Integrated bioinformatics to identify potential key biomarkers for COVID-19-related chronic urticaria by Teng Zhang, Hao Feng, Xiaoyan Zou, Shixiong Peng

“…Finally, the key gene-drug interaction network, including 84 possible therapeutical medicines, was developed, and their protein-protein docking might make this prediction more feasible.ConclusionsTo sum up, FCGR3A, TNF, and CCL3 might be potential biomarkers for COVID-19-related CU, and the common pathways and related molecules we explored in this study might provide new ideas for further mechanistic research.…”
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Dexamethasone mitigates remdesivir-induced liver toxicity in human primary hepatocytes and COVID-19 patients by Kaiyan Liu, Sydney Stern, Emily L. Heil, Linhao Li, Rula Khairi, Scott Heyward, Hongbing Wang

“…Human primary hepatocytes and HepG2 cells were used as in vitro models for toxicity and drug-drug interaction studies. Real-world data from hospitalized COVID-19 patients were analyzed for drug-induced elevation of serum ALT and AST. …”
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Synergistic Effect of β-Lapachone and Aminooxyacetic Acid on Central Metabolism in Breast Cancer by Mario C. Chang, Rohit Mahar, Marc A. McLeod, Anthony G. Giacalone, Xiumei Huang, David A. Boothman, Matthew E. Merritt

“…Differences in citrate, glutamate, and succinate fractional enrichments indicate synergistic effects on central metabolism based on the coefficient of drug interaction. Metabolic modeling suggests that increased glutamine anaplerosis is protective in the case of MAS inhibition.…”
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Deregulated FASN Expression in BRAF Inhibitor-Resistant Melanoma Cells Unveils New Targets for Drug Combinations by Serena Stamatakos, Giovanni Luca Beretta, Elisabetta Vergani, Matteo Dugo, Cristina Corno, Elisabetta Corna, Stella Tinelli, Simona Frigerio, Emilio Ciusani, Monica Rodolfo, Paola Perego, Laura Gatti

“…The expression of FASN was found to be inversely associated with drug resistance in BRAF-mutant cell lines, both in a set of six resistant/sensitive matched lines and in the Cancer Cell Line Encyclopedia. A favorable drug interaction in resistant cells was also observed with U18666 A inhibiting DHCR24, which increased upon FASN targeting. …”
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A Feasibility Study to Increase Chronic Hepatitis C Virus RNA Testing and Linkage to Care among Clients Attending Homeless Services in Amsterdam, The Netherlands by Ellen Generaal, Hilje Logtenberg van der Grient, Eberhard Schatz, Daniela K. van Santen, Anders Boyd, Sara K. Woods, Bert L. C. Baak, Maria Prins

“…Of these, five (71%) were linked to care, of whom four (57%, 4/7) initiated treatment and one (14%, 1/7) delayed treatment due to a drug–drug interaction. Of these four people, two completed treatment (50%), of whom one (25%) achieved sustained virologic response after 12 weeks. …”
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Adverse reaction signals mining and hemorrhagic signals comparison of ticagrelor and clopidogrel: A pharmacovigilance study based on FAERS by Shu Tang, Zhanshen Wu, Liqing Xu, Qiang Wen, Xiaojian Zhang

“…At the PT level, the more frequent ADR signals for ticagrelor were dyspnoea, contusion, and haemorrhage, while clopidogrel were gastrointestinal haemorrhage, anaemia, and drug interaction. The hemorrhagic signals of both were mainly focused on the SOC level of gastrointestinal disorders, injury disorders and vascular disorders and nervous system disorders. …”
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Screening and identification of genes related to ferroptosis in keratoconus by Xiaojun Wu, Qing Deng, Zhe Han, Feixue Ni, Daxi Sun, Yuxue Xu

“…Through further analysis, aldo–keto reductase family 1 member C3 (AKR1C3) was selected, and negatively correlated with mature CD56 natural killer (NK) cells and macrophages. Then, gene-drug interaction network analysis and miRNA prediction were performed through the website. …”
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Co-Delivery of CPT-11 and Panobinostat with Anti-GD2 Antibody Conjugated Immunoliposomes for Targeted Combination Chemotherapy by Gils Jose, Yu-Jen Lu, Jung-Tung Hung, Alice L. Yu, Jyh-Ping Chen

“…From in vitro cytotoxicity assay, CPT-11 showed synergism drug interaction with panobinostat to support co-delivery of both drugs with ImmuLipCP for targeted synergistic combination chemotherapy. …”
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Medication Administration through Enteral Feeding Tubes in Mechanically Ventilated Critically Ill Patients: Evaluation of the Potential Medication Errors by Mandana Izadpanah, Negin Amraie, Farhad Soltani, Leila Kouti, Sepideh Sayyadi, Maryam Aghakouchakzadeh, Maryam Hariri

“…Results:Errors occurred in percentage of total prescriptions as follows: Drug-drug interaction 26%, wrong preparation 22.28%, wrong form 12.09%, wrong time 11.57%, drug-food interaction 6.73%, wrong dose 5.53%, wrong route 3.8%, extra dose 0.86%, omission 0.18%, deteriorated drug 0.18%, and unordered drug 0.0%. …”
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Association of Pulmonary Sepsis and Immune Checkpoint Inhibitors: A Pharmacovigilance Study by Shuang Xia, Hui Gong, Yichang Zhao, Lin Guo, Yikun Wang, Bikui Zhang, Mayur Sarangdhar, Yoshihiro Noguchi, Miao Yan

