Toward Unified AI Drug Discovery with Multimodal Knowledge by Yizhen Luo, Xing Yi Liu, Kai Yang, Kui Huang, Massimo Hong, Jiahuan Zhang, Yushuai Wu, Zaiqing Nie

“…KEDD outperforms state-of-the-art models by an average of 5.2% on drug–target interaction prediction, 2.6% on drug property prediction, 1.2% on drug–drug interaction prediction, and 4.1% on protein–protein interaction prediction. …”
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Segurança do doente: potenciais interações medicamentosas favorecidas pela sobreposição de medicamentos programados pelo enfermeiro by Andressa Aline Bernardo Bueno, Célia Pereira Caldas, Flavia Giron Camerini, Cintia Silva Fassarella, Aline Affonso Luna

“…As potenciais interações medicamentosas foram identificadas por meio da ferramenta Drug Interaction Checker (Medscape®). Resultados: Foram analisadas 3066 doses, com concentração de 4 horários, evidenciando uma padronização institucional de horários. …”
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Effect of verapamil on systemic exposure and safety of umeclidinium and vilanterol: a randomized and open-label study by Mehta R, Kelleher D, Preece A, Hughes S, Crater G

“…The UMEC/VI combination is unlikely to have a clinically meaningful drug–drug interaction with moderate P-glycoprotein transporter and CYP3A4 inhibitor drugs. …”
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Hyperkalemia, self-medication, and over-the-counter drug usage in patients with cardiovascular disease in the perspective of polypragmasy by Bán Erika-Gyöngyi, Simon-Szabó Zsuzsánna, Dho-Nagy Eszter-Anna, Lechsner Patrick

“…Multiple drug combinations were observed, and self-medication rates were very high, which should be reduced substantially to obtain a more successful pharmacotherapy and a reduced drug interaction-induced side effect.…”
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Sensitization of MCF7 Cells with High Notch1 Activity by Cisplatin and Histone Deacetylase Inhibitors Applied Together by Anna Wawruszak, Jarogniew Luszczki, Marta Halasa, Estera Okon, Sebastian Landor, Cecilia Sahlgren, Adolfo Rivero-Muller, Andrzej Stepulak

“…The type of drug–drug interaction between CDDP and HDIs was determined by isobolographic analysis. …”
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Exploring inter-ethnic and inter-patient variability and optimal dosing of osimertinib: a physiologically based pharmacokinetic modeling approach by Feng Liang, Yimei Zhang, Qian Xue, Na Yao

“…And then the PBPK models were validated using the multiple clinical PK and drug-drug interaction (DDI) study data.Results: The model demonstrated good consistency with the observed data, with most of prediction-to-observation ratios of 0.8–1.25 for AUC, Cmax, and Ctrough. …”
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The antidiabetic effect of methanolic extract of Holarrhena pubescens seeds is mediated through multiple mechanisms of action by AbdulRahman A I Alyahya, Mohammed Asad, Mohammed Sanad Alhussaini, Kamal Eldin Ahmed Abdelsalam, Essa Awad Alenezi

“…Its potential for herb-drug interaction was evaluated in the cytochrome P450 3A4 (CYP3A4) inhibition assay. …”
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Topical Issues of Drug Safety, Possibilities of Improving of Pharmacovigilance by M. V. Zhuravleva, B. K. Romanov, G. I. Gorodetskaya, O. V. Muslimova, V. S. Krysanova, E. Yu. Demchenkova

“…The expediency of using a scale for determining the degree of reliability of a causal relationship «an undesirable reaction — drug interaction» when analyzing spontaneous reports of undesirable reactions that may be caused by drug interactions is noted. …”
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Appropriateness of Proton Pump Inhibitor Use in Hospitalized Patients: A Cross Sectional Study in a Tertiary Care Hospital in North India by Shivani Juneja, Proteesh Rana, Sreehari V Manoj, Rohit Kalia, Ratinder Pal Singh

“…The inappropriate use of PPIs leads to an increased risk of adverse effects, drug interaction, and unnecessary hospital expenditure for such patients. …”
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FKBP5 blockade may provide a new horizon for the treatment of stress‐associated disorders: An in‐silico study by Ali A. Asadi‐Pooya, Mahdi Malekpour, Bardia Zamiri, Mohammad Kashkooli, Negar Firouzabadi

