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2481
Quercetin Is a Flavonoid Breast Cancer Resistance Protein Inhibitor with an Impact on the Oral Pharmacokinetics of Sulfasalazine in Rats
Published 2020-04-01“…Considering the high dietary intake of quercetin as well as its consumption as a dietary supplement, issuing a caution regarding its food–drug interactions should be considered.…”
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2482
Modulation of Immunological, Biochemical, and Histopathological Changes of Airway Remodeling by Withania somnifera in an Experimental Model of Allergic Asthma in Rats
Published 2023-06-01“…Further, WS extract attenuated histopathological changes and maintained lung integrity. In herb-drug interactions, sub-threshold doses of WS extract and DEX showed synergistic effects on all parameters studied as compared to either form of monotherapy.Conclusion: These results indicated that WS exerted significant protective effects against airway remodeling in the experimental model by modulating inflammatory and fibrotic cytokines, and could have the potential for developing a therapeutic alternative/adjunct for the treatment of airway remodeling of bronchial asthma.…”
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2483
Multidisciplinary Guidelines for the Rational Use of Topical Non-Steroidal Anti-Inflammatory Drugs for Musculoskeletal Pain (2022)
Published 2023-02-01“…However, there are currently no evidence-based recommendations about drug selection, drug administration, drug interactions, and use in special populations or other pharmacology-related content of such medications. …”
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2484
Deciphering the Interactions of SARS-CoV-2 Proteins with Human Ion Channels Using Machine-Learning-Based Methods
Published 2022-02-01“…Additionally, various U.S. food and drug administration (FDA)-approved drugs interacting with the potential HICs were identified. …”
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2485
PC945, a Novel Inhaled Antifungal Agent, for the Treatment of Respiratory Fungal Infections
Published 2020-12-01“…In two lung transplant patients, PC945 treated an invasive pulmonary <i>Aspergillus</i> infection that had been unresponsive to multiple antifungal agents (systemic ± inhaled) without systemic side effects or detected drug–drug interactions.…”
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2486
NITROUS OXIDE/OXYGEN CONSCIOUS SEDATION IN ASA CLASS II DENTAL PATIENTS – PART 2
Published 2022-03-01“…When deciding on dental treatment under sedation, the plan should be carefully determined because compared to general patients, ASA Class II patients are more likely to experience complications because of their underlying medical conditions and potential drug interactions. The purpose of this study was to evaluate the Ramsay Sedation Score on nitrous oxide-oxygen mixture conscious sedation in a sample of ASA II patient’s. …”
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2487
The Biological Interaction of SARS-CoV-2 Infection and Osteoporosis: A Preliminary Study
Published 2022-05-01“…Predictive analyses of transcription factor/gene interactions, protein/drug interactions, and DEG/miRNA networks associated with these DEGs were also conducted. …”
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2488
High Incidence of Invasive Fungal Diseases in Patients with FLT3-Mutated AML Treated with Midostaurin: Results of a Multicenter Observational SEIFEM Study
Published 2022-05-01“…The potential drug-drug interactions of midostaurin may impact the choice of antifungal (AF) prophylaxis in FLT3-positive acute myeloid leukemia (AML) patients. …”
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2489
Circulating Small EVs miRNAs as Predictors of Pathological Response to Neo-Adjuvant Therapy in Breast Cancer Patients
Published 2022-10-01“…Functional analysis of miRNA target genes and drug interactions revealed that candidate miRNAs and their targets, can be regulated by different NAT regimens. …”
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2490
Tutorial: Statistical analysis and reporting of clinical pharmacokinetic studies
Published 2022-08-01“…It is also the key to describing variability in drug response caused by drug‐drug interactions (DDIs), pharmacogenetics, impaired kidney and liver function, etc. …”
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2491
Diagnosis and management of tuberculosis infection in inclusion health populations in London
Published 2024-02-01“…Discussion Provision of TB infection diagnosis and management to this socially excluded population has several challenges including maintaining people in care and drug-drug interactions. Peer-support workers provided this service safely and effectively with appropriate support. …”
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2492
Performance Verification of CYP2C19 Enzyme Abundance Polymorphism Settings within the Simcyp Simulator v21
Published 2022-10-01“…Physiologically based pharmacokinetic (PBPK) modeling has a number of applications, including assessing drug–drug interactions (DDIs) in polymorphic populations, and should be iteratively refined as science progresses. …”
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2493
Emerging therapeutic drug monitoring technologies: considerations and opportunities in precision medicine
Published 2024-03-01“…In this mini-review, we discuss emerging TDM technologies and their applications, and factors that influence TDM including drug interactions, polypharmacy, and supplement use. We also discuss how using TDM within single subject (N-of-1) and aggregated N-of-1 clinical trial designs provides opportunities to better capture drug response and activity at the individual level. …”
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2494
Tumor Treating Fields (TTFields) Therapy Concomitant with Taxanes for Cancer Treatment
Published 2023-01-01“…Multimodal treatment combinations can help improve patient outcomes; however, implementation is limited by additive toxicities and potential drug–drug interactions. As such, there is a high unmet need to develop additional therapies to enhance the efficacy of SOC treatments without increasing toxicity. …”
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2495
The Selective NMDA Receptor GluN2B Subunit Antagonist CP-101,606 with Antidepressant Properties Modulates Cytochrome P450 Expression in the Liver
Published 2021-10-01“…The obtained results imply engagement of the glutamatergic system in the neuroendocrine regulation of cytochrome P450 and potential involvement of drugs acting on NMDA receptors in metabolic drug–drug interactions.…”
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2496
Discovering Synergistic Compounds with BYL-719 in PI3K Overactivated Basal-like PDXs
Published 2023-03-01“…BYL-719 is a PIK3CA inhibitor that has been found to have low drug-drug interactions, which increases the likelihood that it could be useful for combinatorial therapy. …”
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2497
Therapeutic Drug Monitoring of Quinidine in Pediatric Patients with <i>KCNT1</i> Genetic Variants
Published 2022-10-01“…These data underlie the utility of TDM for QND not only to monitor its toxic effects but also to evaluate possible drug–drug interactions.…”
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2498
Prevalence of Medicinal Herbs Consumption in Pregnant Women Referring to Bojnurd Health Care Centers
Published 2017-11-01“…Introduction: Pregnant women use medicinal herbs for different reasons, and there is a belief that medicinal herbs are safe and without side effects, while medicinal herbs have side effects or drug interactions for the mother. Therefore, this study was performed with aim to evaluate the prevalence of medicinal herbs consumption in pregnant women referring to Bojnurd health care centers. …”
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2499
Stability Characterization of the Novel Anti-Cancer HM-10/10 HDL-Mimetic Peptide
Published 2023-06-01“…Furthermore, HM-10/10 demonstrated no evidence of time-dependent drug–drug interactions, although it demonstrated CYP450 induction slightly above cutoff. …”
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2500
The System Profile of Renal Drug Transporters in Tubulointerstitial Fibrosis Model and Consequent Effect on Pharmacokinetics
Published 2022-01-01“…With the widespread clinical use of drug combinations, the incidence of drug–drug interactions (DDI) has significantly increased, accompanied by a variety of adverse reactions. …”
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