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1981
The Role of Bruton’s Kinase Inhibitors in Chronic Lymphocytic Leukemia: Current Status and Future Directions
Published 2022-02-01“…This review summarizes the pharmacology, clinical efficacy, safety, dosing, and drug–drug interactions associated with the treatment of CLL with BTK inhibitors and examines their further implications.…”
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Article -
1982
Gastroesophageal reflux disease: actual aspects of diagnostics and treatment in real clinical practice of therapist
Published 2019-10-01“…The results of numerous foreign and Russian studies indicate the effectiveness and safety of pantoprazole in the treatment of GERD, especially in multimorbid patients due to the lower potential of drug interactions. The presence on the Russian pharmaceutical market of two forms of release of the generic drug pantoprazole Panum® increases the availability of effective and safe therapy for GERD and other acid-dependent diseases.…”
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Article -
1983
Therapeutic Approach to Post-Transplant Recurrence of Hepatocellular Carcinoma: Certainties and Open Issues
Published 2023-11-01“…Improved liver function post LT makes multiple therapeutic strategies theoretically feasible, but patient management is complicated by the need to adjust immunosuppressive therapy and to assess potential toxicities and drug–drug interactions. Finally, there is controversy and uncertainty about the use of recently introduced immunotherapeutic drugs, mainly due to the risk of organ rejection. …”
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Article -
1984
Pharmacodynamic Interactions between Puerarin and Metformin in Type-2 Diabetic Rats
Published 2022-10-01“…Herb–drug interactions are vital in effectively managing type-2-diabetes complications. …”
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Article -
1985
Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex
Published 2023“…An attractive approach to target intracellular macromolecular interfaces and to model putative drug interactions is to design small high-affinity proteins. …”
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Journal Article -
1986
Pharmacology of new oral anticoagulants: mechanism of action, pharmacokinetics, pharmacodynamics
Published 2013-12-01“…The route of elimination of dabigatran is primarily renal, whereas FXa inhibitors are mainly eliminated by the biliary-fecal route. The drug interactions of DOACs are mainly limited to drugs that act on P-glycoprotein for dabigatran and on P-glycoprotein and/or cytochrome P3A4 for anti-Xa. …”
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Article -
1987
Clinical Pharmacology in Sarcoidosis: How to Use and Monitor Sarcoidosis Medications
Published 2024-02-01“…We also discuss the use of these agents in special situations including hepatic insufficiency, renal insufficiency, pregnancy, breastfeeding, vaccination, and drug–drug interactions. It is hoped that this manuscript will provide valuable practical guidance to clinicians who care for sarcoidosis patients.…”
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Article -
1988
Prevalence of HIV infection in Turkey and importance of cardiovascular disease
Published 2017-03-01“…When selecting a statin to reach target LDL-C levels, potential drug interactions with antiretroviral drugs must be considered. …”
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Article -
1989
Comorbid patient with GERD and cardiovascular disease receiving antiplatelet therapy. The possibilities of choosing a proton pump inhibitor on a case study
Published 2019-10-01“…Given the polymorbidity of patients and polypragmasia, the practitioner should strive to prescribe drugs with the lowest risk of drug interactions. These requirements are met by PPI rabeprazole, the metabolism of which is predictable. …”
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Article -
1990
Strategies to Inspire Students’ Engagement in Pharmacology Courses
Published 2021-03-01“…Therefore, knowledge and information on topics such as prescribing medication, drug interactions, dosage adjustments, and the correct drug dose calculation for medicine are essential for preventing and reducing medication errors, which is a key element in patient safety. …”
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Article -
1991
Acute urinary retention after alprazolam use: a case report
Published 2018-04-01“…When prescribing a drug to a patient, a thorough knowledge of its mode of action, adverse effects and potential drug interactions are important in preventing drug-induced urinary retention, especially in patients who have other risk factors for urinary retention.…”
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Article -
1992
Prospective Nutraceutical Effects of Cinnamon Derivatives Against Insulin Resistance in Type II Diabetes Mellitus—Evidence From the Literature
Published 2023-09-01“…It was also found that the type and dosage of cinnamon as well as subject characteristics including drug interactions are likely to affect the response to cinnamon. …”
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Article -
1993
Irrational polypharmacy and potentially inappropriate medications in patients with dementia: Treatment strategies
Published 2023-03-01“…The burden of irrational polypharmacy has also been associated with a greater risk of adverse drug events, drug-drug interactions, medication non-adherence and a higher risk of potentially inappropriate medication (PIM) use. …”
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Article -
1994
Non-vitamin K antagonist oral anticoagulants in adults with congenital heart disease
Published 2022-09-01“…NOACs are an efficient alternative to VKA with reduced bleeding propensity, relatively low dietary and drug interactions, and the potential to eliminate the need for international normalized ratio monitoring in patients with nonvalvular AF. …”
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Article -
1995
Patient considerations in the management of toe onychomycosis – role of efinaconazole
Published 2015-06-01“…Oral treatments require laboratory monitoring due to risk of hepatotoxicity and may be contraindicated in some patients due to risk of drug–drug interactions. Topical treatments require prolonged application and are not very effective. …”
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Article -
1996
Diabetes Patients Perceptions on Drugs Consultation Program by Pharmacists
Published 2016-12-01“…The results showed that the information regarding drugs interactions, adverse drugs reaction (ADR), and drugs dosage were among the aspects that should be included in drugs consultation service by pharmacists. …”
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Article -
1997
Monitoring strategies for patients treated with the new oral anticoagulants and the need for laboratory evaluation of hemostasis
Published 2013-12-01“…These agents offer advantages over vitamin K antagonists including rapid onset, shorter half-lives, fewer drug interactions, and the lack of a need for routine monitoring. …”
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Article -
1998
Direct-acting antivirals for chronic Hepatitis C are effective and safe: an observational study in Londrina/PR
Published 2022-08-01“…Effectiveness was evaluated by sustained virologic response (SVR) and safety was evaluated by adverse events (AEs) and drug interactions (DIs). The mean population (N=30) was 56.6±11.3 years old and almost all patients had comorbidities (93.3%) and concomitant drugs (96.7%). …”
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Article -
1999
Crystal Structure of CYP3A4 Complexed with Fluorol Identifies the Substrate Access Channel as a High-Affinity Ligand Binding Site
Published 2022-10-01“…Cytochrome P450 3A4 (CYP3A4) is a major human drug-metabolizing enzyme, notoriously known for its extreme substrate promiscuity, allosteric behavior, and implications in drug–drug interactions. Despite extensive investigations, the mechanism of ligand binding to CYP3A4 is not fully understood. …”
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Article -
2000
General principles of pharmacotherapy selection in elderly patients for different comorbidities
Published 2022-06-01“…Due to frequent comorbidities and treatments in the elderly, medication-related problems are very frequent. Drug-drug interactions (DDIs) between somatic medications and psychotropics often occur in this population. …”
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Article