Prediction of trough concentration and ALK occupancy in plasma and cerebrospinal fluid using physiologically based pharmacokinetic modeling of crizotinib, alectinib, and lorlatinib by Bole Li, Shan Liu, Honglei Feng, Chunshuang Du, Liman Wei, Jie Zhang, Guangwei Jia, Chunnuan Wu

“…Therefore, the free drug concentration in cerebrospinal fluid (CSF) is strongly associated with the clinical efficacy.Purpose: The present study aimed to develop physiologically based pharmacokinetic (PBPK) models that can predict the steady-state trough concentration (Ctrough) in plasma and CSF, as well as anaplastic lymphoma kinase (ALK) occupancy (AO), for three inhibitors: crizotinib (CRI), alectinib (ALE), and lorlatinib (LOR).Methods: To achieve this, population PBPK models were successfully developed and validated using multiple clinical pharmacokinetics (PK) and drug–drug interaction (DDI) studies, both in healthy subjects and patients.Results: The prediction-to-observation ratios for plasma AUC, Cmax, and Ctrough in heathy subjects and patients ranged between 0.5 and 2.0. …”
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Combined Methylome and Transcriptome Analyses Reveals Potential Therapeutic Targets for EGFR Wild Type Lung Cancers with Low PD-L1 Expression by Weilei Hu, Guosheng Wang, Lonny B. Yarmus, Yuan Wan

“…Subsequently, based on DrugBank data, NetworkAnalyst 3.0 was used for protein–drug interaction analysis of up-regulated differentially methylated genes. …”
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Nirmatrelvir/ritonavir treatment in SARS-CoV-2 positive kidney transplant recipients – a case series with four patients by Johanna Schneider, Rika Wobser, Wolfgang Kühn, Dirk Wagner, Yakup Tanriver, Gerd Walz

“…Nirmatrelvir is metabolized by the cytochrome P-450 (CYP) 3A4 isozyme CYP3A4 and is therefore co-administered with the irreversible CYP3A4 inhibitor ritonavir, which results in a drug interaction with tacrolimus. A limited number of patients with nirmatrelvir/ritonavir and tacrolimus therapy after kidney transplantation have been reported to date. …”
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Changes in the characteristics of approved New Drug Applications for antihypertensives by MacNeil, John Simon Howe

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Genetic polymorphism of CYP2C9 in patients on warfarin therapy and the clinical relevance / Teh Lay Kek ... [et al.] by Teh, Lay Kek, Salleh, Mohd Zaki, Ismail, Rusli, Ahmad Ishak, Amiruddin

“…The discrepancies observed are due to other factors including patients' compliances, drug interaction or patients having alleles not determined in this study. …”
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Drug‐related problems among hospitalized hypertensive and heart failure patients and physician acceptance of pharmacists' interventions at a teaching hospital in Ghana by Mark Amankwa Harrison, Afia F. A. Marfo, Kwame O. Buabeng, Florence A. Nkansah, Dorcas P. Boateng, Daniel N. A. Ankrah

“…Other frequent DRPs were medication counseling need (25.1%; n = 62), administration errors 10.1%(n = 25), drug interaction (10.5%; n = 26), and “no” or inappropriate monitoring (10.5%; n = 26). …”
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Characteristics of the anti-dementia drug system of Zisu Fang preparations based on pharmacokinetic and pharmacodynamic analysis by Jianye Quan, Shujuan Yang, Fang Zhang, Li Tan, Jing Kong, Yanyan Jiang, Rendi Sun, Renbing Shi

“…Methods: A PK-PD-drug interaction (DI) method was applied to determine the characteristics of index components of Zisu Fang preparations in vivo. …”
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Information sources, attitudes, and practices of Self-Medication by Jordanian patients: A cross-sectional study by Walid Al-Qerem, Afnan Bargooth, Anan Jarab, Amal Akour, Shrouq Abu Heshmeh

“…Background and Objective: Self-medication (SM) has significantly increased worldwide in the past decades, which may have detrimental health consequences including antimicrobial resistance, adverse drug reactions, drug-drug interaction, and dependency. Although several studies have evaluated the extent of SM, such studies are still limited in Jordan. …”
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Physicians and pharmacists' clinical knowledge of statin therapy and monitoring parameters, and the barriers to guideline implementation in clinical practice. by Fahmi Y Al-Ashwal, Syed Azhar Syed Sulaiman, Siti Maisharah Sheikh Ghadzi, Mohammed Abdullah Kubas, Abdulsalam Halboup

