Quercetin Is a Flavonoid Breast Cancer Resistance Protein Inhibitor with an Impact on the Oral Pharmacokinetics of Sulfasalazine in Rats by Yoo-Kyung Song, Jin-Ha Yoon, Jong Kyu Woo, Ju-Hee Kang, Kyeong-Ryoon Lee, Seung Hyun Oh, Suk-Jae Chung, Han-Joo Maeng

“…Considering the high dietary intake of quercetin as well as its consumption as a dietary supplement, issuing a caution regarding its food–drug interactions should be considered.…”
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Modulation of Immunological, Biochemical, and Histopathological Changes of Airway Remodeling by Withania somnifera in an Experimental Model of Allergic Asthma in Rats by Nafaa Hasan Ali, Sana Rehman, Maaz Naqvi, Kavita Gulati, Arunabha Ray

“…Further, WS extract attenuated histopathological changes and maintained lung integrity. In herb-drug interactions, sub-threshold doses of WS extract and DEX showed synergistic effects on all parameters studied as compared to either form of monotherapy.Conclusion: These results indicated that WS exerted significant protective effects against airway remodeling in the experimental model by modulating inflammatory and fibrotic cytokines, and could have the potential for developing a therapeutic alternative/adjunct for the treatment of airway remodeling of bronchial asthma.…”
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Multidisciplinary Guidelines for the Rational Use of Topical Non-Steroidal Anti-Inflammatory Drugs for Musculoskeletal Pain (2022) by Chen Shi, Zhaoming Ye, Zengwu Shao, Bifa Fan, Cibo Huang, Yuan Zhang, Xinying Kuang, Liyan Miao, Xin’an Wu, Rongsheng Zhao, Xiao Chen, Bikui Zhang, Rongsheng Tong, Xin Hu, Zhijian Fu, Jianhao Lin, Xiaomei Li, Tiezheng Sun, Guoqiang Liu, Haibin Dai, Cheng Guo, Bo Zhang, Ting Xu, Aidong Wen, Xiaocong Zuo, Jinmei Liu, Xu Chen, Huibo Li, Jing Wang, Min Luo, Tingting Fan, Yulan Qian, Xiu’mao Li, Wenjie Qiu, Xiaowen Lin, Yingchang Pang, Yunfei Hou, Difei Yao, Wen Kou, Bao Sun, Can Hu, Yanzhe Xia, Ming Zhao, Changyu Zhu, Qian Li, Yu Zhang

“…However, there are currently no evidence-based recommendations about drug selection, drug administration, drug interactions, and use in special populations or other pharmacology-related content of such medications. …”
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Deciphering the Interactions of SARS-CoV-2 Proteins with Human Ion Channels Using Machine-Learning-Based Methods by Nupur S. Munjal, Dikscha Sapra, K. T. Shreya Parthasarathi, Abhishek Goyal, Akhilesh Pandey, Manidipa Banerjee, Jyoti Sharma

“…Additionally, various U.S. food and drug administration (FDA)-approved drugs interacting with the potential HICs were identified. …”
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PC945, a Novel Inhaled Antifungal Agent, for the Treatment of Respiratory Fungal Infections by Alison Murray, Lindsey Cass, Kazuhiro Ito, Nicole Pagani, Darius Armstrong-James, Paras Dalal, Anna Reed, Pete Strong

“…In two lung transplant patients, PC945 treated an invasive pulmonary <i>Aspergillus</i> infection that had been unresponsive to multiple antifungal agents (systemic ± inhaled) without systemic side effects or detected drug–drug interactions.…”
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NITROUS OXIDE/OXYGEN CONSCIOUS SEDATION IN ASA CLASS II DENTAL PATIENTS – PART 2 by Liviu Ioan Tuturici, Octavian Dincă, Cristina Pădurariu, Tiberiu Niță, Cristian Vlădan, Alexandru Bucur

