-
2621
Beneficial Metabolic Effect of a Nutraceuticals Combination (Monacolin K, Yeasted Red Rice, Polyphenolic Extract of Annurca Apple and Berberine) on Acquired Hypercholesterolemia: A...
Published 2021-04-01“…Its treatment with statin is limited by costs, side effects, and drugs interactions. Nutraceuticals appear to have an important metabolic effect on cholesterol reduction as well as on body weight and glycemia. …”
Get full text
Article -
2622
Experiences and Perceptions of Medical Cannabis among People Living with Chronic Pain and Community Pharmacists: A Qualitative Study in Canada
Published 2023-12-01“…Pharmacists’ perspectives included (1) challenges in monitoring drug interactions with cannabis in the context of scarce research data, (2) informing and treating patients self-medicating with cannabis amid its growing popularity, and (3) financial costs and legal constraints for patients.Conclusions This study highlights patients’ and pharmacists’ urgent need for reliable information regarding the benefits and risks of cannabis. …”
Get full text
Article -
2623
Major areas of interest of artificial intelligence research applied to health care administrative data: a scoping review
Published 2022-07-01“…We determined ten areas of interest, the most common being health diagnostic or treatment outcome prediction (32%); representation of medical data, clinical pathways, and data temporality (i.e., transformation of raw medical data into compact and analysis-friendly format) (22%); and adverse drug effects, drug-drug interactions, and medication cascades (15%). Less attention has been devoted to areas such as health effects of polypharmacy (1%); and reinforcement learning (1%). …”
Get full text
Article -
2624
Systematic analysis of prognostic and immunologic characteristics associated with coronavirus disease 2019 regulators in acute myeloid leukemia
Published 2022-09-01“…Their protein–protein interactions (PPIs) and protein–drug interactions were then recognized by multiple bioinformatics algorithms. …”
Get full text
Article -
2625
Ibrexafungerp, a Novel Triterpenoid Antifungal in Development for the Treatment of Mold Infections
Published 2022-10-01“…Currently, available antifungal drugs such as azoles and echinocandins, as well as combinations of the same, offer some degree of efficacy in the prevention and treatment of invasive mold infections, but their use is often limited by drug resistance mechanisms, toxicity, drug-drug interactions, and the relative paucity of oral treatment options. …”
Get full text
Article -
2626
Bleeding and venous thromboembolism events in cancer patients taking direct oral anticoagulants vs. low molecular weight heparin
Published 2023-03-01“…Secondary objectives included the rate of first VTE recurrence and the effect of concomitant antiplatelet agents and/or significant drug interactions on major bleeding or recurrent VTE. Materials and methods: Using the electronic medical record at the University of Rochester Medical Center, we retrospectively identified adult patients with active malignancy who had a diagnosis of VTE requiring therapeutic anticoagulation within the study period of July 1st, 2015 to June 1st, 2019. …”
Get full text
Article -
2627
Integrative bioinformatics analysis to identify novel biomarkers associated with non-obstructive azoospermia
Published 2023-03-01“…After identifying the hub genes, immune infiltration and hub gene–RNA-binding protein (RBP)–transcription factor (TF)–miRNA–drug interactions were analyzed.ResultsA total 46 differentially expressed ARGs were identified between the azoospermia and control groups. …”
Get full text
Article -
2628
Influence of CYP2d6 on drug metabolism and methods for determining its activity
Published 2018-02-01“…It also provides information on drug-drug interactions involving inhibition of cytochrome P450 isoenzyme CYP2D6. …”
Get full text
Article -
2629
Simulation of optimal dose regimens of photoactivated curcumin for antimicrobial resistance pneumonia in COVID-19 patients: A modeling approach
Published 2023-09-01“…The comedication of current medicines for AMR pneumonia with corticosteroids may lead to suboptimal treatment or toxicities due to drug-drug interactions (DDIs). Objective: This study aimed to propose new promising dosage regimens of photoactivated curcumin when co-administered with corticosteroids for the treatment of antimicrobial resistance (AMR) pneumonia in COVID-19 patients. …”
Get full text
Article -
2630
Molecular Properties of Drugs Handled by Kidney OATs and Liver OATPs Revealed by Chemoinformatics and Machine Learning: Implications for Kidney and Liver Disease
Published 2021-10-01“…The results provide a strong molecular basis for tissue-specific targeting strategies, understanding drug–drug interactions as well as drug–metabolite interactions, and suggest a strategy for how drugs with comparable efficacy might be chosen in chronic liver or kidney disease (CKD) to minimize toxicity.…”
