Experiences and Outcomes of Using e-Prescribing for Opioids: Rapid Scoping Review by Sara J T Guilcher, Stephanie R Cimino, Mina Tadrous, Lisa M McCarthy, Jessica Riad, Andrea C Tricco, Simon Hagens, Jennifer Lien, Sukirtha Tharmalingam, Tara Gomes

“…The main outcomes identified were related to opioid prescribing rates, alerts (eg, adverse drug events and drug-drug interactions), the quantity and duration of opioid prescriptions, the adoption of e-prescribing technology, attitudes toward e-prescribing, and potential challenges with the implementation of e-prescribing into clinical practice. e-Prescribing, including key features such as alerts and dose order sets, may reduce prescribing errors. …”
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COVID-19 Treatments Sold Online Without Prescription Requirements in the United States: Cross-sectional Study Evaluating Availability, Safety and Marketing of Medications by Sachiko Ozawa, Joanna Billings, Yujiao Sun, Sushan Yu, Benjamin Penley

“…ConclusionsThe lack of safety measures by illegitimate online pharmacies endanger patients, facilitating access to medications without appropriate oversight by health care providers to monitor clinical response, drug interactions, and adverse effects. We demonstrated how easy it is to go online to buy medications that are touted to treat COVID-19 even when current clinical evidence does not support their use for self-treatment. …”
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Penggunaan Obat Anti Epilepsi untuk Terapi Profilaksis Bangkitan pada Cedera Otak Traumatik by Rovina Ruslami, Tatang Bisri

“…PHT has numoerus side effects and drug interactions, has complex non-linear pharmacokinetics that require therapeutic drug monitoring. …”
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Parkinson's disease: Present and future of cell therapy by F.J. Sancho-Bielsa

“…Furthermore, most patients are elderly individuals with concomitant diseases, which increases the risk of drug–drug interactions. In this context, the discovery of adult neurogenesis has caused a dramatic change in the therapeutic approach, aiming to repair the nervous system. …”
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Study the response of Qurevo (ombitasvir, paritaprevir, and ritonavir) in end-stage renal disease patients with hepatitis C virus by Howayda Abd Elhameed Elshinnawy, Iman Ibrahim Sarhan, Ossama Ashraf Ahmed, Meryhan Osama Mohamed, Cherry Reda Kamel

“…Hepatic decompensation, hypersensitivity (angioedema), teratogenicity, and drug interactions did not occur in any patient (0%). Other events occurred in 11 patients (22%). …”
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Sex differences in the hepatotropic effects of antiulcer drugs and placenta cryoextract in an experimental rat liver injury model by Hladkykh Fedir V., Koshurba Illia V., Komorovsky Roman R., Chyzh Mykola O., Koshurba Yuri V., Marchenko Mykhailo M.

“…Tailoring treatment strategies based on sex is particularly noteworthy among patients with comorbid illnesses due to the potential for drug interactions and the impact of concurrent diseases on clinical outcomes. …”
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Local Liver Irradiation Concurrently Versus Sequentially with Cabozantinib on the Pharmacokinetics and Biodistribution in Rats by Yu-Chuen Huang, Pei-Ying Hsieh, Li-Ying Wang, Tung-Hu Tsai, Yu-Jen Chen, Chen-Hsi Hsieh

“…Concurrent and sequential regimens involving RT and cabozantinib were designed. The RT–drug interactions of cabozantinib under RT were confirmed in a free-moving rat model. …”
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Unravelling the dilemma of self-medication in Egypt: a cross-sectional survey on knowledge, attitude, and practice of the general Egyptian population by Hossam Tharwat Ali, Mostafa Barakat, Ahmed Reda Abdelhalim, Ibrahim Noureddin Al-Kurd, Muhammad Kamal-Eldeen Muhammad, Mohamed Mostafa Sharkawy, Mohamed Elbahnasawy, Samar Ahmed Amer, Self-Medication Collaborative Group

“…It can be associated with various problems such as the delayed seeking of medical advice, drug interactions, and serious events such as antimicrobial drug resistance. …”
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Risk of 30-day hospital readmission associated with medical conditions and drug regimens of polymedicated, older inpatients discharged home: a registry-based cohort study by Armin von Gunten, Filipa Pereira, Boris Wernli, Maria Manuela Martins, Henk Verloo, Carla Meyer-Massetti, Saviana Di Giovanni, Zhivko Taushanov

