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1541
Integrated bioinformatics to identify potential key biomarkers for COVID-19-related chronic urticaria
Published 2022-12-01“…Finally, the key gene-drug interaction network, including 84 possible therapeutical medicines, was developed, and their protein-protein docking might make this prediction more feasible.ConclusionsTo sum up, FCGR3A, TNF, and CCL3 might be potential biomarkers for COVID-19-related CU, and the common pathways and related molecules we explored in this study might provide new ideas for further mechanistic research.…”
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1542
Dexamethasone mitigates remdesivir-induced liver toxicity in human primary hepatocytes and COVID-19 patients
Published 2023-03-01“…Human primary hepatocytes and HepG2 cells were used as in vitro models for toxicity and drug-drug interaction studies. Real-world data from hospitalized COVID-19 patients were analyzed for drug-induced elevation of serum ALT and AST. …”
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1543
Synergistic Effect of β-Lapachone and Aminooxyacetic Acid on Central Metabolism in Breast Cancer
Published 2022-07-01“…Differences in citrate, glutamate, and succinate fractional enrichments indicate synergistic effects on central metabolism based on the coefficient of drug interaction. Metabolic modeling suggests that increased glutamine anaplerosis is protective in the case of MAS inhibition.…”
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1544
Deregulated FASN Expression in BRAF Inhibitor-Resistant Melanoma Cells Unveils New Targets for Drug Combinations
Published 2021-05-01“…The expression of FASN was found to be inversely associated with drug resistance in BRAF-mutant cell lines, both in a set of six resistant/sensitive matched lines and in the Cancer Cell Line Encyclopedia. A favorable drug interaction in resistant cells was also observed with U18666 A inhibiting DHCR24, which increased upon FASN targeting. …”
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1545
A Feasibility Study to Increase Chronic Hepatitis C Virus RNA Testing and Linkage to Care among Clients Attending Homeless Services in Amsterdam, The Netherlands
Published 2021-06-01“…Of these, five (71%) were linked to care, of whom four (57%, 4/7) initiated treatment and one (14%, 1/7) delayed treatment due to a drug–drug interaction. Of these four people, two completed treatment (50%), of whom one (25%) achieved sustained virologic response after 12 weeks. …”
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1546
Adverse reaction signals mining and hemorrhagic signals comparison of ticagrelor and clopidogrel: A pharmacovigilance study based on FAERS
Published 2022-10-01“…At the PT level, the more frequent ADR signals for ticagrelor were dyspnoea, contusion, and haemorrhage, while clopidogrel were gastrointestinal haemorrhage, anaemia, and drug interaction. The hemorrhagic signals of both were mainly focused on the SOC level of gastrointestinal disorders, injury disorders and vascular disorders and nervous system disorders. …”
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1547
Screening and identification of genes related to ferroptosis in keratoconus
Published 2023-08-01“…Through further analysis, aldo–keto reductase family 1 member C3 (AKR1C3) was selected, and negatively correlated with mature CD56 natural killer (NK) cells and macrophages. Then, gene-drug interaction network analysis and miRNA prediction were performed through the website. …”
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1548
Co-Delivery of CPT-11 and Panobinostat with Anti-GD2 Antibody Conjugated Immunoliposomes for Targeted Combination Chemotherapy
Published 2020-10-01“…From in vitro cytotoxicity assay, CPT-11 showed synergism drug interaction with panobinostat to support co-delivery of both drugs with ImmuLipCP for targeted synergistic combination chemotherapy. …”
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1549
Medication Administration through Enteral Feeding Tubes in Mechanically Ventilated Critically Ill Patients: Evaluation of the Potential Medication Errors
Published 2019-12-01“…Results:Errors occurred in percentage of total prescriptions as follows: Drug-drug interaction 26%, wrong preparation 22.28%, wrong form 12.09%, wrong time 11.57%, drug-food interaction 6.73%, wrong dose 5.53%, wrong route 3.8%, extra dose 0.86%, omission 0.18%, deteriorated drug 0.18%, and unordered drug 0.0%. …”
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1550
Association of Pulmonary Sepsis and Immune Checkpoint Inhibitors: A Pharmacovigilance Study
Published 2022-12-01“…We also detected drug interaction signals based on the Ω shrinkage measure. …”
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1551
High-Throughput Metabolic Soft-Spot Identification in Liver Microsomes by LC/UV/MS: Application of a Single Variable Incubation Time Approach
Published 2022-11-01“…CYP-mediated fast metabolism may lead to poor bioavailability, fast drug clearance and significant drug interaction. Thus, metabolic stability screening in human liver microsomes (HLM) followed by metabolic soft-spot identification (MSSID) is routinely conducted in drug discovery. …”
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1552
Could MRONJ Be Related to Osimertinib Monotherapy in Lung Cancer Patients after Denosumab Suspension?
