MagMD: Database summarizing the metabolic action of gut microbiota to drugs by Jiajia Zhou, Jian Ouyang, Zihao Gao, Haipeng Qin, Wu Jun, Tieliu Shi

“…The established microbiota databases provide useful information about the gut microbe-drug interactions. However, these databases generally lacked the detailed effects on substance and the metabolites, which are helpful in elucidating the mechanisms underlying drug biotransformation and personalized medicine. …”
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Post-COVID Syndrome and Tachycardia: Theoretical Base and Treatment Experience by V. I. Podzolkov, A. E. Bragina, A. I. Tarzimanova, L. V. Vasil'eva, E. P. Batrakova, N. V. Lobova, E. E. Bykova, M. M. Khachuroeva

“…A clinical example of the use of ivabradine in a patient after a coronavirus infection is presented. Drug interactions and individual tolerance of ivabradine in patients after coronavirus infection are being discussed. …”
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Non-pharmacological Approaches to Treatment of Patients over 60 Years as a Way to Improve Pharmacotherapy Safety and Prevent Polypharmacy by A. P. Pereverzev, O. N. Tkacheva, Yu. V. Kotovskaya, Yu. S. Onuchina, E. N. Dudinskaya, A. V. Naumov

“…However, the availability of highly effective drugs on the market also has a reverse side — the appearance of adverse drug reactions (ADRs), in particular as a result of drug-drug interactions. The use of non-pharmacological methods of treatment and prevention of diseases seems particularly relevant for patients of the older age group, as it allows not only to reduce the drug burden, to reduce the risk of ADRs but also to improve the patient’s state in case of diseases that have no effective pharmacotherapy and pharmacological prophylaxis. …”
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Jacalin-Curcumin Complex Sensitizes the Breast Cancer MDA-MB-231 Cell Line by Lidiya Petrova, Nikolay Gergov, Marie Stoup, Silvina Zapryanova, Els J. M. Van Damme, Nicolas Lebègue, Maxime Liberelle, Diana Zasheva, Vanya Bogoeva

“…Protein–drug interactions are crucial for understanding drug delivery and cell functions. …”
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Serotonin syndrome and neuroleptic malignant syndrome: A case report of intersecting symptomatology by Loulwa Maktabi, PharmD, BCPS, Denver Shipman, PharmD, BCPP, Justin P. Reinert, PharmD, MBA, BCCCP

“…Discussion Clinicians at the bedside must be cognizant of the potential for clinically relevant drug-drug interactions that may present with overlapping pathologies.…”
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Chronological Review and Rational and Future Prospects of Cannabis-Based Drug Development by Dvora Namdar, Omer Anis, Patrick Poulin, Hinanit Koltai

“…FDA registration of single, few, or multiple molecules as drugs is a challenging process, and certain considerations that should be reviewed in this process, including issues of drug–drug interactions, are also discussed here.…”
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Development and Experimental Validation of Regularized Machine Learning Models Detecting New, Structurally Distinct Activators of PXR by Steffen Hirte, Oliver Burk, Ammar Tahir, Matthias Schwab, Björn Windshügel, Johannes Kirchmair

“…In consequence, PXR decreases the efficacy of many small-molecule drugs and induces drug-drug interactions. The prediction of PXR activators with theoretical approaches such as machine learning (ML) proves challenging due to the ligand promiscuity of PXR, which is related to its large and flexible binding pocket. …”
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In-Depth Analysis of Physiologically Based Pharmacokinetic (PBPK) Modeling Utilization in Different Application Fields Using Text Mining Tools by Aleksandra Krstevska, Jelena Đuriš, Svetlana Ibrić, Sandra Cvijić

“…Regarding the application areas, the results revealed that 26% of the publications described the use of PBPK modeling in early drug development, risk assessment and toxicity assessment, followed by absorption/formulation modeling (25%), prediction of drug-disease interactions (20%), drug-drug interactions (DDIs) (17%) and pediatric drug development (12%). …”
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Immune-Related Protein Interaction Network in Severe COVID-19 Patients toward the Identification of Key Proteins and Drug Repurposing by Pakorn Sagulkoo, Apichat Suratanee, Kitiporn Plaimas

“…Finally, poly (I:C), mitomycin C, decitabine, gemcitabine, hydroxyurea, tamoxifen, and curcumin were the potential drugs interacting with the key proteins to heal severe COVID-19. …”
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The IDentif.AI-x pandemic readiness platform: Rapid prioritization of optimized COVID-19 combination therapy regimens by Agata Blasiak, Anh T. L. Truong, Alexandria Remus, Lissa Hooi, Shirley Gek Kheng Seah, Peter Wang, De Hoe Chye, Angeline Pei Chiew Lim, Kim Tien Ng, Swee Teng Teo, Yee-Joo Tan, David Michael Allen, Louis Yi Ann Chai, Wee Joo Chng, Raymond T. P. Lin, David C. B. Lye, John Eu-Li Wong, Gek-Yen Gladys Tan, Conrad En Zuo Chan, Edward Kai-Hua Chow, Dean Ho

