Beneficial Metabolic Effect of a Nutraceuticals Combination (Monacolin K, Yeasted Red Rice, Polyphenolic Extract of Annurca Apple and Berberine) on Acquired Hypercholesterolemia: A... by Roberta D’Assante, Mariarosaria De Luca, Sergio Ferraro, Andrea Ferraro, Antonio Ruvolo, Francesco Natale, Pietro Sotgiu, Maurizio Petitto, Romolo Rizzo, Umberto De Maria, Luigi Liguori, Gianluigi Gentile, Paola Ragucci, Vittorio Donadio, Valeria Valente, Antonio Cittadini

“…Its treatment with statin is limited by costs, side effects, and drugs interactions. Nutraceuticals appear to have an important metabolic effect on cholesterol reduction as well as on body weight and glycemia. …”
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Experiences and Perceptions of Medical Cannabis among People Living with Chronic Pain and Community Pharmacists: A Qualitative Study in Canada by Lise Dassieu, Emilie Paul-Savoie, Élise Develay, Ana Cecilia Villela Guilhon, Line Guénette, Kadija Perreault, Hélène Beaudry, Laurent Dupuis, Claudie Audet, Anaïs Lacasse

“…Pharmacists’ perspectives included (1) challenges in monitoring drug interactions with cannabis in the context of scarce research data, (2) informing and treating patients self-medicating with cannabis amid its growing popularity, and (3) financial costs and legal constraints for patients.Conclusions This study highlights patients’ and pharmacists’ urgent need for reliable information regarding the benefits and risks of cannabis. …”
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Major areas of interest of artificial intelligence research applied to health care administrative data: a scoping review by Olga Bukhtiyarova, Amna Abderrazak, Yohann Chiu, Yohann Chiu, Stephanie Sparano, Marc Simard, Marc Simard, Caroline Sirois, Caroline Sirois

“…We determined ten areas of interest, the most common being health diagnostic or treatment outcome prediction (32%); representation of medical data, clinical pathways, and data temporality (i.e., transformation of raw medical data into compact and analysis-friendly format) (22%); and adverse drug effects, drug-drug interactions, and medication cascades (15%). Less attention has been devoted to areas such as health effects of polypharmacy (1%); and reinforcement learning (1%). …”
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Systematic analysis of prognostic and immunologic characteristics associated with coronavirus disease 2019 regulators in acute myeloid leukemia by Mingjie Shi, Mingjie Shi, Lidan Chen, Yue Wei, Riling Chen, Riling Chen, Riling Chen, Runmin Guo, Runmin Guo, Fei Luo, Fei Luo, Fei Luo

“…Their protein–protein interactions (PPIs) and protein–drug interactions were then recognized by multiple bioinformatics algorithms. …”
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Ibrexafungerp, a Novel Triterpenoid Antifungal in Development for the Treatment of Mold Infections by David A. Angulo, Barbara Alexander, Riina Rautemaa-Richardson, Ana Alastruey-Izquierdo, Martin Hoenigl, Ashraf S. Ibrahim, Mahmoud A. Ghannoum, Thomas R. King, Nkechi E. Azie, Thomas J. Walsh

“…Currently, available antifungal drugs such as azoles and echinocandins, as well as combinations of the same, offer some degree of efficacy in the prevention and treatment of invasive mold infections, but their use is often limited by drug resistance mechanisms, toxicity, drug-drug interactions, and the relative paucity of oral treatment options. …”
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Bleeding and venous thromboembolism events in cancer patients taking direct oral anticoagulants vs. low molecular weight heparin by Frank A. Lattuca, Jeremiah Moore, Carissa Treptow, Kendra Delibert, Andrea Baran, Frank Akwaa

“…Secondary objectives included the rate of first VTE recurrence and the effect of concomitant antiplatelet agents and/or significant drug interactions on major bleeding or recurrent VTE. Materials and methods: Using the electronic medical record at the University of Rochester Medical Center, we retrospectively identified adult patients with active malignancy who had a diagnosis of VTE requiring therapeutic anticoagulation within the study period of July 1st, 2015 to June 1st, 2019. …”
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Integrative bioinformatics analysis to identify novel biomarkers associated with non-obstructive azoospermia by Yucheng Zhong, Jun Zhao, Hao Deng, Yaqin Wu, Li Zhu, Meiqiong Yang, Qianru Liu, Guoqun Luo, Wenmin Ma, Wenmin Ma, Huan Li

