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1761
Strategy for improving the quality of treatment for children with acute respiratory infections
Published 2020-11-01“…According to statistics, the number of drugs to be administered to treat ARVI reaches three or more INNs in 70% of cases, which involves the risk of drug-drug interactions and adverse events. For example, administration of two drugs leads to drug-drug interactions in 6% of patients, administration of five drugs increases the frequency of such effects up to 50%, and if a patient administers 10 drugs, this indicator reaches 100% of cases. …”
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1762
DEEPCYPs: A deep learning platform for enhanced cytochrome P450 activity prediction
Published 2023-04-01“…Five of the CYPs (1A2, 2C9, 2C19, 2D6, and 3A4) are responsible for metabolizing the vast majority of approved drugs. Adverse drug-drug interactions, many of which are mediated by CYPs, are one of the important causes for the premature termination of drug development and drug withdrawal from the market. …”
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1763
PHARMACOGENETICS OF ORGANIC CATION TRANSPORTERS
Published 2018-06-01“…For OCT3 at the moment, there are 4 polymorphisms: A116S, T400I, A439V, and M370I. Drug-drug interactions involving OCT occur when the substrate is inhibitor of the transporter. …”
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1764
Prevalence and Factors Influencing Use of Herbal Medicines During Pregnancy in Hail, Saudi Arabia: A cross-sectional study
Published 2020-03-01“…Healthcare providers should therefore ensure that patients disclose the use of herbal medicines during pregnancy to avoid treatment complications or adverse herb-drug interactions. Keywords: Herbal Medicine; Plant Preparations; Pregnancy; Complementary Therapies; Health Behaviors; Prevalence; Herb-Drug Interactions; Saudi Arabia.…”
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1765
Clindamycin use evaluation retrospective observational study in critical care units in Alexandria Main University Hospital
Published 2024-03-01“…There were no severe drug interactions with clindamycin. Inappropriate indications were 320 defined Daily Dose (DDD) of total clindamycin consumption (765 DDD) and a cost of 29951.5 LE (42% of total cost). …”
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1766
The evolution of polypharmacy: appropriate and problematic polypharmacy, choosing the right strategy and tactics
Published 2021-10-01“…The problem with polypharmacy is associated with an increased risk of adverse reactions, drug-drug interactions, and decreased patient compliance. To improve polypharmacy, various methodologies are used to optimize drug use for maximum benefit and least harm. …”
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1767
Conformity assessment of medical prescriptions and dispensation of antimicrobials
Published 2014-03-01“…Moderate (n=23; 4.08%) and minor (n=4; 0.72%) drug interactions were identified. Conclusion: The results of the present study demonstratethe non-compliance of both the medical prescriptions assessed and the dispensation process with the current legislation. …”
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1768
The roles of CYP2C19 and CYP3A4 in the in vitro metabolism of β‐eudesmol in human liver: Reaction phenotyping and enzyme kinetics
Published 2023-12-01“…However, the complex constituents of herbal products increase the risk of adverse drug interactions. β‐eudesmol has demonstrated inhibitory effects on rCYP2C19 and rCYP3A4 in the previous research. …”
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1769
Pharmacodynamic modeling of moderate sedation and rationale for dosing using midazolam, propofol and alfentanil
Published 2023-01-01“…Unintended deep sedation can occur if drug interactions are overlooked. We present a pharmacodynamic model for moderate sedation using midazolam, alfentanil and propofol. …”
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1770
Evaluating the Professional Practice of Pharmacists Working at Pharmacies in Isfahan City, Iran
Published 2013-07-01“…Four significant drug interactions were included in the prescription; 121 pharmacists (82% of) did not shown any responses to them. …”
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1771
Maraviroc: a review of its use in HIV infection and beyond
Published 2015-10-01“…Keywords: chemokine receptors, human immunodeficiency virus, CCR5 antagonists, pharmacokinetics, pharmacodynamics, drug interactions, mutations, resistance, AIDS…”
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1772
Lopinavir/ritonavir affects pharmacokinetic exposure of artemether/lumefantrine in HIV-uninfected healthy volunteers.
Published 2009“… OBJECTIVES: Antimalarial combination therapy is used in persons with HIV infection in the absence of data on drug interactions. The objective of this study was to investigate the pharmacokinetics (PK) of antimalarial combination artemether/lumefantrine (AL) when administered with the protease inhibitor combination lopinavir/ritonavir (LPV/r) in HIV-uninfected healthy volunteers to determine if important drug interactions exist between these agents. …”
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1773
MFSynDCP: multi-source feature collaborative interactive learning for drug combination synergy prediction
Published 2024-04-01“…This model includes a graph aggregation module with an adaptive attention mechanism for learning drug interactions and a multi-source feature interaction learning controller for managing information transfer between different data sources, accommodating both drug and cell line features. …”
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1774
Sex-Specific Cannabidiol- and Iloperidone-Induced Neuronal Activity Changes in an In Vitro MAM Model System of Schizophrenia
Published 2021-05-01“…Our findings indicate that CBD induces rapid increases in cortical neuronal activity, with sex-specific drug interactions upon ILO coadministration. This suggests that sex should be a consideration when implementing adjunct therapy for treatment of SZ.…”
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1775
Post-COVID Syndrome in Bipolar Affective Disorder Patient
Published 2023-08-01“…COVID-19 patients who have bipolar disorder require therapeutic adjustments to avoid specific drug interactions between psychotropic drugs and those used in COVID-19 protocols. …”
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1776
Drugs increase the risk of suicide in the elderly
Published 2022-11-01“…The greatest challenge of pharmacotherapy in the elderly is polypharmacy, drug interactions, different metabolism, pharmacokinetics and pharmacodynamics of the drugs used, as well as the side effects appearing in chronic therapy. …”
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1777
Mechanistic insights into the role of plant polyphenols and their nano-formulations in the management of depression
Published 2022-11-01“…Additionally, there are a number of drawbacks to standard antidepressants, such as anti-cholinergic side effects, drug-drug interactions, and food-drug interactions, which prompts researchers to look at alternative approaches to the treatment of depression. …”
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1778
An acute episode of rhabdomyolysis associated with everolimus and cabergoline intake in a postpartum kidney recipient
Published 2017-12-01“…Moreover, the inhibitors of the proliferative signal may have potential drug interactions, which can result in additional complications.Rhabdomyolysis is one of them. …”
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1779
Short-term glucocorticoid-related side effects and adverse reactions: a narrative review and practical approach
Published 2022-01-01“…Unfortunately, metabolic side effects, drug interactions and adverse reactions commonly lead to glucocorticoid-related side effects, thereby compromising their intended anti-inflammatory and immunosuppressive effects. …”
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1780
Antifungal Stewardship
Published 2017-03-01“…Side effects and drug interactions of antifungal drugs are high and costly. …”
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Article