“…We also detected drug interaction signals based on the Ω shrinkage measure. …”
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High-Throughput Metabolic Soft-Spot Identification in Liver Microsomes by LC/UV/MS: Application of a Single Variable Incubation Time Approach by Yanlin Zhu, Guiying Chen, Kerong Zhang, Chang Chen, Weiqing Chen, Mingshe Zhu, Hongliang Jiang

“…CYP-mediated fast metabolism may lead to poor bioavailability, fast drug clearance and significant drug interaction. Thus, metabolic stability screening in human liver microsomes (HLM) followed by metabolic soft-spot identification (MSSID) is routinely conducted in drug discovery. …”
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Could MRONJ Be Related to Osimertinib Monotherapy in Lung Cancer Patients after Denosumab Suspension? by Marta Forte, Antonio d’Amati, Luisa Limongelli, Massimo Corsalini, Gianfranco Favia, Giuseppe Ingravallo, Giuseppe Barile, Saverio Capodiferro

“…Also, this report could trigger in the scientific community the necessity to evaluate further guidelines for similar doubtful cases in which the drug interaction, the mono-suspension, and the possible removable prosthesis-related additional trauma should be considered causes or con-causes.…”
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Multifunctional lipid-based nanocarriers with antibacterial and anti‐inflammatory activities for treating MRSA bacteremia in mice by Chia-Chih Liao, Huang-Ping Yu, Shih-Chun Yang, Ahmed Alalaiwe, You-Shan Dai, Fu-Chao Liu, Jia-You Fang

“…The minimum bactericidal concentration of free ciprofloxacin against MRSA increased from 1.95 to 15.63 µg/ml when combined with rolipram, indicating a possible drug-drug interaction that reduced the antibacterial effect. …”
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Development and Validation of a Prognostic Classifier Based on Lipid Metabolism-Related Genes for Breast Cancer by Wang N, Gu Y, Li L, Chi J, Liu X, Xiong Y, Zhong C

“…Potential compounds targeting prognostic genes were screened by Connectivity Map (CMap) database and a prognostic gene-drug interaction network was constructed using Comparative Toxicogenomics Database (CTD). …”
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Recognition and Management of Serotonin Toxidrome in the Emergency Department—Case Based Review by Bianca Codrina Morarasu, Adorata Elena Coman, Cristina Bologa, Catalina Lionte, Ovidiu Rusalim Petris, Alexandr Ceasovschih, Victorita Sorodoc, Raluca Ecaterina Haliga, Gabriela Puha, Alexandra Stoica, Oana Sirbu, Mihai Constantin, Laurentiu Sorodoc

“…With an underestimated frequency, SS can develop following an overdose, a therapeutic dose increase, or drug to drug interaction of at least one serotonergic agent. It can present with autonomic signs, neuromuscular changes and an altered mental status. …”
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Effects of dietary butyrate supplementation and oral nonsteroidal anti-inflammatory drug administration on serum inflammatory markers and productivity of dairy cows during the calv... by L.E. Engelking, D.J. Ambrose, M. Oba

“…There was a supplement by drug interaction effect on plasma glucose concentration on d 4; in cows administered the placebo drug, butyrate supplementation decreased plasma glucose concentration compared with control-fed cows (62.8 vs. 70.1 mg/dL). …”
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Interações Medicamentosas na Farmacoterapia de Idosos com Câncer atendidos em um Ambulatório de Onco-Hematologia by Caroline de Oliveira Faria, Cristiane Moreira Reis, Andrezza Gouvêa Santos, Adriano Max Moreira Reis

“…Identificaram-se interações medicamentosas potenciais empregando o software Drug Interaction Checking. A regressão logística foi utilizada para determinar os fatores associados às interações medicamentosas potenciais. …”
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Docking and molecular dynamics studies of human ezrin protein with a modelled SARS-CoV-2 endodomain and their interaction with potential invasion inhibitors by Selvaa Kumar Chellasamy, Eleanor Watson

“…Protein-ligand docking studies confirmed better ezrin-drug interaction for quercetin, minocycline, calcifediol, calcitriol, selamectin, ivermectin and ergocalciferol. …”
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Common <i>UGT1A6</i> Variant Alleles Determine Acetaminophen Pharmacokinetics in Man by María de las Olas Cerezo-Arias, Javier Gómez-Tabales, Manuel Martí, Elena García-Martín, José A. G. Agúndez

“…The effect is related to the <i>UGT1A6*2</i> and <i>UGT1A6*4</i> variant alleles, whereas no effect of <i>UGT1A6*3</i> and <i>UGT1A9*3</i> alleles, BMI, or drug–drug interaction was identified in this study. We conclude that sex and <i>UGT1A6</i> variants determine acetaminophen pharmacokinetics, thus providing evidence to eventually developing pharmacogenomics procedures and recommendations for acetaminophen use.…”
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Immediate Platelet Inhibition Strategy for Comatose Out-of-Hospital Cardiac Arrest Survivors Undergoing Percutaneous Coronary Intervention and Mild Therapeutic Hypothermia by Peter Kordis, Jernej Berden, Ursa Mikuz, Marko Noc

“…We observed no significant drug–drug interaction with ticagrelor.…”
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