Management of Antiretroviral Therapy with Boosted Protease Inhibitors—Darunavir/Ritonavir or Darunavir/Cobicistat by Ruxandra-Cristina Marin, Tapan Behl, Nicoleta Negrut, Simona Bungau

“…The potential of clinically significant drug interactions in patients taking COBI or RTV is high due to the potent inhibitory effect on cytochrome CYP 450, which attracts significant changes in the pharmacokinetics of PIs. …”
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Descriptors of Cytochrome Inhibitors and Useful Machine Learning Based Methods for the Design of Safer Drugs by Tyler C. Beck, Kyle R. Beck, Jordan Morningstar, Menny M. Benjamin, Russell A. Norris

“…Drug–drug interactions commonly arise from major cytochrome P450 (CYP) inhibition. …”
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COMORBID PATIENT IN GASTROENTEROLOGY: INDIVIDUAL APPROACH by I. G. Bakulin, S. A. Sayganov, M. I. Skalinskaya, E. V. Skazyayeva, I. V. Lapinskii

“…The rationale for the replacement of proton pump inhibitors is given, taking into account the probability of inter-drug interactions in a patient with high cardiovascular risk taking acetylsalicylic acid and having a high risk of gastrointestinal tract bleeding. …”
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Kidney Drug Transporters in Pharmacotherapy by Joanna Łapczuk-Romańska, Maria Droździk, Stefan Oswald, Marek Droździk

“…The kidney tubule epithelia cells express membrane carriers and transporters, which play an important role in drug elimination, and can determine drug nephrotoxicity and drug–drug interactions, as well as constituting direct drug targets. …”
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Off-label antipsychotics prescription to adolescents with acute psychotic episodes does not cause adverse drug reactions by D. V. Ivashchenko, N. I. Buromskaya, A. D. Malakhova, N. A. Tsarkova, L. M. Savchenko, Yu. S. Shevchenko, D. A. Sychev

“…However, an increase in potentially dangerous drug interactions and prescriptions with duplicates drug classes frequency could be considered red flags. …”
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Dolutegravir‐induced acquired sideroblastic anemia in a HIV positive patient: A challenging hematologic complication by Kiran Dhonju, Ashmita Gautam, Abhinav Dahal, Niraj Kumar Sharma, Divas Adhikari, Lina Devkota, Prabhat Adhikari, Sampurna Tuladhar, Bishnu Deep Pathak, Sabin Banmala

“…Key Clinical Message Dolutegravir, the most recent antiretroviral drug with high efficacy, good tolerability, infrequent drug–drug interactions, and a favorable safety profile has not been reported in current literature as a cause of acquired sideroblastic anemia. …”
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Polypharmacy among the elderly in Hermanos Cruz polyclinic by Jessica María González Casanova, Frank Otoniel Machado Ortiz, María de la Caridad Casanova Moreno, Francisco Machado Reyes

“…The existence of several diseases generates the consumption of multiple drugs, and therefore polypharmacy and drug interactions.…”
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Medication-Related Problems Identified and Addressed by Pharmacists Dispensing COVID-19 Antivirals at a Community Pharmacy by Danielle Kieck, Leeann Mahalick, Thanh Truc Vo

“…A retrospective review was conducted to assess documented MRPs, including significant drug–drug interactions and inappropriate dosing requiring intervention, for prescriptions dispensed from 9 February 2022 to 29 April 2022. …”
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Diffuse Large B-Cell Lymphoma in the HIV Setting by Maria Huguet, José-Tomás Navarro, José Moltó, Josep-Maria Ribera, Gustavo Tapia

“…The use of cART during chemotherapy treatment was initially controversial due to the potential risk of adverse drug–drug interactions. However, the availability of current cART regimens with less potential to cause drug interactions and evidence that cART improves survival rates in NHL strongly support the use of cART in PWH with DLBCL. …”
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Isavuconazole for Treating Invasive Mould Disease in Solid Organ Transplant Recipients by Jose Tiago Silva, Jose Tiago Silva, Shahid Husain, José María Aguado, José María Aguado

“…The clinical responses appeared comparable to that found in other high-risk patient populations. Drug-drug interactions with immunosuppressive agents were manageable after the reduction of tacrolimus and the adjustment of mTOR inhibitors at the beginning of treatment. …”
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Evaluation of Encapsulation Potential of Selected Star-Hyperbranched Polyglycidol Architectures: Predictive Molecular Dynamics Simulations and Experimental Validation by Mateusz Gosecki, Malgorzata Urbaniak, Nuno Martinho, Monika Gosecka, Mire Zloh

