ROSUVASTATIN - THE MOST POTENT STATIN IN CARDIOVASCULAR DISEASE PREVENTION by A. E. Semenova, I. V. Sergienko

“…High hepatoselectivity and the absence of any significant interaction with cytochrome P450 system mitigate the likelihood of side effects and drug interactions. The above mentioned characteristics of rosuvastatin enable its effective and safe use in treating a wide range of patients.…”
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Pharmacogenomic Impact of CYP2C19 Variation on Clopidogrel Therapy in Precision Cardiovascular Medicine by Sherry-Ann Brown, Naveen Pereira

“…Interestingly, response to clopidogrel appears to be modulated by additional factors, such as sociodemographic characteristics, risk factors for ischemic heart disease, and drug-drug interactions. Furthermore, systems medicine studies suggest that a broader approach may be required to adequately assess, predict, preempt, and manage variation in antiplatelet response. …”
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Iron deficiency anemia in males: a dosing dilemma? by Abu Baker Sheikh, Nismat Javed, Zainab Ijaz, Venus Barlas, Rahul Shekhar, Blavir Rukov

“…The treatment is complicated by differing pharmacodynamics of administrative routes, equations with design effects, ongoing losses, additional daily requirement, plateauing of markers required for iron absorption, food–drug interactions, gender, and age. Accounting for these factors in one dosing regimen becomes difficult, specifically in males. …”
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Comedications with Immune Checkpoint Inhibitors: Involvement of the Microbiota, Impact on Efficacy and Practical Implications by Julien Colard-Thomas, Quentin Dominique Thomas, Marie Viala

“…The immune system and the gut microbiota are involved in their complex mechanisms of action. However, drug interactions have been suspected of disrupting the fine equilibrium necessary for optimal ICI efficacy. …”
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Left atrial appendage thrombosis during therapy with rivaroxaban in elective cardioversion for permanent atrial fibrillation by Walter Serra, Mauro Li Calzi, Paolo Coruzzi

“…Patients with increased risk of thromboembolism have not been adequately studied and the monitoring of anticoagulant effects can also have important benefits in case of drug interactions. We report a case of a 68-year old man with AF from September 2014. …”
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Vascularization Strategies in 3D Cell Culture Models: From Scaffold-Free Models to 3D Bioprinting by Shamapto Guha Anthon, Karolina Papera Valente

“…Over the years, multiple techniques have successfully demonstrated vascularization in 3D cell cultures, simulating in vivo-like drug interactions, proposing the use of 3D systems as drug screening platforms to eliminate the deviations between preclinical and in vivo testing. …”
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Efficacy of Carbamazepine and Its Derivatives in the Treatment of Bipolar Disorder by Anna Grunze, Benedikt L. Amann, Heinz Grunze

“…Especially with carbamazepine, tolerability issues and drug–drug interactions need to be kept in mind. <i>Conclusions:</i> Two of the medications discussed in this review, carbamazepine and oxcarbazepine, match Class A criteria according to the criteria proposed by Ketter and Calabrese, meaning acute antimanic efficacy, prevention of manic relapses, and not causing or worsening depression.…”
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Thrombocytopenia Induced by Direct Oral Anticoagulants: a Clinical Case and Literature Review by B. A. Tatarsky, N. V. Kazennova

“…According to the regulatory domestic and foreign documents, the use of direct oral anticoagulants in patients with atrial fibrillation has priority in comparison with vitamin K antagonists, since they have a predictable anticoagulant effect, the possibility of taking fixed doses without the need for routine anticoagulant monitoring, rapid onset and termination of action, relatively low potential for food and drug interactions. Direct oral anticoagulants are used for the prevention of thromboembolic complications in patients with atrial fibrillation, for the prevention of deep vein thrombosis in patients who have undergone surgery on the knee or hip joints, for emergency treatment and secondary prevention of deep vein thrombosis and pulmonary embolism. …”
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Modulation of triple artemisinin-based combination therapy pharmacodynamics by Plasmodium falciparum genotype by Ansbro, MR, Itkin, Z, Chen, L, Zahoranszky-Kohalmi, G, Amaratunga, C, Miotto, O, Peryea, T, Hobbs, CV, Suon, S, Sá, JM, Dondorp, AM, van der Pluijm, RW, Wellems, TE, Simeonov, A, Eastman, RT

“…Analysis revealed drug–drug interactions unique to specific genetic backgrounds, including antagonism between piperaquine and pyronaridine associated with gene amplification of plasmepsin II/III, two aspartic proteases that localize to the parasite digestive vacuole. …”

Inhibition of ATP-sensitive potassium channels by haloperidol. by Yang, S, Proks, P, Ashcroft, F, Rupnik, M

“…This suggests that the drug interacts with the Kir6.2 subunit of the channel. …”

