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2361
Opportunities, Challenges and Pitfalls of Using Cannabidiol as an Adjuvant Drug in COVID-19
Published 2021-02-01“…However, one should be aware of side effects of CBD (which are rarely serious), drug interactions (also extending to drugs acting against COVID-19) and the proper route of its administration (vaping may be dangerous). …”
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2362
Interactions between Immunosuppressive Therapy and Direct-Acting Antivirals in Kidney Transplant Recipient with Hepatitis C Infection
Published 2020-05-01“…DAAs give encouraging results in the eradication of HCV in renal transplant recipients, although they are associated with potential adverse drug interactions. The preliminary data of our study suggest that it is not necessary to change the dose of immunosuppressive drugs during therapy and that creatinine and proteinuria remain stationary. …”
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2363
Mebendazole Inhibits <i>Histoplasma capsulatum</i> In Vitro Growth and Decreases Mitochondrion and Cytoskeleton Protein Levels
Published 2023-03-01“…Itraconazole and amphotericin B are used to treat histoplasmosis; however, both antifungals have potentially severe pharmacokinetic drug interactions and toxicity. The present study determined the minimal inhibitory and fungicidal concentrations of mebendazole, a drug present in the NIH Clinical Collection, to establish whether it has fungicidal or fungistatic activity against <i>Histoplasma capsulatum</i>. …”
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2364
Favipiravir Use in COVID-19 Treatment
Published 2021-03-01“…In the scope of the review, under the title of pharmacology of favipiravir, adverse effects and drug interactions in addition to pharmacokinetic and pharmacodynamic properties are mentioned. …”
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2365
Entrectinib, a new multi-target inhibitor for cancer therapy
Published 2022-06-01“…In this review, we give a brief introduction to TKK, ROS1 and ALK, and on this basis, we give a detailed and comprehensive introduction to the mechanism of action, pharmacokinetics, pharmacodynamics, clinical efficacy, tolerability and drug interactions of entrectinib.…”
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2366
Phytoconstituents and Pharmacological Activities of Indian Camphorweed (<i>Pluchea indica</i>): A Multi-Potential Medicinal Plant of Nutritional and Ethnomedicinal Importance
Published 2022-04-01“…However, further studies on the drug interactions, mechanism of action, pharmacokinetics, toxicology, and metabolism, as well as clinical trials, should be carried out.…”
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2367
Biocompatible PEO-b-PCL Nanosized Micelles as Drug Carriers: Structure and Drug–Polymer Interactions
Published 2020-09-01“…Light scattering and nuclear magnetic resonance (NMR) provide information on micelle structure and polymer–drug interactions. According to dynamic light scattering (DLS) analysis, the PEO-b-PCL micelles and LSR-loaded PEO-b-PCL nanocarriers formed nanostructures in the range of 17–26 nm in aqueous milieu. …”
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2368
Prevention and Management of Infections in Lung Transplant Recipients
Published 2023-12-01“…One must also be vigilant about drug interactions of antibiotics and immunosuppressive agents. …”
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2369
Mycobacterium Tuberculosis Infection after Kidney Transplantation: A Comprehensive Review
Published 2022-09-01“…Regarding treatment challenges in KT recipients with TB, drug interactions, drug toxicities and therapeutical adherence must be considered.…”
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2370
Adsorption of the rhNGF Protein on Polypropylene with Different Grades of Copolymerization
Published 2023-03-01“…The surface properties of drug containers should reduce the adsorption of the drug and avoid packaging surface/drug interactions, especially in the case of biologically-derived products. …”
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2371
Pattern of Drugs and Therapeutic Agents Exposure among Pediatric Inpatients in the Fatima University Medical Center
Published 2018-08-01“…The most common results of many drugs and therapeutic agents are increased adverse drug reactions, drug-drug interactions and higher costs. Objectives: To assess the prevalence and patterns of exposure to drugs and therapeutic agents among pediatric inpatients. …”
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2372
HIV and an Ageing Population—What Are the Medical, Psychosocial, and Palliative Care Challenges in Healthcare Provisions
Published 2023-09-01“…The treatment of such conditions may lead to polypharmacy and may increase the risk of cART drug–drug interactions. In addition, the risk of developing infection and cancer is high. …”
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2373
Enantioselectivity in Drug Pharmacokinetics and Toxicity: Pharmacological Relevance and Analytical Methods
Published 2021-05-01“…The choice of models for pharmacokinetic studies as well as the subsequent data interpretation must also be aware of genetic factors (such as polymorphic metabolic enzymes), sex, patient age, hepatic diseases, and drug interactions. Therefore, the pharmacokinetics and toxicity of a racemate or an enantiomerically pure drug are not equal and need to be studied. …”
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2374
Evaluation of Trigger Tool Methodology Related to Adverse Drug Events in Hospitalized Patients
Published 2019-12-01“…Summary: The positive predictive value (PPV) for elevated INR was 35% (confidence interval [CI] 21–53%), hypoglycemia was 70.4% (CI 62–78%), and 53% for naloxone administration (CI 45–60%). Drug interactions were the most common factor that may have contributed to an ele-vated INR, with a mean INR of 7.9. …”
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2375
Anti-Pseudomonas aeruginosa activity of natural antimicrobial peptides when used alone or in combination with antibiotics
Published 2023-09-01“…This review particularly focuses on summarizing the inhibitory activity of natural antimicrobial peptides against P. aeruginosa planktonic cells and biofilms, as well as the drug interactions when these peptides used in combination with conventional antibiotics. …”
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2376
Pharmacology of Free Fatty Acid Receptors and Their Allosteric Modulators
Published 2021-02-01“…While the majority of marketed GPCR drugs interact exclusively with the orthosteric binding site, allosteric mechanisms in GPCR biology stay medically underexploited, with only several allosteric ligands currently approved. …”
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2377
Assessing insomnia management in community pharmacy setting in Jordan: A simulated patient approach.
Published 2019-01-01“…No information was provided in relation to potential drug interactions or contraindications. No advice was offered on lifestyle or good sleeping hygiene. …”
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2378
rTMS efficacy in major depression disorder: comparing two reviews
Published 2023-03-01“…The body of TMS literature suggests that daily, left prefrontal TMS for 3–6 weeks has antidepressanteffects that are clinically meaningful (30% remission), with low side effects and nodrug-drug interactions. Furthermore, TMS shows promise in several other psychiatricdisorders, particularly treating acute and chronic pain. …”
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2379
Bidirectional pharmacokinetics of doravirine, tenofovir, and feminizing hormones in transgender women (IDentify): A randomized crossover trial
Published 2024-03-01“…Abstract Transgender women may have concerns of drug interactions between feminizing hormone therapy (FHT) and antiretrovirals, leading to nonadherence. …”
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2380
Pharmacological Efficacy of Ginseng against Respiratory Tract Infections
Published 2021-07-01“…Further analysis needs to be re-focused on clinical trials to study ginseng’s efficacy and safety in treating pathogenic infections and in determining ginseng-drug interactions.…”
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