Efeitos da atorvastatina e do polimorfismo T-786C do gene eNOS sobre parâmetros do metabolismo lipídico plasmático Effects of atorvastatin and T-786C polymorphism of eNOS gene on p... by Vanessa Helena de Souza Zago, José Eduardo Tanus dos Santos, Mirian Regina Gardin Danelon, Roger Marcelo Mesquita da Silva, Natália Baratella Panzoldo, Eliane Soler Parra, Fernanda Alexandre, Vítor Wilson de Moura Virgínio, Eder Carlos Rocha Quintão, Eliana Cotta de Faria

“…Interestingly, we observed genotype/drug interactions on CETP (p < 0.07) and lipoprotein (a) (Lp(a)) (p < 0.056), leading to a borderline decrease in CETP, but with no effect on Lp(a). …”
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4423 Impact of Gender on High On-Treatment Platelet Reactivity (HPR) and Major Adverse Cardiovascular Events (MACEs) in Caribbean Hispanic patients using Clopidogrel by Hector Jose Nunez Medina, Jorge Duconge, Luis A. Velez, Laura I. Fernandez, Orlando Arce

“…Multiple factors have been associated with the presence of HTPR in patients with CAD and PAD, including CYP2C19 loss of function polymorphism, drug-drug interactions, and medical comorbidities. Gender differences are another factor that might influence the levels of platelet inhibition while on Clopidogrel and hence, HTPR. …”
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Methadone and buprenorphine for the management of opioid dependence: a systematic review and economic evaluation. by Connock, M, Juarez-Garcia, A, Jowett, S, Frew, E, Liu, Z, Taylor, R, Fry-Smith, A, Day, E, Lintzeris, N, Roberts, T, Burls, A, Taylor, R

“…Future research should be directed towards the safety and effectiveness of MMT and BMT; potential safety concerns regarding methadone and buprenorphine, specifically mortality and key drug interactions; efficacy of substitution medications (in particular patient subgroups, such as within the criminal justice system, or within young people); and uncertainties in cost-effectiveness identified by current economic models.…”

Methadone and buprenorphine for the management of opioid dependence: a systematic review and economic evaluation. by Connock, M, Juarez-Garcia, A, Jowett, S, Frew, E, Liu, Z, Taylor, R, Fry-Smith, A, Day, E, Lintzeris, N, Roberts, T, Burls, A, Taylor, R

“…Future research should be directed towards the safety and effectiveness of MMT and BMT; potential safety concerns regarding methadone and buprenorphine, specifically mortality and key drug interactions; efficacy of substitution medications (in particular patient subgroups, such as within the criminal justice system, or within young people); and uncertainties in cost-effectiveness identified by current economic models.…”

Influence of ORM1, PXR, CAR, CYP3A4 and CYP3A5 gene polymorphisms in mediating susceptibility risk to chronic myeloid leukaemia and response to imatinib mesylate therapy by Maddin, Najlaa

“…Associations between human genetic variants and predisposition to diseases and adverse events for different kinds of drug interactions with hundreds of protein like receptors, transporters and metabolizing enzymes have been described. …”
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Global real-world evidence of sofosbuvir/velpatasvir (SOF/VEL) as a highly effective treatment in underserved patient populations because of mental health disorders, incarceration... by L. Barrett, S. Rosati, M. Garcia-Retortillo, H. Wedemeyer, E. Teti, FA Pérez Hernández, M. Selfridge, A. Wong, S. Rodriguez-Tajes, L.E. Morano-Amado, C. Brixko, E. Jimenez-Mutiloa, J. O'Loan, M. Milella, F. Campanale, G. Macedo, M. Guerra-Veloz, I. Maida, R. Ranieri, A. Martins, A. Bascia, M. Buti, C.M. Fernandez-Rodriguez, B. Conway, J. Foucher, S. Fagiuoli, A. Ramji, M. Fenech, P. Ryan, S. Borgia, A. Mangia, J. Mendez-Navarro, I. Ntalla, C. Hernández, M. Mertens, K. Vanstraelen, V. Calvaruso

“…Sofosbuvir/velpatasvir (SOF/VEL) is a protease inhibitor-free, pangenotypic, panfibrotic, single duration, single tablet regimen, to be taken without regards to food and with limited drug-drug interactions, allowing treatment simplification. Purpose: This real world data (RWD) analysis evaluates the effectiveness and safety of SOF/VEL for 12 weeks in a heterogeneous HCV population who suffer a mental health disorder, are incarcerated, or homeless. …”
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Long-term open-label vebicorvir for chronic HBV infection: Safety and off-treatment responses by Man-Fung Yuen, Scott Fung, Xiaoli Ma, Tuan T. Nguyen, Tarek Hassanein, Hie-Won Hann, Magdy Elkhashab, Ronald G. Nahass, James S. Park, Ira M. Jacobson, Walid S. Ayoub, Steven-Huy Han, Edward J. Gane, Katie Zomorodi, Ran Yan, Julie Ma, Steven J. Knox, Luisa M. Stamm, Maurizio Bonacini, Frank Weilert, Alnoor Ramji, Michael Bennett, Natarajan Ravendhran, Sing Chan, Douglas T. Dieterich, Paul Yien Kwo, Eugene R. Schiff, Ho S. Bae, Jacob Lalezari, Kosh Agarwal, Mark S. Sulkowski

