-
2041
Development and Performance Verification of the PBPK Model for Antazoline and Its Metabolite and Its Utilization for Pharmacological Hypotheses Formulating
Published 2022-03-01“…When used to feed the PD model (e.g., simulating ECG), concentration-time profiles predicted by the model enable the assessment of antazoline’s effect in various clinical scenarios with the possibility to account for population differences or CP mediated drug-drug interactions.…”
Get full text
Article -
2042
Combined confocal Raman and quantitative phase microscopy system for biomedical diagnosis
Published 2011“…This new approach allows monitoring cell development and cell-drug interactions with minimal perturbation of the biological system of interest.…”
Get full text
Get full text
Article -
2043
Factors in determining seizure control in pediatric patients on antiepileptic medication: a review of the literature
Published 2020“…Furthermore, there is certain factors that need to be explored in the future, such as unaddressed parental concern on treatment/medication, denial of disease and drug-drug interactions. Conclusions Factors that had been identified can be used in the prevention and control programs, while factors which is less studied should be further studied in the future.…”
Get full text
Article -
2044
Isolation of Antidepressants and Their Metabolites from Saliva Using Supported Liquid Extraction (SLE)
Published 2023-02-01“…The determination of antidepressant drugs and their metabolites in the body, mainly in the blood, allows for the monitoring of drug levels and their metabolism, helps identify drug interactions, and reduces the likelihood of increased side effects. …”
Get full text
Article -
2045
Pattern of Timing Adherence Could Guide Recommendations for Personalized Intake Schedules
Published 2012-11-01“…The complete delineation of timing adherence allows for the calculation of objective adherence parameters and the linking of exposure with drug-drug interactions. A sub-analysis was performed on 68 patients, who were prescribed lipid lowering therapy. …”
Get full text
Article -
2046
Review of bosentan in the management of pulmonary arterial hypertension
Published 2008-01-01“…The safety and tolerability of bosentan as well as drug interactions are discussed. Dosage recommendations in adults and pediatrics are presented. …”
Get full text
Article -
2047
Episodic memories and their relevance for psychoactive drug use and addiction
Published 2013-05-01“…In that, understanding how addictive drugs interact with episodic memory circuits in the brain may provide crucial information for how drug use and addiction are established.…”
Get full text
Article -
2048
Chinese Herbal Medicine on Cardiovascular Diseases and the Mechanisms of Action
Published 2016-12-01“…Future research should focus on well-designed clinic trial, in-depth mechanic study, investigations on side effects of herbs and drug interactions. Studies on developing new agents with effectiveness and safety from traditional Chinese medicine is promising for prevention and treatment of patients with cardiovascular diseases.…”
Get full text
Article -
2049
Treatment algorithms for special cases
Published 2022-04-01“…It should be noted that the elderly have comorbidities and concomitant drug use, which increases the likelihood of side effects and drug interactions of psoriasis medications. In the presence of a viral disease, many agents used in the treatment of psoriasis carry the risk of exacerbating the infection due to their immunosuppressive properties. …”
Get full text
Article -
2050
Insomnia in general practice: the role of doxylamine
Published 2020-03-01“…We also discuss the pharmacology of doxylamine, drug interactions, and prescription modes. There are also three clinical case studies, presenting the typical acute insomnia patients and logic for their evaluation, underlining key clinical features of this disorder.…”
Get full text
Article -
2051
Novos medicamentos antiepilépticos.
Published 1995-01-01“…Yet, the ideal AE, that is, with a well-known mechanism of action, effective in monotherapy for all epileptic fits, with a perfect pharmacokinetic profile, with no adverse or teratogenic effects, with no drug interactions and available under many formulations, is far from being developed. …”
Get full text
Article -
2052
Progress in the Treatment of Antisense Oligonucleotides in Duchenne Muscular Dystrophy
Published 2022-04-01“…In addition, the likelihood of drug-drug interactions of ASO is low. Existing clinical studies have shown that they have certain clinical benefits and good tolerability, bringing new options for DMD treatment. …”
Get full text
Article -
2053
Increased amisulpride serum concentration in a patient treated with concomitant pregabalin and trazodone: a case report
Published 2022-11-01“…This could be helpful information for psychiatrists in order to avoid drug–drug interactions between amisulpride and pregabalin. We recommend TDM of amisulpride in patients treated concomitantly with other drugs eliminated mainly by the kidneys.…”
Get full text
Article -
2054
The Use of Direct Oral Anticoagulants for Prevention of Stroke and Systemic Embolic Events in East Asian Patients with Nonvalvular Atrial Fibrillation
Published 2018-06-01“…DOACs do not require monitoring of the international normalized ratio to determine the optimal dose, and have a lower potential for food and drug interactions, improved benefit-risk profiles, and a quicker onset and offset of action relative to warfarin. …”
Get full text
Article -
2055
Polypharmacy in Outpatients with Bipolar Disorder: Associated Factors and Treatment Characteristics in Türkiye
Published 2023-09-01“…Moreover, interventions are needed to minimize the possible side effects, and risk of drug-drug interactions related to the use of multiple drugs, determine the benefit/harm ratio and reduce unnecessary psychotropic drug use.…”
Get full text
Article -
2056
Physicians’ knowledge and communication about traditional, complementary and alternative medicine use among Latino patients at Kaiser Permanente, Oakland CA
Published 2014-03-01“…Physicians were more concerned with the misuse of prescription drugs among Latino patients than the potential for herbal toxicity or herb-drug interactions. The results indicate a need to include questions about pharmaceuticals in future research on Latino health practices, and also point to the need for research on how education, income and acculturation affect health beliefs and TCAM practices within different Latino subgroups.…”
Get full text
Article -
2057
Recent findings and advancements in the detection of designer benzodiazepines: a brief review
Published 2023-12-01“…Further research should focus on elucidating their pharmacokinetic properties and metabolism in humans, especially in view of genetic polymorphisms and drug interactions that could inform clinical treatment choices. …”
Get full text
Article -
2058
Topical issues of the efficiency and safety of using the first direct thrombin inhibitor in real clinical practice
Published 2016-01-01“…An increased risk for bleeding was generally associated with undesirable drug interactions, polypragmasia, and underestimated kidney dysfunction. …”
Get full text
Article -
2059
The Algorithm of Herbal Medicine Usage in Nursing Homes, Isfahan, Iran
Published 2012-05-01“…They commonly face drug interactions as well. On the other hand, most of the elderly believe in the effects of medicinal plants and widely use them to treat their diseases. …”
Get full text
Article -
2060
Polypharmacy is a challenge for our generation, and the knowledge of deprescribing is a needed skill of our health care professionals
Published 2022-04-01“…Polypharmacy is frequently linked to adverse drug reactions (ADR), drug interactions, falls, prescribing cascades, patient non-adherence to medications, and even more severe outcomes such as hospitalisation and death. …”
Get full text
Article