-
2021
Inflammation, impaired motor function and visceral hypersensitivity: the main mechanisms of functional disorders of the gastrointestinal tract (materials of the Expert Council and...
Published 2022-05-01“…This often leads to the prescription of a complex of various medications to such patients, which increases the risk of undesirable drug interactions and side effects. Multitargeted therapy involves the use of drugs that simultaneously affect different pathogenetic links. …”
Get full text
Article -
2022
Feasibility study of a clinical decision support system for polymedicated patients in primary care
Published 2023-06-01“…Moreover, older adults are commonly exposed to polypharmacy, leading to increased risk of drug interactions and related adverse events, and higher costs for the healthcare systems. …”
Get full text
Article -
2023
Deprescribing for Older Adults in the Community: Recent Developments and Implications for China
Published 2022-05-01“…It is a great challenge to ensure medication safety in healthcare for older adults, since polypharmacy in this group may increase the risk of potentially inappropriate medications, leading to adverse drug reactions, drug-drug interactions, hospitalizations, increased medical costs, and even deaths. …”
Get full text
Article -
2024
Current antiretroviral therapy: A review
Published 2023-12-01“…Schemes with the least number and spectrum of side effects, no effect on metabolic processes and minimal drug interactions have advantages. Switching patients to injectable therapy regimens with a frequency of administration of drugs once every 2 months can significantly improve the quality of life of patients and, accordingly, adherence to their treatment. …”
Get full text
Article -
2025
Management Standards of Polypharmacy in Type 2 Diabetes Combined with Atherosclerotic Cardiovascular Diseases in the Elderly
Published 2024-02-01“…Polypharmacy plays a good role in disease control in older adults with multiple comorbidities, but it also poses a number of problems such as potential drug interactions and adverse drug reactions if applied in an irrational and unscientific manner. …”
Get full text
Article -
2026
The influence of augmented renal clearance on vancomycin blood concentrations in patients with traumatic brain injury: Case report
Published 2022-01-01“…The clinical pharmacologist is a significant team member for the treatment of critically ill patients due to his/her expert knowledge of pharmacokinetics and drug interactions, especially important in this category of patients, contributing to positive clinical outcomes.…”
Get full text
Article -
2027
Label-Free Bioelectrochemical Methods for Evaluation of Anticancer Drug Effects at a Molecular Level
Published 2020-03-01“…Some relevant examples of anticancer drug interactions are presented which demonstrate the usefulness of such methods for the characterization of the mechanism of action of anticancer drugs that are targeted against various biomolecules.…”
Get full text
Article -
2028
Indomethacin Increases Quercetin Affinity for Human Serum Albumin: A Combined Experimental and Computational Study and Its Broader Implications
Published 2020-08-01“…These results provide a new insight into drug-drug interactions, which can be important in situations when displacement from HSA or other proteins is undesirable or even desirable. …”
Get full text
Article -
2029
Association between Drug-Related Problems and Blood Pressure of Hypertensive Patients Admitted to Universitas Sumatera Utara Hospital
Published 2023-02-01“…The most frequently occurred DRPs were drug interactions. There was a significant association between the number of DRPs experienced by the patients and their BPs (p=0.02). …”
Get full text
Article -
2030
Envisaging Antifungal Potential of Histatin 5: A Physiological Salivary Peptide
Published 2021-12-01“…Conventional antifungal agents though effective invariably exhibit drug interactions, treatment-related toxicity, and fail to elicit significant effect, thus indicating a need to look for suitable alternatives. …”
Get full text
Article -
2031
Therapeutic Drug Monitoring of Antiseizure Medications Using Volumetric Absorptive Microsampling: Where Are We?