“…Most AEs and laboratory abnormalities were related to elevations in alanine aminotransferase and occurred during the off-treatment or NrtI-restart phases. No drug–drug interactions between VBR + NrtI and no cases of treatment-emergent resistance among patients who adhered to treatment were observed. …”
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Synergic Effect of Phthalide Lactones and Fluconazole and Its New Analogues as a Factor Limiting the Use of Azole Drugs against Candidiasis by Piotr Krężel, Teresa Olejniczak, Aleksandra Tołoczko, Joanna Gach, Marek Weselski, Robert Bronisz

“…Synergy assays performed in vitro were used to assess drug interactions Fractional Inhibitory Concentration Index. …”
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Methadone and buprenorphine for the management of opioid dependence: A systematic review and economic evaluation by Connock, M, Juarez-Garcia, A, Jowett, S, Frew, E, Liu, Z, Taylor, R, Fry-Smith, A, Day, E, Lintzeris, N, Roberts, T, Burls, A, Taylor, R

“…Future research should be directed towards the safety and effectiveness of MMT and BMT; potential safety concerns regarding methadone and buprenorphine, specifically mortality and key drug interactions; efficacy of substitution medications (in particular patient subgroups, such as within the criminal justice system, or within young people); and uncertainties in cost-effectiveness identified by current economic models. © Queen's Printer and Controller of HMSO 2007. …”

Multi-scale based software for effective analysis of anticancer drug efficacy in a computer simulated target environment by Muniraj, Vivek Sheraton

“…The emergence of spatially preferential drug efficacy of cisplatin and paclitaxel resulting from variations in mechanisms of cell-drug interactions is explored. Using lab-grown 3D spheroids of HeLa-C3 cells and mechanistic model simulations, it is shown that cell repair probability, intracellular drug concentration and cell’s mitosis phase interact to determine the outcomes of drug actions on a local cell population. …”
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3567 An Analysis of Current Trends in Inclusion of Historically Underrepresented Populations in Clinical Trials: Women and Geriatrics by Jacqueline Chen, Kaitlyn Park, Sun Young Uhm, Amelia Spinrad, Apurva Uniya, Nancy Pire-Smerkanich, Eunjoo Pacifici

“…Likewise, older adults and geriatrics have been excluded in CTs arbitrarily or to avoid adverse events associated with drug-drug interactions and comorbidities. Over the past few decades, the FDA has worked to address this issue and increase diversity and transparency in CTs. …”
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Electronic prescribing systems in hospitals to improve medication safety: a multimethods research programme by Aziz Sheikh, Jamie Coleman, Antony Chuter, Robin Williams, Richard Lilford, Ann Slee, Zoe Morrison, Kathrin Cresswell, Ann Robertson, Sarah Slight, Hajar Mozaffar, Lisa Lee, Sonal Shah, Sarah Pontefract, Abby King, Valeri Wiegel, Samuel Watson, Nde-Eshimuni Salema, David Bates, Anthony Avery, Alan Girling, Lucy McCloughan, Neil Watson

“…Clinical decision support implementation by error type was found to differ significantly between sites, ranging from 0% to 88% across clinical contraindication, dose/frequency, drug interactions and other error types (p < 0.001). Overall, 43 out of 78 (55%) of the errors had some degree of clinical decision support implemented in at least one of the hospitals. …”
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2444 Development of an instrument to identify factors influencing point of care recruitment in primary care settings: A pilot study at University of Utah Health by Teresa Taft, Charlene Weir, Heidi Kramer, Julio Facelli

“…Perceived information needs regarding trials that providers are referring patients to included: trial purpose, design, benefits and risks, potential side effects, intervention details, medication class (mechanism of action), drug interactions with study drug, study timeline, coordinator contact information, link to print off patient handouts, enrollment instructions, and a link to study website. (2) It’s just we don’t know any of the information ... and it can’t take any of our time. ... …”
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The Effect of Adding Ondansetron and Metoclopramide to Intravenous Acetaminophen on Pain Control and Post-operative Nausea and Vomiting: A Randomized Double-blind Clinical Trial by Mohsen Saber Moghaddamranjbar, Amir Zoka, Jamshid Jamali

“…Moreover, since postoperative nausea and vomiting (PONV) is the other complaints of these patients, it is important to adopt measures to address this issue (1-5).Today, acetaminophen is one of the most widely used analgesics due to its efficacy, safety, low side effects, and rare drug interactions (5, 6). Acetaminophen has different mechanism of actions that some of them have not been identified yet. …”
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