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2201
ROSUVASTATIN - THE MOST POTENT STATIN IN CARDIOVASCULAR DISEASE PREVENTION
Published 2018-06-01“…High hepatoselectivity and the absence of any significant interaction with cytochrome P450 system mitigate the likelihood of side effects and drug interactions. The above mentioned characteristics of rosuvastatin enable its effective and safe use in treating a wide range of patients.…”
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2202
Pharmacogenomic Impact of CYP2C19 Variation on Clopidogrel Therapy in Precision Cardiovascular Medicine
Published 2018-01-01“…Interestingly, response to clopidogrel appears to be modulated by additional factors, such as sociodemographic characteristics, risk factors for ischemic heart disease, and drug-drug interactions. Furthermore, systems medicine studies suggest that a broader approach may be required to adequately assess, predict, preempt, and manage variation in antiplatelet response. …”
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2203
Iron deficiency anemia in males: a dosing dilemma?
Published 2021-01-01“…The treatment is complicated by differing pharmacodynamics of administrative routes, equations with design effects, ongoing losses, additional daily requirement, plateauing of markers required for iron absorption, food–drug interactions, gender, and age. Accounting for these factors in one dosing regimen becomes difficult, specifically in males. …”
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2204
Comedications with Immune Checkpoint Inhibitors: Involvement of the Microbiota, Impact on Efficacy and Practical Implications
Published 2023-04-01“…The immune system and the gut microbiota are involved in their complex mechanisms of action. However, drug interactions have been suspected of disrupting the fine equilibrium necessary for optimal ICI efficacy. …”
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2205
Left atrial appendage thrombosis during therapy with rivaroxaban in elective cardioversion for permanent atrial fibrillation
Published 2015-09-01“…Patients with increased risk of thromboembolism have not been adequately studied and the monitoring of anticoagulant effects can also have important benefits in case of drug interactions. We report a case of a 68-year old man with AF from September 2014. …”
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2206
Vascularization Strategies in 3D Cell Culture Models: From Scaffold-Free Models to 3D Bioprinting
Published 2022-11-01“…Over the years, multiple techniques have successfully demonstrated vascularization in 3D cell cultures, simulating in vivo-like drug interactions, proposing the use of 3D systems as drug screening platforms to eliminate the deviations between preclinical and in vivo testing. …”
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2207
Efficacy of Carbamazepine and Its Derivatives in the Treatment of Bipolar Disorder
Published 2021-04-01“…Especially with carbamazepine, tolerability issues and drug–drug interactions need to be kept in mind. <i>Conclusions:</i> Two of the medications discussed in this review, carbamazepine and oxcarbazepine, match Class A criteria according to the criteria proposed by Ketter and Calabrese, meaning acute antimanic efficacy, prevention of manic relapses, and not causing or worsening depression.…”
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2208
Thrombocytopenia Induced by Direct Oral Anticoagulants: a Clinical Case and Literature Review
Published 2022-11-01“…According to the regulatory domestic and foreign documents, the use of direct oral anticoagulants in patients with atrial fibrillation has priority in comparison with vitamin K antagonists, since they have a predictable anticoagulant effect, the possibility of taking fixed doses without the need for routine anticoagulant monitoring, rapid onset and termination of action, relatively low potential for food and drug interactions. Direct oral anticoagulants are used for the prevention of thromboembolic complications in patients with atrial fibrillation, for the prevention of deep vein thrombosis in patients who have undergone surgery on the knee or hip joints, for emergency treatment and secondary prevention of deep vein thrombosis and pulmonary embolism. …”
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2209
Modulation of triple artemisinin-based combination therapy pharmacodynamics by Plasmodium falciparum genotype
Published 2020“…Analysis revealed drug–drug interactions unique to specific genetic backgrounds, including antagonism between piperaquine and pyronaridine associated with gene amplification of plasmepsin II/III, two aspartic proteases that localize to the parasite digestive vacuole. …”
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2210
Inhibition of ATP-sensitive potassium channels by haloperidol.
