Interdisciplinary problem of post-transplant diabetes mellitus: literature review by A. V. Balashova, V. R. Mustafina, I. V. Glinkina

“…Which organ was transplanted, patient characteristics and possible drug interactions with immunosuppressive therapy should be taken into account while managing PTDM. …”
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Development of Physiologically Based Pharmacokinetic Model for Orally Administered Fexuprazan in Humans by Yoo-Seong Jeong, Min-Soo Kim, Nora Lee, Areum Lee, Yoon-Jee Chae, Suk-Jae Chung, Kyeong-Ryoon Lee

“…Physiologically based pharmacokinetic (PBPK) models predict drug interactions as pharmacokinetic profiles in biological matrices can be mechanistically simulated. …”
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A Systematic Ex-Vivo Study of the Anti-Proliferative/Cytotoxic Bioactivity of Major Olive Secoiridoids’ Double Combinations and of Total Olive Oil Phenolic Extracts on Multiple Cel... by Aikaterini Papakonstantinou, Petrina Koumarianou, Panagiotis Diamantakos, Eleni Melliou, Prokopios Magiatis, Haralabia Boleti

“…Individual OOPs were used to treat cells for 72 h in half of their EC₅₀ values for each cell line and their synergistic, additive or antagonistic interactions were evaluated by calculating the coefficient for drug interactions (CDI) for each double combination of OOPs. …”
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Marine Cyanobacterial Peptides in Neuroblastoma: Search for Better Therapeutic Options by Salman Ahmed, Waqas Alam, Michael Aschner, Rosanna Filosa, Wai San Cheang, Philippe Jeandet, Luciano Saso, Haroon Khan

“…Marine peptides possess several advantages over proteins or antibodies, including small size, simple manufacturing, cell membrane crossing capabilities, minimal drug–drug interactions, minimal changes in blood–brain barrier (BBB) integrity, selective targeting, chemical and biological diversities, and effects on liver and kidney functions. …”
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Physicochemical characterization and phase II metabolic profiling of echinochrome A, a bioactive constituent from sea urchin, and its physiologically based pharmacokinetic modeling... by Dong-Gyun Han, Jinsook Kwak, Eugene Choi, Seong-Wook Seo, Elena A. Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Hyoung Kyu Kim, Jin Han, Jong Hyuk Byun, Il Hyo Jung, Hwayoung Yun, In-Soo Yoon

“…Our proposed PBPK model of echinochrome A could be a valuable tool for predicting drug interactions in previously unexplored scenarios and for optimizing dosage regimens and drug formulations.…”
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The Pharmacist’s Role in the Implementation of FASTHUG-MAIDENS, a Mnemonic to Facilitate the Pharmacotherapy Assessment of Critically Ill Patients: A Cross-Sectional Study by Jose Miguel Chaverri-Fernández, Esteban Zavaleta-Monestel, Josué Murillo-Cubero, José Pablo Díaz-Madriz, Brayan Leiva-Montero, Sebastián Arguedas-Chacón, Raquel Arguedas-Herrera

“…FASTHUG-MAIDENS is a modified version that incorporates key pharmacotherapeutic elements such as delirium management, drug dosing, and drug interactions for an appropriate medication assessment of critically ill patients. …”
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Infectious Inflammatory Processes and the Role of Bioactive Agent Released from Imino-Chitosan Derivatives Experimental and Theoretical Aspects by Loredana Himiniuc, Razvan Socolov, Vlad Ghizdovat, Maricel Agop, Emil Anton, Bogdan Toma, Lacramioara Ochiuz, Decebal Vasincu, Ovidiu Popa, Viviana Onofrei

“…These mechanisms are conditioned by the intensity of the polymer–drug interactions. It was demonstrated that the proposed mathematical model confirmed a prolonged release of the aldehyde, respecting the trend established by in vitro release experiments. …”
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Epidemiology of Invasive Fungal Diseases in Patients with Hematologic Malignancies and Hematopoietic Cell Transplantation Recipients Managed with an Antifungal Diagnostic Driven Ap... by Maria Daniela Bergamasco, Carlos Alberto P. Pereira, Celso Arrais-Rodrigues, Diogo B. Ferreira, Otavio Baiocchi, Fabio Kerbauy, Marcio Nucci, Arnaldo Lopes Colombo

