Evaluation of the pharmacokinetics of trazpiroben (TAK‐906) in the presence and absence of the proton pump inhibitor esomeprazole by Jatinder Kaur Mukker, George Dukes, Lisi Wang, Susanna Huh, Polyna Khudyakov, Mitsuhiro Nishihara, Chunlin Chen

“…The lack of evidence of any clinically meaningful drug–drug interaction supports the co‐administration of esomeprazole with trazpiroben.…”
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Physiologically based pharmacokinetic modeling for development and applications of a virtual celiac disease population using felodipine as a model drug by Farzaneh Salem, Ali Nimavardi, Jennypher Mudunuru, Debra Tompson, Jackie Bloomer, David B. Turner, Kunal S. Taskar

“…Therefore, exposure to CYP3A4 substrates and extent of drug interactions is altered. A physiologically‐based pharmacokinetic (PBPK) population for different severities of CeD was developed. …”
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Safety and Efficacy of Direct Antiviral Agents for Hepatitis C in Patients with Malignancies Other Than Liver Cancer: A Case Series by Fabian Patauner, Maria Stanzione, Gianfranca Stornaiuolo, Veronica Martone, Roberta Palladino, Nicola Coppola, Emanuele Durante-Mangoni, Rosa Zampino

“…DAA treatment was well tolerated; no patients had to stop DAA treatment or showed any adverse event or drug-drug interaction specifically attributable to DAAs. (4) Conclusions: DAA treatment should be promptly offered to oncologic patients with chronic hepatitis C in order to achieve aminotransferase normalization and viremia control, making antineoplastic therapy feasible and safe.…”
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Evaluation of the potential impact on pharmacokinetics of various cytochrome P450 substrates of increasing IL‐6 levels following administration of the T‐cell bispecific engager glo... by Nassim Djebli, Neil Parrott, Felix Jaminion, Amaury O'Jeanson, Elena Guerini, David Carlile

“…Consideration may be given for potential drug–drug interaction during the first cycle in patients who are receiving concomitant CYP substrates with a narrow therapeutic index via monitoring for toxicity or for drug concentrations.…”
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Protease Inhibitory Effect of Natural Polyphenolic Compounds on SARS-CoV-2: An In Silico Study by Rajveer Singh, Anupam Gautam, Shivani Chandel, Arijit Ghosh, Dhritiman Dey, Syamal Roy, Velayutham Ravichandiran, Dipanjan Ghosh

“…Further predictions for these compounds also showed no involvement in drug-drug interaction and no toxicity.…”
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Phytochemical Profile and Chemopreventive Properties of Cooked Glutinous Purple Rice Extracts Using Cell-Based Assays and Rat Model by Huina Guo, Arpamas Chariyakornkul, Warunyoo Phannasorn, Sugunya Mahatheeranont, Rawiwan Wongpoomchai

“…In summary, the methanol extract of the cooked glutinous purple rice might be a promising cancer chemopreventive fraction, which was neither genotoxic nor posing adverse effects on phytochemical–drug interaction in rats.…”
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Case Report: Performing a Medication Safety Review Assisted by Pharmacogenomics to Explain a Prescribing Cascade Resulting in a Patient Fall by Joshua Russell, Meghan J. Arwood, Nicole M. Del Toro-Pagán, Nishita S. Amin, Michele D. Cambridge, Jacques Turgeon, Veronique Michaud

“…This case report also illustrates how a more timely multi-drug interaction assessment (preferably in conjunction with preemptive PGx testing) may have informed a different prescribing pattern, reduced/avoided a prescribing cascade, and potentially prevented a drug-related fall.…”
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OntoPharma: ontology based clinical decision support system to reduce medication prescribing errors by Elena Calvo-Cidoncha, Concepción Camacho-Hernando, Faust Feu, Xavier Pastor-Duran, Carles Codina-Jané, Raimundo Lozano-Rubí

“…An advisory board selected four use cases: maximum dosage alert, drug-drug interaction checker, renal failure adjustment, and drug allergy checker. (2) Implementing the ontology in a formal representation. …”
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In vitro metabolic characterization of the SARS-CoV-2 papain-like protease inhibitors GRL0617 and HY-17542 by Hyunki Cho, Hyunki Cho, Young Jun Kim, Jung-Woo Chae, Markus R. Meyer, Sang Kyum Kim, Chang Seon Ryu

“…The hepatic cytochrome P450 (CYP) isoforms responsible for their metabolism were identified using recombinant enzymes. The drug–drug interaction potential mediated by cytochrome P450 inhibition was estimated. …”
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PXR Suppresses PPARα-Dependent <i>HMGCS2</i> Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α by Ryota Shizu, Kanako Ezaki, Takumi Sato, Ayaka Sugawara, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari

“…Drug-induced activation of PXR sometimes causes drug–drug interactions due to the induced metabolism of co-administered drugs. …”
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Main Approaches to Assessing the Quality of Drug Therapy in Cardiology by S. Yu. Martsevich, N. P. Kutishenko, Yu. V. Lukina, N. A. Komkova, N. A. Dmitrieva, O. A. Drapkina

