Inflammation, impaired motor function and visceral hypersensitivity: the main mechanisms of functional disorders of the gastrointestinal tract (materials of the Expert Council and... by V. T. Ivashkin, I. V. Maev, A. S. Trukhmanov, A. A. Sheptulin, T. L. Lapina, V. I. Simanenkov, K. A. Sokolov

“…This often leads to the prescription of a complex of various medications to such patients, which increases the risk of undesirable drug interactions and side effects. Multitargeted therapy involves the use of drugs that simultaneously affect different pathogenetic links. …”
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Feasibility study of a clinical decision support system for polymedicated patients in primary care by Juan Manuel Pinar Manzanet, Giuseppe Fico, Beatriz Merino‐Barbancho, Liss Hernández, Cecilia Vera‐Muñoz, Germán Seara, Macarena Torrego, Henar Gonzalez, Jonas Wastesson, Johan Fastbom, Julio Mayol, Kristina Johnell, Tomás Gómez‐Gascón, María Teresa Arredondo

“…Moreover, older adults are commonly exposed to polypharmacy, leading to increased risk of drug interactions and related adverse events, and higher costs for the healthcare systems. …”
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Deprescribing for Older Adults in the Community: Recent Developments and Implications for China by Yuanyuan XU, Zhijie XU, Yating NI, Xujian LIANG, Xueting HU, Zheming FANG, Yue ZHU, Lizheng FANG

“…It is a great challenge to ensure medication safety in healthcare for older adults, since polypharmacy in this group may increase the risk of potentially inappropriate medications, leading to adverse drug reactions, drug-drug interactions, hospitalizations, increased medical costs, and even deaths. …”
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Current antiretroviral therapy: A review by Alexey V. Kravchenko, Viktor V. Maleyev

“…Schemes with the least number and spectrum of side effects, no effect on metabolic processes and minimal drug interactions have advantages. Switching patients to injectable therapy regimens with a frequency of administration of drugs once every 2 months can significantly improve the quality of life of patients and, accordingly, adherence to their treatment. …”
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Management Standards of Polypharmacy in Type 2 Diabetes Combined with Atherosclerotic Cardiovascular Diseases in the Elderly by ZENG Senxiang, YANG Rui, DENG Xun, YANG Ruitao, YANG Xiaoyan

“…Polypharmacy plays a good role in disease control in older adults with multiple comorbidities, but it also poses a number of problems such as potential drug interactions and adverse drug reactions if applied in an irrational and unscientific manner. …”
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The influence of augmented renal clearance on vancomycin blood concentrations in patients with traumatic brain injury: Case report by Miljković Milijana, Dragojević-Simić Viktorija, Kovačević Aleksandra, Stamenković Dušica, Đurasinović Tatjana, Kostić Dejan, Rančić Nemanja

“…The clinical pharmacologist is a significant team member for the treatment of critically ill patients due to his/her expert knowledge of pharmacokinetics and drug interactions, especially important in this category of patients, contributing to positive clinical outcomes.…”
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Label-Free Bioelectrochemical Methods for Evaluation of Anticancer Drug Effects at a Molecular Level by Francesco Tadini-Buoninsegni, Ilaria Palchetti

“…Some relevant examples of anticancer drug interactions are presented which demonstrate the usefulness of such methods for the characterization of the mechanism of action of anticancer drugs that are targeted against various biomolecules.…”
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Indomethacin Increases Quercetin Affinity for Human Serum Albumin: A Combined Experimental and Computational Study and Its Broader Implications by Hrvoje Rimac, Tana Tandarić, Robert Vianello, Mirza Bojić

“…These results provide a new insight into drug-drug interactions, which can be important in situations when displacement from HSA or other proteins is undesirable or even desirable. …”
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Association between Drug-Related Problems and Blood Pressure of Hypertensive Patients Admitted to Universitas Sumatera Utara Hospital by Mutiara Siahaan, Azizah Nasution, Wiryanto Wiryanto, Iksen Iksen

“…The most frequently occurred DRPs were drug interactions. There was a significant association between the number of DRPs experienced by the patients and their BPs (p=0.02). …”
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Envisaging Antifungal Potential of Histatin 5: A Physiological Salivary Peptide by Pratibha Sharma, Mehak Chaudhary, Garima Khanna, Praveen Rishi, Indu Pal Kaur

“…Conventional antifungal agents though effective invariably exhibit drug interactions, treatment-related toxicity, and fail to elicit significant effect, thus indicating a need to look for suitable alternatives. …”
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Therapeutic Drug Monitoring of Antiseizure Medications Using Volumetric Absorptive Microsampling: Where Are We? by Annachiara D’Urso, Marcello Locatelli, Angela Tartaglia, Linda Molteni, Cristian D’Ovidio, Fabio Savini, James Rudge, Ugo de Grazia

“…Therapeutic drug monitoring (TDM) of antiseizure medications (ASMs) represents a valuable tool to establish an appropriate patient therapy, to collect important information about drugs’ interactions and to evaluate patient’s metabolic capabilities. …”
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Polypharmacy and Mental Health Issues in the Senior Hemodialysis Patient by Maša Knehtl, Tadej Petreski, Tadej Petreski, Nejc Piko, Robert Ekart, Robert Ekart, Sebastjan Bevc, Sebastjan Bevc