“…The practice of antifungal prophylaxis with mold-active azoles has been challenged recently because of drug–drug interactions with novel targeted therapies. This is a retrospective, single-center cohort study of consecutive cases of proven or probable IFD, diagnosed between 2009 and 2019, in adult hematologic patients and HCT recipients managed with fluconazole prophylaxis and an antifungal diagnostic-driven approach for mold infection. …”
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Voclosporin: Unique Chemistry, Pharmacology and Toxicity Profile, and Possible Options for Implementation into the Management of Lupus Nephritis by Ajinath Kale, Vishwadeep Shelke, Yutian Lei, Anil Bhanudas Gaikwad, Hans-Joachim Anders

“…Voclosporin (VOC), a novel CNI, no longer requires drug level monitoring and seems to lack these adverse effects, although hypertension and drug–drug interactions still occur. VOC demonstrated efficacy superior to standard-of-care in controlling active lupus nephritis in the phase 2 AURA-LV and the phase 3 AURORA-1 trials and was approved for the treatment of active lupus nephritis. …”
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Heterogeneous network propagation with forward similarity integration to enhance drug–target association prediction by Piyanut Tangmanussukum, Thitipong Kawichai, Apichat Suratanee, Kitiporn Plaimas

“…Consequently, the optimal model uses the target similarity based on protein sequences and the fused drug similarity, which combines the similarity measures based on chemical structures, the Jaccard scores of drug–disease associations, and the cosine scores of drug–drug interactions. With an accuracy of 99.8%, this model significantly outperforms others that utilize different similarity measures of drugs and target proteins. …”
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Growth‐mediated negative feedback shapes quantitative antibiotic response by S Andreas Angermayr, Tin Yau Pang, Guillaume Chevereau, Karin Mitosch, Martin J Lercher, Tobias Bollenbach

“…The shape of the dose–response curve varies drastically between antibiotics and plays a key role in treatment, drug interactions, and resistance evolution. However, the mechanisms shaping the dose–response curve remain largely unclear. …”
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Pathogen-driven gene expression patterns lead to a novel approach to the identification of common therapeutic targets by Mohammad Uzzal Hossain, Nadim Ferdous, Mahjerin Nasrin Reza, Ishtiaque Ahammad, Zachary Tiernan, Yi Wang, Fergus O’Hanlon, Zijia Wu, Shishir Sarker, A. K. M. Mohiuddin, Keshob Chandra Das, Chaman Ara Keya, Md. Salimullah

“…Investigating the differences between diseased and healthy states using differentially expressed genes aids in understanding disease pathophysiology and enables the exploration of protein-drug interactions. This study aimed to find the most common genes in diarrhea-causing bacteria such as Salmonella enterica serovar Typhimurium, Campylobacter jejuni, Escherichia coli, Shigella dysenteriae (CESS) to find new drugs. …”
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Frequency of Direct Oral Anticoagulants Usage in Acute Pulmonary Thromboembolism Treatment in Turkey (TUPEDO) by Elif Tanrıverdi, Nuri Tutar, Ayşegül Şentürk, Ayşe Bahadır, Nimet Aksel, Nur Aleyna Yetkin, Gülistan Karadeniz, Nazlı Çetin, Ali Tabaru, Binnaz Zeynep Yıldırım, Hatice Selimoğlu Şen, Neslihan Özçelik, Emine Özsarı, Fatih Uzer, Tuğba Çiçek, Dorina Esendağlı, İclal Hocanlı, Nagihan Durmuş Koçak, Utku Tapan, Bahar Kurt, Sibel Arınç, Murat Kavas, Füsun Şahin, Dilek Ergun, Elif Yılmazel Uçar, Talat Kılıç, İnci Gülmez, Jülide Celdir Emre, Deniz Doğan, Fatma Özdemir, Mustafa Düger, Suha Alzafer, Esra Yarar, Damla Serce Unat, Bilge Salık

