-
2721
Assessing Medication Use Quality in Older Outpatients Using the Beers Criteria: Findings from a Single-Center Retrospective Study
Published 2023-06-01“…For PIM identification, the 2019 American Geriatric Society (AGS) Beers criteria were applied, considering all five PIM categories: PIM category I (medications that are potentially inappropriate in most older adults), II (disease-/syndrome-exacerbating drugs), III (medications that should be used with caution), IV (clinically important drug–drug interactions), and V (medications that should be avoided or have their dosage reduced based on renal function). …”
Get full text
Article -
2722
Development of a highly reproducible system to evaluate inhibition of cytochrome P450 3A4 activity by natural medicines
Published 2015-08-01“…However, information regarding natural medicine-drug interactions that influence drug metabolism is limited owing to the lack of efficient screening method for such interactions. …”
Get full text
Article -
2723
Antiviral Drugs and Vaccines for Omicron Variant: A Focused Review
Published 2023-01-01“…If Paxlovid is not available or cannot be administered due to drug interactions, then the next best choice is sotrovimab. …”
Get full text
Article -
2724
Spotlight on isavuconazole in the treatment of invasive aspergillosis and mucormycosis: design, development, and place in therapy
Published 2018-04-01“…One of these advances has been the introduction of isavuconazole, a second-generation broad spectrum triazole with a favorable pharmacokinetic and safety profile and few drug–drug interactions. Phase III trials in patients with IA and mucormycosis demonstrated that isavuconazole has similar efficacy to voriconazole for the treatment of IA (SECURE trial) and liposomal amphotericin B for the treatment of mucormycosis (VITAL trial with subsequent case–control analysis) and a favorable safety profile with significantly fewer ocular, hepatobiliary, and skin and soft tissue adverse events compared to voriconazole. …”
Get full text
Article -
2725
Human liver microsomes study on the inhibitory effect of plantainoside D on the activity of cytochrome P450 activity
Published 2022-07-01“…Its effect on cytochrome P450 enzymes (P450) is a risk factor for inducing adverse drug-drug interactions. To assess the effect of plantainoside D on the activity of major P450 isoenzymes in human liver microsomes. …”
Get full text
Article -
2726
Dolutegravir plus rilpivirine as dual regimen in virologically suppressed HIV-1 infected patients in a clinical setting
Published 2019-04-01“…Objectives: There are scarce data on the combination of dolutegravir (DTG) plus rilpivirine (RPV) in the real world, including patients with hepatitis C virus (HCV) coinfection, toxicity or previous failure, or at risk for severe drug–drug interactions (DDIs). Methods: Prospective cohort study of virologically suppressed HIV-1 infected patients, without resistance to DTG or RPV, switched to this dual regimen because of toxicity or risk of DDIs (NCT02491242). …”
Get full text
Article -
2727
Identification of ferroptosis and drug resistance related hub genes to predict the prognosis in Hepatocellular Carcinoma
Published 2023-05-01“…Functional enrichment, pathway enrichment and GSEA analysis were performed to investigate the potential molecular mechanism, and construction of PPI, mRNA-miRNA, mRNA-RBP, mRNA-TF and mRNA-drugs interaction networks to predict its interaction with different molecules. …”
Get full text
Article -
2728
Analysis of the toxicity induced by carboplatin and paclitaxel regimen in ovarian cancer patients
Published 2022-09-01“…Of these, 47% had some comorbidity, 71% were polymedicated, 2% were exposed to drug interactions with the regimen studied, 73% had toxicities, 35% of which were grade > 2. …”
Get full text
Article -
2729
DTiGNN: Learning drug-target embedding from a heterogeneous biological network based on a two-level attention-based graph neural network
Published 2023-03-01“…Using the integrated similarity networks, drug interactions, drug-disease associations, protein interactions and protein-disease association, the HBN is constructed. …”
Get full text
Article -
2730
The Long-Acting Echinocandin, Rezafungin, Prevents Pneumocystis Pneumonia and Eliminates Pneumocystis from the Lungs in Prophylaxis and Murine Treatment Models
Published 2021-09-01“…For such patients, standard antifungal prophylaxis currently comprises an azole for <i>Candida</i> and <i>Aspergillus</i> plus trimethoprim-sulfamethoxazole (TMP-SMX) for Pneumocystis pneumonia (PCP) despite drug-drug-interactions and intolerability that may limit their use, thus, alternatives are desirable. …”
