Showing 381 - 400 results of 2,974 for search '"drug interaction"', query time: 0.20s Refine Results
  1. 381

    A dual graph neural network for drug-drug interactions prediction based on molecular structure and interactions. by Mei Ma, Xiujuan Lei

    Published 2023-01-01
    “…Second, in order to improve the final features, we separated the drug-drug interactions into pairwise interactions between each drug's unique substructures. …”
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    Critical role of growth medium for detecting drug interactions in Gram-negative bacteria that model in vivo responses by Kathleen P. Davis, Yoelkys Morales, Rachel J. Ende, Ryan Peters, Anne L. McCabe, Joan Mecsas, Bree B. Aldridge

    Published 2024-03-01
    “…Here, we tested the hypothesis that drug-drug interactions vary in different media, and determined which in vitro models best predict drug interactions in the lungs. …”
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  4. 384

    A dual graph neural network for drug–drug interactions prediction based on molecular structure and interactions by Mei Ma, Xiujuan Lei

    Published 2023-01-01
    “…Author summary Drug-drug interactions (DDIs) may cause adverse effects that damage the body. …”
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    Investigation of pharmacokinetic drug interaction between clesacostat and DGAT2 inhibitor ervogastat in healthy adult participants by Aarti Sawant‐Basak, Arthur J. Bergman, Jessica Mancuso, Sakambari Tripathy, James R. Gosset, Laure Mendes da Costa, William P. Esler, Roberto A. Calle

    Published 2024-02-01
    “…Cumulative safety and no clinically meaningful PK drug interactions observed in this study supported co‐administration of these two novel agents in additional studies exploring efficacy and safety in the management of NAFLD.…”
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    Potential Cytochrome P450 Drug-Drug Interaction Among Adult and Adolescent Patients Undergoing Tonsillectomy by Sai Nimmagadda, Stephanie Jung-ying Wong MD, Madlin Faria PharmD, Paul Allen PhD, John Faria MD

    Published 2020-06-01
    “…Objective To assess the frequency of potential drug-drug interactions affecting cytochrome P450 (CYP)–mediated metabolism of opioids among adult and adolescent patients who underwent adenotonsillectomy. …”
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  14. 394

    Importance of Therapeutic Drug Monitoring to Detect Drug Interaction between Pazopanib and Warfarin: A Case Report by Shinya Takasaki, Hisanobu Adachi, Yoshihide Kawasaki, Masafumi Kikuchi, Akihiro Ito, Nariyasu Mano

    Published 2020-05-01
    “…In this case, blood levels of pazopanib were abnormally high, possibly causing liver dysfunction and drug interactions, leading to his PT-INR prolongation. …”
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  15. 395

    Evaluation of the drug–drug interaction potential of brigatinib using a physiologically‐based pharmacokinetic modeling approach by Michael J. Hanley, Karen Rowland Yeo, Meera Tugnait, Shinji Iwasaki, Narayana Narasimhan, Pingkuan Zhang, Karthik Venkatakrishnan, Neeraj Gupta

    Published 2024-04-01
    “…In vitro studies indicated that brigatinib is primarily metabolized by CYP2C8 and CYP3A4 and inhibits P‐gp, BCRP, OCT1, MATE1, and MATE2K. Clinical drug–drug interaction (DDI) studies with the strong CYP3A inhibitor itraconazole or the strong CYP3A inducer rifampin demonstrated that CYP3A‐mediated metabolism was the primary contributor to overall brigatinib clearance in humans. …”
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