PRACTICAL ASPECTS OF APIXABAN USE IN CLINICAL PRACTICE: VIEW POINT OF CLINICAL PHARMACOLOGIST by D. A. Sychev, I. I. Sinitsina, G. Yu. Zakharova, M. I. Savel'eva, A. V. Ryabova, A. V. Kryukov, A. Yu. Yurovskii

“…The article is devoted to apixaban use in clinical practice: examination before apixaban administration, clinical situation when laboratory control and monitoring are needed, drugs interactions (at the level of CYP3A4, P-gp), management of patients with bleeding because of apixaban therapy (including antidotes application), perioperative management of patients receiving apixaban.…”
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Latest Concepts in Endodontic Management of Pregnant Patients by Maryam Kuzekanani

“…Tooth decay, oral health, local and general anesthesia, analgesics, antibiotic prescription, drug interactions, and X-ray radiation are the most important considerations that may impact treatment planning and endodontic practice in pregnancy. …”
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Review of Pharmacologic Considerations in the Use of Azole Antifungals in Lung Transplant Recipients by Megan E. Klatt, Gregory A. Eschenauer

“…Focus is drawn to analysis of drug-interactions, adverse drug reactions, pharmacokinetic considerations, and the role of therapeutic drug monitoring with special emphasis on data from the post-lung transplant population.…”
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Diffusive drug delivery in the brain extracellular space from a cellular scale microtube by Störi, M-J, Oluwasanya, PW, Proctor, CM

“…The effectiveness of state-of-the-art systemic treatments for neurological disorders is hampered not only by the difficulty in crossing the blood brain barrier but also off-target drug interactions. In this study, a delivery method is simulated for a novel U-shaped microtube locally infusing drugs directly into the extracellular space of the brain and relying on diffusion as a transport mechanism. …”

Case reports of covert use of phenobarbital in patients taking diankexing and diankening, traditional herbal medicine for epilepsy by Khean Jin, G., Wee Tah, M., Mustafa, A.M., Chong Tin, T.

“…Physicians should be aware of possible adulterations with conventional antiepileptic drugs in patients purported taking traditional medicine, with potential adverse effects and drug interactions.…”
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Drugs of Abuse and Their Impact on Viral Pathogenesis by Jason T. Blackard, Kenneth E. Sherman

“…This review focuses on the myriad of mechanisms by which drugs of abuse impact viral replication and disease progression. Virus–drug interactions can accelerate viral disease progression and lead to increased risk of virus transmission.…”
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Mepolizumab in allergic bronchopulmonary aspergillosis complicated by infection by Toru Hamada, Tomoya Katsuta, Kento Aibara, Shohei Nozu, Junya Nakamura, Haruka Kondo, Sayaka Tachibana, Koji Inoue, Norihiko Nakanishi, Tomonori Moritaka

“…However, long-term use of these medications can lead to infections and drug interactions. We present the case of a 71-year-old woman with ABPA who was diagnosed with hepatitis B and active hepatitis C, and sputum analysis revealed the presence of bacteria. …”
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Healthy Living: Food Can Affect Your Medicines by Paulina Wittkowsky, Linda B. Bobrof

“…Follow the information in this revised 2-page fact sheet to reduce your risk of common food and drug interactions. Written by Paulina Wittkowsky and Linda B. …”
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Imprudent Gastro-protective Approach in Majority of Specialists’ Clinics of a Tertiary Hospital by Hardik Rameshbhai Patel, Priti Dhande

“…Medication instructions were lacking with most of the drugs. Drug interactions with co-prescribed drugs could be anticipated in 79 cases. …”
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Apixaban by Gianluca Airoldi, Mauro Campanini

“…It also has low potential for drug-drug interactions and is eliminated through mixed renal and metabolic pathways (both CYP-mediated and CYP-independent). …”
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Healthcare Professionals and Undergraduate Students’ Knowledge Toward Drug-Food Interactions in the Eastern Region of Saudi Arabia by Alhubail SA, Alharthi MM, Alsayyah FF, Younis NS

“…The DFI section included questions that assessed the general knowledge of DFI and knowledge of specific food and drug interactions.Results: A total of 401 participants completed the study questionnaire; 41.4% were undergraduate students, 37.2% were pharmacists, 10.5% were nurses, and 9.5% were doctors. …”
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Exposure of LS-180 Cells to Drugs of Diverse Physicochemical and Therapeutic Properties Up-regulates P-glycoprotein Expression and Activity by Alaa H Abuznait, Shawn G Patrick, Amal Kaddoumi

