Beyond pillbox: a national cross-sectional study on the attitudes, practices, and knowledge of community pharmacists regarding complementary and alternative medicine by Farah Naja, Nada Abbas, Sharfa Khaleel, Falak Zeb, Tareq A. H. Osaili, Reyad Shaker Obaid, MoezAlIslam Faris, Hadia Radwan, Leila Cheikh Ismail, Haydar Hassan, Mona Hashim, Hamzah AlZubaidi

“…For the knowledge questions, more than 50% of community pharmacists correctly answered the functions of complementary and alternative medicine, however lower percentages were noted for the side effects and drug interactions questions. Most community pharmacists had positive attitudes towards complementary and alternative medicine, except for particular aspects such as efficacy, where 40% agreed that complementary and alternative medicine is only effective in treating minor complaints. …”
Get full text

Interaction Profiles of Central Nervous System Active Drugs at Human Organic Cation Transporters 1–3 and Human Plasma Membrane Monoamine Transporter by Thomas J. F. Angenoorth, Stevan Stankovic, Marco Niello, Marion Holy, Simon D. Brandt, Harald H. Sitte, Julian Maier

“…Our results highlight the significance of investigating drug interactions with hOCTs and hPMAT, due to their role in regulating monoamine concentrations and xenobiotic clearance.…”
Get full text

In Vitro Metabolism of DWP16001, a Novel Sodium-Glucose Cotransporter 2 Inhibitor, in Human and Animal Hepatocytes by Ju-Hyun Kim, Dong Kyun Kim, Won-Gu Choi, Hye-Young Ji, Ji-Soo Choi, Im-Sook Song, Sangkyu Lee, Hye Suk Lee

“…Overall, DWP16001 is weakly metabolized in human hepatocytes, but there is a potential for the pharmacokinetic modulation and drug–drug interactions, involved in the responsible metabolizing enzymes of DWP16001 in humans.…”
Get full text

The safety and potential efficacy of exosomes overexpressing CD24 (EXO-CD24) in mild-moderate COVID-19 related ARDS by Ioannis Grigoropoulos, Georgios Tsioulos, Artemis Kastrissianakis, Shiran Shapira, Orr Green, Vasiliki Rapti, Maria Tsakona, Thomas Konstantinos, Athina Savva, Dimitra Kavatha, Dimitrios Boumpas, Konstantinos Syrigos, Ioannis Xynogalas, Konstantinos Leontis, Vasileios Ntousopoulos, Vissaria Sakka, Zafeiris Sardelis, Andreas Fotiadis, Lamprini Vlassi, Chrysoula Kontogianni, Anastasia Levounets, Garyfalia Poulakou, Mina Gaga, Ronan MacLoughlin, Justin Stebbing, Nadir Arber, Anastasia Antoniadou, Sotirios Tsiodras

“…Of all the documented adverse events, none were considered treatment related. No drug-drug interactions were noted. Two patients succumbed to COVID-19. …”
Get full text

Nucleic Acid-Sensing and Interferon-Inducible Pathways Show Differential Methylation in MZ Twins Discordant for Lupus and Overexpression in Independent Lupus Samples: Implications... by Miranda C. Marion, Paula S. Ramos, Prathyusha Bachali, Adam C. Labonte, Kip D. Zimmerman, Hannah C. Ainsworth, Sarah E. Heuer, Robert D. Robl, Michelle D. Catalina, Jennifer A. Kelly, Timothy D. Howard, Peter E. Lipsky, Amrie C. Grammer, Carl D. Langefeld

“…The DM-DE genes were also informatically queried for potential gene–drug interactions, yielding a list of 41 drugs including a known SLE therapy. …”
Get full text

Use of proton pump inhibitors and macrolide antibiotics and risk of acute kidney injury: a self-controlled case series study by Keiko Ikuta, Shunsaku Nakagawa, Chinami Yamawaki, Kotaro Itohara, Daiki Hira, Satoshi Imai, Atsushi Yonezawa, Takayuki Nakagawa, Minoru Sakuragi, Noriaki Sato, Eiichiro Uchino, Motoko Yanagita, Tomohiro Terada

“…Although macrolide antibiotics are considered to have relatively low nephrotoxicity, they are well known to increase the risk of AKI due to drug-drug interactions. In this study, we aimed to investigate the association between PPI use and the development of AKI. …”
Get full text

The Effect of the Selective N-methyl-D-aspartate (NMDA) Receptor GluN2B Subunit Antagonist CP-101,606 on Cytochrome P450 2D (CYP2D) Expression and Activity in the Rat Liver and Bra... by Anna Haduch, Ewa Bromek, Renata Pukło, Joanna Jastrzębska, Przemysław Jan Danek, Władysława Anna Daniel

