Assessing Medication Use Quality in Older Outpatients Using the Beers Criteria: Findings from a Single-Center Retrospective Study by Kittipak Jenghua, Kanchira Wutthi, Chanisorn Wannakrachang, Sitanan Chathongyos, Panadda Ngamsom

“…For PIM identification, the 2019 American Geriatric Society (AGS) Beers criteria were applied, considering all five PIM categories: PIM category I (medications that are potentially inappropriate in most older adults), II (disease-/syndrome-exacerbating drugs), III (medications that should be used with caution), IV (clinically important drug–drug interactions), and V (medications that should be avoided or have their dosage reduced based on renal function). …”
Get full text

Development of a highly reproducible system to evaluate inhibition of cytochrome P450 3A4 activity by natural medicines by Yu Sato, Takamitsu Sasaki, Shogo Takahashi, Takeshi Kumagai, Kiyoshi Nagata

“…However, information regarding natural medicine-drug interactions that influence drug metabolism is limited owing to the lack of efficient screening method for such interactions. …”
Get full text

Antiviral Drugs and Vaccines for Omicron Variant: A Focused Review by Nidhi Garg, Ananya Sree Kunamneni, Pankaj Garg, Sandeep Sharma, Divakar Sharma, Adinarayana Kunamneni

“…If Paxlovid is not available or cannot be administered due to drug interactions, then the next best choice is sotrovimab. …”
Get full text

Spotlight on isavuconazole in the treatment of invasive aspergillosis and mucormycosis: design, development, and place in therapy by Jenks JD, Salzer HJ, Prattes J, Krause R, Buchheidt D, Hoenigl M

“…One of these advances has been the introduction of isavuconazole, a second-generation broad spectrum triazole with a favorable pharmacokinetic and safety profile and few drug–drug interactions. Phase III trials in patients with IA and mucormycosis demonstrated that isavuconazole has similar efficacy to voriconazole for the treatment of IA (SECURE trial) and liposomal amphotericin B for the treatment of mucormycosis (VITAL trial with subsequent case–control analysis) and a favorable safety profile with significantly fewer ocular, hepatobiliary, and skin and soft tissue adverse events compared to voriconazole. …”
Get full text

Human liver microsomes study on the inhibitory effect of plantainoside D on the activity of cytochrome P450 activity by Jin Zhou, Xian Qian, Yanqing Zhou, Shili Xiong, Shuxia Ji, Ying Wang, Ping Zhao

“…Its effect on cytochrome P450 enzymes (P450) is a risk factor for inducing adverse drug-drug interactions. To assess the effect of plantainoside D on the activity of major P450 isoenzymes in human liver microsomes. …”
Get full text

Dolutegravir plus rilpivirine as dual regimen in virologically suppressed HIV-1 infected patients in a clinical setting by Jose L. Casado, Marta Monsalvo, María Fontecha, Pilar Vizcarra, Miguel A Rodriguez, María Jesús Vivancos, Santiago Moreno

“…Objectives: There are scarce data on the combination of dolutegravir (DTG) plus rilpivirine (RPV) in the real world, including patients with hepatitis C virus (HCV) coinfection, toxicity or previous failure, or at risk for severe drug–drug interactions (DDIs). Methods: Prospective cohort study of virologically suppressed HIV-1 infected patients, without resistance to DTG or RPV, switched to this dual regimen because of toxicity or risk of DDIs (NCT02491242). …”
Get full text

Identification of ferroptosis and drug resistance related hub genes to predict the prognosis in Hepatocellular Carcinoma by Chengjun Li, Xiaomeng Cui, Yarui Li, Dan Guo, Shuixiang He

“…Functional enrichment, pathway enrichment and GSEA analysis were performed to investigate the potential molecular mechanism, and construction of PPI, mRNA-miRNA, mRNA-RBP, mRNA-TF and mRNA-drugs interaction networks to predict its interaction with different molecules. …”
Get full text

Analysis of the toxicity induced by carboplatin and paclitaxel regimen in ovarian cancer patients by Thaís A. GOUVÊA, Gabriela V. CHAVES, Mario J. SOBREIRA-DA-SILVA

“…Of these, 47% had some comorbidity, 71% were polymedicated, 2% were exposed to drug interactions with the regimen studied, 73% had toxicities, 35% of which were grade > 2. …”
Get full text

DTiGNN: Learning drug-target embedding from a heterogeneous biological network based on a two-level attention-based graph neural network by Saranya Muniyappan, Arockia Xavier Annie Rayan, Geetha Thekkumpurath Varrieth

“…Using the integrated similarity networks, drug interactions, drug-disease associations, protein interactions and protein-disease association, the HBN is constructed. …”
Get full text

The Long-Acting Echinocandin, Rezafungin, Prevents Pneumocystis Pneumonia and Eliminates Pneumocystis from the Lungs in Prophylaxis and Murine Treatment Models by Melanie T. Cushion, Alan Ashbaugh

“…For such patients, standard antifungal prophylaxis currently comprises an azole for <i>Candida</i> and <i>Aspergillus</i> plus trimethoprim-sulfamethoxazole (TMP-SMX) for Pneumocystis pneumonia (PCP) despite drug-drug-interactions and intolerability that may limit their use, thus, alternatives are desirable. …”
Get full text