Published 2004“…This suggests that the drug interacts with the Kir6.2 subunit of the channel. …”
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2211
Pathogen-driven gene expression patterns lead to a novel approach to the identification of common therapeutic targets
Published 2022“…Investigating the differences between diseased and healthy states using differentially expressed genes aids in understanding disease pathophysiology and enables the exploration of protein-drug interactions. This study aimed to find the most common genes in diarrhea-causing bacteria such as <em>Salmonella enterica</em> serovar Typhimurium, <em>Campylobacter jejuni</em>, <em>Escherichia coli</em>, <em>Shigella dysenteriae</em> (CESS) to find new drugs. …”
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2212
Inhibiting the proton pump: mechanisms, benefits, harms, and questions
Published 2016“…However, the risks of gastric and pancreatic cancer are unclear. Drug-drug interactions can occur through effects on P glycoprotein and cytochrome P450 (CYP) isoenzymes. …”
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2213
An atlas of G-protein coupled receptor expression and function in human subcutaneous adipose tissue.
Published 2015“…This atlas highlights knowledge gaps in the current understanding of adipose tissue GPCR function, and identifies GPCR/ligand/drug interactions that might affect lipolysis, which is important for understanding and predicting metabolic side effects of drugs. …”
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2214
Population pharmacokinetics and electrocardiographic effects of dihydroartemisinin-piperaquine in healthy volunteers
Published 2017“…<p>AIMS: The aims of the presented study were to evaluate the pharmacokinetic properties of dihydroartemisinin and piperaquine, potential drug-drug interactions with concomitant primaquine treatment, and piperaquine effects on the electrocardiogram in healthy volunteers.…”
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2215
The effect of various drugs on the glucuronidation of zidovudine (azidothymidine; AZT) by human liver microsomes.
Published 1991“…Further studies are necessary to characterise the inhibition observed but the method described enables a screen of potentially important drug interactions to be carried out.…”
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2216
Integration and co-location of HIV/AIDS, tuberculosis and drug treatment services
Published 2007“…Key aspects of integration programmes include: co-location of services convenient to the patient; provision of effective substance use treatment, including pharmacotherapies; cross-training of generalist and specialist care providers; and provision of enhanced monitoring of drug-drug interactions and adverse side effects. Central to implementing this agenda will be fostering the political will to fund infrastructure and service delivery, expanding street-level outreach to IDUs, and training community health workers capable of cost effectively delivering these services. …”
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2217
ZeroBind: a protein-specific zero-shot predictor with subgraph matching for drug-target interactions
Published 2023-11-01“…In this study, we propose a protein-specific meta-learning framework ZeroBind with subgraph matching for predicting protein-drug interactions from their structures. During the meta-training process, ZeroBind formulates training a protein-specific model, which is also considered a learning task, and each task uses graph neural networks (GNNs) to learn the protein graph embedding and the molecular graph embedding. …”
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2218
Genophenotypic Factors and Pharmacogenomics in Adverse Drug Reactions
Published 2021-12-01“…ADRs show differential features depending upon genotype, age, sex, race, pathology, drug category, route of administration, and drug–drug interactions. Pharmacogenomics (PGx) provides the physician effective clues for optimizing drug efficacy and safety in major problems of health such as cardiovascular disease and associated disorders, cancer and brain disorders. …”
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2219
Evaluating the Role of Probiotics in the Prevention and Management of Age-Related Diseases
Published 2022-03-01“…These diseases can be co-morbid and are usually managed using a disease-specific approach that can eventually lead to polypharmacy, low medication adherence rates and undesired drug-drug interactions. Novel studies suggest targeting the shared biological basis of age-related diseases to retard the onset and manage their manifestations. …”
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2220
HIV-1/HBV Coinfection Accurate Multitarget Prediction Using a Graph Neural Network-Based Ensemble Predicting Model
Published 2023-04-01“…HIV treatment is complicated by drug interactions, antiretroviral (ARV) hepatotoxicity, and HBV-related immune reconditioning and inflammatory syndromes. …”
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