“…On the other hand, one should remember the so-called "drug-related problems" (DRP), which include contraindications to the prescription of certain drugs in a particular patient, the possibility of developing side effects of drug therapy, aggravated by polypharmacy, inter-drug interaction, improper dosage of drugs, etc.In this publication, an attempt is made to identify the main components by which the quality of the prescribed therapy can be evaluated in the treatment of cardiovascular diseases: compliance of prescriptions with official instructions for preparations, modern clinical guidelines, adequate selection of a specific drug within the class, drug formulation, salt of the drug, evaluation of important safety parameters and efficacy of the prescribed drug. …”
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Protective Role of St. John’s Wort and Its Components Hyperforin and Hypericin against Diabetes through Inhibition of Inflammatory Signaling: Evidence from In Vitro and In Vivo Stu... by Michela Novelli, Pellegrino Masiello, Pascale Beffy, Marta Menegazzi

“…Careful quantitative analysis of SJW components and suitable dosage, with monitoring of possible drug–drug interaction in a context of remarkable tolerability, are easily achievable pre-requisites for forthcoming clinical applications.…”
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Challenges in drug discovery and description targeting Leishmania spp.: enzymes, structural proteins, and transporters by Alexis Mendoza-León, María Luisa Serrano G., Alicia Ponte-Sucre

“…The activities of ABC-Transporters are related to the main causes of drug resistance, and the collected evidence suggests that for the ABC-Transporter blocker glibenclamide, there is a: (1) differential susceptibility of Leishmania spp. vs. macrophages; (2) greater susceptibility of axenic amastigotes vs. promastigotes; and (3) glibenclamide-glucantime synergistic drug interaction in macrophage-infected cells. Herein, we discuss the potential value of designing ABC-Transporter blockers for combination therapy in the treatment of leishmaniasis. …”
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A gap between acceptance and knowledge of herbal remedies by physicians: The need for educational intervention by Fortuné Maurice, Bhola Savrina, Bernard Tricia, Khan Kristi, Williams Arlene F, Clement Yuri N, Medupe Oneil, Nagee Kerry, Seaforth Compton E

“…This raises important public health concerns, especially as it relates to safety issues including adverse effects and herb-drug interactions. Most Western-trained physicians are ignorant of the risks and benefits of this healthcare modality and assessment of acceptance and knowledge would identify appropriate intervention strategies to improve physician-patient communication in this area.…”
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In vivo efficacy of pitavastatin combined with itraconazole against Aspergillus fumigatus in silkworm models by Hidetaka Majima, Teppei Arai, Katsuhiko Kamei, Akira Watanabe

“…As opposed to most statins, PIT has little drug–drug interaction with azoles in humans and can be used safely with ITC. …”
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Novel drug-repository contact lens for prolonging the antimicrobial-cornea interaction for bacterial keratitis treatment: randomised controlled trial results by Lional Raj Daniel Raj Ponniah, Velupillai Ranilakshmi, Heber Anandan, Jeyakumar Caroline, Antonysamy Arulanandham

“…The lens was designed to increase the corneal lesion-antimicrobial drug interaction time.Methods Patients with BK were randomised (1:1) into two groups: topical antimicrobial treatment only (group 1) and DDCL plus antimicrobial treatment (group 2). …”
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A comprehensive assessment of VCAN transcriptional expression and evaluation as an effective prognostic biomarker against breast cancer: in silico study by Md. Hasan Jafre Shovon, Dhrubo Ahmed Khan, Md. Mohaimenul Islam Tareq, Md. Imtiaz, Md Nazmul Hasan Zilani, Md. Nazmul Hasan

“…Five distinct compounds are linked to the methylation and mutagenesis of VCAN, according to the gene–drug interaction. Conclusions The upregulation of VCAN is closely correlated with promoter methylation and the clinical features of breast cancer patients. …”
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Identification and validation of differentially expressed genes for targeted therapy in NSCLC using integrated bioinformatics analysis by Reem Altaf, Umair Ilyas, Anmei Ma, Anmei Ma, Meiqi Shi

“…The system-level network showed important interactions between these genes, and the drug interaction network showed that these genes are affected by several types of chemicals that could serve as potential drug targets.ConclusionsThe study demonstrates the importance of systemic genetics in identifying potential drug- targeted therapies for NSCLC. …”
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Mannitol Polymorphs as Carrier in DPIs Formulations: Isolation Characterization and Performance by Ayça Altay Benetti, Annalisa Bianchera, Francesca Buttini, Laura Bertocchi, Ruggero Bettini

“…We concluded that, also for mannitol, the physicochemical properties stemming from different crystal structures represent a tool for modulating carrier-drug interaction and, in turn, aerosolization performance.…”
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Pharmacokinetics of Venetoclax Co-Administered with Posaconazole in Patients with Acute Myeloid Leukemia by Simona De Gregori, Eleonora Gelli, Mara Capone, Giulia Gambini, Elisa Roncoroni, Marianna Rossi, Claudia Patricia Tobar Cabrera, Gianluca Martini, Ludovica Calabretta, Luca Arcaini, Riccardo Albertini, Patrizia Zappasodi

“…The risk of fungal infection in the early phase of treatment is not negligible; therefore, posaconazole (PCZ) is commonly administered as primary prophylaxis. A drug–drug interaction between VEN and PCZ is well known, but the trend of serum levels of venetoclax when both drugs are overlapped is not clear. …”
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