Pharmacogenetic CYP2D6 variability, phenoconversion and treatment outcomes: A Danish population-based cohort study in 6,798 individuals initiating atomoxetine treatment by K. Ishtiak-Ahmed, C. Lunenburg, J. Thirstrup, L. Clausen, P. Thomsen, C. Gasse

“…Individuals’ CYP2D6-status could change due to drug-drug-interactions of weak, intermediate, or strong-CYP2D6 inhibitors (phenoconversion), which we accounted for by time-varying phenotype assessment. …”
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Interventions and Impact of Pharmacist-Delivered Services for People Infected with COVID-19: A Systematic Review by Ali Ahmed, Maria Tanveer, Sunil Shrestha, Asmita Priyadarshini Khatiwada, Saval Khanal, Juman Abdulelah Dujaili, Vibhu Paudyal

“…Identification of dosage errors (<i>n</i> = 6 studies), regimen modifications (<i>n</i> = 5), removal of obsolete/duplicate medications (<i>n</i> = 5), identification and management of adverse drug reactions (<i>n</i> = 4), drug interactions prevention (<i>n</i> = 2), and physicians acceptance rate (<i>n</i> = 3) of therapy-related services delivered in-person or via tele-pharmacy were among the pharmacist-delivered services. …”
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Bioanalytical Method Using Ultra-High-Performance Liquid Chromatography Coupled with High-Resolution Mass Spectrometry (UHPL-CHRMS) for the Detection of Metformin in Human Plasma by Ye-Ji Kang, Hyeon-Cheol Jeong, Tae-Eun Kim, Kwang-Hee Shin

“…Metformin is the first-line medicine for the treatment of type 2 diabetes. Drug interactions between metformin and other drugs, food, or beverages cannot only cause changes in the pharmacokinetic profiles but also affect the efficacy of metformin. …”
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Effectiveness of Interventions to Improve the Anticholinergic Prescribing Practice in Older Adults: A Systematic Review by Mohammed S. Salahudeen, Adel Alfahmi, Anam Farooq, Mehnaz Akhtar, Sana Ajaz, Saud Alotaibi, Manal Faiz, Sheraz Ali

“…Older people are prone to drug-related problems such as adverse effects, ineffectiveness, underdosage, overdosage, and drug interactions. Anticholinergic medications are associated with poor outcomes in older patients, and there is no specific intervention strategy for reducing drug burden from anticholinergic activity medications. …”
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Development of a web-based virtual simulated learning environment for pharmacy practice education by Arash Najimi, Shirinsadat Badri, Mahdiyeh Azizkhani, Samaneh Zolghadr, Shaghayegh Roofeh, Sayyed Ali Sepehr, Sajjad Mohammadi

“…For teaching patient counseling and clinical skills, instructors wrote scenarios covering the most prevalent pharmacy practice issues, mainly focused on medication use during pregnancy or lactation, OTC recommendations, information related to drug interactions and adverse drug reactions, and interactions between prescription drugs and patient's underlying disease. …”
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Individual Pharmacotherapy Management (IPM) - I: a group-matched retrospective controlled clinical study on prevention of complicating delirium in the elderly trauma patients and i... by Luise Drewas, Hassan Ghadir, Rüdiger Neef, Karl-Stefan Delank, Ursula Wolf

“…Our targeted IPM focus on 6 frontline aspects with reduction of antipsychotics, anticholinergic burden, benzodiazepines, serotonergic opioids, elimination of pharmacokinetic and pharmacodynamic drug interactions and overdosage reduced complicating delirium from 5% to almost zero at 0.5%. …”
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Characteristics of 2-drug regimen users living with HIV-1 in a real-world setting: A large-scale medical claim database analysis in Japan by Daniel J. Ruzicka, Mayuko Kamakura, Naho Kuroishi, Nobuyuki Oshima, Miyuki Yamatani, Jingbo Yi, Bruce Crawford, Kunihisa Tsukada, Shinichi Oka

“…<h4>Background</h4> Regimen simplification to 2-drug antiretroviral therapy (2-ART) may address potential tolerability issues, increase adherence, and reduce toxicity and potential drug-drug-interactions among people living with HIV-1 (PLWH). …”
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Cryo-EM Structures of the Klebsiella pneumoniae AcrB Multidrug Efflux Pump by Zhemin Zhang, Christopher E. Morgan, Robert A. Bonomo, Edward W. Yu