Dielectrophoresis as a Tool to Reveal the Potential Role of Ion Channels and Early Electrophysiological Changes in Osteoarthritis by Rula Abdallat, Emily Kruchek, Csaba Matta, Rebecca Lewis, Fatima H. Labeed

“…As a consequence, rapid assessment of cell electrophysiology could play a significant role in unravelling the mechanisms underlying drug interactions and progression of diseases, such as OA. …”
Get full text

Emergent trends in organ-on-a-chip applications for investigating metastasis within tumor microenvironment: A comprehensive bibliometric analysis by Chunrong He, Fangfang Lu, Yi Liu, Yuanhu Lei, Xiaoxu Wang, Ning Tang

“…Conclusion: The organ-on-a-chip domain has demonstrated a transformative impact on understanding disease mechanisms and drug interactions, particularly within the tumor microenvironment. …”
Get full text

Risk Factors Associated With Polypharmacy and Potentially Inappropriate Medication Use in Ambulatory Care Among the Elderly in the United States: A Cross-Sectional Study by Khue Nguyen, Vinita Subramanya, Ambar Kulshreshtha

“…It is linked to prescribing potentially inappropriate medications (PIMs), which have been shown to be associated with an increased risk of adverse drug interactions and reduced compliance, and in some cases result in prescribing cascades where more drugs are prescribed to manage adverse outcomes. …”
Get full text

EVALUASI PENGGUNAAN ANTIBIOTIKA PADA PASIEN PEDIATRI DENGAN KEGANASAN HEMATOLOGI YANG MENGALAMI DEMAM NEUTROPENIA SELAMA KEMOTERAPI DI INSTALASI KESEHATAN ANAK RSUP.DR.SARDJITO YOG... by , Nurul Ambariyah, , Prof. Dr. Zullies Ikawati, Apt

“…DRPs that occured related with the administration of antibiotics are contraindication, inappropriate dosing, adverse drug reaction and drug interactions. Selection of antibiotic therapy in pediatric hematologic malignancy with febrile neutropenia is in accordance with Standard Pelayanan Medik RS Dr. …”

EVALUASI KESESUAIAN TERAPI DAN EFEK SAMPING PENGGUNAAN ANTIHIPERTENSI PADA PASIEN DIABETES MELLITUS TIPE 2 DENGAN GAGAL GINJAL KRONIK YANG MENJALANI HEMODIALISIS RUTIN DI RSU PKU M... by , Fef. Rukminingsih, , Prof. Dr. Djoko Wahyono, SU., Apt.

“…The use of drugs in a longtime potentially causes side effects and drug interactions as well. Objective: This research is aimed to discover the appropriate therapy and antihypertensive usage side effects on type 2 diabetes mellitus with chronic kidney patients who received regular haemodialysis treatment at RSU PKU Muhammadiyah Yogyakarta during February â�� April 2011. …”

Contrasting effects of phosphatidylinositol 4,5-bisphosphate (PIP2 ) on cloned TMEM16A and TMEM16B channels by Ta, C, Acheson, K, Rorsman, N, Jongkind, R, Tammaro, P

“…</p> <h4>Conclusions and Implications</h4> <p>PIP2 acts as a modifier of TMEM16A and TMEM16B channel gating. Drugs interacting with PIP2 signalling may affect TMEM16A and TMEM16B channel gating and have potential uses in basic science and implications for therapy.…”

Clinical pharmacokinetics of digoxin 1980. by Aronson, J

“…The most important digoxin-drug interactions are those involving quinidine and drugs which deplete the body of potassium. …”

Impact of educational outreach intervention on enhancing health care providers' knowledge about statin therapy prescribing in Malaysian patients with type 2 diabetes mellitus by Elnaem, Mohamed Hassan, Nik Mohamed, Mohamad Haniki, Huri, Hasniza Zaman, Azarisman, Shah Mohd Shah

“…Forty-five percent (n20) could state the drug to drug interactions, and 52.3% (n23) could identify the statin therapy that can be given at any time day/evening. …”

Plasmodium knowlesi exhibits distinct in vitro drug susceptibility profiles from those of Plasmodium falciparum by van Schalkwyk, Donelly A., Blasco, Benjamin, Davina Nuñez, Rocio, Liew, Jonathan Wee Kent, Amir, Amirah, Lau, Yee Ling, Leroy, Didier, Moon, Robert W, Sutherland, Colin J.

“…Lastly, we used isobologram analysis to explore the interaction of a selection of drug combinations and showed similar drug interactions across species. The species differences in drug susceptibility reported by us here and previously, support adding in vitro drug screens against P. knowlesi to those using P. falciparum strains to inform new drug discovery and lead optimisation. © 2019 The Authors…”

Polypharmacy and precision medicine by Kenji Fujita, Nashwa Masnoon, John Mach, Lisa Kouladjian O’Donnell, Sarah N. Hilmer

“…Specifically, this review aims to (1) summarise challenges in achieving precision medicine specific to polypharmacy; (2) synthesise the current approaches to precision medicine in polypharmacy; (3) provide a summary of the literature in the field of prediction of unknown drug–drug interactions (DDI) and (4) propose a novel approach to provide precision medicine for patients with polypharmacy. …”
Get full text