Hospital Pharmacy Professionals and Cardiovascular Care: A Cross-Sectional Study Assessing Knowledge, Attitudes, and Practices in Saudi Arabia by Fahad Alzahrani, Reem A. Alhusayni, Nosaiba B. Khairi, Ammar A. Bahauddin, Shadi Tamur

“…The study results revealed inadequate knowledge levels with an average score of 3.87 out of 7, indicating significant gaps in comprehending drug interactions, managing lipid levels, and addressing resistant hypertension. …”
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Are we providing complete drug information to its users? Status of information adequacy of package insert in India by Shubha Singhal, Rima B Shah, Kiran G Piparva, Siddhartha Dutta

“…Most PIs provided generic names, ROA, and indications for use. 85%, 12%, 29.16%, and 3.33% provided information on PIs on the ability to drive, drug–food interactions, drug–drug interactions, and addiction potential, respectively. …”
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Global prevalence of polypharmacy among the COVID-19 patients: a comprehensive systematic review and meta-analysis of observational studies by Hooman Ghasemi, Niloofar Darvishi, Nader Salari, Amin Hosseinian-Far, Hakimeh Akbari, Masoud Mohammadi

“…Since there is no definitive cure for COVID-19, the multiplicity of drugs used to treat this disease can affect the severity of the disease and its side effects as a result of drug interactions. This highlights the importance of controlling and managing prescription drugs for patients with COVID-19.…”
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Multilevel predictors of concurrent opioid use during methadone maintenance treatment among drug users with HIV/AIDS. by Bach Xuan Tran, Arto Ohinmaa, Steve Mills, Anh Thuy Duong, Long Thanh Nguyen, Philip Jacobs, Stan Houston

“…Disease stage and drug interactions between antiretrovirals or TB drugs and MMT could explain some of the observed predictors of ongoing drug use; these findings could inform changes in MMT program design and implementation.…”
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Various effects of repeated rifampin dosing on coproporphyrin levels in humans by Jonny Kinzi, Markus Grube, Karin Brecht, Isabell Seibert, Werner Siegmund, Henriette E. Meyer zu Schwabedissen

“…In the context of drug–drug interactions, several preclinical and clinical studies assessed the effect of the OATP1B‐index inhibitor rifampin on CPI levels. …”
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Potential Pharmacokinetic Effect of Chicken Xenobiotic Receptor Activator on Sulfadiazine: Involvement of P-glycoprotein Induction by Mei Li, Ziyong Xu, Wang Lu, Liping Wang, Yujuan Zhang

“…Studies on pharmacokinetic drug–drug interactions have highlighted the importance of P-glycoprotein (P-gp) because of its involvement in substrate drug transport. …”
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Analysis of Potential Biomarkers in Frontal Temporal Dementia: A Bioinformatics Approach by Inara Deedar Momin, Jessica Rigler, Kumaraswamy Naidu Chitrala

“…We conducted a comorbidity analysis for COVID-19 and breast cancer, followed by an analysis of potential drug interactions, pathogenicity, analysis of genetic variants, and functional enrichment analysis. …”
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Exploring Herbal Medicine Use during Palliative Cancer Care: The Integrative Physician as a Facilitator of Pharmacist–Patient–Oncologist Communication by Noah Samuels, Eran Ben-Arye

“…Oncology healthcare professionals may lack the knowledge needed to guide their patients on the safe and effective use of herbal medicinal products, a number of which have potentially harmful effects, which include direct toxicity and negative herb–drug interactions. The current review addresses the prevalence and expectations of oncology patients from herbal medicine, as well as evidence for the beneficial or harmful effects of this practice (potential and actual), especially when the herbal products are used in conjunction with anticancer agents. …”
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Assessment of knowledge and practice of cardiovascular nurses regarding warfarin by Maryam Ehsani, Mansoureh Ashghali Farahani, Shima Haghani, Shiva Khaleghparast, Mahboubeh Malekmohammadi Memar

“…RESULTS: The mean scores of knowledge (18.51 ± 3.87) and practice (10.53 ± 2.12) were slightly higher than the median, and the lowest mean score was related to knowledge on drug interactions (7.62). The practice had a statistically significant relationship with knowledge (P < 0.001). …”
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Drug-induced arrhythmias by M. V. Leonova

“…The drug-induced arrhythmias can be caused by conditions leading to altered drug pharmacokinetics and increased plasma concentrations and metabolites having proarrhythmogenic effects, as well as drug-drug interactions.Beta-blockers, non-dihydropyridine calcium channel blockers, other antiarrhythmic drugs, ivabradine, digoxin, anesthetics (bupivacaine, propofol) are the most common culprits in causing drug-induced bradyarrhythmias. …”
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Integrated bioinformatic analysis of mitochondrial metabolism-related genes in acute myeloid leukemia by Xiqin Tong, Fuling Zhou