“…Methods Several databases were used to find all the approved drugs that potentially have interactions with FKBP51 protein [ie, CTD gene‐chemical interaction section of FKBP51 protein of Harmonizome of Mayaanlab, DrugCenteral database, PDID (Protein Drug Interaction Database), DGIdb (the Drug Gene Interaction database)]. …”
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Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration by Shin Chang-Sik, Jung Donald, Borghini-Fuhrer Isabelle, Duparc Stephan, Morris Carrie A, Fleckenstein Lawrence

“…Rectal AS administration yields pharmacokinetic results similar to those obtained from oral administration, with the exceptions of delayed AS Cmax and longer AS half-life. Drug interaction studies conducted with oral AS suggest that AS does not appreciably alter the pharmacokinetics of atovaquone/proguanil, chlorproguanil/dapsone, or sulphadoxine/pyrimethamine, and mefloquine and pyronaridine do not alter the pharmacokinetics of DHA. …”
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Hospitalisations Related to the Combination of ACE Inhibitors and/or Angiotensin Receptor Blockers with Diuretics and NSAIDs: A Post Hoc Analysis on the Risks Associated with Tripl... by Irene Mattioli, Alessandra Bettiol, Giada Crescioli, Roberto Bonaiuti, Guido Mannaioni, Alfredo Vannacci, Niccolò Lombardi

“…In this subset, drug–drug interaction contributed to kidney injury. Most patients presented a Charlson comorbidity index of 4–5. …”
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Medication concepts, records, and lists in electronic medical record systems by Chang, Jaime

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EVALUASI PENGGUNAAN METAMIZOL PADA BEBERAPA TEMPAT PELAYANAN FARMASI DI KABUPATEN CILACAP by , Marina Kurniawati, , Prof. Dr. Zullies Ikawati, Apt.

“…Objective : The study aimed to evaluate use of metamizole in some pharmacies in Kabupaten Cilacap, find out uses, indications, adverse drug reaction and drug interaction with metamizole. Methode : This was a prospective study which use questioner form and interview to those subjects. …”

Activity of ivermectin and its metabolites against asexual blood stage Plasmodium falciparum and its interactions with antimalarial drugs by Yipsirimetee, A, Tipthara, P, Hanboonkunupakarn, B, Tripura, R, Lek, D, Kümpornsin, K, Lee, MCS, Sattabongkot, J, Dondorp, AM, White, NJ, Kobylinski, KC, Tarning, J, Chotivanich, K

“…Potential pharmacodynamic drug-drug interactions of ivermectin with artemisinins, ACT-partner drugs, and atovaquone were studied&nbsp;<em>in vitro</em>&nbsp;using mixture assays providing isobolograms and derived fractional inhibitory concentrations. …”

Phase I dose escalation study of Linsitinib (OSI-906) and Erlotinib in patients with advanced solid tumors by Macaulay, V, Middleton, M, Eckhardt, S, Rudin, C, Juergens, R, Gedrich, R, Gogov, S, McCarthy, S, Poondru, S, Stephens, A, Gadgeel, S

“…There was no evidence of drug-drug interaction. Pharmacodynamic data showed IGF-1 elevation and reduced IGF-1R/INSR phosphorylation, suggesting pathway inhibition. …”

Effects of cytochrome P450 (CYP) 2D6 inhibitions in in vivo toxicity studies of mitragynine by Chik, Z.

“…In our study, the effects of CYP2D6 on mitragynine’s metabolism and drug-drug interaction (DDI)-induced toxicity were investigated intensively using quinidine, a CYP2D6 inhibitor. …”
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Evaluation of the effects of mitragyna speciosa alkaloid extract on cytochrome P450 enzymes using a high throughput assay by Kong, W.M., Chik, Z., Ramachandra, M., Subramaniam, U., Aziddin, R.E.R., Mohamed, Z.

“…This study shows that MSE may contribute to an herb-drug interaction if administered concomitantly with drugs that are substrates for CYP3A4, CYP2D6 and CYP1A2.…”
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Role of OATP4C1 in Renal Handling of Remdesivir and its Nucleoside Analog GS-441524: The First Approved Drug for Patients with COVID-19 by Toshihiro Sato, Masamitsu Maekawa, Nariyasu Mano, Takaaki Abe, Hiroaki Yamaguchi

“…Furthermore, we evaluated the potential drug interaction via OATP4C1 by calculating the Ki value of remdesivir. …”
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The inhibitory and inducing effects of ritonavir on hepatic and intestinal CYP3A and other drug-handling proteins by Nancy H.C. Loos, Jos H. Beijnen, Alfred H. Schinkel

“…This might result in a more favorable drug-drug interaction profile compared to ritonavir, although the actual benefit appears to be limited. …”
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