NSAID-induced damage to the gastrointestinal tract: new opportunities for the prevention of gastro- and enteropathies by V. N. Drozdov, Yu. V. Meshcheryakov, S. Yu. Serebrova, E. V. Shikh

“…The absence of effects on cytochrome P450 enzyme activity, which minimizes the risks of drug interactions and changes in bioavailability, biotransformation and excretion of the drug itself during its course use is an additional advantage of rebamipide.…”
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Suspected Rivaroxaban-Induced Anaphylaxis Secondary to Ingestion of Rivaroxaban and Nimesulide Without Cross-Reactivity to Dabigatran – A Case Report by Gumbis G, Česnavičiūtė I, Didžiokaitė G, Gegeckienė D, Kvedarienė V

“…Even though rivaroxaban rarely causes serious allergic reactions, when prescribing it, it is important to analyze patients’ medical history for possible previously experienced drug-induced allergic reactions and to be aware of the risks of possible undesired drug interactions.Keywords: Xarelto, anticoagulant, DOAC, adverse drug reaction, allergy…”
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Severe Cutaneous Adverse Reaction Caused by Carbamazepine and Levofloxacin After Varicella Zoster Virus Infection by Wang M, Lin L, Wang L, Li L

“…The associated factors for the SCARs in our patient included age, history of allergy, viral infection, and drugs interacting with specific HLA loci. Improving our understanding of these factors can improve the treatment and prevention of SCARs in these patients.Keywords: severe cutaneous adverse reaction, SCARs, acute generalized exanthematous pustulosis, AGEP, drug reaction with eosinophilia and systematic syndrome, DRESS syndrome, overlapping feature, carbamazepine, varicella zoster virus infection…”
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Co-Administered Polymeric Nano-Antidotes for Improved Photo-Triggered Response in Glioblastoma by Janel Kydd, Rahul Jadia, Prakash Rai

“…The specific aims of this research were to synthesize, characterize and assess cell viability and drug interactions for polyethylene-glycolated (PEGylated) polymeric based CED and BPD NPs which were less than 100 nm in size for enhanced permeation and retention effects. …”
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Individualized Pharmaceutical Care for Antifungal Therapy in a Patient with Aspergillus tubingensis Spondylitis After Discontinuation of Rifampicin: A Case Report by Li J, Cai X, Xu Y, Zhang R

“…Treatment of AS is challenging due to its prolonged duration, substantial side effects, and complex drug–drug interactions. However, there is a lack of experience in individualized pharmaceutical care of AS by clinical pharmacists, especially in the presence of rifampicin, which has sustained liver enzyme induction after discontinuation. …”
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Chemical Stability Study of H₁ Antihistaminic Drugs from the First and the Second Generations, Diphenhydramine, Azelastine and Bepotastine, in Pure APIs and in the Prese... by Anna Gumieniczek, Karolina Lejwoda, Natalia Data

“…As far as the solid mixtures were concerned, all drugs interacted with excipients, especially under high temperature/high humidity or UV/VIS light. …”
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Community pharmacists' response to complaints of gastroesophageal reflux: A simulated patient study in the Northern United Arab Emirates. by Fatima Boura, Moawia M Al-Tabakha, Nageeb Hassan, Mohamad Darwich

“…Thus, the risk for drug-drug interactions (DDI) is a serious concern. This potentially makes the community pharmacist (CP) act as a primary intervention by providing the appropriate counseling and dispensing practice.…”
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Drug transporters OAT1 and OAT3 have specific effects on multiple organs and gut microbiome as revealed by contextualized metabolic network reconstructions by Neema Jamshidi, Sanjay K. Nigam

“…The results suggest that drugs interacting with OAT1 and OAT3 can have far reaching consequences on metabolism in organs (e.g. skin) beyond the kidney. …”
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Safer citalopram use in primary care: Can staff education and prescribing prompts improve adherence to national guidance? A closed loop clinical audit, service evaluation and quali... by Mark Waller

“…Results: Following the presentation of the first cycle findings and the introduction of the EMIS safety prompt, there was a statistically significant reduction in incorrect citalopram dose prescription in the over 65s (8 vs 1), a statistically significant reduction in the incidence of dangerous drug interactions involving citalopram (44 vs 8) and a significant reduction in the incidence of unsafe prescribing of citalopram overall (47 vs 9). …”
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Interplay of Breast Cancer Resistance Protein (Bcrp/Abcg2), Sex, and Fed State in Oral Pharmacokinetic Variability of Furosemide in Rats by Sheena Sharma, Vijaya Saradhi Mettu, Bhagwat Prasad