“…Further research is needed to explore hospital readmissions caused solely by specific drugs and drug–drug interactions.…”
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Assessment of Contributing Factors and Treatment Practices for Therapeutic Efficacy and Drug-Related Problems in Suicidal Psychotic Patients by Saimon Shahzad, Sami Ullah, Zahid Nazar, Muhammad Riaz, Fazli Khuda, Atif Ali Khan Khalil, Mikhlid H. Almutairi, Amany A. Sayed, Sultan Mehtap Büyüker, Nazimuddin Khan

“…DRPs were also detected, including drug-selection problems (17.88%), dose-related problems (20.64%), potential drug–drug interactions (24.31%), adverse drug reactions (11.46%) and other problems like inadequate education and counseling (21.55%). …”
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Evaluation of medication safety assessment tools for pharmacist-led medication reviews: the Eastern European pilot project by Anita Tuula, Piotr Merks, Magdalena Waszyk-Nowaczyk, Mariola Drozd, Galina Petrova, Reka Viola, Veera Bobrova, Michael Scott, Marje Oona, Daisy Volmer

“…Databases for identification of potential drug-drug interactions (pDDIs) and adverse drug reactions (ADRs) named Inxbase/Riskbase, as well as an integrated tool comprising potentially inappropriate medicines (PIMs) lists EU(7)-PIM and EURO-FORTA, were applied retroactively to the MR pilot data to investigate possibilities for their use and to describe medication use and potential risks in the study population.Results: A total of 318 patients were included in the study, 250 of them elderly (≥65 years). …”
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Prevalence and predictors of potentially inappropriate medications among elderly patients attending government primary care clinics by Chandra Sejara Rao, Hemah Devi

“…Elderly patient may become victims of potentially inappropriate medication (PIM) when their drug interactions and effect of the drug on other underlying diseases are not being properly investigated during follow ups with medical officers. …”
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Drug-Related Problems in Prescribing for Pediatric Outpatients in Vietnam by Thao H. Nguyen, Vy T. T. Le, Dung N. Quach, Han G. Diep, Nguyet K. Nguyen, Anh N. Lam, Suol T. Pham, Katja Taxis, Thang Nguyen, Phuong M. Nguyen

“…DRPs included inappropriate drug selection (35.6%), wrong time of dosing relative to meals (35.6%), inappropriate dosage form (9.3%), inappropriate indication (7.1%), and drug-drug interactions (0.3%). The consensus of experts was average when evaluating each aspect of efficiency reduction, safety reduction, and treatment cost increase, with Fleiss’ coefficients of 0.558, 0.511, and 0.541, respectively (<i>p</i> < 0.001). …”
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Assessing pharmaceutical consultations: Comparing pharmacy-recommended medications for minor ailments and regulatory compliance in a Latin American healthcare network by Esteban Zavaleta-Monestel, Jorge Arturo Villalobos-Madriz, Bruno Serrano-Arias, Sebastián Arguedas-Chacón, José Pablo Diaz-Madriz, Mery Alejandra Ferreto-Meza, Betzy María Romero-Chavarría, Priscila Zumbado-Amerling

“…While over-the-counter (OTC) medications are relatively safe and cost-effective, there is a risk of misuse due to factors such as inaccurate self-diagnosis, inadequate dosing, addiction, adverse drug reactions, and drug interactions. To ensure proper use and prevent irrational self-medication, pharmacists can play a crucial role in guiding patients. …”
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Solanidine is a sensitive and specific dietary biomarker for CYP2D6 activity by Johanna I. Kiiski, Mikko Neuvonen, Mika Kurkela, Päivi Hirvensalo, Kreetta Hämäläinen, E. Katriina Tarkiainen, Johanna Sistonen, Mari Korhonen, Sofia Khan, Arto Orpana, Anne M. Filppula, Marko Lehtonen, Mikko Niemi

“…Since potato consumption is common worldwide, this biomarker could be useful for evaluating CYP2D6-mediated drug–drug interactions and to improve prediction of CYP2D6 activity in addition to genotyping.…”
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Why a distinct medical stream is necessary to support patients using cannabis for medical purposes by Cecilia Costiniuk, Caroline A. MacCallum, Michael Boivin, Sergio Rueda, Gary Lacasse, Zach Walsh, Paul J. Daeninck, Shari Margolese, Enrico Mandarino, Jagpaul Kaur Deol, Tatiana Sanchez, Alan D. Bell