“…<h4>Conclusion</h4>Physicians and pharmacists had suboptimal clinical knowledge regarding statin therapy, dose intensities, drug-drug interaction, contraindications, and monitoring parameters. …”
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The Comparative Bioavailability of Fluticasone and Azelastine Delivered as a Single Fixed Dose Combination (MP-AzeFlu) in Comparison to Two Different Formulations of Azelastine and... by Qi W, Liu Y, Xue W, Li K, Gorski JC, Liu M, Yan T, Nguyen DT, Ramalingam RK

“…KG (A Viatris Company), Bad-Homburg, Germany; 5Global Medical Affairs, Mylan Pharmaceuticals Private Limited (Now Viatris), Bengaluru, IndiaCorrespondence: Kexin Li, Clinical Trial Centre, Beijing Hospital, No. 1 Dahua Road, Dongdan Dongcheng District, Beijing, People’s Republic of China, Email kexinli6202@163.comObjective: Two studies (Study I and Study II) were conducted in healthy Chinese volunteers to confirm that there was no pharmacokinetic drug interaction between AZE and FLU in MP-AzeFlu. The secondary objective was to evaluate the pharmacokinetic parameters of MP-AzeFlu compared with the commercially available mono-components.Methods: Both studies were a randomized, open-label, three-period, six-sequence, single-dose cross-over trial (William’s design) conducted at Beijing Hospital (Beijing, China) in September and October of 2019 in 30 healthy adult male and female volunteers. …”
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Span 60/Cholesterol Niosomal Formulation as a Suitable Vehicle for Gallic Acid Delivery with Potent In Vitro Antibacterial, Antimelanoma, and Anti-Tyrosinase Activity by Sara Zolghadri, Ali Ghanbari Asad, Fatemeh Farzi, Fatemeh Ghajarzadeh, Zeinab Habibi, Mahdie Rahban, Samaneh Zolghadri, Agata Stanek

“…The physicochemical properties of nanosystems in terms of size, zeta potential, drug entrapment, drug release, morphology, and system–drug interaction were characterized using different methods. …”
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ApoE Mimetic Peptide COG1410 Exhibits Strong Additive Interaction with Antibiotics Against Mycobacterium smegmatis by Zhao YY, Wang C, Wang WX, Han LM, Zhang C, Yu JY, Chen W, Hu CM

“…The localization of COG1410 was observed by confocal laser scan microscopy. The drug–drug interaction was determined by a checkerboard assay.Results: COG1410 was a potent bactericidal agent against M. smegmatis in vitro and within the macrophages with MIC 16 μg/mL, but invalid against M. abscess and M. tuberculosis. …”
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Evaluation of the Antinociceptive, Antiallodynic, Antihyperalgesic and Anti-Inflammatory Effect of Polyalthic Acid by Juan Rodríguez-Silverio, María Elena Sánchez-Mendoza, Héctor Isaac Rocha-González, Juan Gerardo Reyes-García, Francisco Javier Flores-Murrieta, Yaraset López-Lorenzo, Geovanna Nallely Quiñonez-Bastidas, Jesús Arrieta

“…Moreover, the effectiveness of treating hyperalgesia with a combination of polyalthic acid and naproxen was analyzed, as well as the type of drug–drug interaction involved. Nociception was examined by injecting 1% formalin into the right hind paw and thermal hyperalgesia and inflammation by injecting a 1% carrageenan solution into the left hind paw of rats. …”
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Mechanism of Antifungal Activity by 5-Aminoimidazole-4-Carbohydrazonamide Derivatives against <i>Candida albicans</i> and <i>Candida krusei</i> by Fátima Cerqueira, Marta Maia, Carla Gabriel, Rui Medeiros, Sara Cravo, Ana Isabel Ribeiro, Daniela Dantas, Alice Maria Dias, Lucília Saraiva, Liliana Raimundo, Eugénia Pinto

