Prophylactic and therapeutic efficacy of dietary Nigella sativa L. supplementation against hepatopathy in rats induced by kavalactone and kavalactone with alcohol by Hasan, Mohammed Abdulabbas

“…Ethanol potentiated the sedative and hypnotic activity of KL and markedly increased the toxicity whereas, KL toxicity is likely due to herbal drug interaction rather than direct liver toxicity from KL alone. …”
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The association between chronic severe pain and neuroticism personality trait among patients on methadone maintenance therapy in Alor Star, Kedah by Koh, Chin Hong

“…In the case of MMT, drug-to-drug interaction of methadone with OTC analgesics could be fatal. …”
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Association of a Common <i>NOS1AP</i> Variant with Attenuation of QTc Prolongation in Men with Heroin Dependence Undergoing Methadone Treatment by Kuan-Cheng Chang, Ke-Wei Chen, Chieh-Liang Huang, Wen-Ling Liao, Mei-Yao Wu, Yu-Kai Lin, Yi-Tzone Shiao, Wei-Hsin Chung, Yen-Nien Lin, Hsien-Yuan Lane

“…There was no significant gene-drug interaction in contributing to the adjusted QTc (<i>p</i> = 0.2164) in male carriers of the rs164148 variants. …”
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Aprazamento seguro da terapia analgésica com opioides no paciente queimado: um estudo transversal [Safe opioid analgesic therapy dose scheduling for burn patients: a cross-sectiona... by Danielle de Mendonça Henrique, Lolita Dopico da Silva, Flavia Giron Camerini, Karla Biancha Silva Andrade, Sandra Regina Maciqueira Pereira, Cintia Silva Fassarella

“…There was potential for drug interactions in 66.6% of the cases, while 88.8% of the drug pairs studied can cause severe harm. …”
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Using PIM-Taiwan, PRISCUS, and Beers criteria to assess potentially inappropriate medication use among older adults with 90-day rehospitalization: a population-based study in Taiwa... by Kun-Pin Hsieh, Kun-Pin Hsieh, Ru-Yu Huang, Yi-Hsin Yang, Yi-Hsin Yang, Pei-Shan Ho, Pei-Shan Ho, Pei-Shan Ho, Kuang-Peng Chen, Chun-Liong Tung, Ya-Lan Chu, Jui-Hsiu Tsai, Jui-Hsiu Tsai

“…Patients with 90-day rehospitalization had higher rates of the potentially harmful drug-drug interaction (DDI) pairs of serotonin syndrome (n = 19; 48.8%), QT prolongation (n = 4; 30.8%), extrapyramidal symptoms (EPS) (n = 102; 24.5%), and hypokalemia (n = 275; 20.1%).Conclusion: Beers criteria was more efficient in predicting 90-day rehospitalization among older adults experiencing PIM in Taiwan than either PIM-Taiwan or PRISCUS. …”
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Generation of Human iPSC–Derived Intestinal Epithelial Cell Monolayers by CDX2 TransductionSummary by Kazuo Takayama, Ryosuke Negoro, Tomoki Yamashita, Kanae Kawai, Moe Ichikawa, Takanori Mori, Noriyuki Nakatsu, Kazuo Harada, Sumito Ito, Hiroshi Yamada, Yoshiyuki Yamaura, Kazumasa Hirata, Seiichi Ishida, Hiroyuki Mizuguchi

“…Moreover, the drug-drug interaction and drug-food interaction could be observed by using our human iPS-IECM in the presence of an inducer and inhibitor of CYP3A4, i.e., rifampicin and grape fruit juice, respectively. …”
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MATE1 Deficiency Exacerbates Dofetilide-Induced Proarrhythmia by Muhammad Erfan Uddin, Eric D. Eisenmann, Yang Li, Kevin M. Huang, Dominique A. Garrison, Zahra Talebi, Alice A. Gibson, Yan Jin, Mahesh Nepal, Ingrid M. Bonilla, Qiang Fu, Xinxin Sun, Alec Millar, Mikhail Tarasov, Christopher E. Jay, Xiaoming Cui, Heidi J. Einolf, Ryan M. Pelis, Sakima A. Smith, Przemysław B. Radwański, Douglas H. Sweet, Jörg König, Martin F. Fromm, Cynthia A. Carnes, Shuiying Hu, Alex Sparreboom

“…The urinary excretion of dofetilide was also dependent on the MATE1 genotype, and we found that this transport mechanism provides a mechanistic basis for previously recorded drug-drug interactions of dofetilide with various contraindicated drugs, including bictegravir, cimetidine, ketoconazole, and verapamil. …”
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Machine Learning-Based Prediction of Impulse Control Disorders in Parkinson&#x2019;s Disease From Clinical and Genetic Data by Johann Faouzi, Samir Bekadar, Fanny Artaud, Alexis Elbaz, Graziella Mangone, Olivier Colliot, Jean-Christophe Corvol

“…<italic>Methods:</italic> We used data from two longitudinal PD cohorts (training set: PPMI, Parkinson&#x2019;s Progression Markers Initiative; test set: DIGPD, Drug Interaction With Genes in Parkinson&#x2019;s Disease). …”
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Do antibody–drug conjugates increase the risk of sepsis in cancer patients? A pharmacovigilance study by Shuang Xia, Shuang Xia, Shuang Xia, Yi-Chang Zhao, Yi-Chang Zhao, Yi-Chang Zhao, Lin Guo, Lin Guo, Lin Guo, Hui Gong, Hui Gong, Hui Gong, Yi-Kun Wang, Yi-Kun Wang, Yi-Kun Wang, Rui Ma, Rui Ma, Rui Ma, Bi-Kui Zhang, Bi-Kui Zhang, Bi-Kui Zhang, Yue Sheng, Mayur Sarangdhar, Mayur Sarangdhar, Mayur Sarangdhar, Yoshihiro Noguchi, Miao Yan, Miao Yan, Miao Yan

