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1461
Toward Unified AI Drug Discovery with Multimodal Knowledge
Published 2024-01-01“…KEDD outperforms state-of-the-art models by an average of 5.2% on drug–target interaction prediction, 2.6% on drug property prediction, 1.2% on drug–drug interaction prediction, and 4.1% on protein–protein interaction prediction. …”
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1462
Segurança do doente: potenciais interações medicamentosas favorecidas pela sobreposição de medicamentos programados pelo enfermeiro
Published 2020-08-01“…As potenciais interações medicamentosas foram identificadas por meio da ferramenta Drug Interaction Checker (Medscape®). Resultados: Foram analisadas 3066 doses, com concentração de 4 horários, evidenciando uma padronização institucional de horários. …”
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1463
Effect of verapamil on systemic exposure and safety of umeclidinium and vilanterol: a randomized and open-label study
Published 2013-03-01“…The UMEC/VI combination is unlikely to have a clinically meaningful drug–drug interaction with moderate P-glycoprotein transporter and CYP3A4 inhibitor drugs. …”
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1464
Hyperkalemia, self-medication, and over-the-counter drug usage in patients with cardiovascular disease in the perspective of polypragmasy
Published 2023-06-01“…Multiple drug combinations were observed, and self-medication rates were very high, which should be reduced substantially to obtain a more successful pharmacotherapy and a reduced drug interaction-induced side effect.…”
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1465
Sensitization of MCF7 Cells with High Notch1 Activity by Cisplatin and Histone Deacetylase Inhibitors Applied Together
Published 2021-05-01“…The type of drug–drug interaction between CDDP and HDIs was determined by isobolographic analysis. …”
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1466
Exploring inter-ethnic and inter-patient variability and optimal dosing of osimertinib: a physiologically based pharmacokinetic modeling approach
Published 2024-03-01“…And then the PBPK models were validated using the multiple clinical PK and drug-drug interaction (DDI) study data.Results: The model demonstrated good consistency with the observed data, with most of prediction-to-observation ratios of 0.8–1.25 for AUC, Cmax, and Ctrough. …”
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1467
The antidiabetic effect of methanolic extract of Holarrhena pubescens seeds is mediated through multiple mechanisms of action
Published 2023-06-01“…Its potential for herb-drug interaction was evaluated in the cytochrome P450 3A4 (CYP3A4) inhibition assay. …”
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1468
Topical Issues of Drug Safety, Possibilities of Improving of Pharmacovigilance
Published 2019-09-01“…The expediency of using a scale for determining the degree of reliability of a causal relationship «an undesirable reaction — drug interaction» when analyzing spontaneous reports of undesirable reactions that may be caused by drug interactions is noted. …”
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1469
Appropriateness of Proton Pump Inhibitor Use in Hospitalized Patients: A Cross Sectional Study in a Tertiary Care Hospital in North India
Published 2023-07-01“…The inappropriate use of PPIs leads to an increased risk of adverse effects, drug interaction, and unnecessary hospital expenditure for such patients. …”
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1470
FKBP5 blockade may provide a new horizon for the treatment of stress‐associated disorders: An in‐silico study
Published 2023-06-01“…Methods Several databases were used to find all the approved drugs that potentially have interactions with FKBP51 protein [ie, CTD gene‐chemical interaction section of FKBP51 protein of Harmonizome of Mayaanlab, DrugCenteral database, PDID (Protein Drug Interaction Database), DGIdb (the Drug Gene Interaction database)]. …”
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1471
Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration
Published 2011-09-01“…Rectal AS administration yields pharmacokinetic results similar to those obtained from oral administration, with the exceptions of delayed AS Cmax and longer AS half-life. Drug interaction studies conducted with oral AS suggest that AS does not appreciably alter the pharmacokinetics of atovaquone/proguanil, chlorproguanil/dapsone, or sulphadoxine/pyrimethamine, and mefloquine and pyronaridine do not alter the pharmacokinetics of DHA. …”
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1472
Hospitalisations Related to the Combination of ACE Inhibitors and/or Angiotensin Receptor Blockers with Diuretics and NSAIDs: A Post Hoc Analysis on the Risks Associated with Tripl...
Published 2023-01-01“…In this subset, drug–drug interaction contributed to kidney injury. Most patients presented a Charlson comorbidity index of 4–5. …”
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1473
Medication concepts, records, and lists in electronic medical record systems
Published 2007Get full text
Thesis -
1474
EVALUASI PENGGUNAAN METAMIZOL PADA BEBERAPA TEMPAT PELAYANAN FARMASI DI KABUPATEN CILACAP
Published 2011“…Objective : The study aimed to evaluate use of metamizole in some pharmacies in Kabupaten Cilacap, find out uses, indications, adverse drug reaction and drug interaction with metamizole. Methode : This was a prospective study which use questioner form and interview to those subjects. …”
Thesis -
1475
Activity of ivermectin and its metabolites against asexual blood stage Plasmodium falciparum and its interactions with antimalarial drugs
Published 2023“…Potential pharmacodynamic drug-drug interactions of ivermectin with artemisinins, ACT-partner drugs, and atovaquone were studied <em>in vitro</em> using mixture assays providing isobolograms and derived fractional inhibitory concentrations. …”
Journal article -
1476
Phase I dose escalation study of Linsitinib (OSI-906) and Erlotinib in patients with advanced solid tumors
Published 2016“…There was no evidence of drug-drug interaction. Pharmacodynamic data showed IGF-1 elevation and reduced IGF-1R/INSR phosphorylation, suggesting pathway inhibition. …”
Journal article -
1477
Effects of cytochrome P450 (CYP) 2D6 inhibitions in in vivo toxicity studies of mitragynine
Published 2017“…In our study, the effects of CYP2D6 on mitragynine’s metabolism and drug-drug interaction (DDI)-induced toxicity were investigated intensively using quinidine, a CYP2D6 inhibitor. …”
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Conference or Workshop Item -
1478
Evaluation of the effects of mitragyna speciosa alkaloid extract on cytochrome P450 enzymes using a high throughput assay
Published 2011“…This study shows that MSE may contribute to an herb-drug interaction if administered concomitantly with drugs that are substrates for CYP3A4, CYP2D6 and CYP1A2.…”
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1479
Role of OATP4C1 in Renal Handling of Remdesivir and its Nucleoside Analog GS-441524: The First Approved Drug for Patients with COVID-19
Published 2021-05-01“…Furthermore, we evaluated the potential drug interaction via OATP4C1 by calculating the Ki value of remdesivir. …”
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1480
The inhibitory and inducing effects of ritonavir on hepatic and intestinal CYP3A and other drug-handling proteins
Published 2023-06-01“…This might result in a more favorable drug-drug interaction profile compared to ritonavir, although the actual benefit appears to be limited. …”
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