Pathways by Di Zhao, Xin Jiang, Xinxin Meng, Dandan Liu, Yanwei Du, Lijing Zhao, Hongyu Jiang

“…The use of doxorubicin (DOX) as an anthraquinone antineoplastic agent is limited due to its cardiotoxicity. …”
Get full text

Expression of α-DIOXYGENASE 1 in Tomato and Arabidopsis Contributes to Plant Defenses Against Aphids by Carlos Augusto Avila, Lirio Milenka Arevalo-Soliz, Argelia Lorence, Fiona L. Goggin

“…We report here that the potato aphid (Macrosiphum euphorbiae) induces Slα-DOX1 but not Slα-DOX2 expression in tomato (Solanum lycopersicum). …”
Get full text

MG53蛋白对小鼠阿霉素急性心肌毒性的影响及机制 by 卢维哲, 刘海琼, 杨涵滟, 宋旭东, 陈爱华

“…结果心脏超声结果显示：与假手术组（Sham）相比，阿霉素组（DOX）及心肌原位注射对照腺相关病毒组（DOX+AAV9-NC）小鼠心脏功能显著下降（EF：Sham：86.06 ± 2.08 <italic>vs. …”
Get full text