Published 2024-02-01“…Also, this report could trigger in the scientific community the necessity to evaluate further guidelines for similar doubtful cases in which the drug interaction, the mono-suspension, and the possible removable prosthesis-related additional trauma should be considered causes or con-causes.…”
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1553
Multifunctional lipid-based nanocarriers with antibacterial and anti‐inflammatory activities for treating MRSA bacteremia in mice
Published 2021-02-01“…The minimum bactericidal concentration of free ciprofloxacin against MRSA increased from 1.95 to 15.63 µg/ml when combined with rolipram, indicating a possible drug-drug interaction that reduced the antibacterial effect. …”
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1554
Development and Validation of a Prognostic Classifier Based on Lipid Metabolism-Related Genes for Breast Cancer
Published 2022-06-01“…Potential compounds targeting prognostic genes were screened by Connectivity Map (CMap) database and a prognostic gene-drug interaction network was constructed using Comparative Toxicogenomics Database (CTD). …”
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1555
Recognition and Management of Serotonin Toxidrome in the Emergency Department—Case Based Review
Published 2022-12-01“…With an underestimated frequency, SS can develop following an overdose, a therapeutic dose increase, or drug to drug interaction of at least one serotonergic agent. It can present with autonomic signs, neuromuscular changes and an altered mental status. …”
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1556
Effects of dietary butyrate supplementation and oral nonsteroidal anti-inflammatory drug administration on serum inflammatory markers and productivity of dairy cows during the calv...
Published 2022-05-01“…There was a supplement by drug interaction effect on plasma glucose concentration on d 4; in cows administered the placebo drug, butyrate supplementation decreased plasma glucose concentration compared with control-fed cows (62.8 vs. 70.1 mg/dL). …”
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1557
Interações Medicamentosas na Farmacoterapia de Idosos com Câncer atendidos em um Ambulatório de Onco-Hematologia
Published 2018-03-01“…Identificaram-se interações medicamentosas potenciais empregando o software Drug Interaction Checking. A regressão logística foi utilizada para determinar os fatores associados às interações medicamentosas potenciais. …”
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1558
Docking and molecular dynamics studies of human ezrin protein with a modelled SARS-CoV-2 endodomain and their interaction with potential invasion inhibitors
Published 2022-10-01“…Protein-ligand docking studies confirmed better ezrin-drug interaction for quercetin, minocycline, calcifediol, calcitriol, selamectin, ivermectin and ergocalciferol. …”
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1559
Common <i>UGT1A6</i> Variant Alleles Determine Acetaminophen Pharmacokinetics in Man
Published 2022-04-01“…The effect is related to the <i>UGT1A6*2</i> and <i>UGT1A6*4</i> variant alleles, whereas no effect of <i>UGT1A6*3</i> and <i>UGT1A9*3</i> alleles, BMI, or drug–drug interaction was identified in this study. We conclude that sex and <i>UGT1A6</i> variants determine acetaminophen pharmacokinetics, thus providing evidence to eventually developing pharmacogenomics procedures and recommendations for acetaminophen use.…”
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1560
Immediate Platelet Inhibition Strategy for Comatose Out-of-Hospital Cardiac Arrest Survivors Undergoing Percutaneous Coronary Intervention and Mild Therapeutic Hypothermia
Published 2024-04-01“…We observed no significant drug–drug interaction with ticagrelor.…”
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