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2161
High-dose vitamin C and cancer
Published 2016-01-01“…Although intake of high doses of vitamin C is alleged to be harmless, based on that it is in the group of water soluble vitamins and is not stored in the body, there are many side effects and drug interactions reported in the literature. For now, it is better to abstain from this treatment, until the benefit of the treatment (if any) is clearly demonstrated, considering the potential side effects and interactions.…”
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2162
Invasive Respiratory Fungal Infections in COVID-19 Critically Ill Patients
Published 2022-04-01“…Several antifungal drugs are currently available, but the development of new molecules with reduced toxicity, less drug-interactions and potentially active on difficult to treat strains, is highly warranted. …”
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2163
Immunosuppressive Treatment in Antiphospholipid Syndrome: Is It Worth It?
Published 2021-02-01“…Lifelong anticoagulation with vitamin K antagonists remains the cornerstone of the therapy for thrombotic APS, but frequently the use of anticoagulation may be problematic due to the increased risk of bleeding, drug interactions, or comorbidities. Immunosuppressant drugs are widely used to treat several autoimmune conditions, in which their safety and effectiveness have been largely demonstrated. …”
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2164
Anticoagulant Treatment in Patients with Atrial Fibrillation and Chronic Kidney Disease
Published 2021-01-01“…Results: According to guidelines, DOACs are the treatment of choice for patients with CKD 1–3 (Crcl ≥ 30 mL/min) due to their high efficacy, better safety profile, and fewer food/drug and drug/ drug interactions than warfarin. For patients with CKD 4 (Crcl 15-29 mL/min), there are no such strong recommendations as to which group of anticoagulants is the better choice, and for those with CKD 5 (Crcl <15 mL/min), the choice is currently narrowed to warfarin or apixaban. …”
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2165
Vincristine-Induced Peripheral Neuropathy (VIPN) in Pediatric Tumors: Mechanisms, Risk Factors, Strategies of Prevention and Treatment
Published 2021-04-01“…Furthermore, both patient-related risk factors (age, race, ethnicity and genetic polymorphisms) and treatment-related risk factors (dose, time of infusion and drug–drug interactions) are involved in the pathogenesis of VIPN. …”
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2166
BRCT Domains: Structure, Functions, and Implications in Disease—New Therapeutic Targets for Innovative Drug Discovery against Infections
Published 2023-06-01“…Interestingly, sequence variations among species are considered positive traits in the search for suitable therapeutic targets, since non-specific drug interactions might be reduced. These main characteristics of BRCT, as well as its critical implications in key biological processes in the cell, have prompted the study of these domains as therapeutic targets. …”
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2167
Depressive states in the structure of postcovid syndrome: features and therapy
Published 2022-04-01“…Clinical experience has demonstrated the feasibility of antidepressant therapy for postcovid depression and the high efficacy and safety, including the risk of drug interactions, of using vortioxetine, including prescribing the drug to the elderly and the somatically impaired. …”
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2168
Diet and Nutrition in Pediatric Inflammatory Bowel Diseases
Published 2021-02-01“…Moreover, many IBD-related factors, such as poor dietary intake, nutrients loss and drugs interact with nutritional status, thus paving the way for the development of many therapeutic strategies in which nutrition represents the cornerstone, either as first-line therapy or as reversing nutritional deficiencies and malnutrition in IBD patients. …”
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2169
Antimicrobial and P450 Inhibitory Properties of Common Functional Foods
Published 2014-06-01“…CONCLUSION: Results demonstrated the possible risk of food-drug interactions from spice and herb plants may affect drug disposition and safety. …”
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2170
The Pharmacist’s Role in Managing COVID-19 in Chronic Kidney Disease Patients: A Review of Existing Strategies and Future Implications
Published 2022-08-01“…Given the massive increase in off-label use of medications to treat COVID-19, pharmacists can contribute substantially towards dosing decisions, reporting adverse medication events, and managing drug–drug interactions in COVID-19 patients suffering from CKD. …”
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2171
The Era of Rhythm Control: A Review of the Epidemiology and Clinical Impact of Anti-Arrhythmic Medications in Atrial Fibrillation
Published 2023-03-01“…Providers must balance the increased emphasis on rhythm control with the overall clinical impact on their patients due to drug-to-drug interactions and adverse effects that can occur with different co-morbidities. …”
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2172
The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice
Published 2021“…Thus, our results reveal a potential new mechanism for unexpected drug–drug or food–drug interactions.…”
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Journal Article -
2173
The Utilization of Plant-Material-Loaded Vesicular Drug Delivery Systems in the Management of Pulmonary Diseases
Published 2023-12-01“…Most bioactive constituents from plants are of limited effectiveness, due to poor solubility, limited permeability, first-pass metabolism, efflux transporters, chemical instability, and food–drug interactions However, when combined with vesicular drug delivery systems (VDDS), herbal medicines can be delivered at a predetermined rate and can exhibit site-specific action. …”
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2174
Investigating the Role of Clinical Decision Support Systems in Reducing Medical Errors
Published 2023-06-01“…From a physician’s point of view, decision support systems can be helpful by reducing the risk of severe allergic reactions and drug interactions (60%), quick access to patient records (50%), and computerized order registries (30%). …”
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2175
Development of an In Vitro System to Study the Interactions of Aerosolized Drugs with Pulmonary Mucus
Published 2020-02-01“…In this study, a simple in vitro system was developed to investigate the factors promoting drug interactions with airway mucus in physiologically relevant conditions. …”
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2176
Current Therapeutic Interventions for COVID-19
Published 2020-12-01“…Especially in some drug combinations, side effects like prolonged QT interval, drug-drug interactions, and restrictions on the use of some drugs in the pediatric age group or pregnancy limit the specific, evidence-based and reliable treatment. …”
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2177
Marked on the skin
Published 2018-07-01“…Conclusion: The main dermatological lesions in HIV/ AIDS patients described in the scientific articles were the following: pruritic papular eruptions; Kaposi’s Sarcoma lesions; mucocutaneous eruptions and ulcerations; Molluscum Contagiosum lesions; Psoriasis lesions; rashes due to drug interactions; maculopapular eruptions, urticarias and hyperpigmentation of cutaneous attachments as adverse reactions to antiretrovirals; and erythematous papules. …”
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2178
Prescriptions of Antipsychotics in Younger and Older Geriatric Patients with Polypharmacy, Their Safety, and the Impact of a Pharmaceutical-Medical Dialogue on Antipsychotic Use
Published 2022-12-01“…The binary logistic regression analyses of geriatric patients with antipsychotics revealed that ADRs and drug–drug interactions (DDIs) were particularly related to the number of medications prescribed. …”
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2179
The Self-Administered Use of Complementary and Alternative Medicine (CAM) Supplements and Antioxidants in Cancer Therapy and the Critical Role of Nrf-2—A Systematic Review
Published 2022-10-01“…Dietary supplements and vitamins are taken for different reasons, but often during conventional cancer treatment involving chemotherapy or radiotherapy and in a self-decided manner without seeking medical advice from healthcare professionals. Drug–drug interactions with dietary supplements or vitamins involving multiple signaling pathways are well described. …”
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2180
Advances in Therapy for Irritable Bowel Syndrome with Diarrhea: Role of Rifaximin in Combination with Metronidazole
Published 2024-01-01“…Rifaximin, with its broad anti-bacterial action, along with eubiotic activity, limited systemic exposure, gut-specific action, and limited potential for drug interactions along with metronidazole is proposed as a novel treatment option for IBS-D. …”
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