“…The role P-glycoprotein (P-gp) plays in drug interactions via its inhibition is well established. …”
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Threats to patient safety in the primary care office: concerns of physicians and nurses by David Schwappach, Katrin Gehring, Markus Battaglia, Roman Buff, Felix Huber, Peter Sauter, Markus Wieser

“…Safety of medication (8.8%), triage by nurses (7.2%) and drug interactions (6.8%) were the threats cited most frequently. …”
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Potentially inappropriate medications with older people in intensive care and associated factors: a historic cohort study by Karina Sichieri, Danilo Donizetti Trevisan, Ricardo Luís Barbosa, Silvia Regina Secoli

“…Factors associated with PIMs use were the number of medications (odds ratio [OR] = 1.17), length of hospital stay (OR = 1.07), and excessive potential drug interactions (OR = 2.43). CONCLUSIONS: Approximately half of the older adults in ICUs received PIM. …”
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KAJIAN DRUG RELATED PROBLEMS PADA PASIEN ANAK DENGAN INFEKSI SALURAN NAFAS BAWAH DAN ASMAI RUMAH SAKIT PANTI RAPIH YOGYAKARTA PERIODE 1 JANUARI - 30 JUNI 2006 by , Dyah Anggraeni Budhi Prastiwi, S.Far, , Prof. Dr. Zullies Ikawati, Apt.

“…The result of research to children in patients with asthma showed Indications of untherapy does not exist, Unnecessary drug therapy is 18.18%, wrong drug is 4.54%, Too low dosage does not exist, too high dosage is 13.63%, Drug interactions is 50% and disobedience is 4.54%.…”

Biomarkers, designs, and interpretations of resting-state fMRI in translational pharmacological research: A review of state-of-the-Art, challenges, and opportunities for studying b... by Khalili-Mahani, N, Rombouts, S, van Osch, M, Duff, E, Carbonell, F, Nickerson, L, Becerra, L, Dahan, A, Evans, A, Soucy, J, Wise, R, Zijdenbos, A, van Gerven, J

“…This review aims to bridge between technical and clinical researchers who seek reliable neuroimaging biomarkers for studying drug interactions with the brain. About 85 pharma-RSfMRI studies using BOLD signal (75% of all) or arterial spin labeling (ASL) were surveyed to investigate the acute effects of psychoactive drugs. …”

Current opportunities for the treatment of respiratory diseases in paediatric practice by V. N. Drozdov, S. Yu. Serebrova, O. А. Vorobyeva, A. K. Starodubtsev, O. V. Dobrovolsky

“…Immediacy of the problem of combination therapy of respiratory diseases in paediatric practice is caused by their multifactorial pathogenesis in children and the need to achieve a high clinical effect in the use of drugs at relatively low doses and with minimum risks of serious adverse effects and drug interactions. The fixed-dose combination of salbutamol, bromhexine and guaifenesin produced in the form of tablets and syrup fully meets these requirements, which makes it possible to use it in children and adults with acute, chronic infectious (ARVI, bacterial pneumonia, respiratory tuberculosis, etc.) and non-infectious (bronchial asthma, pulmonary cystic fibrosis, primary ciliary dyskinesia, etc.) diseases.…”
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Effects of Antiarrhythmic Drugs on Antiepileptic Drug Action—A Critical Review of Experimental Findings by Kinga K. Borowicz-Reutt

“…Concomitant treatment with antiarrhythmic and antiseizure medications creates, however, the possibility of drug–drug interactions. This is due, among other reasons, to a similar mechanism of action. …”
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Features of GERD therapy in obese patients: A review by Natalia V. Bakulina, Sergey V. Tikhonov, Anastasia Yu. Efremova, Vakhtang V. Mirtskhulava

“…At the same time, pharmacodynamic and pharmacokinetic features determine the advantage of the rabeprazole molecule in obese patients, including the minimal risk of drug-drug interactions.…”
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Antiarrhythmic Drugs Use in Elderly Patients. Vaughan Williams Class III and IV Drugs by E. A. Ushkalova, S. K. Zyryanov, K. E. Zatolochina, A. P. Pereverzev, N. A. Chukhareva

“…Elderly patients are more vulnerable to adverse drug reactions (ADRs) because of age-related changes of pharmacokinetics, co-morbidity and drug interactions. Аmioadarone is not considered as the drug of choice in elderly patients because of the high risk of serious ADRs. …”
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