“…In addition, high-risk patients with more immune-cell infiltration had higher Tumor Immune Dysfunction and Exclusion scores, indicating poor immunotherapy response. mRNA-drug interactions and drug sensitivity analyses were performed to explore potential druggable hub genes. …”
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Pharmacogenomics in Psychiatric Disorders by Roxana-Georgiana Tauser

“…<p>The broad arsenal of psychotropic medications is characterised by significant interindividual variability in clinical response and adverse effects, stringent monitoring requirements, potential drug-drug interactions, difficult long-term adherence and high costs. …”
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Misunderstanding of dosing regimen instructions among patients with chronic diseases receiving polypharmacy at the University of Gondar comprehensive specialized hospital by Eyayaw Ashete Belachew, Ashenafi Kibret Sendekie, Samuel Agegnew Wondm, Emneteab Mesfin Ayele, Adeladlew Kassie Netere

“…More than 90% of patients had no understanding of drug-drug interactions (DDIs). Sex (X2 = 16.837; P<0.0001), educational level (X2 = 50.251; P < 0.0001), residence (X2 = 5.164; P < 0.023) and duration of stay on medication (X2 = 13.806; P < 0.0003) were significantly associated with misunderstanding of dosage regimen instructions. …”
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A clinical phase I dose-finding design with adaptive shrinking boundaries for drug combination trials by Zhaohang Li, Ze Xu, Aijun Zhang, Guanpeng Qi, Zuojing Li

“…In some cases, patients can benefit from the interaction between two drugs, although there is usually a higher risk of developing toxicity. Due to drug–drug interactions, multidrug combinations often exhibit different toxicity profiles than those of single drugs, leading to a complex trial scenario. …”
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Combination Therapy of Ezetimibe and Rosuvastatin for Dyslipidemia: Current Insights by Chilbert MR, VanDuyn D, Salah S, Clark CM, Ma Q

“…Statins have been the gold standard therapy for hypercholesterolemia treatment due to their ease of dosing, limited drug interactions, and favorable safety profile. Unfortunately, statin therapy alone is not always effective enough to adequately control a patient’s elevated lipid levels and combination therapy may be warranted. …”
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Multi-label classification of symptom terms from free-text bilingual adverse drug reaction reports using natural language processing by Sitthichok Chaichulee, Chissanupong Promchai, Tanyamai Kaewkomon, Chanon Kongkamol, Thammasin Ingviya, Pasuree Sangsupawanich

“…Proper documentation of patient allergy information is critical for safe prescription, avoiding drug interactions, and reducing healthcare costs. Allergy information is regularly obtained during the medical interview, but is often poorly documented in electronic health records (EHRs). …”
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Graph regularized non-negative matrix factorization with prior knowledge consistency constraint for drug–target interactions prediction by Junjun Zhang, Minzhu Xie

“…In the case study, ADA-GRMFC is also used to predict the targets interacting with the drug olanzapine, and all of the 10 highest-scoring targets have been accurately predicted. In predicting drug interactions with target estrogen receptors alpha, 17 of the 20 highest-scoring drugs have been validated.…”
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Successful Dasatinib Treatment of Epidermal Growth Factor Receptor-Mutant Lung Adenocarcinoma and BCR-ABL1-Positive Chronic Myeloid Leukemia: A Case Report by Akihiro Tsukaguchi, Seigo Minami, Hironao Yasuoka, Yoshihiro Kin

“…When administering TKI combination therapy, drug-drug interactions should be considered.…”
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Efficacy of Lignocaine Hydrochloride with Adrenaline, Clonidine and Dexmedetomidine for Surgical Removal of Impacted Mandibular Third Molar: A Research Protocol for a Randomised Cl... by Akash Yogesh Doshi, Nitin Dharmpal Bhola

“…Using newer local anaesthetic drugs minimises side effects and drug interactions. Adrenaline is traditionally used vasoconstrictor along with Lignocaine. …”
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Accuracy of the electronic health record's problem list in describing multimorbidity in patients with heart failure in the emergency department. by Brandon L King, Michelle L Meyer, Srihari V Chari, Karen Hurka-Richardson, Thomas Bohrmann, Patricia P Chang, Jo Ellen Rodgers, Jan Busby-Whitehead, Martin F Casey

“…Rapid assessment of multimorbidity is important for minimizing the risk of harmful drug-disease and drug-drug interactions. We assessed the accuracy of using the electronic health record (EHR) problem list to identify comorbid conditions among patients with chronic HF in the emergency department (ED). …”
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