High-dose vitamin C and cancer by Ahmet Unlu, M.D., Onder Kirca, M.D., Mustafa Ozdogan, M.D., Erdinç Nayır, M.D.

“…Although intake of high doses of vitamin C is alleged to be harmless, based on that it is in the group of water soluble vitamins and is not stored in the body, there are many side effects and drug interactions reported in the literature. For now, it is better to abstain from this treatment, until the benefit of the treatment (if any) is clearly demonstrated, considering the potential side effects and interactions.…”
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Invasive Respiratory Fungal Infections in COVID-19 Critically Ill Patients by Francesca Raffaelli, Eloisa Sofia Tanzarella, Gennaro De Pascale, Mario Tumbarello

“…Several antifungal drugs are currently available, but the development of new molecules with reduced toxicity, less drug-interactions and potentially active on difficult to treat strains, is highly warranted. …”
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Immunosuppressive Treatment in Antiphospholipid Syndrome: Is It Worth It? by Ilaria Mormile, Francescopaolo Granata, Alessandra Punziano, Amato de Paulis, Francesca Wanda Rossi

“…Lifelong anticoagulation with vitamin K antagonists remains the cornerstone of the therapy for thrombotic APS, but frequently the use of anticoagulation may be problematic due to the increased risk of bleeding, drug interactions, or comorbidities. Immunosuppressant drugs are widely used to treat several autoimmune conditions, in which their safety and effectiveness have been largely demonstrated. …”
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Anticoagulant Treatment in Patients with Atrial Fibrillation and Chronic Kidney Disease by Marta Popović, Karmela Altabas, Matias Trbušić

“…Results: According to guidelines, DOACs are the treatment of choice for patients with CKD 1–3 (Crcl ≥ 30 mL/min) due to their high efficacy, better safety profile, and fewer food/drug and drug/ drug interactions than warfarin. For patients with CKD 4 (Crcl 15-29 mL/min), there are no such strong recommendations as to which group of anticoagulants is the better choice, and for those with CKD 5 (Crcl <15 mL/min), the choice is currently narrowed to warfarin or apixaban. …”
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Vincristine-Induced Peripheral Neuropathy (VIPN) in Pediatric Tumors: Mechanisms, Risk Factors, Strategies of Prevention and Treatment by Silvia Triarico, Alberto Romano, Giorgio Attinà, Michele Antonio Capozza, Palma Maurizi, Stefano Mastrangelo, Antonio Ruggiero

“…Furthermore, both patient-related risk factors (age, race, ethnicity and genetic polymorphisms) and treatment-related risk factors (dose, time of infusion and drug–drug interactions) are involved in the pathogenesis of VIPN. …”
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BRCT Domains: Structure, Functions, and Implications in Disease—New Therapeutic Targets for Innovative Drug Discovery against Infections by José Peña-Guerrero, Celia Fernández-Rubio, Alfonso T. García-Sosa, Paul A. Nguewa

“…Interestingly, sequence variations among species are considered positive traits in the search for suitable therapeutic targets, since non-specific drug interactions might be reduced. These main characteristics of BRCT, as well as its critical implications in key biological processes in the cell, have prompted the study of these domains as therapeutic targets. …”
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Depressive states in the structure of postcovid syndrome: features and therapy by N N Petrova, A V Kudryashov, O V Matvievskaya, A A Mukhin, V A Lavrova, E M Chumakov, N V Yaltseva, S V Kuzmina, N V Kostina, E V Akimova, K S Sadovnichiy, A V Antsyborov, M E Dubovets, A A Demeneva, A M Kudryavtseva, A V Akulov, T A Vinogradova, E M Samorukova, E N Shadrina, D I Moroz, E R Mordvintseva

“…Clinical experience has demonstrated the feasibility of antidepressant therapy for postcovid depression and the high efficacy and safety, including the risk of drug interactions, of using vortioxetine, including prescribing the drug to the elderly and the somatically impaired. …”
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Diet and Nutrition in Pediatric Inflammatory Bowel Diseases by Ugo Cucinotta, Claudio Romano, Valeria Dipasquale

“…Moreover, many IBD-related factors, such as poor dietary intake, nutrients loss and drugs interact with nutritional status, thus paving the way for the development of many therapeutic strategies in which nutrition represents the cornerstone, either as first-line therapy or as reversing nutritional deficiencies and malnutrition in IBD patients. …”
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Antimicrobial and P450 Inhibitory Properties of Common Functional Foods by San Nguyen, Huang Huang, Brian C Foster, Teresa W Tam, Tim Xing, Myron L Smith, John T Arnason, Humayoun Akhtar

“…CONCLUSION: Results demonstrated the possible risk of food-drug interactions from spice and herb plants may affect drug disposition and safety.   …”
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The Pharmacist’s Role in Managing COVID-19 in Chronic Kidney Disease Patients: A Review of Existing Strategies and Future Implications by Mohammed Salim Karattuthodi, Shabeer Ali Thorakkattil, Suhaj Abdulsalim, Sathvik Belagodu Sridhar, Sainul Abideen Parakkal, Savera Arain, Hafees Madathil, Ajmal Karumbaru Kuzhiyil, Mamdouh Mohammed Ahmed Ageeli, Mazhuvanchery Kesavan Unnikrishnan