“…Polymers, including non-linear copolymers, have great potential in the development of drug delivery systems with many advantages, but the design requires optimizing polymer–drug interactions. Molecular dynamics (MD) simulations can provide insights into polymer–drug interactions for designing delivery systems, but mimicking formulation processes such as drying is often not included in in silico studies. …”
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Polypharmacy among the elderly in Hermanos Cruz polyclinic by Jessica María González Casanova, Frank Otoniel Machado Ortiz, María de la Caridad Casanova Moreno, Francisco Machado Reyes

“…The existence of several diseases generates the consumption of multiple drugs, and therefore polypharmacy and drug interactions.…”
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Pharmacogenomics of Dementia: Personalizing the Treatment of Cognitive and Neuropsychiatric Symptoms by Barbara Vuic, Tina Milos, Lucija Tudor, Matea Nikolac Perkovic, Marcela Konjevod, Gordana Nedic Erjavec, Vladimir Farkas, Suzana Uzun, Ninoslav Mimica, Dubravka Svob Strac

“…The therapeutic response to currently available drugs is partially effective in only some individuals, with side effects, drug interactions, intolerance, and non-compliance occurring in the majority of dementia patients. …”
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Precision Medicine & Pharmacogenomics: Personalized Medication in Neuropsychiatric Disorders using AI and telepsychiatry by N. Gkouvas

“…Objectives Determine benefits of pharmacogenomic analysis (PGx) in CNS diseases regarding: - cost effectiveness - adverse drug reactions - reduced hospitalizations -drug interactions - efficacy - quality of life - “trial and error” approach avoidance Methods Questionnaires before and after the treatment provided using PGX tests Telepsychiatry for consultation along face to face sessions were conducted. …”
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Admissions for drug-related problems at the Emergency Department of a University Hospital in the Kingdom of Saudi Arabia by Mastour S Alghamdy, Mohammad A Randhawa, Mohye H Al-Wahhas, Mohammad A Al-Jumaan

“…Conclusions: Noncompliance to treatment, overdose toxicity, drug interactions, and drug abuse are important causes of hospital admissions as a result of DRPs. …”
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Politerapi dalam manajemen epilepsi. by Perpustakaan UGM, i-lib

“…This study wanted to remind: what factors should be considered in epilepsy polytherapy. Drug-drug interactions and the risk of side effects might occures. …”

Effect Of Standardised Methanolic Extract Of Phyllanthus Niruri (Linn.) On Phase I And II Drug Metabolism And Its Molecular Mechanism Elucidation In Rat Liver by Bashir, Moath Kahtan

“…Due to the wide use of herbal medicinal products, the possibilities of herb-drug interactions have increased. Little is known about the incidence and consequences of herb-drug interactions in patients who consume P. niruri concomitantly with other drugs. …”
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Evolving field of cardio-oncology by Guo Li, Lijun Zhang, Meiyan Liu

“…Therapy development for cancer and cardiovascular disease (CVD) to prolong lifespan makes the relationship between these two conditions more complex. Drug interactions in cardiology and oncology are associated with metabolism and drug transportation. …”
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Rhabdomyolysis Following Initiation of Posaconazole Use for Antifungal Prophylaxis in a Patient With Relapsed Acute Myeloid Leukemia by Mayur D. Mody MD, Deepak Ravindranathan MD, Harpaul S. Gill MD, Vamsi K. Kota MD

“…Despite clinical data that show that posaconazole is superior to other antifungal prophylaxis medications, posaconazole is known to have many side effects and drug-drug interactions. We present a patient who developed rhabdomyolysis after being started on posaconazole for prophylaxis in the setting of relapsed acute myeloid leukemia.…”
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Equipping providers to offer novel MPTs: Developing counseling messages for the Dual Prevention Pill in clinical studies and beyond by Kate Segal, Danielle M. Harris, Andy Carmone, Lisa B. Haddad, Sanjay Hadigal, Karin Hatzold, Chris Jones, Eva Lathrop, Jennifer Mason, Meridith Mikulich

“…Discontinuation/switching: If you decide to discontinue use of the DPP, but want to be protected from HIV and/or unintended pregnancy, in most cases, you can begin using PrEP or another contraceptive method right away. Drug interactions: There are no drug-drug interactions from combining oral PrEP and COC in the DPP. …”
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