Evaluation of synergism in drug combinations and reference models for future orientations in oncology by Diana Duarte, Nuno Vale

“…We also describe here the novel methods for the accurate quantification of drug interactions in combined treatments. At the end of this manuscript, we covered some of the most recent preclinical and clinical combination studies that reflect the importance of the appropriate, accurate and precise application of the concepts and methodologies here described for the evaluation of synergism.…”
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Prevalence of Adverse Drug Events in Severely Obese Adults and Associated Factors: Clinical Trial Baseline Results by Ana Carolina Figueiredo Modesto, Erika Aparecida Silveira, Annelisa Silva e Alves de Carvalho Santos, Ana Paula dos Santos Rodrigues, Dione Marçal Lima, Mércia Pandolfo Provin, Rita Goreti Amaral

“…The prevalence of ADEs was 32.67% (<i>n</i> = 49) and associated with the age range 40 to 49 years (<i>p</i> = 0.033), diabetes (<i>p</i> = 0.004), multimorbidities ≥ 4 (<i>p</i> = 0.009), self-medication (0.031), and presence of potential drug interactions (0.017). The prevalence of ADEs was high and was associated with drugs commonly used in treatment of obesity-related morbidities and self-medication. …”
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Evaluation of the Potentially Inappropriate Cardiovascular Medication Prescription in Elderly: A Nationwide Study in Turkey by Mehmet Tevfik Kitapçı, Osman Karakuş, Fatma İşli, Mesil Aksoy, Muhammed Cihan Güvel, Canan Uluoğlu

“…Diclofenac-warfarin was the most commonly prescribed concomitant drug use in the potentially clinically important drug–drug interactions group. The rate of potentially inappropriate drug prescribing was higher in males and in aged 80 years and older. …”
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Features of toxic nephropathy development during antibiotic therapy by R. E. Kazakov, G. I. Gorodetskaya, R. V. Archvadze, A. V. Zavtonev, A. V. Danilov, D. L. Fetlam, D. A. Ishalev, N. G. Berdnikova, E. Yu. Demchenkova

“…The authors analysed the dependence of nephrotoxicity on antibacterial agent lipophilicity and drug–drug interactions. The main risk factors for developing nephropathy are older age; male sex; black race; hypovolaemia; arterial hypotension; angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, non-steroidal anti-inflammatory drugs or their combinations; and individual genetic characteristics. …”
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COVID-19 related sleep disorders and the mental health by S. Kryzhanovskiy, M. Samushia, T. Berishvili, S. Chorbinskaya, V. Shmirev

“…The choice of the medical intervention should be based on the severity of the violations identified taking into account the side effects of the prescribed drugs, drug interactions and somatic status of patients Disclosure No significant relationships. …”
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Interactions of the Anti-SARS-CoV-2 Agents Molnupiravir and Nirmatrelvir/Paxlovid with Human Drug Transporters by Éva Bakos, Csilla Temesszentandrási-Ambrus, Csilla Özvegy-Laczka, Zsuzsanna Gáborik, Balázs Sarkadi, Ágnes Telbisz

“…Our current in vitro results should help to estimate the potential drug–drug interactions of these newly developed agents during COVID-19 treatment.…”
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New Formulation–Microporation Combination Approaches to Delivering Ciclopirox across Human Nails by Juliana Kishishita, Camila de Almeida Perez Pimenta, Danielle Patricia Cerqueira Macedo, M. Begoña Delgado-Charro, Leila Bastos Leal

“…Topical treatments for onychomycosis are of interest to those seeking to avoid systemic drug interactions and to improve systemic safety. This work aimed to develop aqueous-based, simple, and cost-effective vehicles that provide high solubility for ciclopirox and enable the delivery of an active through channels created by nail microporation. …”
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Chronic Pulmonary Aspergillosis: Notes for a Clinician in a Resource-Limited Setting Where There Is No Mycologist by Felix Bongomin, Lucy Grace Asio, Joseph Baruch Baluku, Richard Kwizera, David W. Denning

“…In patients co-infected with tuberculosis (TB), it is not possible to treat TB with rifampicin and concurrently administer azoles, because of profound drug interactions. In those with pan-azole resistance or intolerance or progressive disease while on oral triazoles, short-term courses of intravenous liposomal amphotericin B or micafungin is used. …”
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Safety and Efficacy of Dolutegravir Plus Rilpivirine in Treatment-Experienced HIV-Infected Patients: The DORIVIR Study by Rosario Palacios MD, PhD, M. Mayorga MD, C. M. González-Domenech PhD, C. Hidalgo-Tenorio MD, PhD, C. Gálvez MD, PhD, L. Muñoz-Medina MD, J. de la Torre MD, PhD, A. Lozano MD, M. Castaño MD, M. Omar MD, PhD, Jesús Santos MD, PhD

“…Results: A total of 104 participants were included, who switched for the following reasons: toxicity/intolerance (42.3%), convenience (27.8%), and drug interactions (17.3%). Prior regimens are protease inhibitor (56.7%), integrase strand transfer inhibitor (26.9%), and non-nucleoside reverse transcriptase inhibitor (16.3%). …”
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Compatibility of Drotaverine Hydrochloride with Ibuprofen and Ketoprofen Nonsteroidal Anti-Inflammatory Drugs Mixtures by Andreia-Cristina Soare, Viorica Meltzer, Claudiu Colbea, Ioana Stanculescu, Elena Pincu