“…These structures allow us to elucidate specific pump-drug interactions and pinpoint exactly how this pump recognizes antibiotics. …”
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Case report: application of pharmacogenetics in the personalized treatment of an elderly patient with a major depressive episode by Milica Pjevac, Sara Redenšek Trampuž, Tanja Blagus, Vita Dolžan, Jurij Bon, Jurij Bon

“…Therefore, it is of great importance to conduct further pharmacokinetic and pharmacogenetic studies to better assess gene-drug interactions in psychopharmacotherapy.…”
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Risk Awareness and Demographic Characteristics Associated With the Use of Sexual Enhancement Supplements Among University Staff: A Cross-Sectional Study in the United Arab Emirates by Ammar Abdulrahman Jairoun, Sabaa Saleh Al-Hemyari, Moyad Shahwan, Balsam Qubais Saeed, Brian Godman, Amanj Kurdi, Samer H. Zyoud, Baharudin Ibrahim

“…When supplements are adulterated with phosphodiesterase type 5 (PDE-5) inhibitors, dosages can vary widely and there may be an increase in adverse effects and drug–drug interactions which cannot be avoided. Consequently, there is a need to evaluate the public risk awareness toward SES and the associated adverse events as well as explore significant factors associated with knowledge and risk awareness. …”
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Enhanced adsorptive removal of rifampicin and tigecycline from single system using nano-ceria decorated biochar of mango seed kernel by Marwa El-Azazy, Ahmed S. El-Shafie, Reem Al-Mulla, Siham S. Hassan, Hassan I. Nimir

“…Isotherm parameters revealed that Freundlich model best fit Ce–Py–MSK–drug interactions. A maximum adsorption capacity (qm) of 102.25 and 49.28 mg/g was attained for RIFM and TIGC, respectively. …”
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A Systematic Review on the Clinical Pharmacokinetics of Cephalexin in Healthy and Diseased Populations by Mohammed Kanan, Shahd Atif, Faisal Mohammed, Yara Balahmar, Yasir Adawi, Revan AlSaleem, Ahmed Farhan, Manayer Alghoribi, Saud Mohammed, Raghad Alshanbari, Malak Fahad, Rana Kallab, Reem Mohammed, Dimah Alassaf, Ashwag Hazza

“…An increase in AUC_0–∞ was seen in cephalexin on administration with probenecid, i.e., 117 µg.h/mL vs. 68.1 µg.h/mL. Moreover, drug–drug interactions with omeprazole, ranitidine, zinc sulfate, and drug–food interactions for cephalexin and other cephalosporins have also been depicted in different studies with significant changes in all PK parameters. …”
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Pharmacokinetics and tissue distribution of Ramulus Mori (Sangzhi) alkaloids in rats and its effects on liver enzyme activity by Zhihua Liu, Yu Feng, Hang Zhao, Hang Zhao, Jinping Hu, Jinping Hu, Yanmin Chen, Yanmin Chen, Yanmin Chen, Dongdong Liu, Dongdong Liu, Hongliang Wang, Hongliang Wang, Xiangyang Zhu, Hongzhen Yang, Zhufang Shen, Zhufang Shen, Xuejun Xia, Xuejun Xia, Jun Ye, Jun Ye, Yuling Liu, Yuling Liu

“…Conclusively, SZ-A is rapidly and widely distributed in target tissues, with good metabolic stability and a low risk of triggering drug-drug interactions. This study provides a framework for deciphering the material basis of the multiple pharmacological functions of SZ-A, its rational clinical use, and the expansion of its indications.…”
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High Pregnane X Receptor (PXR) Expression Is Correlated with Poor Prognosis in Invasive Breast Carcinoma by Stamatios Theocharis, Constantinos Giaginis, Stefania Gourzi, Paraskevi Alexandrou, Gerasimos Tsourouflis, Panagiotis Sarantis, Eugene Danas, Artemis Michail, Nikolaos Tsoukalas, Alexandros Pergaris, Panagiotis K. Politis, Lydia Nakopoulou

“…Pregnane X Receptor (PXR) is involved in human cancer, either by directly affecting carcinogenesis or by inducing drug-drug interactions and chemotherapy resistance. The clinical significance of PXR expression in invasive breast carcinoma was evaluated in the present study. …”
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Perceptions on artificial intelligence-based decision-making for coexisting multiple long-term health conditions: protocol for a qualitative study with patients and healthcare prof... by Tom Marshall, Krishnarajah Nirantharakumar, Sheila Greenfield, Sarah Flanagan, Thomas Jackson, Francesca Crowe, Shamil Haroon, Jennifer Cooper, Tiffany E Gooden, Niluka Jeewanthi Gunathilaka, Alexander D’Elia