“…Given the massive increase in off-label use of medications to treat COVID-19, pharmacists can contribute substantially towards dosing decisions, reporting adverse medication events, and managing drug–drug interactions in COVID-19 patients suffering from CKD. …”
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The Era of Rhythm Control: A Review of the Epidemiology and Clinical Impact of Anti-Arrhythmic Medications in Atrial Fibrillation by Cicely Anne Dye, Jamario Skeete, Asad Khan, Michael Dunleavy, Michael Dietrich, Annabelle Santos Volgman, Parikshit Sharma, Henry Huang

“…Providers must balance the increased emphasis on rhythm control with the overall clinical impact on their patients due to drug-to-drug interactions and adverse effects that can occur with different co-morbidities. …”
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The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice by Barretto, Sharon Ann, Lasserre, Frederic, Huillet, Marine, Régnier, Marion, Polizzi, Arnaud, Lippi, Yannick, Fougerat, Anne, Person, Elodie, Bruel, Sandrine, Bétoulières, Colette, Naylies, Claire, Lukowicz, Céline, Smati, Sarra, Guzylack, Laurence, Olier, Maïwenn, Théodorou, Vassilia, Mselli-Lakhal, Laila, Zalko, Daniel, Wahli, Walter, Loiseau, Nicolas, Gamet-Payrastre, Laurence, Guillou, Hervé, Ellero-Simatos, Sandrine

“…Thus, our results reveal a potential new mechanism for unexpected drug–drug or food–drug interactions.…”
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The Utilization of Plant-Material-Loaded Vesicular Drug Delivery Systems in the Management of Pulmonary Diseases by Bongani Sannyboy Lukhele, Kokoette Bassey, Bwalya Angel Witika

“…Most bioactive constituents from plants are of limited effectiveness, due to poor solubility, limited permeability, first-pass metabolism, efflux transporters, chemical instability, and food–drug interactions However, when combined with vesicular drug delivery systems (VDDS), herbal medicines can be delivered at a predetermined rate and can exhibit site-specific action. …”
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Investigating the Role of Clinical Decision Support Systems in Reducing Medical Errors by Faezeh Hajieslam, Zohreh Javanmard

“…From a physician’s point of view, decision support systems can be helpful by reducing the risk of severe allergic reactions and drug interactions (60%), quick access to patient records (50%), and computerized order registries (30%). …”
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Development of an In Vitro System to Study the Interactions of Aerosolized Drugs with Pulmonary Mucus by Safar Alqahtani, Clive J. Roberts, Snjezana Stolnik, Cynthia Bosquillon

“…In this study, a simple in vitro system was developed to investigate the factors promoting drug interactions with airway mucus in physiologically relevant conditions. …”
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Current Therapeutic Interventions for COVID-19 by Hacer Efnan Melek ARSOY, Öner ÖZDEMİR

“…Especially in some drug combinations, side effects like prolonged QT interval, drug-drug interactions, and restrictions on the use of some drugs in the pediatric age group or pregnancy limit the specific, evidence-based and reliable treatment. …”
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Marked on the skin by Pâmela Monique Campos, Dagmar Elaine Kaiser, Êrica Rosalba Mallmann Duarte, Alcindo Antônio Ferla, Potiguara de Oliveira Paz, Dóris Baratz Menegon

“…Conclusion: The main dermatological lesions in HIV/ AIDS patients described in the scientific articles were the following: pruritic papular eruptions; Kaposi’s Sarcoma lesions; mucocutaneous eruptions and ulcerations; Molluscum Contagiosum lesions; Psoriasis lesions; rashes due to drug interactions; maculopapular eruptions, urticarias and hyperpigmentation of cutaneous attachments as adverse reactions to antiretrovirals; and erythematous papules. …”
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Prescriptions of Antipsychotics in Younger and Older Geriatric Patients with Polypharmacy, Their Safety, and the Impact of a Pharmaceutical-Medical Dialogue on Antipsychotic Use by Eva-Maria Gebauer, Albert Lukas

“…The binary logistic regression analyses of geriatric patients with antipsychotics revealed that ADRs and drug–drug interactions (DDIs) were particularly related to the number of medications prescribed. …”
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The Self-Administered Use of Complementary and Alternative Medicine (CAM) Supplements and Antioxidants in Cancer Therapy and the Critical Role of Nrf-2—A Systematic Review by Paula Krejbich, Marc Birringer

“…Dietary supplements and vitamins are taken for different reasons, but often during conventional cancer treatment involving chemotherapy or radiotherapy and in a self-decided manner without seeking medical advice from healthcare professionals. Drug–drug interactions with dietary supplements or vitamins involving multiple signaling pathways are well described. …”
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Advances in Therapy for Irritable Bowel Syndrome with Diarrhea: Role of Rifaximin in Combination with Metronidazole by Arif A Faruqui

“…Rifaximin, with its broad anti-bacterial action, along with eubiotic activity, limited systemic exposure, gut-specific action, and limited potential for drug interactions along with metronidazole is proposed as a novel treatment option for IBS-D. …”
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