“…Background: Direct oral anticoagulants (DOACs) have been used in acute pulmonary thromboembolism as an alternative to warfarin due to drug interactions, narrow therapeutic range, and necessary close International Normalized Ratio (INR) monitoring. …”
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A Non-Systemic Phosphodiesterase-5 Inhibitor Suppresses Colon Proliferation in Mice by Avelina Lee, Iryna Lebedyeva, Wenbo Zhi, Vani Senthil, Herjot Cheema, Michael W. Brands, Weston Bush, Nevin A. Lambert, Madeline Snipes, Darren D. Browning

“…A drawback to conventional PDE5i are their side-effects and drug–drug interactions. We designed an analog of the prototypical PDE5i sildenafil by replacing the methyl group on the piperazine ring with malonic acid to reduce lipophilicity, and measured its entry into the circulation and effects on colon epithelium. …”
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Ways to Improve Insights into Clindamycin Pharmacology and Pharmacokinetics Tailored to Practice by Laura Armengol Álvarez, Greet Van de Sijpe, Stefanie Desmet, Willem-Jan Metsemakers, Isabel Spriet, Karel Allegaert, Jef Rozenski

“…Furthermore, drug–drug interactions derived from CYP3A4 inducers and inhibitors, and the data on the impact of the disease state on the CYP system, are still limited. …”
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Designing a Useful Lipid Raft Model Membrane for Electrochemical and Surface Analytical Studies by Michalina Zaborowska, Damian Dziubak, Dorota Matyszewska, Slawomir Sek, Renata Bilewicz

“…A model biomimetic system for the study of protein reconstitution or drug interactions should include lipid rafts in the mixed lipid monolayer, since they are usually the domains embedding membrane proteins and peptides. …”
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COVID-19 Associated Pulmonary Aspergillosis (CAPA)—From Immunology to Treatment by Amir Arastehfar, Agostinho Carvalho, Frank L. van de Veerdonk, Jeffrey D. Jenks, Philipp Koehler, Robert Krause, Oliver A. Cornely, David S. Perlin, Cornelia Lass-Flörl, Martin Hoenigl

“…Finally, the treatment of CAPA is complicated by drug–drug interactions associated with broad spectrum azoles, renal tropism and damage caused by SARS-CoV-2, which may challenge the use of liposomal amphotericin B, as well as the emergence of azole-resistance. …”
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In-Silico Identification of Novel Pharmacological Synergisms: The Trabectedin Case by Laura Mannarino, Nicholas Ravasio, Maurizio D’Incalci, Sergio Marchini, Marco Masseroli

“…We set a workflow allowing the identification of genes selectively modulated by a drug and possible novel drug interactions. To show its effectiveness, we selected trabectedin as a case-study drug. …”
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The Anti-Cancer Drug Dabrafenib Is a Potent Activator of the Human Pregnane X Receptor by Nicolas Creusot, Matthieu Gassiot, Elina Alaterre, Barbara Chiavarina, Marina Grimaldi, Abdelhay Boulahtouf, Lucia Toporova, Sabine Gerbal-Chaloin, Martine Daujat-Chavanieu, Alice Matheux, Roger Rahmani, Céline Gongora, Alexandre Evrard, Philippe Pourquier, Patrick Balaguer

“…Moreover, its unintentional activation by pharmaceutical drugs can mediate drug–drug interactions and cause severe adverse events. In that context, the potential of the anticancer BRAF inhibitor dabrafenib suspected to activate hPXR and the human constitutive androstane receptor (hCAR) has not been thoroughly investigated yet. …”
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Physicochemical Properties and Transdermal Absorption of a Flurbiprofen and Lidocaine Complex in the Non-Crystalline Form by Qihui Xu, Takayuki Furuishi, Kaori Fukuzawa, Etsuo Yonemochi

“…Amorphous drug formulations exploiting drug–drug interactions have been extensively studied. This study aims to develop a transdermal system containing an amorphous complex of the nonsteroidal anti-inflammatory drug (NSAID) flurbiprofen (FLU) and lidocaine (LDC) for alleviating chronic pain. …”
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