“…When deciding on dental treatment under sedation, the plan should be carefully determined because compared to general patients, ASA Class II patients are more likely to experience complications because of their underlying medical conditions and potential drug interactions. The purpose of this study was to evaluate the Ramsay Sedation Score on nitrous oxide-oxygen mixture conscious sedation in a sample of ASA II patient’s. …”
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The Biological Interaction of SARS-CoV-2 Infection and Osteoporosis: A Preliminary Study by Xin Kang, Xiaodong Wen, Jingqi Liang, Liang Liu, Yan Zhang, Qiong Wang, Hongmou Zhao

“…Predictive analyses of transcription factor/gene interactions, protein/drug interactions, and DEG/miRNA networks associated with these DEGs were also conducted. …”
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High Incidence of Invasive Fungal Diseases in Patients with FLT3-Mutated AML Treated with Midostaurin: Results of a Multicenter Observational SEIFEM Study by Chiara Cattaneo, Francesco Marchesi, Irene Terrenato, Valentina Bonuomo, Nicola Stefano Fracchiolla, Mario Delia, Marianna Criscuolo, Anna Candoni, Lucia Prezioso, Davide Facchinelli, Crescenza Pasciolla, Maria Ilaria Del Principe, Michelina Dargenio, Caterina Buquicchio, Maria Enza Mitra, Francesca Farina, Erika Borlenghi, Gianpaolo Nadali, Vito Pier Gagliardi, Luana Fianchi, Mariarita Sciumè, Pierantonio Menna, Alessandro Busca, Giuseppe Rossi, Livio Pagano

“…The potential drug-drug interactions of midostaurin may impact the choice of antifungal (AF) prophylaxis in FLT3-positive acute myeloid leukemia (AML) patients. …”
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Circulating Small EVs miRNAs as Predictors of Pathological Response to Neo-Adjuvant Therapy in Breast Cancer Patients by Oana Baldasici, Loredana Balacescu, Daniel Cruceriu, Andrei Roman, Carmen Lisencu, Bogdan Fetica, Simona Visan, Andrei Cismaru, Ancuta Jurj, Lucian Barbu-Tudoran, Valentina Pileczki, Laurian Vlase, Oana Tudoran, Ovidiu Balacescu

“…Functional analysis of miRNA target genes and drug interactions revealed that candidate miRNAs and their targets, can be regulated by different NAT regimens. …”
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Tutorial: Statistical analysis and reporting of clinical pharmacokinetic studies by Ann‐Cathrine Dalgård Dunvald, Ditte Bork Iversen, Andreas Ludvig Ohm Svendsen, Katrine Agergaard, Ida Berglund Kuhlmann, Christina Mortensen, Nanna Elman Andersen, Erkka Järvinen, Tore Bjerregaard Stage

“…It is also the key to describing variability in drug response caused by drug‐drug interactions (DDIs), pharmacogenetics, impaired kidney and liver function, etc. …”
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Diagnosis and management of tuberculosis infection in inclusion health populations in London by Adam Gray, Julian Surey, Martha Veitch, Dee Menezes, John Gibbons, Mark Leonard, Binta Sultan, Hanif Esmail, Al Story

“…Discussion Provision of TB infection diagnosis and management to this socially excluded population has several challenges including maintaining people in care and drug-drug interactions. Peer-support workers provided this service safely and effectively with appropriate support. …”
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Performance Verification of CYP2C19 Enzyme Abundance Polymorphism Settings within the Simcyp Simulator v21 by Caroline Sychterz, Iain Gardner, Manting Chiang, Ramakrishna Rachumallu, Sibylle Neuhoff, Vidya Perera, Samira Merali, Brian J. Schmidt, Lu Gaohua

“…Physiologically based pharmacokinetic (PBPK) modeling has a number of applications, including assessing drug–drug interactions (DDIs) in polymorphic populations, and should be iteratively refined as science progresses. …”
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Emerging therapeutic drug monitoring technologies: considerations and opportunities in precision medicine by Winnie S. Liang, Winnie S. Liang, Brett Beaulieu-Jones, Brett Beaulieu-Jones, Susan Smalley, Michael Snyder, Michael Snyder, Laura H. Goetz, Nicholas J. Schork, Nicholas J. Schork

