Management of oropharyngeal candidiasis with localized oral miconazole therapy: efficacy, safety, and patient acceptability by Cookinham S, Collins CD, Smith J

“…Miconazole buccal tablets exhibit few drug interactions because of low systemic absorption and are generally well tolerated with a safety profile similar to comparators. …”
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Calcitonin Gene-Related Peptide (CGRP)-Targeted Treatments—New Therapeutic Technologies for Migraine by Linda Sangalli, Stefania Brazzoli

“…As they are migraine-specific therapies, they largely expand their use to patients that could not tolerate previous treatments, either for systemic contraindications or drug-to-drug interactions, or where any other available option was not efficacious. …”
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Are improper kinetic models hampering drug development? by Ryan Walsh

“…The empirical approach to inhibition modeling presented here is broadly applicable allowing easy comparison and rational analysis of drug interactions. To demonstrate this, a simple kinetic model of DAPT, a compound that both activates and inhibits γ-secretase is examined using excel. …”
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Alleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitis. by Wei Dou, Subhajit Mukherjee, Hao Li, Madhukumar Venkatesh, Hongwei Wang, Sandhya Kortagere, Ariel Peleg, Sridhar S Chilimuri, Zheng-Tao Wang, Ying Feng, Eric R Fearon, Sridhar Mani

“…Pharmacological targeting of intestinal PXR using natural metabolically labile ligands could serve as effective and potent therapeutics for gut inflammation that avert systemic drug interactions.…”
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OpenVigil FDA - Inspection of U.S. American Adverse Drug Events Pharmacovigilance Data and Novel Clinical Applications. by Ruwen Böhm, Leocadie von Hehn, Thomas Herdegen, Hans-Joachim Klein, Oliver Bruhn, Holger Petri, Jan Höcker

“…OpenVigil FDA provides disproportionality analyses to (i) identify the drug most likely evoking a new adverse event, (ii) compare two drugs concerning their safety profile, (iii) check arbitrary combinations of two drugs for unknown drug-drug interactions and (iv) enhance the relevance of results by identifying confounding factors and eliminating them using background correction. …”
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Mathematical Modelling of the Molecular Mechanisms of Interaction of Tenofovir with Emtricitabine against HIV by Sara Iannuzzi, Max von Kleist

“…However, it is unclear whether, and which, direct drug–drug interactions mediate the apparent synergy. The goal of this work was to refine a mechanistic model for the molecular mechanism of action (MMOA) of nucleoside analogues in order to analyse whether putative direct interactions may account for the in vitro observed synergistic effects. …”
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Electrophysiological Characterization of Spontaneously Contracting Cell Aggregates Obtained from Rainbow Trout Larvae with Multielectrode Arrays by Julia M. Mehnert, Matthias Brandenburger, Bianka Grunow

“…Ranging from cell-based systems to model organisms, no model available to date reflects the complexity of the human heart and evokes the great need for improved and more affordable systems. Many drugs interact with hERG potassium channels and consequently cause life threatening ventricular arrhythmias, further highlighting the importance of suitable model systems. …”
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Supplementary Pharmacotherapy for the Behavioral Abnormalities Caused by Stressors in Humans, Focused on Post-Traumatic Stress Disorder (PTSD) by Jeffrey Fessel

“…Using low doses of chosen drugs will limit both toxicity and drug-drug interactions. A clinical trial is required to validate both the advocated concept and the choice of drugs.…”
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Safety issues regarding melatonin use in child and adolescent patients with sleep problems by Eunsoo Moon, Jung Hyun Lee

“…It is necessary to monitor potential drug interactions with medications such as inhibitors and enhancers of cytochrome P450 1A2 (CYP1A2). …”
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Cardiovascular Toxicity of Antineoplastic Treatments in Hematological Diseases: Focus on Molecular Mechanisms to Improve Therapeutic Management by Serena Barachini, Gabriele Buda, Iacopo Petrini

“…Understanding how these drugs interact with the heart and blood vessels is essential for predicting, detecting, and managing chemotherapy-related heart issues.…”
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Physicians’ attitude towards community pharmacists’ contribution in the treatment decision making by Rebar Ali Mohammed, Bushra Hassan Marouf