“…The potential for polypharmacy, adverse events, drug interactions and development of additional health conditions complicates prescribing decisions for these patients. …”
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Remdesivir or Nirmatrelvir/Ritonavir Therapy for Omicron SARS-CoV-2 Infection in Hematological Patients and Cell Therapy Recipients by José Luis Piñana, Inmaculada Heras, Tommaso Francesco Aiello, Irene García-Cadenas, Lourdes Vazquez, Javier Lopez-Jimenez, Pedro Chorão, Cristina Aroca, Carolina García-Vidal, Ignacio Arroyo, Eva Soler-Espejo, Lucia López-Corral, Alejandro Avendaño-Pita, Anna Arrufat, Valentín Garcia-Gutierrez, Elena Arellano, Lorena Hernández-Medina, Clara González-Santillana, Julia Morell, José Ángel Hernández-Rivas, Paula Rodriguez-Galvez, Mireia Mico-Cerdá, Manuel Guerreiro, Diana Campos, David Navarro, Ángel Cedillo, Rodrigo Martino, Carlos Solano

“…Nirmatrelvir/ritonavir demonstrated a comparable safety profile to remdesivir, despite a higher risk of drug interactions. Conclusions: Nirmatrelvir/ritonavir proved to be a safe and effective option for treating mild cases in the outpatient setting, while remdesivir was preferred for severe cases, where corticosteroids and co-infection significantly predicted worse outcomes. …”
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The Time in Therapeutic Range and Bleeding Complications of Warfarin in Different Geographic Regions of Turkey: A Subgroup Analysis of WARFARIN-TR Study by Salih Kılıç, Ahmet Çelik, Hüseyin Altuğ Çakmak, Abdülmecit Afşin, Ahmet İlker Tekkeşin, Gönül Açıksarı, Mehmet Erdem Memetoğlu, Fatma Özpamuk Karadeniz, Ekrem Şahan, Mehmet Hayri Alıcı, Yüksel Dereli, Ümit Yaşar Sinan, Mehdi Zoghi

“…Awareness was evaluated based on the patients’ knowledge of the effect of warfarin and food-drug interactions with simple questions developed based on a literature review. …”
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Antimycobacterial activity of scopoletin from ethanolic extract of Hymenodictyon floribundum (Hochst. &amp; Steud.) B.L.Rob. Stem bark by Alphonce Ignace Marealle, Alfredi Alfed Moyo, Francis Machumi, Michael Qwarse, Yona M. Chenyambuga, Matthias Heydenreich, Mainen Moshi

“…The available tuberculosis (TB) therapies are taken for long time with complex regimens associated with adverse effects and drug-drug interactions. The emergence of multidrug resistant (MDR) and extensively drug resistant (XDR) strains of Mycobacterium tuberculosis and HIV co-infections necessitates the need for continued search for new effective anti-TB alternative leads with different mechanisms of action and safety profile. …”
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New Multifunctional Agents Based on Conjugates of 4-Amino-2,3-polymethylenequinoline and Butylated Hydroxytoluene for Alzheimer’s Disease Treatment by Galina F. Makhaeva, Nadezhda V. Kovaleva, Elena V. Rudakova, Natalia P. Boltneva, Sofya V. Lushchekina, Irina I. Faingold, Darya A. Poletaeva, Yuliya V. Soldatova, Raisa A. Kotelnikova, Igor V. Serkov, Anatoly K. Ustinov, Alexey N. Proshin, Eugene V. Radchenko, Vladimir A. Palyulin, Rudy J. Richardson

“…Compounds possessed low activity against carboxylesterase, indicating likely absence of clinically unwanted drug-drug interactions. Kinetics were consistent with mixed-type reversible inhibition of both cholinesterases. …”
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Cost-effectiveness of the ONCORAL multidisciplinary programme for the management of outpatients taking oral anticancer agents at risk of drug-related event: protocol for a pragmati... by Florence Ranchon, Catherine Rioufol, Laure Huot, Pascale Guerre, Guillaume Descotes, Anne-Gaëlle Caffin, Chloé Herledan

“…The secondary outcomes will be evaluation of OAA management consequences (relative-dose intensity, adherence, adverse drug events, drug–drug interactions, and proven medication errors), evaluation of overall survival and cancer-related quality of life, and patient-reported outcomes in relation to the treatment. …”
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