“…In this mini-review, we discuss emerging TDM technologies and their applications, and factors that influence TDM including drug interactions, polypharmacy, and supplement use. We also discuss how using TDM within single subject (N-of-1) and aggregated N-of-1 clinical trial designs provides opportunities to better capture drug response and activity at the individual level. …”
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Tumor Treating Fields (TTFields) Therapy Concomitant with Taxanes for Cancer Treatment by Ignace Vergote, Teresa Macarulla, Fred R. Hirsch, Carsten Hagemann, David Scott Miller

“…Multimodal treatment combinations can help improve patient outcomes; however, implementation is limited by additive toxicities and potential drug–drug interactions. As such, there is a high unmet need to develop additional therapies to enhance the efficacy of SOC treatments without increasing toxicity. …”
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The Selective NMDA Receptor GluN2B Subunit Antagonist CP-101,606 with Antidepressant Properties Modulates Cytochrome P450 Expression in the Liver by Ewa Bromek, Anna Haduch, Marta Rysz, Joanna Jastrzębska, Renata Pukło, Olga Wójcikowska, Przemysław Jan Danek, Władysława Anna Daniel

“…The obtained results imply engagement of the glutamatergic system in the neuroendocrine regulation of cytochrome P450 and potential involvement of drugs acting on NMDA receptors in metabolic drug–drug interactions.…”
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Discovering Synergistic Compounds with BYL-719 in PI3K Overactivated Basal-like PDXs by David C. Boyd, Emily K. Zboril, Amy L. Olex, Tess J. Leftwich, Nicole S. Hairr, Holly A. Byers, Aaron D. Valentine, Julia E. Altman, Mohammad A. Alzubi, Jacqueline M. Grible, Scott A. Turner, Andrea Ferreira-Gonzalez, Mikhail G. Dozmorov, J. Chuck Harrell

“…BYL-719 is a PIK3CA inhibitor that has been found to have low drug-drug interactions, which increases the likelihood that it could be useful for combinatorial therapy. …”
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Therapeutic Drug Monitoring of Quinidine in Pediatric Patients with <i>KCNT1</i> Genetic Variants by Alessandro Ferretti, Raffaele Simeoli, Sara Cairoli, Nicola Pietrafusa, Marina Trivisano, Carlo Dionisi Vici, Nicola Specchio, Bianca Maria Goffredo

“…These data underlie the utility of TDM for QND not only to monitor its toxic effects but also to evaluate possible drug–drug interactions.…”
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Prevalence of Medicinal Herbs Consumption in Pregnant Women Referring to Bojnurd Health Care Centers by Seyed Hamid Hosseini, Rezvan Rajabzadeh, Halimeh Nosrati, Fateme Naseri, Mahdi Toroski, Hamidreza Mohaddes Hakkak, Mohammad Hossein Ayati

“…Introduction: Pregnant women use medicinal herbs for different reasons, and there is a belief that medicinal herbs are safe and without side effects, while medicinal herbs have side effects or drug interactions for the mother. Therefore, this study was performed with aim to evaluate the prevalence of medicinal herbs consumption in pregnant women referring to Bojnurd health care centers. …”
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Stability Characterization of the Novel Anti-Cancer HM-10/10 HDL-Mimetic Peptide by Michael P. Dempsey, Katelyn E. Andersen, Brittney M. Wells, Mitchell A. Taylor, Clay L. Cashman, Lesley B. Conrad, Claire A. Kearney, Mary B. Conklin, Emily R. Via, Emily M. Doe, Ravikiran Komirisetty, Susan Dearborn, Srinivasa T. Reddy, Robin Farias-Eisner

“…Furthermore, HM-10/10 demonstrated no evidence of time-dependent drug–drug interactions, although it demonstrated CYP450 induction slightly above cutoff. …”
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The System Profile of Renal Drug Transporters in Tubulointerstitial Fibrosis Model and Consequent Effect on Pharmacokinetics by Birui Shi, Yan Zhang, Baolin Huang, Huiping Lin, Qiong Zhou, Yujue Wang, Zheng Cai, Menghua Liu

“…With the widespread clinical use of drug combinations, the incidence of drug–drug interactions (DDI) has significantly increased, accompanied by a variety of adverse reactions. …”
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