High monocytic MDSC signature predicts multi-drug resistance and cancer relapse in non-Hodgkin lymphoma patients treated with R-CHOP by Sukanya Dhar, Mohona Chakravarti, Nilanjan Ganguly, Akata Saha, Shayani Dasgupta, Saurav Bera, Anirban Sarkar, Kamalika Roy, Juhina Das, Avishek Bhuniya, Sarbari Ghosh, Madhurima Sarkar, Srabanti Hajra, Saptak Banerjee, Chiranjib Pal, Bhaskar Saha, Kalyan Kusum Mukherjee, Rathindranath Baral, Anamika Bose

“…In-vivo and in-vitro doxorubicin (Dox) resistance models were developed with murine Dalton’s lymphoma and Jurkat/Raji cell-lines respectively and impact of responsible immune cells on generation of drug resistance was studied by RT-PCR, flow-cytometry and colorimetric assays. …”
Get full text

Nanozymes with Peroxidase-like Activity for Ferroptosis-Driven Biocatalytic Nanotherapeutics of Glioblastoma Cancer: 2D and 3D Spheroids Models by Sandhra M. Carvalho, Alexandra A. P. Mansur, Izabela B. da Silveira, Thaisa F. S. Pires, Henrique F. V. Victória, Klaus Krambrock, M. Fátima Leite, Herman S. Mansur

“…Furthermore, the results demonstrated that the 2D in vitro model overestimated the relative efficiency of the anticancer agents (i.e., nanozymes and the DOX drug) compared to the 3D spheroid models. These findings are notable as they evidenced that the 3D spheroid model resembles more precisely the TME of “real” brain cancer tumors in patients than 2D cell cultures. …”
Get full text

Platinum(IV) Complexes of the 1,3,5-Triamino Analogue of the Biomolecule Cis-Inositol Designed as Innovative Antineoplastic Drug Candidates by Vyara Velcheva, Kaspar Hegetschweiler, Georgi Momekov, Stefka Ivanova, Angel Ugrinov, Bernd Morgenstern, Galina Gencheva

“…The antiproliferative tests involved eight cancer cell models, among which chemosensitive (derived from leukemias and solid tumors) and chemoresistant human Acute myeloid leukemia lines (HL-60/Dox, HL-60/CDDP), as well as the non-malignant kidney’ cells HEK-293T showed that the complexes <b>1A</b> and <b>2A</b> are characterized by a fundamentally different profile of chemosensitivity and spectrum of cytotoxic activity compared to cisplatin. …”
Get full text

Anti-cancer activity of guggulsterone by modulating apoptotic markers: a systematic review and meta-analysis by Meenakshi Gupta, Deepti Singh, Shruti Rastogi, Shruti Rastogi, Hifzur R. Siddique, Noura Al-Dayan, Ajaz Ahmad, Mohammad Sikander, Maryam Sarwat

“…The reliability of the selected studies was assessed using ToxRTool.Results: Based on this review, guggulsterone significantly affected pancreatic cancer (MiaPaCa-2, Panc-1, PC-Sw, CD18/HPAF, Capan1, PC-3), hepatocellular carcinoma (Hep3B, HepG2, PLC/PRF/5R), head and neck squamous cell carcinoma (SCC4, UM-22b, 1483), cholangiocarcinoma (HuCC-T1, RBE, Sk-ChA-1, Mz-ChA-1) and oesophageal adenocarcinoma (CP-18821, OE19), prostrate cancer (PC-3), colon cancer (HT-29), breast cancer (MCF7/DOX), gut derived adenocarcinoma (Bic-1), gastric cancer (SGC-7901), colorectal cancer (HCT116), bladder cancer (T24, TSGH8301), glioblastoma (A172, U87MG, T98G), histiocytic leukemia (U937), acute myeloid leukemia (HL60, U937) and non-small cell lung cancer (A549, H1975) by inducing apoptotic pathways, inhibiting cell proliferation, and regulating the expression of genes involved in apoptosis. …”
Get full text

Bottlebrush and related polymer architectures for biomedical applications by Nguyen, Hung VanThanh.

Get full text

Role of the ISKpn element in mediating mgrB gene mutations in ST11 hypervirulent colistin-resistant Klebsiella pneumoniae by Lanlan Zhu, Ping Li, Ping Li, Ping Li, Guangyi Zhang, Zhiyong He, Xingyu Tao, Xingyu Tao, Yicheng Ji, Wenjing Yang, Xiaofang Zhu, Wanying Luo, Wanying Luo, Wenjian Liao, Chuanhui Chen, Yang Liu, Yang Liu, Wei Zhang, Wei Zhang

“…Additionally, 85% resisted both DOX and TOB. The MICs for colistin across these strains ranged between 16 to 64 mg/L, with a median of 40 mg/L. …”
Get full text