Neuroblastoma and its targets therapies: a medicinal chemistry review by Gerges, Amgad, Canning, Una

“…It concludes by proposing that future medicinal chemistry research into NB should consider other possible target therapies and adopt a multi‐target drug approach rather than a one‐drug‐one‐target approach for improved efficacy and less drug‐drug interaction for the treatment of NB Stage 4 (NBS4) patients.…”
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Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase. by Roelofs, A, Edwards, C, Russell, R, Ebetino, F, Rogers, M, Hulley, P

“…We conclude that the synergistic drug interaction results from an enhancement by apomine of the effects of lovastatin, mediated by down-regulation of HMG-CoA reductase by apomine. …”

Pharmacometric and electrocardiographic evaluation of chloroquine and azithromycin in healthy volunteers by Chotsiri, P, Tarning, J, Hoglund, RM, Watson, JA, White, NJ

“…Chloroquine and azithromycin pharmacokinetics were described satisfactorily by two- and three-compartment distribution models, respectively. No drug–drug interaction between chloroquine and azithromycin was observed. …”

A phase 1b study of glasdegib + azacitidine in patients with untreated acute myeloid leukemia and higher-risk myelodysplastic syndromes by Sekeres, MA, Schuster, M, Joris, M, Krauter, J, Maertens, J, Breems, D, Gyan, E, Kovacsovics, T, Verma, A, Vyas, P, Wang, ES, Ching, K, O'Brien, T, Gallo Stampino, C, Ma, WW, Kudla, A, Chan, G, Zeidan, AM

“…In the LIC, the safety profile of glasdegib + azacitidine was determined to be consistent with those of glasdegib or azacitidine alone, with no evidence of drug–drug interaction. In the expansion cohort, the most frequently (≥ 10%) reported non-hematologic Grade ≥ 3 treatment-emergent adverse events were decreased appetite, electrocardiogram QT prolongation, and hypertension in the AML cohort and sepsis, diarrhea, hypotension, pneumonia, and hyperglycemia in the MDS cohort. …”

Ex vivo activity of histone deacetylase inhibitors against multidrug-resistant clinical isolates of Plasmodium falciparum and P. vivax. by Marfurt, J, Chalfein, F, Prayoga, P, Wabiser, F, Kenangalem, E, Piera, K, Fairlie, D, Tjitra, E, Anstey, N, Andrews, K, Price, R

“…Further studies optimizing the selectivity and in vivo efficacy of HDAC inhibitors in Plasmodium spp. and defining drug interaction with common antimalarial compounds are warranted to investigate the role of HDAC inhibitors in antimalarial therapy.…”

Itraconazole-induced Torsade de Pointes in a patient receiving methadone substitution therapy by Robson, N.Z., Vicknasingam, B., Narayanan, S.

“…This cardiac arrhythmia was most likely as a result of a drug interaction between methadone and itraconazole because the patient presented with no other risk factors. …”
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Management of tuberculosis and latent tuberculosis infection in human immunodeficiency virus-infected persons by Lee, S.S., Meintjes, G., Kamarulzaman, A., Leung, C.C.

“…Treatment of TB/HIV co-infection involves the concurrent use of standard antiretrovirals and antimycobacterials during which harmful drug interaction may occur. The pharmacokinetic interaction between rifamycin and antiretrovirals is a case in point, requiring dosage adjustment and preferential use of rifabutin, if available. …”
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Cloning and expression of CYP2D6*1 and CYP2D6*10 and its application in vitro drug-herbs interaction studies by Lee, Wee Leng

“…There is lack of data on local herbal-drug interaction. The objective of this study was to generate an in vitro drug-herbs int1eraction assay and use it to analyse local herb interaction. …”
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Modulation of cytochrome P450s by strobilanthes crispus anticancer sub-fraction and its potential interaction with tamoxifen metabolism by Fen, Yong Ya

“…The anticancer property of Strobilanthes crispus (S. crispus) suggests its potential benefit as an adjuvant in breast cancer treatment. Potential herb-drug interaction (HDI) has always been a safety concern in pharmacotherapy as alteration in cytochrome P450 (CYP) mediated metabolism may lead to treatment failure and toxicity. …”
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Effects of Pharmacogenomic Testing in Clinical Pain Management: Retrospective Study by Christian Tagwerker, Mary Jane Carias-Marines, David J Smith

“…MethodsA PGx panel is described, encompassing 23 genes and 141 single-nucleotide polymorphisms or indels, combined with PGx dosing guidance and drug-gene interaction (DGI) and drug-drug interaction (DDI) reporting to prevent adverse drug reactions (ADRs). …”
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ClueReader: Heterogeneous Graph Attention Network for Multi-Hop Machine Reading Comprehension by Peng Gao, Feng Gao, Peng Wang, Jian-Cheng Ni, Fei Wang, Hamido Fujita