“…After identifying the hub genes, immune infiltration and hub gene–RNA-binding protein (RBP)–transcription factor (TF)–miRNA–drug interactions were analyzed.ResultsA total 46 differentially expressed ARGs were identified between the azoospermia and control groups. …”
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Influence of CYP2d6 on drug metabolism and methods for determining its activity by V. V. Smirnov, R. H. Abdrashitov, E. A. Egorenkov, G. N. Gildeeva, G. V. Ramenskaya, R. A. Permyakov

“…It also provides information on drug-drug interactions involving inhibition of cytochrome P450 isoenzyme CYP2D6. …”
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Simulation of optimal dose regimens of photoactivated curcumin for antimicrobial resistance pneumonia in COVID-19 patients: A modeling approach by Teerachat Saeheng, Kesara Na-Bangchang

“…The comedication of current medicines for AMR pneumonia with corticosteroids may lead to suboptimal treatment or toxicities due to drug-drug interactions (DDIs). Objective: This study aimed to propose new promising dosage regimens of photoactivated curcumin when co-administered with corticosteroids for the treatment of antimicrobial resistance (AMR) pneumonia in COVID-19 patients. …”
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Molecular Properties of Drugs Handled by Kidney OATs and Liver OATPs Revealed by Chemoinformatics and Machine Learning: Implications for Kidney and Liver Disease by Anisha K. Nigam, Anupam A. Ojha, Julia G. Li, Da Shi, Vibha Bhatnagar, Kabir B. Nigam, Ruben Abagyan, Sanjay K. Nigam

“…The results provide a strong molecular basis for tissue-specific targeting strategies, understanding drug–drug interactions as well as drug–metabolite interactions, and suggest a strategy for how drugs with comparable efficacy might be chosen in chronic liver or kidney disease (CKD) to minimize toxicity.…”
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Considerations and analysis of the implementation of oncogeriatrics in Chile and its importance: Review of current literature by Macarena Honorato, Oscar Calderón, Oscar Calderón, Verónica Rojas, Gerardo Fasce, Gerardo Fasce, Constanza Bartolotti, Constanza Bartolotti, Christian Caglevic

“…Likewise, polypharmacy is frequent and is an important issue to consider in people with cancer due to the risk associated with drug interactions. Oncogeriatric assessment consists of a comprehensive multidimensional evaluation, including functional and biopsychosocial issues, addressing aspects of the neoplastic disease such as the risk of toxicities due to systemic therapy and life expectancy. …”
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Polypharmacy in Osteoporosis Patients by Yavuz Ali Karahan, Aynur Başaran, Banu Ordahan, Pelin Yıldırım, Seher Küçüksaraç, Süleyman Oktar, Neslihan Soran, Gözde Türkoğlu, Levent Tekin, Savaş Karpuz

“…Conclusion: Multi-drug use and drug interactions should be considered during the treatment of osteoporosis and the drugs used should be recorded. …”
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Use of physiologically‐based pharmacokinetic modeling to understand the effect of omeprazole administration on the pharmacokinetics of oral extended‐release nifedipine by Ming‐Liang Tan, Zongming Gao, Andrew Babiskin, Myong‐Jin Kim, Lanyan Fang, Lei Zhang, Liang Zhao

“…Our recent clinical study has demonstrated that drug–drug interactions (DDIs) exist between a PPI, omeprazole, and nifedipine extended‐release formulations, where systemic exposure of nifedipine was increased in subjects after multiple‐dose pretreatment of omeprazole. …”
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Risk Factors for Rivaroxaban-Related Bleeding Events—Possible Role of Pharmacogenetics: Case Series by Livija Šimičević, Ana Marija Slišković, Majda Vrkić Kirhmajer, Lana Ganoci, Hrvoje Holik, Jozefina Palić, Jure Samardžić, Tamara Božina

