The Role of Bruton’s Kinase Inhibitors in Chronic Lymphocytic Leukemia: Current Status and Future Directions by Tadeusz Robak, Magda Witkowska, Piotr Smolewski

“…This review summarizes the pharmacology, clinical efficacy, safety, dosing, and drug–drug interactions associated with the treatment of CLL with BTK inhibitors and examines their further implications.…”
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Gastroesophageal reflux disease: actual aspects of diagnostics and treatment in real clinical practice of therapist by D. I. Trukhan, I. A. Viktorova

“…The results of numerous foreign and Russian studies indicate the effectiveness and safety of pantoprazole in the treatment of GERD, especially in multimorbid patients due to the lower potential of drug interactions. The presence on the Russian pharmaceutical market of two forms of release of the generic drug pantoprazole Panum® increases the availability of effective and safe therapy for GERD and other acid-dependent diseases.…”
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Therapeutic Approach to Post-Transplant Recurrence of Hepatocellular Carcinoma: Certainties and Open Issues by Giuseppe Marrone, Maria Sandrina Leone, Marco Biolato, Antonio Liguori, Giuseppe Bianco, Gabriele Spoletini, Antonio Gasbarrini, Luca Miele, Maurizio Pompili

“…Improved liver function post LT makes multiple therapeutic strategies theoretically feasible, but patient management is complicated by the need to adjust immunosuppressive therapy and to assess potential toxicities and drug–drug interactions. Finally, there is controversy and uncertainty about the use of recently introduced immunotherapeutic drugs, mainly due to the risk of organ rejection. …”
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Pharmacodynamic Interactions between Puerarin and Metformin in Type-2 Diabetic Rats by Zhen Li, Shengguang Wang, Xinyu Wang, Peng Gao, Shiming Zhang, Yingning Mo, Dongsheng Zhao, Long Dai

“…Herb–drug interactions are vital in effectively managing type-2-diabetes complications. …”
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Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex by Frosi, Yuri, Lin, Yen-Chu, Jiang, Shimin, Ramlan, Siti Radhiah, Hew, Kelly, Engman, Alf Henrik, Pillai, Anil, Yeung, Kit, Cheng, Yue Xiang, Cornvik, Tobias, Nordlund, Par, Goh, Megan, Lama, Dilraj, Gates, Zachary P., Verma, Chandra Shekhar, Thean, Dawn, Lane, David P., Asial, Ignacio, Brown, Christopher J.

“…An attractive approach to target intracellular macromolecular interfaces and to model putative drug interactions is to design small high-affinity proteins. …”
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Pharmacology of new oral anticoagulants: mechanism of action, pharmacokinetics, pharmacodynamics by Luca Masotti, Mauro Campanini

“…The route of elimination of dabigatran is primarily renal, whereas FXa inhibitors are mainly eliminated by the biliary-fecal route. The drug interactions of DOACs are mainly limited to drugs that act on P-glycoprotein for dabigatran and on P-glycoprotein and/or cytochrome P3A4 for anti-Xa. …”
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Clinical Pharmacology in Sarcoidosis: How to Use and Monitor Sarcoidosis Medications by Sooyeon Kwon, Marc A. Judson

“…We also discuss the use of these agents in special situations including hepatic insufficiency, renal insufficiency, pregnancy, breastfeeding, vaccination, and drug–drug interactions. It is hoped that this manuscript will provide valuable practical guidance to clinicians who care for sarcoidosis patients.…”
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Prevalence of HIV infection in Turkey and importance of cardiovascular disease by Volkan Korten

“…When selecting a statin to reach target LDL-C levels, potential drug interactions with antiretroviral drugs must be considered. …”
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Comorbid patient with GERD and cardiovascular disease receiving antiplatelet therapy. The possibilities of choosing a proton pump inhibitor on a case study by I. G. Pakhomova