“…On the other hand, an inhibition of the activity of liver CYP2D may slow down the metabolism of co-administered substrates and lead to pharmacokinetic drug–drug interactions.…”
Get full text

Pharmacist-led olaparib follow-up service for ambulatory ovarian cancer patients: A prospective study in a tertiary specialized cancer hospital in China by Yanting Wang, Di Du, Di Du, Jun Yang, Alan H. Lau, Yuanyuan Dai, Yuanyuan Dai, Wangjun Qin, Ning Li, Guohui Li

“…The pharmacists identified 4 clinically significant drug-drug interactions (DDIs) in two patients. Pharmacists made 196 suggestions mainly related to rational use of the medications and management of ADRs.Conclusion: The study provides the first report about pharmacist-led follow-up service for olaparib. …”
Get full text

In vitro characterization of immune modulating drug-eluting immunobeads towards transarterial embolization in cancer by Ayele H. Negussie, Andrew S. Mikhail, Joshua W. Owen, Natalie Hong, Camella J. Carlson, Yiqing Tang, Kendal Paige Carrow, Michal Mauda-Havakuk, Andrew L. Lewis, John W. Karanian, William F. Pritchard, Bradford J. Wood

“…The maximum loading capacity of BMS-202 and Dox in DC Bead LUMI exceeded the maximum theoretical loading capacity of the beads expected from ionic interaction alone suggesting additional drug-bead or drug-drug interactions may play a role. Slightly more release was observed for BMS-202 at early time points followed by a slower release compared to Dox. …”
Get full text

Discontinuing statins or not in the elderly? Study protocol for a randomized controlled trial by Fabrice Bonnet, Antoine Bénard, Pierre Poulizac, Mélanie Afonso, Aline Maillard, Francesco Salvo, Driss Berdaï, Nathalie Salles, Nicolas Rousselot, Sébastien Marchi, Nathalie Hayes, Jean-Philippe Joseph

“…Discussion There is some debate on the value of statins in people over 75 years old, especially for primary prevention of CV events, due to a lack of evidence of their efficacy in this population, potential compliance-related events, drug-drug interactions and side effects that could impair quality of life. …”
Get full text

Synergistic interactions of cytarabine-adavosertib in leukemic cell lines proliferation and metabolomic endpoints by Gabriel O. Rodríguez-Vázquez, Adriana O. Diaz-Quiñones, Nataliya Chorna, Iris K. Salgado-Villanueva, Jing Tang, Walter I. Silva Ortiz, Héctor M. Maldonado

“…In both cell lines analysis of concentration-inhibition curves of adavosertib-cytarabine combinations and synergy matrixes supported mutually synergistic drug interactions. Overall mean ( ± SD) synergy scores were higher in Jurkat than CCRF-CEM: Jurkat, ZIP 22.51 ± 1.1, Bliss 22.49 ± 1.1, HSA 23.44 ± 1.0, Loewe 14.16 ± 1.2; and, CCRF-CEM, ZIP 9.17 ± 1.9, Bliss 8.13 ± 2.1, HSA 11.48 ± 1.9 and Loewe 4.99 ± 1.8. …”
Get full text

High dose oral and intravenous rifampicin for improved survival from adult tuberculous meningitis: a phase II open-label randomised controlled trial (the RifT study) [version 1; re... by Fiona V. Cresswell, Kenneth Ssebambulidde, Daniel Grint, Lindsey te Brake, Abdul Musabire, Rachel R. Atherton, Lillian Tugume, Conrad Muzoora, Robert Lukande, Mohammed Lamorde, Rob Aarnoutse, David Meya, David R. Boulware, Alison M. Elliott

“…Discussion: HIV co-infection affects the bioavailability of rifampicin in the initial days of therapy, risk of drug toxicity and drug interactions, and ultimately mortality from TBM. Our study aims to demonstrate, in a predominantly HIV-positive population, the safety and pharmacokinetic superiority of one or both investigational arms compared to current standard of care. …”
Get full text

Prospective prescription review system correlated with more rational PPI medication use, better clinical outcomes and reduced PPI costs: experience from a retrospective cohort stud... by Xiucong Fan, Danxia Chen, Siwei Bao, Xiaohui Dong, Fang Fang, Rong Bai, Yuyi Zhang, Xiaogang Zhang, Weijun Tang, Yabin Ma, Xiaobo Zhai

