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1661
Prophylactic and therapeutic efficacy of dietary Nigella sativa L. supplementation against hepatopathy in rats induced by kavalactone and kavalactone with alcohol
Published 2018“…Ethanol potentiated the sedative and hypnotic activity of KL and markedly increased the toxicity whereas, KL toxicity is likely due to herbal drug interaction rather than direct liver toxicity from KL alone. …”
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Thesis -
1662
The association between chronic severe pain and neuroticism personality trait among patients on methadone maintenance therapy in Alor Star, Kedah
Published 2017“…In the case of MMT, drug-to-drug interaction of methadone with OTC analgesics could be fatal. …”
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Thesis -
1663
Association of a Common <i>NOS1AP</i> Variant with Attenuation of QTc Prolongation in Men with Heroin Dependence Undergoing Methadone Treatment
Published 2022-05-01“…There was no significant gene-drug interaction in contributing to the adjusted QTc (<i>p</i> = 0.2164) in male carriers of the rs164148 variants. …”
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1664
Aprazamento seguro da terapia analgésica com opioides no paciente queimado: um estudo transversal [Safe opioid analgesic therapy dose scheduling for burn patients: a cross-sectiona...
Published 2017-08-01“…There was potential for drug interactions in 66.6% of the cases, while 88.8% of the drug pairs studied can cause severe harm. …”
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1665
Using PIM-Taiwan, PRISCUS, and Beers criteria to assess potentially inappropriate medication use among older adults with 90-day rehospitalization: a population-based study in Taiwa...
Published 2023-07-01“…Patients with 90-day rehospitalization had higher rates of the potentially harmful drug-drug interaction (DDI) pairs of serotonin syndrome (n = 19; 48.8%), QT prolongation (n = 4; 30.8%), extrapyramidal symptoms (EPS) (n = 102; 24.5%), and hypokalemia (n = 275; 20.1%).Conclusion: Beers criteria was more efficient in predicting 90-day rehospitalization among older adults experiencing PIM in Taiwan than either PIM-Taiwan or PRISCUS. …”
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1666
Generation of Human iPSC–Derived Intestinal Epithelial Cell Monolayers by CDX2 TransductionSummary
Published 2019-01-01“…Moreover, the drug-drug interaction and drug-food interaction could be observed by using our human iPS-IECM in the presence of an inducer and inhibitor of CYP3A4, i.e., rifampicin and grape fruit juice, respectively. …”
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1667
MATE1 Deficiency Exacerbates Dofetilide-Induced Proarrhythmia
Published 2022-08-01“…The urinary excretion of dofetilide was also dependent on the MATE1 genotype, and we found that this transport mechanism provides a mechanistic basis for previously recorded drug-drug interactions of dofetilide with various contraindicated drugs, including bictegravir, cimetidine, ketoconazole, and verapamil. …”
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1668
Machine Learning-Based Prediction of Impulse Control Disorders in Parkinson’s Disease From Clinical and Genetic Data
Published 2022-01-01“…<italic>Methods:</italic> We used data from two longitudinal PD cohorts (training set: PPMI, Parkinson’s Progression Markers Initiative; test set: DIGPD, Drug Interaction With Genes in Parkinson’s Disease). …”
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1669
Do antibody–drug conjugates increase the risk of sepsis in cancer patients? A pharmacovigilance study
Published 2022-11-01“…For each treatment group, we detected drug interaction signals, and conducted subgroup analyses (age, gender, and regimens) and sensitivity analyses.Results: A total of 24,618 cases were reported with ADCs between Q1, 2004 and Q3, 2021. …”
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1670
First-in-human phase Ib trial of M9241 (NHS-IL12) plus avelumab in patients with advanced solid tumors, including dose expansion in patients with advanced urothelial carcinoma
Published 2023-05-01“…The maximum-tolerated dose was not reached, and DL5 was declared the recommended phase II dose, considering an observed drug–drug interaction at DL4. Two patients with advanced bladder cancer (DL2 and DL4) had prolonged complete responses. …”
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1671
Screening and identification of potential hub genes and immune cell infiltration in the synovial tissue of rheumatoid arthritis by bioinformatic approach
Published 2023-01-01“…Finally, the gene-drug interaction network was constructed using DrugCentral database, and identification of drug molecules based on hub genes using the Drug Signature Database (DSigDB) by Enrichr. …”
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1672
Identification of molecular pathways associated with Newcastle disease virus (AF2240) persistent infection in urothelial cell carcinoma
Published 2020“…Oncomine validation showed that the top hub genes identified in the network that includes RPL8, THBS1, F2 from TCCSUPPi and TP53 and RAC1 from EJ28Pi are involved in development and progression of bladder cancer. Protein-drug interaction network analysis identified several potential drug targets that could potentially prevent UCC cells from acquiring NDV persistent infection. …”
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Thesis -
1673
Evaluation of potential interactions of oral medications prescribed in a kidney and liver transplant unit
Published 2023-08-01“…Objective: To identify, quantify and classify, according to the degree of severity, potential drug interactions (PDI) present in prescriptions for oral medications for patients admitted to a transplant unit. …”
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1674
The promise and challenges of ChatGPT in community pharmacy: A comparative analysis of response accuracy
Published 2024-01-01“…The assessment encompasses Drug-Drug Interactions, Adverse Drug Effects, Drug Dosage, and Alternative Therapies, each comprising 20 questions, totaling 80 questions. …”
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1675
Evaluation of the use of chlorpromazine for agitation in pediatric patients
Published 2023-03-01“…Data were analyzed using descriptive statistics assessing the incidence of drug-drug interactions (DDIs), incidences of inefficacy, inappropriate dosing, and side effects. …”
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1676
Membrane Carriers and Transporters in Kidney Physiology and Disease
Published 2021-04-01“…The renal carriers and transporters are also targets of drugs used in clinical practice, and intentional drug–drug interactions in the kidney are produced to increase therapeutic efficacy. …”
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1677
The Effect Of Standardized Extract Of Eurycoma Longifolia On Phase I And Phase Ii Metabolic Pathways And Rosiglitazone Pharmacokinetics
Published 2013“…However, herbal preparations have the potential to cause toxicity, herb-drug interactions and may affect the drug therapeutic effects. …”
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Thesis -
1678
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1679
Drug dosage modifications in 24 million in-patient prescriptions covering eight years: A Danish population-wide study of polypharmacy.
Published 2023-09-01“…In comparison to co-medications pairs that were previously classified as drug-drug interactions, pairs not classified as drug-drug interactions had higher odds ratios of dosage modifications than drug pairs with an established interaction. …”
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1680
New anticancer drugs from naturally derived products : a study on growth inhibition of leukemic cells using design of experiments approach.
Published 2010“…With the use of the classical one-factor-at-a-time (OFAT) method, a huge amount of resources is required when many drugs are involved. Understanding drug interactive effects is also vital in formulating the best drug combination for anticancer treatments, but this is not well understood from the OFAT method. …”
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Final Year Project (FYP)