“…Evaluations on the open-domain multi-hop reading dataset <span style="font-variant: small-caps;">WikiHop</span> and drug–drug interaction dataset <span style="font-variant: small-caps;">MedHop</span> proved the validity of <i>ClueReader</i> and showed the feasibility of its application of the model in the molecular biology domain.…”
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GDF10 and IDO1 as a thyroid cancer prognostic biomarker associated with immune infiltration by Zhao-bao Lv, Jun-jing Zhang, Cheng Xiang

“…Finally, the hub gene and the immunity checkpoint-miRNA (or transcription factor, drug) interaction network were constructed. A drug-sensitive analysis also was performed. …”
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General practitioners' attitudes and preparedness towards Clinical Decision Support in e-Prescribing (CDS-eP) adoption in the West of Ireland: a cross sectional study by O'Brien Timothy, Murphy Andrew W, O'Donnell James M, Hor Chee, Kropmans Thomas JB

“…Lack of a strategic implementation plan (78%) is the main perceived barrier to the incorporation of CDS-eP into clinical practice, followed by i) lack of financial incentives (70%), ii) lack of standardized product software (61%), iii) high sensitivity of drug-drug interaction or medication allergy markers (46%), iv) concern about overriding physicians' prescribing decisions(44%) and v) lack of convincing evidence on the systems' effectiveness (22%).…”
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Are HIV positive patients resistant to statin therapy? by Bennett Matthew T, Johns Kevin W, Bondy Gregory P

“…Rosuvastatin is effective at lowering LDL and poses a low risk for drug-drug interaction as it does not share the same metabolic pathway as HAART drugs. …”
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Development and Evaluation of a Physiologically Based Pharmacokinetic Model for Predicting Haloperidol Exposure in Healthy and Disease Populations by Mohammed S. Alasmari, Fawaz Alasmari, Abdullah F. Alasmari, Aws Alshamsan, Sary Alsanea, Muhammad F. Rasool, Faleh Alqahtani

“…After evaluating the developed PBPK model in healthy adults, it was used to predict haloperidol–rifampicin drug–drug interaction and was extended to tuberculosis patients. …”
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A comprehensive medication review of a polypharmacy patient population: A cross-sectional observational study by Frantzeska Nimee, James Steier, Georgios Papandreou, Maria Skouroliakou

“…A total of 172 DRPs were observed in the study population. 75.6% of all DRPs were classified as drug-drug interaction problems, with a mean of 1.42 identified drug-drug interactions per study subject. …”
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Effect of itraconazole and fluconazole on the pharmacokinetics of valemetostat: An open‐label, phase I study in healthy subjects by Masaya Tachibana, Shunji Matsuki, Yutaro Maekawa, Kana Kuroda, Takako Shimizu, Junko Tsutsumi, Hitoshi Ishizuka

“…Itraconazole and fluconazole are antifungal medications often used as typical inhibitors of cytochrome P450 3A (CYP3A [itraconazole and fluconazole]) and P‐glycoprotein (P‐gp [itraconazole]) in drug–drug interaction studies. Valemetostat is a substrate of CYP3A and P‐gp in vitro. …”
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Selected cytostatic drugs in the treatment of brain glioma – literature review by Jarosław Bała, Kinga Mitruczuk, Natalia Walo, Paula Wróblewska-Łuczka

“…Summary The latest results of drug interaction studies confirm the need for further research into combination therapy regimens using both newl-discovered therapeutics and combinations of already known drugs.…”
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The Effects of Polyphenol, Tannic Acid, or Tannic Acid in Combination with Pamidronate on Human Osteoblast Cell Line Metabolism by Hermizi Hapidin, Nor Munira Hashim, Mohamad Zahid Kasiram, Hasmah Abdullah

“…The combination index value was utilized to analyze the degree of drug interaction, while trypan blue assay was applied to analyze the cells proliferation effect. …”
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Hospital information system-based pharmacovigilance for elderly patients: practices and results by Nan Zhou, Zhiyuan Fang, Dong Liang, Jiangping Lian, Huan Han, Rui Li

“…Number of medication risk assessment entries, number of intervened medical orders on outpatients and inpatients number of medical order prompts, and number of physician communication with prescription-checking pharmacists were noted. Potential drug interaction rate was compared between pre- implementation from May to October 2020 and post-implementation from November 2020 to April 2021. …”
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