Diagnosis of gilbert’s syndrome via pyrosequencing in clinical practice by L. I. Melnikova, L. Yu. Ilchenko, E. A. Dunaeva, M. V. Kozitsyna, O. P. Dribnokhodova, K. O. Mironov

“…GS is characterized by unconjugated hyperbilirubinemia; drug metabolism disorders and the development of drug-drug interactions. For diagnosis of GS, molecular biological methods are used to determine single nucleotide polymorphisms (SNP). …”
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Mental Health Polypharmacy in “Non-Coded” Primary Care Patients: The Effect of Deprescribing by Waseem Jerjes, Daniele Ramsay, Harvey Stevenson, Karima Lalji

“…Additionally, a marked reduction in reported side effects and drug interactions was observed. Improvements in mental health control, as evidenced by PHQ-9 and GAD-7 scores, were noted. …”
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Associations between polypharmacy and potentially inappropriate medications with risk of falls among the elderly in Saudi Arabia by Khalid S. AlHarkan, Safaa Alsousi, Mujtaba AlMishqab, Majd Alawami, Jaffar Almearaj, Hassan Alhashim, Hassan Alamrad, Layla M. Alghamdi, Abdulelah Almansour, Reem S. AlOmar

“…It assesses the appropriateness of drug prescriptions (i.e., correct dose, duration, and indications) to ensure the safety of these drugs, reducing drug interactions and decreasing the hazards of side effects. …”
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Pattern of medications causing adverse drug reactions and the predisposing risk factors among medical in-patients in clinical practice: A prospective study by Peter Ehizokhale Akhideno, Olumuyiwa John Fasipe, Ambrose Ohumagho Isah, Omagbemi Sampson Owhin, Oluseyi Ademola Adejumo

“…Background: Pharmacological interventions sometimes carry inherent significant risks which include adverse drug reactions (ADRs), drug interactions (DIs) and other consequences of inappropriate medication use. …”
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Valproate-induced severe symptomatic hyponatremia in a patient with schizoaffective disorder: a case study and literature review by K. Heflin, M. ElSayed

“…None of the previous case reports showed specific drug interactions to be particularly likely causes of hyponatremia. …”
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Exploration of the common genetic landscape of COVID-19 and male infertility by Yinwei Chen, Taotao Sun, Kang Liu, Penghui Yuan, Chang Liu

“…Pharmacologic agent prediction displayed protein-drug interactions of ascorbic acid, biotin, caffeine, and L-cysteine with CORGs. …”
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Cannabinoids as a Potential Alternative to Opioids in the Management of Various Pain Subtypes: Benefits, Limitations, and Risks by Samuel P. Ang, Shawn Sidharthan, Wilson Lai, Nasir Hussain, Kiran V. Patel, Amitabh Gulati, Onyeaka Henry, Alan D. Kaye, Vwaire Orhurhu

“…However, there is still potential for addiction, altered brain development, psychiatric comorbidities, and drug–drug interactions. Conclusion Cannabinoids may be effective in specific subtypes of pain, but current evidence and guidelines do not yet support its use as the first-line treatment for any type of acute or chronic pain. …”
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Potentially Inappropriate Medication Use among Underserved Older Latino Adults by Ebony King, Mohsen Bazargan, Nana Entsuah, Sayaka W. Tokumitsu, Cheryl Wisseh, Edward K. Adinkrah

“…Lack of continuity of care often leads to fragmented care, putting vulnerable patients at risk of polypharmacy and drug–drug interactions as clinicians lack access to a current and complete list of medications patients are using at any given time. …”
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A phenotypic screen of the Global Health Priority Box identifies an insecticide with anthelmintic activity by Harrison T. Shanley, Aya C. Taki, Joseph J. Byrne, Nghi Nguyen, Tim N. C. Wells, Abdul Jabbar, Brad E. Sleebs, Robin B. Gasser