“…Thirteen patients were carriers of <i>ABCB1</i>, <i>ABCG2</i>, <i>CYP2J2</i>, and/or <i>CYP3A4</i>/5 gene polymorphisms. Possible drug–drug interactions with increased bleeding risk were identified in nine patients. …”
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Evaluation of the Synthetic Multifunctional Peptide Hp-MAP3 Derivative of Temporin-PTa by Patrícia Souza e Silva, Alexya Sandim Guindo, Pedro Henrique Cardoso Oliveira, Luiz Filipe Ramalho Nunes de Moraes, Ana Paula de Araújo Boleti, Marcos Antonio Ferreira, Caio Fernando Ramalho de Oliveira, Maria Ligia Rodrigues Macedo, Luana Rossato, Simone Simionatto, Ludovico Migliolo

“…In recent years, antimicrobial peptides isolated from amphibian toxins have gained attention as new multifunctional drugs interacting with different molecular targets. We aimed to rationally design a new peptide from temporin-PTa. …”
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The Effectiveness of Laser Applications and Photodynamic Therapy on Relevant Periodontal Pathogens (<i>Aggregatibacter actinomycetemcomitans</i>) Associated with Immunomodulating A... by Maria-Alexandra Martu, Ionut Luchian, Mihai Mares, Sorina Solomon, Oana Ciurcanu, Vlad Danila, Elena Rezus, Liliana Foia

“…In view of the immunocompromised status of some patients under immunosuppressive therapy and potential drug interactions that can be established between systemic antimicrobial agents, the research of local, minimally invasive methods of inactivating periodontal pathogens in the context of these systemic therapies with modifying drugs of the immune response is justified. …”
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An overview of glucagon-like peptide-1 receptor agonists for the treatment of metabolic syndrome: A drug repositioning by Maryam Rameshrad, Bibi Marjan Razavi, Jean-Daniel Lalau, Marc E. De Broe, Hossein Hosseinzadeh

“…Herein, the pharmacology of GLP-1RAs, their side effects, drug interactions and their effects in MetS is assessed. …”
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Evaluation and clinical implications of interactions between compound Danshen dropping pill and warfarin associated with the epoxide hydrolase gene by Xixi Chen, Xixi Chen, Xurui Zuo, Yingqiang Zhao, Yuhong Huang, Chunxiao Lv

“…However, warfarin has a narrow therapeutic index, wide interindividual variability (genetic and non-genetic factors), and is susceptible to drug-drug interactions. Our previous study indicated that CDDP might interact with warfarin in individuals with the epoxide hydrolase gene (EPHX1; single-nucleotide polymorphism: rs2292566) A/A subtype. …”
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In Vitro Metabolic Fate of the Synthetic Cannabinoid Receptor Agonists QMPSB and QMPCB (SGT-11) Including Isozyme Mapping and Esterase Activity by Matthias J. Richter, Lea Wagmann, Tanja M. Gampfer, Simon D. Brandt, Markus R. Meyer

“…Knowing their metabolic fate is crucial for the identification of toxicological screening targets and to predict possible drug interactions. The presented study aimed to identify the in vitro phase I/II metabolites of QMPSB and QMPCB and to study the contribution of different monooxygenases and human carboxylesterases by using pooled human liver S9 fraction (pHLS9), recombinant human monooxygenases, three recombinant human carboxylesterases, and pooled human liver microsomes. …”
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Development and Validation of an Explainable Machine Learning-Based Prediction Model for Drug–Food Interactions from Chemical Structures by Quang-Hien Kha, Viet-Huan Le, Truong Nguyen Khanh Hung, Ngan Thi Kim Nguyen, Nguyen Quoc Khanh Le

“…The increasing number of multiple-drug prescriptions leads to the rise of drug–drug interactions (DDIs) and DFIs. These adverse interactions lead to other implications, e.g., the decline in medicament’s effect, the withdrawals of various medications, and harmful impacts on the patients’ health. …”
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