“…Given the polymorbidity of patients and polypragmasia, the practitioner should strive to prescribe drugs with the lowest risk of drug interactions. These requirements are met by PPI rabeprazole, the metabolism of which is predictable. …”
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Strategies to Inspire Students’ Engagement in Pharmacology Courses by Hussein N. Rubaiy

“…Therefore, knowledge and information on topics such as prescribing medication, drug interactions, dosage adjustments, and the correct drug dose calculation for medicine are essential for preventing and reducing medication errors, which is a key element in patient safety. …”
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Acute urinary retention after alprazolam use: a case report by Demet Saglam Aykut, R. A. Emel Uysal

“…When prescribing a drug to a patient, a thorough knowledge of its mode of action, adverse effects and potential drug interactions are important in preventing drug-induced urinary retention, especially in patients who have other risk factors for urinary retention.…”
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Prospective Nutraceutical Effects of Cinnamon Derivatives Against Insulin Resistance in Type II Diabetes Mellitus—Evidence From the Literature by Saima Naz Mohsin MS, Faiza Saleem PhD, Ayesha Humayun PhD, Afifa Tanweer PhD, Ambreen Muddassir FCPS

“…It was also found that the type and dosage of cinnamon as well as subject characteristics including drug interactions are likely to affect the response to cinnamon. …”
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Irrational polypharmacy and potentially inappropriate medications in patients with dementia: Treatment strategies by M. Štuhec

“…The burden of irrational polypharmacy has also been associated with a greater risk of adverse drug events, drug-drug interactions, medication non-adherence and a higher risk of potentially inappropriate medication (PIM) use. …”
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Non-vitamin K antagonist oral anticoagulants in adults with congenital heart disease by Ji-Eun Ban

“…NOACs are an efficient alternative to VKA with reduced bleeding propensity, relatively low dietary and drug interactions, and the potential to eliminate the need for international normalized ratio monitoring in patients with nonvalvular AF. …”
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Patient considerations in the management of toe onychomycosis – role of efinaconazole by LaSenna CE, Tosti A

“…Oral treatments require laboratory monitoring due to risk of hepatotoxicity and may be contraindicated in some patients due to risk of drug–drug interactions. Topical treatments require prolonged application and are not very effective. …”
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Diabetes Patients Perceptions on Drugs Consultation Program by Pharmacists by Rudi Sumaryono, Moelyono Moektiwardoyo, Ari Yulianto

“…The results showed that the information regarding drugs interactions, adverse drugs reaction (ADR), and drugs dosage were among the aspects that should be included in drugs consultation service by pharmacists. …”
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Monitoring strategies for patients treated with the new oral anticoagulants and the need for laboratory evaluation of hemostasis by Andrea Fontanella, Pierpaolo Di Micco

“…These agents offer advantages over vitamin K antagonists including rapid onset, shorter half-lives, fewer drug interactions, and the lack of a need for routine monitoring. …”
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Direct-acting antivirals for chronic Hepatitis C are effective and safe: an observational study in Londrina/PR by Hodnei Takashi Machado, Camilo Molino Guidoni

“…Effectiveness was evaluated by sustained virologic response (SVR) and safety was evaluated by adverse events (AEs) and drug interactions (DIs). The mean population (N=30) was 56.6±11.3 years old and almost all patients had comorbidities (93.3%) and concomitant drugs (96.7%). …”
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Crystal Structure of CYP3A4 Complexed with Fluorol Identifies the Substrate Access Channel as a High-Affinity Ligand Binding Site by Irina F. Sevrioukova

“…Cytochrome P450 3A4 (CYP3A4) is a major human drug-metabolizing enzyme, notoriously known for its extreme substrate promiscuity, allosteric behavior, and implications in drug–drug interactions. Despite extensive investigations, the mechanism of ligand binding to CYP3A4 is not fully understood. …”
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General principles of pharmacotherapy selection in elderly patients for different comorbidities by M. Stuhec

“…Due to frequent comorbidities and treatments in the elderly, medication-related problems are very frequent. Drug-drug interactions (DDIs) between somatic medications and psychotropics often occur in this population. …”
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