Published 2021-06-01“…Therapeutic drug monitoring (TDM) of antiseizure medications (ASMs) represents a valuable tool to establish an appropriate patient therapy, to collect important information about drugs’ interactions and to evaluate patient’s metabolic capabilities. …”
Get full text
Article -
2032
Polypharmacy and Mental Health Issues in the Senior Hemodialysis Patient
Published 2022-05-01“…This narrative review will focus on common issues and medications of CKF patients, their comorbidities, mental health issues, use of psychotropic medications and their altered pharmacokinetics when used in HD, polypharmacy, and drug interactions, as well as deprescribing algorithms developed for these patients.…”
Get full text
Article -
2033
Integration of Computational Docking into Anti-Cancer Drug Response Prediction Models
Published 2023-12-01“…Although various computational methods and data have been used to develop drug response prediction models, it remains a challenging problem due to the complexities of cancer mechanisms and cancer-drug interactions. To better characterize the interaction between cancer and drugs, we investigate the feasibility of integrating computationally derived features of molecular mechanisms of action into prediction models. …”
Get full text
Article -
2034
Therapeutic Drug Monitoring of Ivacaftor, Lumacaftor, Tezacaftor, and Elexacaftor in Cystic Fibrosis: Where Are We Now?
Published 2022-08-01“…Hence, CFTR modulators are characterized by an important interindividual pharmacokinetic variability and are also prone to drug–drug interactions. However, these CFTR modulators are given at standardized dosages, while they meet all criteria for a formal therapeutic drug monitoring (TDM) program that should be considered in cases of clinical toxicity, less-than-expected clinical response, drug or food interactions, distinct patient subgroups (i.e., pediatrics), and for monitoring short-term adherence. …”
Get full text
Article -
2035
Evaluation of Concomitant Use of Anticancer Drugs and Herbal Products: From Interactions to Synergic Activity
Published 2022-10-01“…Although CAM usually refers to all the “natural or organic” products/methods that are generally considered less toxic, there are concerns about drug interactions, especially in patients participating in clinical trials with experimental agents. …”
Get full text
Article -
2036
Clinical Case: Atypical Warfarin-induced Skin Necrosis
Published 2019-11-01“…Conceivably there are several risk factors for the WISN development: a noncompliance of the antivitamin K regiment intake or the repeated therapy, a liver dysfunction or drug interactions, but a clear relationship has not been established yet as there have been only several hundred cases of WISN registered worldwide. …”
Get full text
Article -
2037
Clinical Case: Atypical Warfarin-induced Skin Necrosis
Published 2019-11-01“…Conceivably there are several risk factors for the WISN development: a noncompliance of the antivitamin K regiment intake or the repeated therapy, a liver dysfunction or drug interactions, but a clear relationship has not been established yet as there have been only several hundred cases of WISN registered worldwide. …”
Get full text
Article -
2038
Undetectable serum lithium concentrations after coadministration of liquid lithium citrate and apple juice: A case report
Published 2021-01-01“…Lithium concentrations may be impacted by a number of causes, such as underlying medical conditions, drug interactions, and diet. As the majority of these factors remained stable during the patient's admission and the serum lithium concentration became detectable after switching from apple juice to an alternative non–apple juice liquid, it led to the identification of a possible incompatibility.…”
Get full text
Article -
2039
What Is the Best Predictor of Phenobarbital Pharmacokinetics to Use for Initial Dosing in Neonates?
Published 2021-02-01“…Several covariates have been considered: body weight and height, body surface area, gestational and postnatal age, laboratory parameters of renal and hepatic functions, asphyxia, therapeutic hypothermia, extracorporeal membrane oxygenation (ECMO), drug interactions, and genetic polymorphisms. The most frequently studied and well-founded covariate for the estimation of phenobarbital dosing is actual body weight. …”
Get full text
Article -
2040
Antifungal Prophylaxis in Solid Organ Transplant Recipients
Published 2015-12-01“…If the antifungal prophylaxis is given to all patients, antimicrobial resistance and drug-drug interactions may occur. Therefore, it is important to identify patients at a high risk of developing IFI. …”
Get full text
Article