“…IDentif.AI-x revealed EIDD-1931 to be a strong candidate upon which multiple drug combinations can be derived, and pinpointed a number of clinically actionable drug interactions, which were further reconfirmed in SARS-CoV-2 variants B.1.351 (Beta) and B.1.617.2 (Delta). …”
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Studying metabolism with multi-organ chips: new tools for disease modelling, pharmacokinetics and pharmacodynamics by Tanvi Shroff, Kehinde Aina, Christian Maass, Madalena Cipriano, Joeri Lambrecht, Frank Tacke, Alexander Mosig, Peter Loskill

“…This field urgently requires a push towards more physiologically accurate recapitulations of drug interactions and disease progression in the body. …”
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Hodgkin Lymphoma in People Living with HIV by Jose-Tomas Navarro, José Moltó, Gustavo Tapia, Josep-Maria Ribera

“…As a consequence, interdisciplinary collaboration between HIV specialists and hemato-oncologists for the management of potential drug–drug interactions and overlapping toxicities between antiretroviral and antineoplastic drugs is crucial for the optimal treatment of PLWH with HL. …”
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Attitude, Beliefs, and Use of Herbal Remedies by Patients in the Riyadh Region of Saudi Arabia by Ahmad H. Alghadir, Amir Iqbal, Zaheen A. Iqbal

“…This exposes them to the risk of harmful side effects and drug interactions. Conclusions: Physicians and pharmacists should work to provide evidence-based information about HMs to patients about effectiveness and side effects and be vigilant while writing prescriptions and dispensing drugs to them. …”
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Cannabis Dopaminergic Effects Induce Hallucinations in a Patient with Parkinson’s Disease by Katie Pizzolato, David Thacker, Nicole Del Toro-Pagán, Abeer Hanna, Jacques Turgeon, Adriana Matos, Nishita Amin, Veronique Michaud

“…These conditions support the importance of considering herb–drug interactions and PGx data when performing a medication safety review.…”
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The Use of Complementary and Alternative Medicine among Peritoneal Dialysis Patients at a Second-Level Hospital in Yucatán Mexico by Carlos Gracida-Osorno, Sandra Luz Jiménez-Martínez, Andrés Humberto Uc-Cachón, Gloria María Molina-Salinas

“…Conclusion: The use of CAM is popular among renal patients, and physicians are not adequately informed; in particular, the CAM type ingested represents a risk for drug interactions and toxicity.…”
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Common and Rare Hematological Manifestations and Adverse Drug Events during Treatment of Active TB: A State of Art by Maria Letizia Minardi, Ilenia Fato, Francesco Di Gennaro, Silvia Mosti, Annelisa Mastrobattista, Carlotta Cerva, Raffaella Libertone, Annalisa Saracino, Delia Goletti, Enrico Girardi, Massimo Andreoni, Fabrizio Palmieri, Gina Gualano

“…Close monitoring of drug interactions and hematological adverse events is always recommended.…”
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Combination Therapy with Doxorubicin-Loaded Reduced Albumin Nanoparticles and Focused Ultrasound in Mouse Breast Cancer Xenografts by Daehyun Kim, Seung Soo Lee, Woo Young Yoo, Hyungwon Moon, Aesin Cho, So Yeon Park, Yoon-Seok Kim, Hyun Ryoung Kim, Hak Jong Lee

“…Because chemotherapeutic drugs are often associated with serious side effects, the central topic in modern drug delivery is maximizing the localization of drugs at the target while minimizing non-specific drug interactions at unwanted regions. To address this issue, biocompatible nanoparticles have been developed to enhance the drug half-life while minimizing the associated toxicity. …”
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The Effect of Plasma Protein Binding on the Therapeutic Monitoring of Antiseizure Medications by Bruno Charlier, Albino Coglianese, Federica De Rosa, Ugo de Grazia, Francesca Felicia Operto, Giangennaro Coppola, Amelia Filippelli, Fabrizio Dal Piaz, Viviana Izzo

“…To reduce the risk of adverse effects and drug interactions, ASMs levels should be closely evaluated in biological fluids performing an appropriate Therapeutic Drug Monitoring (TDM). …”
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Real-world use of dimehtyl fumarate in patients with plaque psoriasis: a Delphi-based expert consensus by Martina Burlando, Elena Campione, Aldo Cuccia, Giovanna Malara, Luigi Naldi, Francesca Prignano, Leonardo Zichichi

“…DMF treatment is characterized by dosage flexibility, sustained efficacy, high rates of drug survival, and low potential for drug–drug interactions. It can be used in a broad range of patients, including the elderly or those with comorbidities. …”
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Clinical Considerations and Outcomes for Spine Surgery Patients with a History of Transplant: A Systematic Scoping Review Protocol by Roshini Kalagara, Zerubabbel K. Asfaw, Matthew T. Carr, Addison Quinones, Lisa Genadry, Zaid Nakadar, Anzila Haris, Alexander J. Schupper, Jonathan S. Gal, Tanvir F. Choudhri

“…Spine surgery patients with a history of organ transplantation are a complex population due to their unique anesthetic considerations, immunologic profiles, drug interactions, and potential organ dysfunction. It is common for these patients to develop neck/back pain and pathology that warrants surgical intervention. …”
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