“…Further work should seek to establish the protein–drug interactions of MMV1794206 in a nematode model, to unravel the mechanism of action, in addition to an advanced structure–activity relationship investigation to optimise anthelmintic activity and eliminate mammalian cell toxicity. …”
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ChatGPT and Clinical Training: Perception, Concerns, and Practice of Pharm-D Students by Zawiah M, Al-Ashwal FY, Gharaibeh L, Abu Farha R, Alzoubi KH, Abu Hammour K, Qasim QA, Abrah F

“…Adoption of ChatGPT in clinical training varied, with some students not using it at all, while others utilized it for tasks like evaluating drug-drug interactions and developing care plans. Previous users tended to have higher perceived benefits and lower concerns, but the differences were not statistically significant.Conclusion: Utilizing ChatGPT in clinical training offers opportunities, but students’ lack of trust in it for clinical decisions highlights the need for collaborative human-ChatGPT decision-making. …”
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Cocaine regulates antiretroviral therapy CNS access through pregnane-x receptor-mediated drug transporter and metabolizing enzyme modulation at the blood brain barrier by Rodnie Colón Ortiz, Stephen Knerler, Lisa B. Fridman, Alicia Mercado, Amira-Storm Price, Jose J. Rosado-Franco, Hannah Wilkins, Bianca R. Flores, Benjamin C. Orsburn, Dionna W. Williams

“…While understudied, illicit substances share drug transport and metabolism pathways with ART, increasing the potential for adverse drug:drug interactions. This is particularly important when considering the brain as it is relatively undertreated compared to peripheral organs and is vulnerable to substance use-mediated damage. …”
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Safety of geriatric patients undergoing endobronchial ultrasound-guided transbronchial needle aspiration with deep sedation: a retrospective study by Mehtap Tunç, Hilal Sazak, Ayperi Öztürk, Aydın Yılmaz, Ali Alagöz

“…Decreased propofol dose in the regimen using propofol alone has shown us that anesthetists are more sensitive to the administration of sedative agents in geriatric patients, taking into account comorbidities and drug interactions.…”
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Utilizing sinapic acid as an inhibitory antiviral agent against MERS-CoV PLpro by Mudassar Shahid, Ahmed L. Alaofi, Mushtaq Ahmad Ansari, Sheikh Fayaz Ahmad, Saleh Alsuwayeh, Ehab Taha, Mohammad Raish

“…The thermal shift assay (TSA) was used in the current study to determine whether the drug interact with the recombinant MERS-CoV PLpro. Also, inhibition assay was conducted as the hydrolysis of fluorogenic peptide from the Z-RLRGG-AMC-peptide bond in the presence of SA to determine the level of inhibition of the MERS-CoV PLpro. …”
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Self-medication practice in Yemen and the role of community pharmacy dispensers, pharmacy education, and health authorities / Sami Mohammed Hamood Albawani by Hamood Albawani, Sami Mohammed

“…However, irrational use of drugs can lead to serious side effects, toxicity and drug interactions. Very few studies have been reported about self-medication practice in Yemen and no studies were found in the literature regarding the role of community drug dispensers, pharmacy education and health care authorities in Yemen. …”
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Statin therapy in multimorbid older patients with polypharmacy- a cross-sectional analysis of the Swiss OPERAM trial population by Luise Adam, Luise Adam, Luise Adam, Oliver Baretella, Oliver Baretella, Martin Feller, Martin Feller, Manuel Raphael Blum, Manuel Raphael Blum, Dimitrios David Papazoglou, Benoit Boland, Benoit Boland, Drahomir Aujesky, Stéphanie Baggio, Stéphanie Baggio, Nicolas Rodondi, Nicolas Rodondi