“…For each treatment group, we detected drug interaction signals, and conducted subgroup analyses (age, gender, and regimens) and sensitivity analyses.Results: A total of 24,618 cases were reported with ADCs between Q1, 2004 and Q3, 2021. …”
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First-in-human phase Ib trial of M9241 (NHS-IL12) plus avelumab in patients with advanced solid tumors, including dose expansion in patients with advanced urothelial carcinoma by Renee N Donahue, Jeffrey Schlom, James L Gulley, Mario Sznol, Andreas Schroeder, Julius Strauss, Luc Dirix, Michele Maio, Frank Beier, Alain Ravaud, Jean-Laurent Deville, Marco Maruzzo, XiaoZhe Wang, Yulia Vugmeyster, Sarah Chennoufi, Yo-Ting Tsai, Russell K Pachynski, Theodore S Gourdin, Joerg Seebeck

“…The maximum-tolerated dose was not reached, and DL5 was declared the recommended phase II dose, considering an observed drug–drug interaction at DL4. Two patients with advanced bladder cancer (DL2 and DL4) had prolonged complete responses. …”
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Screening and identification of potential hub genes and immune cell infiltration in the synovial tissue of rheumatoid arthritis by bioinformatic approach by Zhi-wei Feng, Yu-chen Tang, Xiao-yun Sheng, Sheng-hong Wang, Yao-bin Wang, Zhong-cheng Liu, Jin-min Liu, Bin Geng, Ya-yi Xia

“…Finally, the gene-drug interaction network was constructed using DrugCentral database, and identification of drug molecules based on hub genes using the Drug Signature Database (DSigDB) by Enrichr. …”
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Identification of molecular pathways associated with Newcastle disease virus (AF2240) persistent infection in urothelial cell carcinoma by Ahmad, Umar

“…Oncomine validation showed that the top hub genes identified in the network that includes RPL8, THBS1, F2 from TCCSUPPi and TP53 and RAC1 from EJ28Pi are involved in development and progression of bladder cancer. Protein-drug interaction network analysis identified several potential drug targets that could potentially prevent UCC cells from acquiring NDV persistent infection. …”
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Evaluation of potential interactions of oral medications prescribed in a kidney and liver transplant unit by Glaydiane Alves SOUSA, Beatriz Ferreira RODRIGUES, Deise Talyse MELO, João Antonio SOUSA, Lizandra Máximo OLIVEIRA, Ricardo Fernandes MESQUITA, Alene Barros OLIVEIRA

“…Objective: To identify, quantify and classify, according to the degree of severity, potential drug interactions (PDI) present in prescriptions for oral medications for patients admitted to a transplant unit. …”
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The promise and challenges of ChatGPT in community pharmacy: A comparative analysis of response accuracy by Ali H. Salama

“…The assessment encompasses Drug-Drug Interactions, Adverse Drug Effects, Drug Dosage, and Alternative Therapies, each comprising 20 questions, totaling 80 questions. …”
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Evaluation of the use of chlorpromazine for agitation in pediatric patients by Rajwoana Ahmed, PharmD, Megan Maroney, PharmD, BCPP, Germin Fahim, PharmD, BCPS, Hoytin Lee Ghin, PharmD, BCPS, Andrew Scott Mathis, PharmD

“…Data were analyzed using descriptive statistics assessing the incidence of drug-drug interactions (DDIs), incidences of inefficacy, inappropriate dosing, and side effects. …”
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Membrane Carriers and Transporters in Kidney Physiology and Disease by Marek Drozdzik, Maria Drozdzik, Stefan Oswald

“…The renal carriers and transporters are also targets of drugs used in clinical practice, and intentional drug–drug interactions in the kidney are produced to increase therapeutic efficacy. …”
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The Effect Of Standardized Extract Of Eurycoma Longifolia On Phase I And Phase Ii Metabolic Pathways And Rosiglitazone Pharmacokinetics by Purwantiningsih, Purwantiningsih

“…However, herbal preparations have the potential to cause toxicity, herb-drug interactions and may affect the drug therapeutic effects. …”
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Herbal supplements : efficacy, toxicity, interactions with western drugs and effects on clinical laboratory tests / by DasGupta, Amitava, Hammett-Stabler, Catherine A., 1952-

Drug dosage modifications in 24 million in-patient prescriptions covering eight years: A Danish population-wide study of polypharmacy. by Cristina Leal Rodríguez, Amalie Dahl Haue, Gianluca Mazzoni, Robert Eriksson, Jorge Hernansanz Biel, Lisa Cantwell, David Westergaard, Kirstine G Belling, Søren Brunak

“…In comparison to co-medications pairs that were previously classified as drug-drug interactions, pairs not classified as drug-drug interactions had higher odds ratios of dosage modifications than drug pairs with an established interaction. …”
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New anticancer drugs from naturally derived products : a study on growth inhibition of leukemic cells using design of experiments approach. by Cheong, Kenneth Theng Wan.

“…With the use of the classical one-factor-at-a-time (OFAT) method, a huge amount of resources is required when many drugs are involved. Understanding drug interactive effects is also vital in formulating the best drug combination for anticancer treatments, but this is not well understood from the OFAT method. …”
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