“…This narrative review will focus on common issues and medications of CKF patients, their comorbidities, mental health issues, use of psychotropic medications and their altered pharmacokinetics when used in HD, polypharmacy, and drug interactions, as well as deprescribing algorithms developed for these patients.…”
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Integration of Computational Docking into Anti-Cancer Drug Response Prediction Models by Oleksandr Narykov, Yitan Zhu, Thomas Brettin, Yvonne A. Evrard, Alexander Partin, Maulik Shukla, Fangfang Xia, Austin Clyde, Priyanka Vasanthakumari, James H. Doroshow, Rick L. Stevens

“…Although various computational methods and data have been used to develop drug response prediction models, it remains a challenging problem due to the complexities of cancer mechanisms and cancer-drug interactions. To better characterize the interaction between cancer and drugs, we investigate the feasibility of integrating computationally derived features of molecular mechanisms of action into prediction models. …”
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Therapeutic Drug Monitoring of Ivacaftor, Lumacaftor, Tezacaftor, and Elexacaftor in Cystic Fibrosis: Where Are We Now? by Eva Choong, Alain Sauty, Angela Koutsokera, Sylvain Blanchon, Pascal André, Laurent Decosterd

“…Hence, CFTR modulators are characterized by an important interindividual pharmacokinetic variability and are also prone to drug–drug interactions. However, these CFTR modulators are given at standardized dosages, while they meet all criteria for a formal therapeutic drug monitoring (TDM) program that should be considered in cases of clinical toxicity, less-than-expected clinical response, drug or food interactions, distinct patient subgroups (i.e., pediatrics), and for monitoring short-term adherence. …”
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Evaluation of Concomitant Use of Anticancer Drugs and Herbal Products: From Interactions to Synergic Activity by Massimiliano Berretta, Lissandra Dal Lago, Mattia Tinazzi, Andrea Ronchi, Gaspare La Rocca, Liliana Montella, Raffaele Di Francia, Bianca Arianna Facchini, Alessia Bignucolo, Monica Montopoli

“…Although CAM usually refers to all the “natural or organic” products/methods that are generally considered less toxic, there are concerns about drug interactions, especially in patients participating in clinical trials with experimental agents. …”
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Clinical Case: Atypical Warfarin-induced Skin Necrosis by T. V. Kondratieva, L. V. Popova, S. S. Karachev, A. S. Lishuta, M. Z. Kanevskaya

“…Conceivably there are several risk factors for the WISN development: a noncompliance of the antivitamin K regiment intake or the repeated therapy, a liver dysfunction or drug interactions, but a clear relationship has not been established yet as there have been only several hundred cases of WISN registered worldwide. …”
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Clinical Case: Atypical Warfarin-induced Skin Necrosis by T. V. Kondratieva, L. V. Popova, S. S. Karachev, A. S. Lishuta, M. Z. Kanevskaya

“…Conceivably there are several risk factors for the WISN development: a noncompliance of the antivitamin K regiment intake or the repeated therapy, a liver dysfunction or drug interactions, but a clear relationship has not been established yet as there have been only several hundred cases of WISN registered worldwide. …”
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Undetectable serum lithium concentrations after coadministration of liquid lithium citrate and apple juice: A case report by Sundus Awan, PharmD, Audrey Abelleira, PharmD, BCPS, Loveleen Khehra, MD, Robin Hieber, PharmD, BCPP

“…Lithium concentrations may be impacted by a number of causes, such as underlying medical conditions, drug interactions, and diet. As the majority of these factors remained stable during the patient's admission and the serum lithium concentration became detectable after switching from apple juice to an alternative non–apple juice liquid, it led to the identification of a possible incompatibility.…”
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What Is the Best Predictor of Phenobarbital Pharmacokinetics to Use for Initial Dosing in Neonates? by Martin Šíma, Danica Michaličková, Ondřej Slanař

“…Several covariates have been considered: body weight and height, body surface area, gestational and postnatal age, laboratory parameters of renal and hepatic functions, asphyxia, therapeutic hypothermia, extracorporeal membrane oxygenation (ECMO), drug interactions, and genetic polymorphisms. The most frequently studied and well-founded covariate for the estimation of phenobarbital dosing is actual body weight. …”
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Antifungal Prophylaxis in Solid Organ Transplant Recipients by Şebnem ŞENOL, Oya Eren KUTSOYLU, Onur KAYA, Meltem AVCI, Meltem IŞIKGÖZ TAŞBAKAN, Vildan AVKAN OĞUZ, Betil Özhak BAYSAN, Sema Alp ÇAVUŞ, Çiğdem Banu ÇETİN, Çağrı ERGİN, Bülent ERTUĞRUL, Selda SAYIN KUTLU, Murat KUTLU, Gülşen MERMUT, Dilek Yeşim METİN, Barçın ÖZTÜRK, Hüsnü PULLUKÇU, Özge TURHAN, Nur YAPAR

“…If the antifungal prophylaxis is given to all patients, antimicrobial resistance and drug-drug interactions may occur. Therefore, it is important to identify patients at a high risk of developing IFI. …”
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