Strategy for improving the quality of treatment for children with acute respiratory infections by A. I. Safina

“…According to statistics, the number of drugs to be administered to treat ARVI reaches three or more INNs in 70% of cases, which involves the risk of drug-drug interactions and adverse events. For example, administration of two drugs leads to drug-drug interactions in 6% of patients, administration of five drugs increases the frequency of such effects up to 50%, and if a patient administers 10 drugs, this indicator reaches 100% of cases. …”
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DEEPCYPs: A deep learning platform for enhanced cytochrome P450 activity prediction by Daiqiao Ai, Hanxuan Cai, Jiajia Wei, Duancheng Zhao, Yihao Chen, Ling Wang

“…Five of the CYPs (1A2, 2C9, 2C19, 2D6, and 3A4) are responsible for metabolizing the vast majority of approved drugs. Adverse drug-drug interactions, many of which are mediated by CYPs, are one of the important causes for the premature termination of drug development and drug withdrawal from the market. …”
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PHARMACOGENETICS OF ORGANIC CATION TRANSPORTERS by V. A. Evteev, R. E. Kazakov, O. A. Muslimova, E. Yu. Demchenkova

“…For OCT3 at the moment, there are 4 polymorphisms: A116S, T400I, A439V, and M370I. Drug-drug interactions involving OCT occur when the substrate is inhibitor of the transporter. …”
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Prevalence and Factors Influencing Use of Herbal Medicines During Pregnancy in Hail, Saudi Arabia: A cross-sectional study by Mohamad Aljofan, Suhaib Alkhamaiseh

“…Healthcare providers should therefore ensure that patients disclose the use of herbal medicines during pregnancy to avoid treatment complications or adverse herb-drug interactions. Keywords: Herbal Medicine; Plant Preparations; Pregnancy; Complementary Therapies; Health Behaviors; Prevalence; Herb-Drug Interactions; Saudi Arabia.…”
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Clindamycin use evaluation retrospective observational study in critical care units in Alexandria Main University Hospital by Heba Othman Shaker, Manal Naguib, Basant Mohamed Abdelaziz, Marwan Mohamed Salah Eldin El Bourini

“…There were no severe drug interactions with clindamycin. Inappropriate indications were 320 defined Daily Dose (DDD) of total clindamycin consumption (765 DDD) and a cost of 29951.5 LE (42% of total cost). …”
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The evolution of polypharmacy: appropriate and problematic polypharmacy, choosing the right strategy and tactics by M. V. Leonova

“…The problem with polypharmacy is associated with an increased risk of adverse reactions, drug-drug interactions, and decreased patient compliance. To improve polypharmacy, various methodologies are used to optimize drug use for maximum benefit and least harm. …”
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Conformity assessment of medical prescriptions and dispensation of antimicrobials by Camila Guimarães Polisel, Raíssa Soares Bergê

“…Moderate (n=23; 4.08%) and minor (n=4; 0.72%) drug interactions were identified. Conclusion: The results of the present study demonstratethe non-compliance of both the medical prescriptions assessed and the dispensation process with the current legislation. …”
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The roles of CYP2C19 and CYP3A4 in the in vitro metabolism of β‐eudesmol in human liver: Reaction phenotyping and enzyme kinetics by Nadda Muhamad, Kesara Na‐Bangchang

“…However, the complex constituents of herbal products increase the risk of adverse drug interactions. β‐eudesmol has demonstrated inhibitory effects on rCYP2C19 and rCYP3A4 in the previous research. …”
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Pharmacodynamic modeling of moderate sedation and rationale for dosing using midazolam, propofol and alfentanil by Jing-Yang Liou, I-Ting Kuo, Weng-Kuei Chang, Chien-Kun Ting, Mei-Yung Tsou

“…Unintended deep sedation can occur if drug interactions are overlooked. We present a pharmacodynamic model for moderate sedation using midazolam, alfentanil and propofol. …”
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Evaluating the Professional Practice of Pharmacists Working at Pharmacies in Isfahan City, Iran by Sayed Abolfazl Mostafavi, Mohsen Chamanara, ٍٍٍٍEhsan Khabazian

“…Four significant drug interactions were included in the prescription; 121 pharmacists (82% of) did not shown any responses to them. …”
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Maraviroc: a review of its use in HIV infection and beyond by Woollard SM, Kanmogne GD