“…Ergosterol content (HPLC-DAD), mitochondrial dehydrogenase activity (MTT), reactive oxygen species (ROS) generation (flow cytometry), germ tube inhibition and drug interaction were evaluated. None of the compounds inhibited ergosterol synthesis. …”
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Therapeutic Doses of Eltrombopag do not Inhibit Hepatic BCRP in Healthy Volunteers: Intravenous Ceftriaxone as a Model by Daniel Valente Neves, Carolina Pinto Vieira, Adriana Rocha, Vera Lucia Lanchote

“…CONCLUSIONS: The results do not support the existence of a clinical pharmacokinetic drug interaction involving hepatic BCRP in human subjects receiving intravenous ceftriaxone and oral eltrombopag.   …”
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A Glance at the Development and Patent Literature of Tecovirimat: The First-in-Class Therapy for Emerging Monkeypox Outbreak by Mazen Almehmadi, Mamdouh Allahyani, Ahad Amer Alsaiari, Mohammed Kanan Alshammari, Abrar Saleh Alharbi, Khansa Hamza Hussain, Lojain Ibrahim Alsubaihi, Mehnaz Kamal, Shahad Saleh Alotaibi, Atheer Nasser Alotaibi, Afeefah Awaid Aldhafeeri, Mohd Imran

“…The authors also trust that there is immense scope for developing new Tecovirimat-based treatments (new drug combinations with other antivirals) for orthopoxvirus and other viral diseases. Drug interaction studies and drug resistance studies on Tecovirimat are also recommended. …”
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Determinants of severe QTc prolongation in a real-world gerontopsychiatric setting by Martin Schulze Westhoff, Sebastian Schröder, Johannes Heck, Tabea Pfister, Kirsten Jahn, Olaf Krause, Olaf Krause, Felix Wedegärtner, Stefan Bleich, Kai G. Kahl, Tillmann H. C. Krüger, Tillmann H. C. Krüger, Adrian Groh

“…Medication lists were examined utilizing the AzCERT classification. Potential drug interactions were identified with the electronic drug interaction program mediQ.ResultsThe overall prevalence of QTc prolongation was 13.6%, with 1.9% displaying severe QTc prolongation (≥ 500 ms). …”
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Exploring the therapeutic potential of an antinociceptive and anti-inflammatory peptide from wasp venom by Priscilla Galante, Gabriel A. A. Campos, Jacqueline C. G. Moser, Danubia B. Martins, Marcia P. dos Santos Cabrera, Marisa Rangel, Luiza C. Coelho, Karina S. Simon, Veronica M. Amado, Jessica de A. I. Muller, Johannes Koehbach, Rink-Jan Lohman, Peter J. Cabot, Irina Vetter, David J. Craik, Monica C. Toffoli-Kadri, Victoria Monge-Fuentes, Jair T. Goulart, Elisabeth F. Schwartz, Luciano P. Silva, Anamelia L. Bocca, Márcia R. Mortari

“…Using this peptide as a template, we designed a new peptide, protonectin-F, which exhibited higher antinociceptive activity and less motor impairment compared to protonectin. In drug interaction experiments with naloxone and AM251, Protonectin-F's activity was decreased by opioid and cannabinoid antagonism, two critical antinociception pathways. …”
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Phase I study of plitidepsin in combination with bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma by María Victoria Mateos, Felipe Prosper, Jesús Martin Sánchez, Enrique M. Ocio, Albert Oriol, Cristina Motlló, Jean‐Marie Michot, Isidro Jarque, Rebeca Iglesias, María Solé, Sara Martínez, Carmen Kahatt, Salvador Fudio, Gema Corral, Ali Zeaiter, Lola Montilla, Vincent Ribrag

“…No major pharmacokinetic drug–drug interaction was found. In conclusion, the triple combination of plitidepsin, BTZ, and DXM showed an acceptable safety profile and had moderate activity in adult patients with r/r MM.…”
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Herb-drug Pharmacokinetic Interaction between Carica Papaya Extract and Amiodarone in Rats by Márcio Rodrigues, Gilberto Alves, Joana Francisco, Ana Fortuna, Amílcar Falcão

“…Conclusions – The results herein found suggest an herb-drug interaction between C. papaya extract and amiodarone, which clearly increase the drug bioavailability. …”
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