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2121
Management of oropharyngeal candidiasis with localized oral miconazole therapy: efficacy, safety, and patient acceptability
Published 2011-07-01“…Miconazole buccal tablets exhibit few drug interactions because of low systemic absorption and are generally well tolerated with a safety profile similar to comparators. …”
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2122
Calcitonin Gene-Related Peptide (CGRP)-Targeted Treatments—New Therapeutic Technologies for Migraine
Published 2023-01-01“…As they are migraine-specific therapies, they largely expand their use to patients that could not tolerate previous treatments, either for systemic contraindications or drug-to-drug interactions, or where any other available option was not efficacious. …”
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2123
Are improper kinetic models hampering drug development?
Published 2014-10-01“…The empirical approach to inhibition modeling presented here is broadly applicable allowing easy comparison and rational analysis of drug interactions. To demonstrate this, a simple kinetic model of DAPT, a compound that both activates and inhibits γ-secretase is examined using excel. …”
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2124
Alleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitis.
Published 2012-01-01“…Pharmacological targeting of intestinal PXR using natural metabolically labile ligands could serve as effective and potent therapeutics for gut inflammation that avert systemic drug interactions.…”
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2125
OpenVigil FDA - Inspection of U.S. American Adverse Drug Events Pharmacovigilance Data and Novel Clinical Applications.
Published 2016-01-01“…OpenVigil FDA provides disproportionality analyses to (i) identify the drug most likely evoking a new adverse event, (ii) compare two drugs concerning their safety profile, (iii) check arbitrary combinations of two drugs for unknown drug-drug interactions and (iv) enhance the relevance of results by identifying confounding factors and eliminating them using background correction. …”
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2126
Mathematical Modelling of the Molecular Mechanisms of Interaction of Tenofovir with Emtricitabine against HIV
Published 2021-07-01“…However, it is unclear whether, and which, direct drug–drug interactions mediate the apparent synergy. The goal of this work was to refine a mechanistic model for the molecular mechanism of action (MMOA) of nucleoside analogues in order to analyse whether putative direct interactions may account for the in vitro observed synergistic effects. …”
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2127
Electrophysiological Characterization of Spontaneously Contracting Cell Aggregates Obtained from Rainbow Trout Larvae with Multielectrode Arrays
Published 2013-11-01“…Ranging from cell-based systems to model organisms, no model available to date reflects the complexity of the human heart and evokes the great need for improved and more affordable systems. Many drugs interact with hERG potassium channels and consequently cause life threatening ventricular arrhythmias, further highlighting the importance of suitable model systems. …”
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2128
Supplementary Pharmacotherapy for the Behavioral Abnormalities Caused by Stressors in Humans, Focused on Post-Traumatic Stress Disorder (PTSD)
Published 2023-02-01“…Using low doses of chosen drugs will limit both toxicity and drug-drug interactions. A clinical trial is required to validate both the advocated concept and the choice of drugs.…”
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2129
Safety issues regarding melatonin use in child and adolescent patients with sleep problems
Published 2022-12-01“…It is necessary to monitor potential drug interactions with medications such as inhibitors and enhancers of cytochrome P450 1A2 (CYP1A2). …”
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2130
Cardiovascular Toxicity of Antineoplastic Treatments in Hematological Diseases: Focus on Molecular Mechanisms to Improve Therapeutic Management
Published 2024-03-01“…Understanding how these drugs interact with the heart and blood vessels is essential for predicting, detecting, and managing chemotherapy-related heart issues.…”
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2131
Physicians’ attitude towards community pharmacists’ contribution in the treatment decision making
Published 2023-01-01“…Furthermore, the physicians’ perspective on the pharmacists’ role showed that advising patients on drug administration (85.1%) and preventing drug interactions (76.6%) were the most common duties of the community pharmacists. …”
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2132
Optimizing doxepin therapy in dermatology: introducing blood level monitoring and genotype testing
Published 2022-01-01“…Then, it explores internal and external reasons why doxepin plasma levels and clinical response vary so significantly between patients, including genetic polymorphisms, drug interactions, comorbidities, sex, and ethnicity. Blood level monitoring is introduced, a tool dermatologists can use to optimize doxepin dosing in patients responding subtherapeutically to typical dermatologic doses. …”
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2133
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2134
COVID-19 and gastrointestinal disease: implications for the gastroenterologist
Published 2020“…The risk for drug-drug interactions is considerable in patients seriously ill with COVID-19 who often require mechanical ventilation and life support. …”
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2135
The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution.
Published 1994“…CONCLUSIONS: These structures show how two drugs interact with a fungal DHFR. A comparison of the three-dimensional structure of this relatively large DHFR with bacterial or mammalian enzyme-inhibitor complexes determined previously highlights some additional secondary structure elements in this particular enzyme species. …”
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2136
The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution.
Published 1994“…CONCLUSIONS: These structures show how two drugs interact with a fungal DHFR. A comparison of the three-dimensional structure of this relatively large DHFR with bacterial or mammalian enzyme-inhibitor complexes determined previously highlights some additional secondary structure elements in this particular enzyme species. …”
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2137
Cognitive-behavioural therapy for non-motor symptoms of Parkinson's disease: a clinical review
Published 2017“…Pharmacological treatment is the main approach in dealing with these symptoms, but it is limited by variable efficacy and risk of drug interactions. Non-pharmacological approaches using the cognitive-behavioural therapy (CBT) model are viable alternatives and in this review paper we summarise the evidence of CBT for three of the most common psychiatric manifestations of PD: depression and anxiety, impulse-control disorders and insomnia. …”
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2138
Evaluation Of Tacrolimus, Associated Adverse Effects, Quality Of Life, And Treatment Satisfaction Among Kidney Transplant Patients In Riyadh, Saudi Arabia
Published 2023“…Due to tacrolimus- unwanted adverse effects, narrow therapeutic index, drug-drug interactions, and significant inter-individual variability in pharmacokinetics, it requires constant therapeutic drug monitoring. …”
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2139
Exploring New Scaffolds for the Dual Inhibition of HIV-1 RT Polymerase and Ribonuclease Associated Functions
Published 2021-06-01“…However, avoiding drugs interactions and patient compliance are issues not fully accomplished so far. …”
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2140
Ionic Polymethacrylate Based Delivery Systems: Effect of Carrier Topology and Drug Loading
Published 2019-07-01“…The studies indicated that the well-defined ionic polymethacrylates, including poly(ionic liquid)s, are advantageous for designing macromolecular carriers due to the variety of structural parameters, which are efficient for tuning of drug loading and release behavior in respect to the specific drug interactions.…”
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