“…D-HCl:Ibu and D-HCl:Ket drug-drug interactions leading to the formation of eutectic compositions with increased bioavailability, obtained by mechanosynthesis, a green, solvent-free method was explored for the first time. …”
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Practice of CYP450 genotyping and phenotyping in children in a real-life setting by Frédérique Rodieux, Youssef Daali, Youssef Daali, Youssef Daali, Victoria Rollason, Victoria Rollason, Caroline F. Samer, Caroline F. Samer, Caroline F. Samer, Kuntheavy Ing Lorenzini, Kuntheavy Ing Lorenzini

“…Many factors play an important role in this variability, such as ontogeny, pharmacogenetics, gender, comorbidities, and drug-drug interactions. Significant work has already been done in adults to understand the impact of genetic polymorphisms on drug-metabolizing enzyme activity and drug response. …”
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Effect of biogenic selenium nanoparticles on ERG11 and CDR1 gene expression in both fluconazole-resistant and -susceptible Candida albicans isolates by Nasrin Parsamehr, Sasan Rezaie, Sadegh Khodavaisy, Samira Salari, Sanaz Hadizadeh, Mohammad Kord, Seyed Amin Ayatollahi Mousavi

“…Given the toxicity of the antimicrobial drugs, resistance to antifungal agents, and drug interactions, the identification of new antifungal agents seems essential. …”
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Clinical research advances of isavuconazole in the treatment of invasive fungal diseases by Tingting Zhang, Tingting Zhang, Yuyan Shen, Yuyan Shen, Sizhou Feng, Sizhou Feng

“…In addition, most studies have shown the efficacy and safety of ISA for the prophylaxis of IFD.ConclusionTaken together, ISA are expected to become a new choice for the treatment and prevention of IFD because of their good tolerability, high bioavailability, and few drug interactions.…”
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A Review on Contaminants of Emerging Concern in the Environment: A Focus on Active Chemicals in Sub-Saharan Africa by Asha S. Ripanda, Mwemezi Johaiven Rwiza, Elias C. Nyanza, Karoli N. Njau, Said A. H. Vuai, Revocatus L. Machunda

“…Most studies that evaluated the toxicity of these substances considered the effects of a single drug, but observations indicated the presence of drug mixtures, hence the need for further evaluation of the effects of drug–drug interactions—including synergistic and additive effects—for environmental sustainability. …”
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Acute Lymphoblastic Leukemia and Invasive Mold Infections: A Challenging Field by Christos Stafylidis, Panagiotis Diamantopoulos, Eleni Athanasoula, Elena Solomou, Amalia Anastasopoulou

“…Administering primary antimold prophylaxis in these patients has been challenging since incorporating azole antifungal agents is troublesome, considering the drug-to-drug interactions (DDIs) and increased toxicity that may occur when these agents are coadministered with vincristine, a fundamental component of ALL chemotherapy regimens. …”
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An Update on Drug–Nutrient Interactions and Dental Decay in Older Adults by Victoria Bell, Ana Rita Rodrigues, Maria Antoniadou, Marios Peponis, Theodoros Varzakas, Tito Fernandes

“…This scenario increases the likelihood of drug interactions, both between medications and with nutrients and the microbiome, triggering complications such as dental decay and other pathologies. …”
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Molecular interactions of Andrographis paniculata Burm. f. Active Compound with Nuclear Receptor (CAR and PXR): An In Silico Assessment Approach by Sundhani, Elza, Nugroho, Agung Endro, Nurrochmad, Arief, Lukitaningsih, Endang

“…The study aims to analyze the potential Herb-Drug Interactions (HDIs) of the chemical compound in Andrographis paniculate Burm. f. against Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR). …”
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Safety perception and determinants of complementary and alternative medicine usage among surgery out-patients in LAUTECH Teaching hospital, ogbomoso, Nigeria by Oluwatosin Stephen Ilori, Olawale Olakunlehin, Oluwatosin Ruth Ilori, Phillip Oluwatobi Awodutire, Chidi Ugwuoke, Olajumoke Shittu

“…Only 15 (13.2 %) and 6 (5.3 %) have ever recorded side effects and drug interactions respectively. Older age group, income less than 10,000 Naira, positive safety perception and belief about CAM were identified as determinants of CAM usage. …”
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Optimal Medical Therapy for Chronic Coronary Syndrome: Realities and Prospects by P. A. Lebedev, I. K. Petrukhina, A. A. Garanin, E. V. Paranina

“…A great achievement of the current stage of development of clinical cardiology and the pharmaceutical industry is the ability to offer patients optimal single pill combinations (SPC) in terms of effectiveness, tolerability, drug interactions, and ease of use. The article substantiates the prospects for a successful solution of this key problem by using a new generation of SPC components belonging to different pharmacological groups. …”
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Misunderstanding of dosing regimen instructions among patients with chronic diseases receiving polypharmacy at the University of Gondar comprehensive specialized hospital. by Eyayaw Ashete Belachew, Ashenafi Kibret Sendekie, Samuel Agegnew Wondm, Emneteab Mesfin Ayele, Adeladlew Kassie Netere

“…More than 90% of patients had no understanding of drug-drug interactions (DDIs). Sex (X2 = 16.837; P<0.0001), educational level (X2 = 50.251; P < 0.0001), residence (X2 = 5.164; P < 0.023) and duration of stay on medication (X2 = 13.806; P < 0.0003) were significantly associated with misunderstanding of dosage regimen instructions.…”
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