“…Furthermore, the physicians’ perspective on the pharmacists’ role showed that advising patients on drug administration (85.1%) and preventing drug interactions (76.6%) were the most common duties of the community pharmacists. …”
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Optimizing doxepin therapy in dermatology: introducing blood level monitoring and genotype testing by Bridget Myers, Vidhatha Reddy, Stephanie Chan, Quinn Thibodeaux, Nicholas Brownstone, John Koo

“…Then, it explores internal and external reasons why doxepin plasma levels and clinical response vary so significantly between patients, including genetic polymorphisms, drug interactions, comorbidities, sex, and ethnicity. Blood level monitoring is introduced, a tool dermatologists can use to optimize doxepin dosing in patients responding subtherapeutically to typical dermatologic doses. …”
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Computer, MD by Feblowitz, Joshua

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COVID-19 and gastrointestinal disease: implications for the gastroenterologist by Hunt, RH, East, JE, Lanas, A, Malfertheiner, P, Satsangi, J, Scarpignato, C, Webb, GJ

“…The risk for drug-drug interactions is considerable in patients seriously ill with COVID-19 who often require mechanical ventilation and life support. …”

The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution. by Champness, J, Achari, A, Ballantine, S, Bryant, P, Delves, C, Stammers, D

“…CONCLUSIONS: These structures show how two drugs interact with a fungal DHFR. A comparison of the three-dimensional structure of this relatively large DHFR with bacterial or mammalian enzyme-inhibitor complexes determined previously highlights some additional secondary structure elements in this particular enzyme species. …”

The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution. by Champness, J, Achari, A, Ballantine, S, Bryant, P, Delves, C, Stammers, D

“…CONCLUSIONS: These structures show how two drugs interact with a fungal DHFR. A comparison of the three-dimensional structure of this relatively large DHFR with bacterial or mammalian enzyme-inhibitor complexes determined previously highlights some additional secondary structure elements in this particular enzyme species. …”

Cognitive-behavioural therapy for non-motor symptoms of Parkinson's disease: a clinical review by Koychev, I, Okai, D

“…Pharmacological treatment is the main approach in dealing with these symptoms, but it is limited by variable efficacy and risk of drug interactions. Non-pharmacological approaches using the cognitive-behavioural therapy (CBT) model are viable alternatives and in this review paper we summarise the evidence of CBT for three of the most common psychiatric manifestations of PD: depression and anxiety, impulse-control disorders and insomnia. …”

Evaluation Of Tacrolimus, Associated Adverse Effects, Quality Of Life, And Treatment Satisfaction Among Kidney Transplant Patients In Riyadh, Saudi Arabia by Ahmed Alboghdadly, Amany Mohamed Hussien

“…Due to tacrolimus- unwanted adverse effects, narrow therapeutic index, drug-drug interactions, and significant inter-individual variability in pharmacokinetics, it requires constant therapeutic drug monitoring. …”
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Exploring New Scaffolds for the Dual Inhibition of HIV-1 RT Polymerase and Ribonuclease Associated Functions by Rita Meleddu, Angela Corona, Simona Distinto, Filippo Cottiglia, Serenella Deplano, Lisa Sequeira, Daniela Secci, Alessia Onali, Erica Sanna, Francesca Esposito, Italo Cirone, Francesco Ortuso, Stefano Alcaro, Enzo Tramontano, Péter Mátyus, Elias Maccioni

“…However, avoiding drugs interactions and patient compliance are issues not fully accomplished so far. …”
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Ionic Polymethacrylate Based Delivery Systems: Effect of Carrier Topology and Drug Loading by Dorota Neugebauer, Anna Mielańczyk, Rafał Bielas, Justyna Odrobińska, Maria Kupczak, Katarzyna Niesyto

“…The studies indicated that the well-defined ionic polymethacrylates, including poly(ionic liquid)s, are advantageous for designing macromolecular carriers due to the variety of structural parameters, which are efficient for tuning of drug loading and release behavior in respect to the specific drug interactions.…”
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