Get full text
Article -
2731
Dielectrophoresis as a Tool to Reveal the Potential Role of Ion Channels and Early Electrophysiological Changes in Osteoarthritis
Published 2021-08-01“…As a consequence, rapid assessment of cell electrophysiology could play a significant role in unravelling the mechanisms underlying drug interactions and progression of diseases, such as OA. …”
Get full text
Article -
2732
Emergent trends in organ-on-a-chip applications for investigating metastasis within tumor microenvironment: A comprehensive bibliometric analysis
Published 2024-01-01“…Conclusion: The organ-on-a-chip domain has demonstrated a transformative impact on understanding disease mechanisms and drug interactions, particularly within the tumor microenvironment. …”
Get full text
Article -
2733
Risk Factors Associated With Polypharmacy and Potentially Inappropriate Medication Use in Ambulatory Care Among the Elderly in the United States: A Cross-Sectional Study
Published 2023-05-01“…It is linked to prescribing potentially inappropriate medications (PIMs), which have been shown to be associated with an increased risk of adverse drug interactions and reduced compliance, and in some cases result in prescribing cascades where more drugs are prescribed to manage adverse outcomes. …”
Get full text
Article -
2734
EVALUASI PENGGUNAAN ANTIBIOTIKA PADA PASIEN PEDIATRI DENGAN KEGANASAN HEMATOLOGI YANG MENGALAMI DEMAM NEUTROPENIA SELAMA KEMOTERAPI DI INSTALASI KESEHATAN ANAK RSUP.DR.SARDJITO YOG...
Published 2012“…DRPs that occured related with the administration of antibiotics are contraindication, inappropriate dosing, adverse drug reaction and drug interactions. Selection of antibiotic therapy in pediatric hematologic malignancy with febrile neutropenia is in accordance with Standard Pelayanan Medik RS Dr. …”
Thesis -
2735
EVALUASI KESESUAIAN TERAPI DAN EFEK SAMPING PENGGUNAAN ANTIHIPERTENSI PADA PASIEN DIABETES MELLITUS TIPE 2 DENGAN GAGAL GINJAL KRONIK YANG MENJALANI HEMODIALISIS RUTIN DI RSU PKU M...
Published 2011“…The use of drugs in a longtime potentially causes side effects and drug interactions as well. Objective: This research is aimed to discover the appropriate therapy and antihypertensive usage side effects on type 2 diabetes mellitus with chronic kidney patients who received regular haemodialysis treatment at RSU PKU Muhammadiyah Yogyakarta during February â�� April 2011. …”
Thesis -
2736
Contrasting effects of phosphatidylinositol 4,5-bisphosphate (PIP2 ) on cloned TMEM16A and TMEM16B channels
Published 2017“…</p> <h4>Conclusions and Implications</h4> <p>PIP2 acts as a modifier of TMEM16A and TMEM16B channel gating. Drugs interacting with PIP2 signalling may affect TMEM16A and TMEM16B channel gating and have potential uses in basic science and implications for therapy.…”
Journal article -
2737
Clinical pharmacokinetics of digoxin 1980.
Published 1980“…The most important digoxin-drug interactions are those involving quinidine and drugs which deplete the body of potassium. …”
Journal article -
2738
Impact of educational outreach intervention on enhancing health care providers' knowledge about statin therapy prescribing in Malaysian patients with type 2 diabetes mellitus
Published 2018“…Forty-five percent (n20) could state the drug to drug interactions, and 52.3% (n23) could identify the statin therapy that can be given at any time day/evening. …”
Article -
2739
Plasmodium knowlesi exhibits distinct in vitro drug susceptibility profiles from those of Plasmodium falciparum
Published 2019“…Lastly, we used isobologram analysis to explore the interaction of a selection of drug combinations and showed similar drug interactions across species. The species differences in drug susceptibility reported by us here and previously, support adding in vitro drug screens against P. knowlesi to those using P. falciparum strains to inform new drug discovery and lead optimisation. © 2019 The Authors…”
Article -
2740
Polypharmacy and precision medicine
Published 2023-01-01“…Specifically, this review aims to (1) summarise challenges in achieving precision medicine specific to polypharmacy; (2) synthesise the current approaches to precision medicine in polypharmacy; (3) provide a summary of the literature in the field of prediction of unknown drug–drug interactions (DDI) and (4) propose a novel approach to provide precision medicine for patients with polypharmacy. …”
Get full text
Article