“…Keywords: chemokine receptors, human immunodeficiency virus, CCR5 antagonists, pharmacokinetics, pharmacodynamics, drug interactions, mutations, resistance, AIDS…”
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Lopinavir/ritonavir affects pharmacokinetic exposure of artemether/lumefantrine in HIV-uninfected healthy volunteers. by German, P, Parikh, S, Lawrence, J, Dorsey, G, Rosenthal, P, Havlir, D, Charlebois, E, Hanpithakpong, W, Lindegardh, N, Aweeka, F

“… OBJECTIVES: Antimalarial combination therapy is used in persons with HIV infection in the absence of data on drug interactions. The objective of this study was to investigate the pharmacokinetics (PK) of antimalarial combination artemether/lumefantrine (AL) when administered with the protease inhibitor combination lopinavir/ritonavir (LPV/r) in HIV-uninfected healthy volunteers to determine if important drug interactions exist between these agents. …”

MFSynDCP: multi-source feature collaborative interactive learning for drug combination synergy prediction by Yunyun Dong, Yunqing Chang, Yuxiang Wang, Qixuan Han, Xiaoyuan Wen, Ziting Yang, Yan Zhang, Yan Qiang, Kun Wu, Xiaole Fan, Xiaoqiang Ren

“…This model includes a graph aggregation module with an adaptive attention mechanism for learning drug interactions and a multi-source feature interaction learning controller for managing information transfer between different data sources, accommodating both drug and cell line features. …”
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Sex-Specific Cannabidiol- and Iloperidone-Induced Neuronal Activity Changes in an In Vitro MAM Model System of Schizophrenia by Rachel-Karson Thériault, Myles St-Denis, Tristen Hewitt, Jibran Y. Khokhar, Jasmin Lalonde, Melissa L. Perreault

“…Our findings indicate that CBD induces rapid increases in cortical neuronal activity, with sex-specific drug interactions upon ILO coadministration. This suggests that sex should be a consideration when implementing adjunct therapy for treatment of SZ.…”
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Post-COVID Syndrome in Bipolar Affective Disorder Patient by Ahmad Firdaus, Adelita Vega Dwiputri, Aderisti Irkadiratna, Adi Satria Nugraha, Adinda Narulitia, Era Catur Prasetya, Absa Secka, Muhammad Muslih

“…COVID-19 patients who have bipolar disorder require therapeutic adjustments to avoid specific drug interactions between psychotropic drugs and those used in COVID-19 protocols.  …”
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Drugs increase the risk of suicide in the elderly by Kornelia Kędziora-Kornatowska, Karolina Winiarek, Joanna Murawska, Karolina Mikut, Justyna Kwiecień, Aleksandra Wijata, Aysheh Al-Shaer

“…The greatest challenge of pharmacotherapy in the elderly is polypharmacy, drug interactions, different metabolism, pharmacokinetics and pharmacodynamics of the drugs used, as well as the side effects appearing in chronic therapy. …”
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Mechanistic insights into the role of plant polyphenols and their nano-formulations in the management of depression by Atul Kabra, Ruchika Garg, James Brimson, Jelena Živković, Saud Almawash, Muhammad Ayaz, Asif Nawaz, Syed Shams Ul Hassan, Syed Shams Ul Hassan, Simona Bungau

“…Additionally, there are a number of drawbacks to standard antidepressants, such as anti-cholinergic side effects, drug-drug interactions, and food-drug interactions, which prompts researchers to look at alternative approaches to the treatment of depression. …”
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An acute episode of rhabdomyolysis associated with everolimus and cabergoline intake in a postpartum kidney recipient by B. I. Yaremin, E. V. Parabina, U. V. Maslikova, V. E. Aleksandrova

“…Moreover, the inhibitors of the proliferative signal may have potential drug interactions, which can result in additional complications.Rhabdomyolysis is one of them. …”
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Short-term glucocorticoid-related side effects and adverse reactions: a narrative review and practical approach by Sarah Noetzlin, Gautier Breville, Jörg D. Seebach, Giacomo Gastaldi

“…Unfortunately, metabolic side effects, drug interactions and adverse reactions commonly lead to glucocorticoid-related side effects, thereby compromising their intended anti-inflammatory and immunosuppressive effects. …”
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Antifungal Stewardship by Sabahat ÇEKEN, Mustafa ERTEK

“…Side effects and drug interactions of antifungal drugs are high and costly. …”
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