“…The rationality evaluation results showed that the frequency of PPI use and the number of drug interactions were significantly higher in the preintervention group than in the postintervention group (P < 0.01). …”
Get full text

Comparative analysis of valproic acid concentrations in terms of dosing and clinical effect monitoring in different age patients with diagnosed epilepsy by Agnieszka Cios, Elżbieta Szczygieł-Pilut, Sylwia Kozłowska, Anna Zajączkowska-Dutkiewicz, Łukasz Hońdo, Anna Wesołowska

“…Conclusions The reasons for the obtained differences could be drug interactions, nutritional style and the lack of compliance. …”
Get full text

Potential effects of commonly applied drugs on neural stem cell proliferation and viability: A hypothesis-generating systematic review and meta-analysis by Katherine R. H. Mortimer, Katherine R. H. Mortimer, Hannah Vernon-Browne, Marietta Zille, Nadine Didwischus, Nadine Didwischus, Nadine Didwischus, Johannes Boltze

“…There is substantial knowledge about drug-drug interactions but almost nothing is known about a potential impact of pharmacotherapy on NSCs. …”
Get full text

Gota en el anciano by Oscar Uribe, Carlos Andrés Agudelo

“…Careful examination of synovial fluid along with identification of monosodium urate crystals are mandatory for an accurate diagnosis of gout. Possible drug interactions between anti-inflammatory and hypouricemic drugs with other medications have to be kept in mind. …”
Get full text

Real-World Financial and Clinical Impact of Diagnostic-Driven and Empirical-Treatment Strategies in High-Risk Immunocompromised Patients with Suspected Aspergillus Infection in the... by Stephanie R. Earnshaw, Cheryl McDade, Andrew Bryan, Monica Ines, Christianne Micallef, Anita Sung, David A. Enoch

“…Prescribing is further complicated by comorbidities, drug interactions and challenges accessing diagnostics. …”
Get full text

Pronounced Declines in Meperidine in the US: Is the End Imminent? by Lavinia R. Harrison, Rhudjerry E. Arnet, Anthony S. Ramos, Poul A. Chinga, Trinidy R. Anthony, John M. Boyle, Kenneth L. McCall, Stephanie D. Nichols, Brian J. Piper

“…The shortage of some parenteral formulations is an important contributor to these declines, however, the most likely explanation for this global decline in use is related to an increased recognition of safety concerns related to important drug interactions and a neurotoxic metabolite. This data may reflect plans to phase out the use of this opioid, especially in the many situations where safer and more preferred opioids are available.…”
Get full text

Amisulpride Augmentation in Schizophrenia Patients with Poor Response to Olanzapine: A 4-week, Randomized, Rater-Blind, Controlled, Pilot Study by W.-M. Bahk, Y. S. Woo, S.-Y. Park, B.-H. Yoon, S.-M. Wang, M.-D. Kim

“…Because risks of antipsychotic polypharmacy include increased drug-drug interactions, pharmacokinetic considerations are important for selection of antipsychotics to be combined. …”
Get full text

Switching to Dolutegravir/Lamivudine Two-Drug Regimen: Durability and Virologic Outcomes by Age, Sex, and Race in Routine US Clinical Care by Pierone G Jr, Brunet L, Fusco JS, Henegar CE, Sarkar S, Van Wyk J, Vannappagari V, Wohlfeiler MB, Fusco GP

“…Gerald Pierone Jr,1 Laurence Brunet,2 Jennifer S Fusco,2 Cassidy E Henegar,3 Supriya Sarkar,3 Jean Van Wyk,4 Vani Vannappagari,3 Michael B Wohlfeiler,5 Gregory P Fusco2 1Department of Adult Primary Care, Whole Family Health Center, Vero Beach, FL, USA; 2Department of Epidemiology, Epividian, Raleigh, NC, USA; 3Epidemiology and Real World Evidence, ViiV Healthcare, Research Triangle Park, NC, USA; 4Global Medical, ViiV Healthcare, Brentford, UK; 5Department of Medicine, AIDS Healthcare Foundation, Miami, FL, USACorrespondence: Laurence Brunet, Epividian, 150 Fayetteville Street, Suite 2300, Raleigh, NC, 27601, USA, Tel +1-919-827-0010, Email laurence.brunet@epividian.comPurpose: Two-drug regimens (2DR) may address drug–drug interactions and toxicity concerns. Dolutegravir/lamivudine (DTG/3TC) 2DR was approved in the US for both treatment-naïve and treatment-experienced individuals with a viral load < 50 copies/mL. …”
Get full text