Investigation and Comparison of Diagnosis and Treatment Guidelines for Community Acquired Pneumonia in terms of Pharmaceutical Care Requirements by Melda BAHAP, Emre KARA, Ahmet Görkem ER, Kutay DEMİRKAN, Serhat ÜNAL

“…This review waswritten to compare five CAP guidelines (British Thoracic Society, National Institute for Health and Care Excellence, European Society of Clinical Microbiology and Infectious Diseases, Spanish Pneumology and Thoracic Surgery Association, Turkish Thoracic Society), to identify and discuss their differences, and to discuss the issues not considered in the guidelines such as drug interactions, dose adjustment in kidney/liver dysfunction, dose adjustment in obesity, serious/common side effects, and pharmacokinetic-pharmacodynamic properties of the drugs.…”
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Comparative analysis of drug-salt-polymer interactions by experiment and molecular simulation improves biopharmaceutical performance by Sumit Mukesh, Goutam Mukherjee, Ridhima Singh, Nathan Steenbuck, Carolina Demidova, Prachi Joshi, Abhay T. Sangamwar, Rebecca C. Wade

“…However, the effects of polymers on drug-drug interactions in aqueous phase are largely unexplored and it is unclear how to choose an optimal salt-polymer combination for a particular drug. …”
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Explainable Artificial Intelligence for Patient Safety: A Review of Application in Pharmacovigilance by Seunghee Lee, Seonyoung Kim, Jieun Lee, Jong-Yeup Kim, Mi-Hwa Song, Suehyun Lee

“…Although artificial intelligence (AI) is actively used in drug surveillance and patient safety, gathering adverse drug reaction information, extracting drug-drug interactions, and predicting effects, XAI is not normally utilized. …”
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Strategies for Successful Over-Expression of Human Membrane Transport Systems Using Bacterial Hosts: Future Perspectives by Michele Galluccio, Lara Console, Lorena Pochini, Mariafrancesca Scalise, Nicola Giangregorio, Cesare Indiveri

“…In addition, roughly 60% of FDA-approved drugs interact with membrane proteins, among which are transporters, often responsible for pharmacokinetics and side effects. …”
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Hypogonadism in Women with Prader-Willi Syndrome—Clinical Recommendations Based on a Dutch Cohort Study, Review of the Literature and an International Expert Panel Discussion by Karlijn Pellikaan, Yassine Ben Brahim, Anna G. W. Rosenberg, Kirsten Davidse, Christine Poitou, Muriel Coupaye, Anthony P. Goldstone, Charlotte Høybye, Tania P. Markovic, Graziano Grugni, Antonino Crinò, Assumpta Caixàs, Talia Eldar-Geva, Harry J. Hirsch, Varda Gross-Tsur, Merlin G. Butler, Jennifer L. Miller, Paul-Hugo M. van der Kuy, Sjoerd A. A. van den Berg, Jenny A. Visser, Aart J. van der Lely, Laura C. G. de Graaff

“…This could be related to unfamiliarity with the syndrome, fear of behavioral changes, hygienic concerns, or drug interactions. To prevent underdiagnosis and undertreatment, we provide practical recommendations for the screening and treatment of hypogonadism in females with PWS.…”
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Virtual twins for model‐informed precision dosing of clozapine in patients with treatment‐resistant schizophrenia by Sam Mostafa, Reza Rafizadeh, Thomas M. Polasek, Chad A. Bousman, Amin Rostami‐Hodjegan, Robert Stowe, Prescilla Carrion, Leslie J. Sheffield, Carl M. J. Kirkpatrick

“…However, refinement is required to improve the prediction of pharmacokinetic drug–drug interactions, particularly with fluvoxamine augmentation.…”
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Prevalence and pattern of use of medications amongst undergraduate students of a Nigerian University by Olubunmi Margaret Ogbodu, Ayobami Precious Adekola, Gloria Thupayagale-Tshweneagae

“…Such practices can lead to increased toxicity, drug interactions, and other adverse effects. This study investigated the prevalence and pattern of use of prescription and OTC medications amongst undergraduate students at the University of Lagos. …”
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Khat, a Cultural Chewing Drug: A Toxicokinetic and Toxicodynamic Summary by Bárbara Silva, Jorge Soares, Carolina Rocha-Pereira, Přemysl Mladěnka, Fernando Remião, on behalf of The OEMONOM Researchers

“…Additionally, the main drug interactions involved with khat are described.…”
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Revolutionizing Medicinal Chemistry: The Application of Artificial Intelligence (AI) in Early Drug Discovery by Ri Han, Hongryul Yoon, Gahee Kim, Hyundo Lee, Yoonji Lee

“…Nonetheless, new relationships and methods have been unveiled, demonstrating AI’s expanding potential in predicting and understanding drug interactions and properties. For its full potential to be realized, interdisciplinary collaboration is essential. …”
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“The Good, the Bad and the Ugly” in the First Year of COVID-19 Pandemic by Berkay Kapar, Deniz Şimşek, Gülay Sain Güven

“…During the first year of COVID-19 pandemic, while there have been rapid developments in diagnosis and treatment of the disease; drug interactions and side effects have created a problem especially in high risk patients with chronic diseases and multiple drug use. …”
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EXPERT EVALUATION OF PRECLINICAL STUDIES OF PRIMARY AND SECONDARY PHARMACODYNAMICS OF MEDICINES by G. N. Engalycheva, R. D. Subaev, D. V. Gorachev, Yu. V. Olefir