Get full text
Article -
2631
Considerations and analysis of the implementation of oncogeriatrics in Chile and its importance: Review of current literature
Published 2023-03-01“…Likewise, polypharmacy is frequent and is an important issue to consider in people with cancer due to the risk associated with drug interactions. Oncogeriatric assessment consists of a comprehensive multidimensional evaluation, including functional and biopsychosocial issues, addressing aspects of the neoplastic disease such as the risk of toxicities due to systemic therapy and life expectancy. …”
Get full text
Article -
2632
Polypharmacy in Osteoporosis Patients
Published 2015-04-01“…Conclusion: Multi-drug use and drug interactions should be considered during the treatment of osteoporosis and the drugs used should be recorded. …”
Get full text
Article -
2633
Use of physiologically‐based pharmacokinetic modeling to understand the effect of omeprazole administration on the pharmacokinetics of oral extended‐release nifedipine
Published 2024-02-01“…Our recent clinical study has demonstrated that drug–drug interactions (DDIs) exist between a PPI, omeprazole, and nifedipine extended‐release formulations, where systemic exposure of nifedipine was increased in subjects after multiple‐dose pretreatment of omeprazole. …”
Get full text
Article -
2634
Risk Factors for Rivaroxaban-Related Bleeding Events—Possible Role of Pharmacogenetics: Case Series
Published 2023-02-01“…Thirteen patients were carriers of <i>ABCB1</i>, <i>ABCG2</i>, <i>CYP2J2</i>, and/or <i>CYP3A4</i>/5 gene polymorphisms. Possible drug–drug interactions with increased bleeding risk were identified in nine patients. …”
Get full text
Article -
2635
Evaluation of the Synthetic Multifunctional Peptide Hp-MAP3 Derivative of Temporin-PTa
Published 2023-01-01“…In recent years, antimicrobial peptides isolated from amphibian toxins have gained attention as new multifunctional drugs interacting with different molecular targets. We aimed to rationally design a new peptide from temporin-PTa. …”
Get full text
Article -
2636
The Effectiveness of Laser Applications and Photodynamic Therapy on Relevant Periodontal Pathogens (<i>Aggregatibacter actinomycetemcomitans</i>) Associated with Immunomodulating A...
Published 2023-01-01“…In view of the immunocompromised status of some patients under immunosuppressive therapy and potential drug interactions that can be established between systemic antimicrobial agents, the research of local, minimally invasive methods of inactivating periodontal pathogens in the context of these systemic therapies with modifying drugs of the immune response is justified. …”
Get full text
Article -
2637
An overview of glucagon-like peptide-1 receptor agonists for the treatment of metabolic syndrome: A drug repositioning
Published 2020-05-01“…Herein, the pharmacology of GLP-1RAs, their side effects, drug interactions and their effects in MetS is assessed. …”
Get full text
Article -
2638
Evaluation and clinical implications of interactions between compound Danshen dropping pill and warfarin associated with the epoxide hydrolase gene
Published 2023-05-01“…However, warfarin has a narrow therapeutic index, wide interindividual variability (genetic and non-genetic factors), and is susceptible to drug-drug interactions. Our previous study indicated that CDDP might interact with warfarin in individuals with the epoxide hydrolase gene (EPHX1; single-nucleotide polymorphism: rs2292566) A/A subtype. …”
Get full text
Article -
2639
In Vitro Metabolic Fate of the Synthetic Cannabinoid Receptor Agonists QMPSB and QMPCB (SGT-11) Including Isozyme Mapping and Esterase Activity
Published 2021-08-01“…Knowing their metabolic fate is crucial for the identification of toxicological screening targets and to predict possible drug interactions. The presented study aimed to identify the in vitro phase I/II metabolites of QMPSB and QMPCB and to study the contribution of different monooxygenases and human carboxylesterases by using pooled human liver S9 fraction (pHLS9), recombinant human monooxygenases, three recombinant human carboxylesterases, and pooled human liver microsomes. …”
Get full text
Article -
2640
Development and Validation of an Explainable Machine Learning-Based Prediction Model for Drug–Food Interactions from Chemical Structures
Published 2023-04-01“…The increasing number of multiple-drug prescriptions leads to the rise of drug–drug interactions (DDIs) and DFIs. These adverse interactions lead to other implications, e.g., the decline in medicament’s effect, the withdrawals of various medications, and harmful impacts on the patients’ health. …”
Get full text
Article