“…For example, patients require guidance in the form of assessing the appropriateness of cannabis use, selection of appropriate products and dosage forms, dosing titration, screening for drug interactions, and safety monitoring. Healthcare providers require access to undergraduate and continuing health education as well as support from their professional organizations to ensure medical cannabis is appropriately prescribed. …”
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Medical Cannabis Received by Patients According to Qualifying Condition in a US State Cannabis Program: Product Choice, Dosing, and Age-Related Trends by Xintian Lyu, BS, Sílvia M. Illamola, PharmD, PhD, Susan E. Marino, PhD, Ilo E. Leppik, MD, Stephen Dahmer, MD, Paloma Lehfeldt, MD, Jeannine M. Conway, PharmD, Rory P. Remmel, PhD, Kyle Kingsley, MD, Angela K. Birnbaum, PhD

“…Complex pharmacokinetics of THC and CBD, possible age-related changes in physiology, unknown efficacy, and potential for drug interactions all increase the need for monitoring of patients receiving cannabis products. …”
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Longitudinal cytokine and multi-modal health data of an extremely severe ME/CFS patient with HSD reveals insights into immunopathology, and disease severity by Fereshteh Jahanbani, Justin Cyril Sing, Rajan Douglas Maynard, Shaghayegh Jahanbani, Janet Dafoe, Whitney Dafoe, Nathan Jones, Kelvin J. Wallace, Azuravesta Rastan, Holden T. Maecker, Hannes L. Röst, Michael P. Snyder, Ronald W. Davis

“…Additionally, the data identified potential roles of BCL6 and TP53 pathways in ME/CFS etiology and emphasized the importance of investigating adverse reactions to medication and supplements and drug interactions in ME/CFS severity and progression.DiscussionOur study advocates for the integration of longitudinal multi-omics with multi-modal health data and artificial intelligence (AI) techniques to better understand ME/CFS and its major comorbidities. …”
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Italian Emergency Department Visits and Hospitalizations for Outpatients’ Adverse Drug Events: 12-Year Active Pharmacovigilance Surveillance (The MEREAFaPS Study) by Niccolò Lombardi, Giada Crescioli, Alessandra Bettiol, Marco Tuccori, Marco Tuccori, Annalisa Capuano, Roberto Bonaiuti, Alessandro Mugelli, Mauro Venegoni, Giuseppe Danilo Vighi, Alfredo Vannacci, Alfredo Vannacci, the MEREAFaPS Study group, Maria Luisa Aiezza, Alessandra Bettiol, Daria Bettoni, Corrado Blandizzi, Roberto Bonaiuti, Valentina Borsi, Annalisa Capuano, Errica Cecchi, Irma Convertino, Giada Crescioli, Martina Del Lungo, Cristina Di Mauro, Gabriella Farina, Sara Ferraro, Annamaria Fucile, Elena Galfrascoli, Elisabetta Geninatti, Linda Giovannetti, Luca Leonardi, Rosa Liccardo, Niccolò Lombardi, Anna Marra, Eleonora Marrazzo, Giovanna Monina, Alessandro Mugelli, Silvia Pagani, Maria Parrilli, Concetta Rafaniello, Francesco Rossi, Marco Rossi, Stefania Rostan, Marco Ruocco, Marita Sironi, Giulia Spada, Liberata Sportiello, Marco Tuccori, Alfredo Vannacci, Mauro Venegoni, Giuditta Violetta Vighi, Giuseppe Danilo Vighi

“…Older age (1.54 [1.48–1.60]), higher number of concomitantly taken drugs (2.22 [2.14–2.31]), the presence of drug-drug interactions (1.52 [1.28–1.81]), and therapeutic error (1.54 [1.34–1.78]), were significantly associated with an increased risk of hospitalization.ConclusionOur long-term active pharmacovigilance study in ED provided a valid estimation of ADE-related hospitalization in a representative sample of the Italian general population and can suggest further focus on medication safety in outpatients, in order to early recognise and prevent ADEs.…”
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Application of a person-centered prescription model improves pharmacotherapeutic indicators and reduces costs associated with pharmacological treatment in hospitalized older patien... by Alexander Ferro-Uriguen, Idoia Beobide-Telleria, Javier Gil-Goikouria, Javier Gil-Goikouria, Petra Teresa Peña-Labour, Andrea Díaz-Vila, Arlovia Teresa Herasme-Grullón, Enrique Echevarría-Orella, Enrique Echevarría-Orella, Jesús Seco-Calvo, Jesús Seco-Calvo

“…Relative to the original model, this adapted model entails a protocol for the tools and assessments to be conducted on people identified as being at the EOL.MeasurementsAfter applying the adapted PCP model, the mean change in the number of regular drugs, STOPPFrail (Screening Tool of Older Persons' Prescriptions in Frail adults with limited life expectancy) criteria, drug burden index (DBI), drug–drug interactions, medication regimen complexity index (MRCI) and 28-days medication cost of chronic prescriptions between admission and discharge was analyzed. …”
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