“…According to the EAEU Rules of registration and evaluation of medicinal products for human use, the Common  Technical Document has to include information  on primary pharmacodynamics, secondary pharmacodynamics, safety pharmacology  studies, and pharmacodynamic drug interactions, which are subject to evaluation  during examination  of the preclinical  study results. …”
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Antifungal Properties of Chemically Defined Propolis from Various Geographical Regions by Marcin Ożarowski, Tomasz M. Karpiński, Rahat Alam, Małgorzata Łochyńska

“…Mechanisms of antifungal activity of propolis extracts and research trends in the aspect of developing new therapies and the assessment of drug interactions are indicated. The review of the research results shows that there is great progress in the definition of propolis extracts. …”
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Venous Thromboembolism and Cancer: A Comprehensive Review from Pathophysiology to Novel Treatment by Mario Enrico Canonico, Ciro Santoro, Marisa Avvedimento, Giuseppe Giugliano, Giulia Elena Mandoli, Maria Prastaro, Anna Franzone, Raffaele Piccolo, Federica Ilardi, Matteo Cameli, Giovanni Esposito

“…The selection of patients who have a balanced risk–benefit profile for management of anticoagulation is complex, given individual patient goals and preferences, different prognosis of specific cancers, common comorbidities, potential drug–drug interactions, underweight states, and the competing risks of morbidity and mortality. …”
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Pharmacology and Adverse Events of Emergency-Use Authorized Medication in Moderate to Severe COVID-19 by Jen-Yu Hsu, Yan-Chiao Mao, Po-Yu Liu, Kuo-Lung Lai

“…The drug-specific pharmacokinetics, toxicity, and drug interactions are summarized in this study. Remdesivir and baricitinib are small-molecule drugs that are mainly metabolized by the kidneys, while tocilizumab and sarilumab are monoclonal antibody drugs with metabolic pathways that are currently not fully understood. …”
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Skin Pigmentation Types, Causes and Treatment—A Review by Amin Mahmood Thawabteh, Alaa Jibreen, Donia Karaman, Alà Thawabteh, Rafik Karaman

“…Albinism, melasma, vitiligo, Addison’s disease, and post-inflammatory hyperpigmentation, which can be brought on by eczema, acne vulgaris, and drug interactions, are the most common skin pigmentation disorders in clinical practice. …”
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Shedding Light on the Pharmacological Interactions between μ-Opioid Analgesics and Angiotensin Receptor Modulators: A New Option for Treating Chronic Pain by Kornél Király, Dávid Á. Karádi, Ferenc Zádor, Amir Mohammadzadeh, Anna Rita Galambos, Mihály Balogh, Pál Riba, Tamás Tábi, Zoltán S. Zádori, Éva Szökő, Susanna Fürst, Mahmoud Al-Khrasani

“…The MOR and angiotensin receptors or drugs interacting with these receptors have been independently investigated in relation to analgesia. …”
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An Up-to-Date Article Regarding Particularities of Drug Treatment in Patients with Chronic Heart Failure by Valentina Buda, Andreea Prelipcean, Dragos Cozma, Dana Emilia Man, Simona Negres, Alexandra Scurtu, Maria Suciu, Minodora Andor, Corina Danciu, Simina Crisan, Cristina Adriana Dehelean, Lucian Petrescu, Ciprian Rachieru

“…The article also highlights several drugs and food supplements that may worsen the prognosis of HF patients and discusses some potential drug–drug interactions, their consequences and recommendations for health care providers, as well as the risks of adverse drug reactions and treatment discontinuation, as an interdisciplinary approach to treatment is essential for HF patients.…”
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Placental efflux transporters and antiseizure or antidepressant medication use impact birth weight in MoBa cohort by Marta H. Hernandez, Jacqueline M. Cohen, Karoline H. Skåra, Thea K. Grindstad, Yunsung Lee, Per Magnus, Pål R. Njølstad, Ole A. Andreassen, Elizabeth C. Corfield, Alexandra Havdahl, Espen Molden, Kari Furu, Maria C. Magnus, Alvaro Hernaez

“…Antidepressant exposure was associated with low birth weight, but there were no gene-drug interactions. The interplay between MRP2-ABCC2 and MDR1-ABCB1 variants and antiseizure medication may impact neonatal birth weight.…”
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Positive kidney profile of dogs with Leishmania sp. and treated with miltefosine by Danillo Brenno de Assis Torres, Nelson Costa Pinheiro, Ellis Sousa Barros, Dennis Leite dos Santos, José Ribamar da Silva Júnior, Porfírio Cadanedo Guerra

“…To stage the disease and carry out treatment, kidney assessment is of great importance, along with drug interactions and the deposition of immune complexes. …”
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Pharmacists’ Role in Managing Patients with Chronic Lymphocytic Leukemia by Kevin Y. Chen, Kelly M. Brunk, Bianka A. Patel, Kurtis J. Stocker, Jessica J. Auten, Kaitlyn M. Buhlinger, Benyam Muluneh

“…This paradigm shift poses new challenges for the medical team, including drug–drug interactions, adherence counseling, and financial toxicity. …”
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