“…Thereby, physicians must weigh potential benefits against potential side effects, drug-drug interactions, and limited life expectancy.AimTo assess the prevalence and determinants of potentially inappropriate statin therapy in multimorbid older patients.MethodsWe conducted a cross-sectional analysis of patients aged ≥70 years with multimorbidity and polypharmacy in the Swiss study center of OPERAM, a cluster-randomized trial on pharmacotherapy optimization to reduce drug-related hospital admissions. …”
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Prediction of the active compounds and mechanism of Biochanin A in the treatment of Legg-Calvé-Perthes disease based on network pharmacology and molecular docking by Jianhong Liu, Zhirui Hua, Shijie Liao, Boxiang Li, Shengping Tang, Qian Huang, Zhendi Wei, Rongbin Lu, Chengsen Lin, Xiaofei Ding

“…To validate the potential target-drug interactions, molecular docking and molecular dynamics simulations were performed and the result was proved by western blot. …”
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Systematic screening identifies ABCG2 as critical factor underlying synergy of kinase inhibitors with transcriptional CDK inhibitors by Vera E. van der Noord, Wanda van der Stel, Gijs Louwerens, Danielle Verhoeven, Hendrik J. Kuiken, Cor Lieftink, Melanie Grandits, Gerhard F. Ecker, Roderick L. Beijersbergen, Peter Bouwman, Sylvia E. Le Dévédec, Bob van de Water

“…These findings therefore further facilitate the development of new (combination) therapies targeting transcriptional CDKs and highlight the importance of evaluating the role of ABC transporters in synergistic drug–drug interactions in general.…”
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Hyperactivation of mTORC1 in a double hit mutant zebrafish model of tuberous sclerosis complex causes increased seizure susceptibility and neurodevelopmental abnormalities by Ann-Sofie De Meulemeester, Lise Heylen, Aleksandra Siekierska, James D. Mills, James D. Mills, James D. Mills, Alessia Romagnolo, Nicole N. Van Der Wel, Eleonora Aronica, Eleonora Aronica, Peter A. M. de Witte

“…Finally, analysis of gene-drug interactions identified interesting pharmacological targets for SEGA, underscoring the value of our small zebrafish vertebrate model for future drug discovery efforts.…”
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Synergistic Anti-Angiogenic Effect of Combined VEGFR Kinase Inhibitors, Lenvatinib, and Regorafenib: A Therapeutic Potential for Breast Cancer by Khuloud Bajbouj, Rizwan Qaisar, Mohammed A. Alshura, Zeinab Ibrahim, Mohamad B. Alebaji, Amenah W. Al Ani, Hanadi M. Janajrah, Mariah M. Bilalaga, Abdelrahman I. Omara, Rebal S. Abou Assaleh, Maha M. Saber-Ayad, Adel B. Elmoselhi

“…Data were analyzed as means ± standard deviation, and the drug–drug interactions with Compusyn software. Cellular migration assay, tube formation assay, and Western blots were conducted to determine the functional and the protein expression of downstream signals such as Caspase-9, anti-apoptotic Survivin, P-ERK, and total-ERK in the control and treatment groups. …”
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Pharmacological treatments and medication-related problems in nursing homes in Catalonia: a multidisciplinary approach by Emilie Anderssen-Nordahl, Emilie Anderssen-Nordahl, Emilie Anderssen-Nordahl, Margarita Sánchez-Arcilla Rosanas, Montserrat Bosch Ferrer, Montserrat Bosch Ferrer, Montserrat Bosch Ferrer, Mònica Sabaté Gallego, Mònica Sabaté Gallego, Mònica Sabaté Gallego, Eladio Fernández-Liz, Eladio Fernández-Liz, Antonio San-José, Maria Estrella Barceló-Colomer, Maria Estrella Barceló-Colomer

“…A detailed description of the clinical characteristics, chronic diseases, pharmacological treatments, recommendations, incomplete data, and MRPs, such as potential drug–drug interactions, therapeutic duplications, contraindications, and drugs deemed inappropriate or of doubtful efficacy, was made. …”
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