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2221
MagMD: Database summarizing the metabolic action of gut microbiota to drugs
Published 2022-01-01“…The established microbiota databases provide useful information about the gut microbe-drug interactions. However, these databases generally lacked the detailed effects on substance and the metabolites, which are helpful in elucidating the mechanisms underlying drug biotransformation and personalized medicine. …”
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2222
Post-COVID Syndrome and Tachycardia: Theoretical Base and Treatment Experience
Published 2021-05-01“…A clinical example of the use of ivabradine in a patient after a coronavirus infection is presented. Drug interactions and individual tolerance of ivabradine in patients after coronavirus infection are being discussed. …”
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2223
Non-pharmacological Approaches to Treatment of Patients over 60 Years as a Way to Improve Pharmacotherapy Safety and Prevent Polypharmacy
Published 2018-12-01“…However, the availability of highly effective drugs on the market also has a reverse side — the appearance of adverse drug reactions (ADRs), in particular as a result of drug-drug interactions. The use of non-pharmacological methods of treatment and prevention of diseases seems particularly relevant for patients of the older age group, as it allows not only to reduce the drug burden, to reduce the risk of ADRs but also to improve the patient’s state in case of diseases that have no effective pharmacotherapy and pharmacological prophylaxis. …”
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2224
Jacalin-Curcumin Complex Sensitizes the Breast Cancer MDA-MB-231 Cell Line
Published 2023-12-01“…Protein–drug interactions are crucial for understanding drug delivery and cell functions. …”
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2225
Serotonin syndrome and neuroleptic malignant syndrome: A case report of intersecting symptomatology
Published 2024-02-01“…Discussion Clinicians at the bedside must be cognizant of the potential for clinically relevant drug-drug interactions that may present with overlapping pathologies.…”
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2226
Chronological Review and Rational and Future Prospects of Cannabis-Based Drug Development
Published 2020-10-01“…FDA registration of single, few, or multiple molecules as drugs is a challenging process, and certain considerations that should be reviewed in this process, including issues of drug–drug interactions, are also discussed here.…”
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2227
Development and Experimental Validation of Regularized Machine Learning Models Detecting New, Structurally Distinct Activators of PXR
Published 2022-04-01“…In consequence, PXR decreases the efficacy of many small-molecule drugs and induces drug-drug interactions. The prediction of PXR activators with theoretical approaches such as machine learning (ML) proves challenging due to the ligand promiscuity of PXR, which is related to its large and flexible binding pocket. …”
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2228
In-Depth Analysis of Physiologically Based Pharmacokinetic (PBPK) Modeling Utilization in Different Application Fields Using Text Mining Tools
Published 2022-12-01“…Regarding the application areas, the results revealed that 26% of the publications described the use of PBPK modeling in early drug development, risk assessment and toxicity assessment, followed by absorption/formulation modeling (25%), prediction of drug-disease interactions (20%), drug-drug interactions (DDIs) (17%) and pediatric drug development (12%). …”
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2229
Immune-Related Protein Interaction Network in Severe COVID-19 Patients toward the Identification of Key Proteins and Drug Repurposing
Published 2022-05-01“…Finally, poly (I:C), mitomycin C, decitabine, gemcitabine, hydroxyurea, tamoxifen, and curcumin were the potential drugs interacting with the key proteins to heal severe COVID-19. …”
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2230
The IDentif.AI-x pandemic readiness platform: Rapid prioritization of optimized COVID-19 combination therapy regimens
Published 2022-06-01“…IDentif.AI-x revealed EIDD-1931 to be a strong candidate upon which multiple drug combinations can be derived, and pinpointed a number of clinically actionable drug interactions, which were further reconfirmed in SARS-CoV-2 variants B.1.351 (Beta) and B.1.617.2 (Delta). …”
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2231
Studying metabolism with multi-organ chips: new tools for disease modelling, pharmacokinetics and pharmacodynamics
Published 2022-03-01“…This field urgently requires a push towards more physiologically accurate recapitulations of drug interactions and disease progression in the body. …”
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2232
Hodgkin Lymphoma in People Living with HIV
Published 2021-08-01“…As a consequence, interdisciplinary collaboration between HIV specialists and hemato-oncologists for the management of potential drug–drug interactions and overlapping toxicities between antiretroviral and antineoplastic drugs is crucial for the optimal treatment of PLWH with HL. …”
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2233
Attitude, Beliefs, and Use of Herbal Remedies by Patients in the Riyadh Region of Saudi Arabia
Published 2022-05-01“…This exposes them to the risk of harmful side effects and drug interactions. Conclusions: Physicians and pharmacists should work to provide evidence-based information about HMs to patients about effectiveness and side effects and be vigilant while writing prescriptions and dispensing drugs to them. …”
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2234
Cannabis Dopaminergic Effects Induce Hallucinations in a Patient with Parkinson’s Disease
Published 2021-10-01“…These conditions support the importance of considering herb–drug interactions and PGx data when performing a medication safety review.…”
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2235
The Use of Complementary and Alternative Medicine among Peritoneal Dialysis Patients at a Second-Level Hospital in Yucatán Mexico
Published 2023-03-01“…Conclusion: The use of CAM is popular among renal patients, and physicians are not adequately informed; in particular, the CAM type ingested represents a risk for drug interactions and toxicity.…”
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2236
Common and Rare Hematological Manifestations and Adverse Drug Events during Treatment of Active TB: A State of Art
Published 2021-07-01“…Close monitoring of drug interactions and hematological adverse events is always recommended.…”
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2237
Combination Therapy with Doxorubicin-Loaded Reduced Albumin Nanoparticles and Focused Ultrasound in Mouse Breast Cancer Xenografts
Published 2020-09-01“…Because chemotherapeutic drugs are often associated with serious side effects, the central topic in modern drug delivery is maximizing the localization of drugs at the target while minimizing non-specific drug interactions at unwanted regions. To address this issue, biocompatible nanoparticles have been developed to enhance the drug half-life while minimizing the associated toxicity. …”
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2238
The Effect of Plasma Protein Binding on the Therapeutic Monitoring of Antiseizure Medications
Published 2021-08-01“…To reduce the risk of adverse effects and drug interactions, ASMs levels should be closely evaluated in biological fluids performing an appropriate Therapeutic Drug Monitoring (TDM). …”
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2239
Real-world use of dimehtyl fumarate in patients with plaque psoriasis: a Delphi-based expert consensus
Published 2022-12-01“…DMF treatment is characterized by dosage flexibility, sustained efficacy, high rates of drug survival, and low potential for drug–drug interactions. It can be used in a broad range of patients, including the elderly or those with comorbidities. …”
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2240
Clinical Considerations and Outcomes for Spine Surgery Patients with a History of Transplant: A Systematic Scoping Review Protocol
Published 2022-06-01“…Spine surgery patients with a history of organ transplantation are a complex population due to their unique anesthetic considerations, immunologic profiles, drug interactions, and potential organ dysfunction. It is common for these patients to develop neck/back pain and pathology that warrants surgical intervention. …”
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