Pathogen-driven gene expression patterns lead to a novel approach to the identification of common therapeutic targets by Hossain, MU, Ferdous, N, Reza, MN, Ahammad, I, Tiernan, Z, Wang, Y, O'Hanlon, F, Wu, Z, Sarker, S, Mohiuddin, AKM, Das, KC, Keya, CA, Salimullah, M

“…Investigating the differences between diseased and healthy states using differentially expressed genes aids in understanding disease pathophysiology and enables the exploration of protein-drug interactions. This study aimed to find the most common genes in diarrhea-causing bacteria such as&nbsp;<em>Salmonella enterica</em>&nbsp;serovar Typhimurium,&nbsp;<em>Campylobacter jejuni</em>,&nbsp;<em>Escherichia coli</em>,&nbsp;<em>Shigella dysenteriae</em>&nbsp;(CESS) to find new drugs. …”

Inhibiting the proton pump: mechanisms, benefits, harms, and questions by Aronson, J

“…However, the risks of gastric and pancreatic cancer are unclear. Drug-drug interactions can occur through effects on P glycoprotein and cytochrome P450 (CYP) isoenzymes. …”

An atlas of G-protein coupled receptor expression and function in human subcutaneous adipose tissue. by Amisten, S, Neville, M, Hawkes, R, Persaud, S, Karpe, F, Salehi, A

“…This atlas highlights knowledge gaps in the current understanding of adipose tissue GPCR function, and identifies GPCR/ligand/drug interactions that might affect lipolysis, which is important for understanding and predicting metabolic side effects of drugs. …”

Population pharmacokinetics and electrocardiographic effects of dihydroartemisinin-piperaquine in healthy volunteers by Chotsiri, P, Wattanakul, T, Hoglund, R, Hanboonkunupakarn, B, Pukrittayakamee, S, Blessborn, D, Jittamala, P, White, N, Day, N, Tarning, J

“…<p>AIMS: The aims of the presented study were to evaluate the pharmacokinetic properties of dihydroartemisinin and piperaquine, potential drug-drug interactions with concomitant primaquine treatment, and piperaquine effects on the electrocardiogram in healthy volunteers.…”

The effect of various drugs on the glucuronidation of zidovudine (azidothymidine; AZT) by human liver microsomes. by Sim, S.M., Back, D.J., Breckenridge, A.M.

“…Further studies are necessary to characterise the inhibition observed but the method described enables a screen of potentially important drug interactions to be carried out.…”

Integration and co-location of HIV/AIDS, tuberculosis and drug treatment services by Sylla, L., Bruce, R.D., Kamarulzaman, A., Altice, F.L.

“…Key aspects of integration programmes include: co-location of services convenient to the patient; provision of effective substance use treatment, including pharmacotherapies; cross-training of generalist and specialist care providers; and provision of enhanced monitoring of drug-drug interactions and adverse side effects. Central to implementing this agenda will be fostering the political will to fund infrastructure and service delivery, expanding street-level outreach to IDUs, and training community health workers capable of cost effectively delivering these services. …”
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ZeroBind: a protein-specific zero-shot predictor with subgraph matching for drug-target interactions by Yuxuan Wang, Ying Xia, Junchi Yan, Ye Yuan, Hong-Bin Shen, Xiaoyong Pan

“…In this study, we propose a protein-specific meta-learning framework ZeroBind with subgraph matching for predicting protein-drug interactions from their structures. During the meta-training process, ZeroBind formulates training a protein-specific model, which is also considered a learning task, and each task uses graph neural networks (GNNs) to learn the protein graph embedding and the molecular graph embedding. …”
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Genophenotypic Factors and Pharmacogenomics in Adverse Drug Reactions by Ramón Cacabelos, Vinogran Naidoo, Lola Corzo, Natalia Cacabelos, Juan C. Carril

“…ADRs show differential features depending upon genotype, age, sex, race, pathology, drug category, route of administration, and drug–drug interactions. Pharmacogenomics (PGx) provides the physician effective clues for optimizing drug efficacy and safety in major problems of health such as cardiovascular disease and associated disorders, cancer and brain disorders. …”
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Evaluating the Role of Probiotics in the Prevention and Management of Age-Related Diseases by Despoina E. Kiousi, Antonia Z. Kouroutzidou, Konstantinos Neanidis, Dimitrios Matthaios, Aglaia Pappa, Alex Galanis

“…These diseases can be co-morbid and are usually managed using a disease-specific approach that can eventually lead to polypharmacy, low medication adherence rates and undesired drug-drug interactions. Novel studies suggest targeting the shared biological basis of age-related diseases to retard the onset and manage their manifestations. …”
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HIV-1/HBV Coinfection Accurate Multitarget Prediction Using a Graph Neural Network-Based Ensemble Predicting Model by Yishu Wang, Yue Li, Xiaomin Chen, Lutao Zhao

“…HIV treatment is complicated by drug interactions, antiretroviral (ARV) hepatotoxicity, and HBV-related immune reconditioning and inflammatory syndromes. …”
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