“…The potential confounding effect of the Bcrp transporter should be considered when FUR is used as a clinical probe of renal organic anion transporter-mediated drug–drug interactions. Unlike human data, no food-effect was observed on FUR PK in rats.…”
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Pharmacokinetics and Efficacy of Fluvoxamine and Amitriptyline in Depression by Sandra Vezmar, Branislava Miljkovic, Katarina Vučicević, Ivana Timotijević, Milica Prostran, Zoran Todorović, Milena Pokrajac

“….: Although often necessary for obtaining remission following major depressive disorder, combined antidepressant treatment is frequently associated with drug interactions and enhanced adverse drug effects. We investigated pharmacokinetic interactions following combined fluvoxamine and amitriptyline treatment and their impact on therapeutic efficacy and tolerability. …”
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Pharmaceutical Formulations with P-Glycoprotein Inhibitory Effect as Promising Approaches for Enhancing Oral Drug Absorption and Bioavailability by Thi-Thao-Linh Nguyen, Van-An Duong, Han-Joo Maeng

“…The co-administration of small molecule P-gp inhibitors with P-gp substrates can result in drug–drug interactions and increased side effects due to the pharmacological activity of these molecules. …”
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What Privacy and Confidentiality Mechanisms are used in the Electronic Health Records (Clinical Master and ICT4 M-Power systems)? A design Science Research Approach. by Glorious Orishaba, David Serunjogi

“… Background:  Patients are required to share information with their doctors to facilitate correct diagnosis and determination of treatment, especially to avoid adverse drug interactions. Despite efforts to fully implement and adopt Electronic Health Records System, there is limited attention to fully secure patients’ details. …”
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Cardiovascular manifestations in COVID-19 patients by Jyotsna Maddury, Mani Krishna, Achukatla Kumar

“…Consideration for potential drug interactions should be taken when treating CVD patients with COVID-19.…”
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Evaluation of treatment simplification strategies in patients living with HIV with multi-drug resistance by Taylor N. Harris, Lindsey R. Buscemi

“…These patients are often prescribed ‘salvage’ antiretroviral therapy (ART) regimens with high pill burdens, leading to potential decreased medication adherence and increased side effects and drug–drug interactions. Materials & Methods: In this retrospective, observational cohort study, we included adult patients with a diagnosis of HIV-1 who received care at our institution’s Ryan White Clinic and who received ‘salvage’ ART, defined as three of more antiretroviral agents from at least three different HIV drug classes. …”
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Modern approaches to the prevention of venous thromboembolic complications in patients with active cancer by Yu. A. Fedotkina, E. P. Panchenko

“…The treatment of an already confirmed VTEC in a cancer patient always involves the additional challenges of drug interactions and increased haemorrhagic risk due to prolonged use of treatment doses of anticoagulants, which may in turn affect the effectiveness of chemotherapy or the efficiency and safety of anticoagulant therapy.…”
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Metabolites of Trichoderma harzianum re-balance T-reg/Th-17 cytokine axis in epileptic rats by Mohamed A. Alblihed

“…Even though many anti-epileptic drugs (AEDs) are available, but have several drawbacks, including multiple drug interactions, suboptimal response rates, significant adverse effects, and a narrow therapeutic index. …”
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Phase I In Vitro Metabolic Profiling of the Synthetic Cannabinoid Receptor Agonists CUMYL-THPINACA and ADAMANTYL-THPINACA by Manuela Carla Monti, Eva Scheurer, Katja Mercer-Chalmers-Bender

“…The results suggest that ADAMANTYL-THPINACA might be more prone to metabolic drug−drug interactions than CUMYL-THPINACA, when co-administrated with strong CYP3A4 inhibitors.…”
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Effects of mulberry leaf extracts on activity and mRNA expression of five cytochrome P450 enzymes in rat by Chenming Sheng, Xiaoyan Shi, Zexian Ding, Yunna Chen, Xiaoqian Shi, Yifan Wu, Wenjing Zhang, Weidong Chen

“…Adverse side effects of drug-drug interactions induced by human cytochrome P450 (CYP450) inhibition is an important consideration in drug discovery. …”
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The pharmacogenetics of the new-generation antipsychotics – A scoping review focused on patients with severe psychiatric disorders by Octavian Vasiliu

“…Pharmacogenetic data about cariprazine is sparse, and relevant information regarding gene-drug interactions for lumateperone and pimavanserin is yet lacking. …”
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