PREVENTION OF STROKE IN ATRIAL FIBRILLATION: THE APPROACHES TO THE CHOICE OF ANTICOAGULANT, DEPENDING ON AGE by A. V. Ardashev, I. V. Zotova

“…The choice of anticoagulant should be based on a comprehensive assessment of a number of factors - the presence of significant valvular disease, kidney function, potential drug interactions, risk of complications of anticoagulant therapy. …”
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Overview of Antifungal Drugs against Paracoccidioidomycosis: How Do We Start, Where Are We, and Where Are We Going? by Lívia do Carmo Silva, Amanda Alves de Oliveira, Dienny Rodrigues de Souza, Katheryne Lohany Barros Barbosa, Kleber Santiago Freitas e Silva, Marcos Antonio Batista Carvalho Júnior, Olívia Basso Rocha, Raisa Melo Lima, Thaynara Gonzaga Santos, Célia Maria de Almeida Soares, Maristela Pereira

“…The limitations of antifungals, such as toxicity, drug interactions, restricted routes of administration, and the reduced bioavailability in target tissues, have become evident in clinical settings. …”
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Role of the pharmacist in the management of postmenopausal breast cancer treatment with vasomotor symptoms: A case report by Megan R. Undeberg, Alanda Barash, Kimberly C. McKeirnan

“…Pharmacists can play an important role in the management of postmenopausal breast cancer and vasomotor symptoms by providing patient education and recommending medications based on treatment guidelines with consideration to side effects and drug interactions.…”
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An unsupervised computational pipeline identifies potential repurposable drugs to treat Huntington's disease and multiple sclerosis by Luca Menestrina, Maurizio Recanatini

“…Combined therapies are then prioritized on the basis of the drugs’ separation on the human interactome and the known drug-drug interactions. We eventually collected a number of molecules, and their plausible combinations, that could be proposed for the treatment of Huntington's disease and multiple sclerosis. …”
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Magnesium Oxide in Constipation by Hideki Mori, Jan Tack, Hidekazu Suzuki

“…Despite these advantages, emerging clinical evidence indicates that the use of magnesium oxide should take account of the most appropriate dose, the serum concentration, drug–drug interactions, and the potential for side effects, especially in the elderly and in patients with renal impairment. …”
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DEFINITION OF ZALEPLON, ZOLPIDEM AND ZOPICLON IN BIOLOGICAL OBJECTS by V. A. Kartashov, G. P. Chepurnaya, L. V. Chernova

“…To diagnose intoxications by these medicines and other purposes (for monitoring the concentration of these medicines in the blood, studying pharmacokinetics, evaluating drug interactions, optimizing treatment control), the development of methods for defining Z-preparations in biological objects becomes important, that is currently developed insufficient. …”
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THE PROBLEM OF THE USE OF NEW ORAL ANTICOAGULANTS IN CANCER PATIENTS RECEIVING CHEMOTHERAPY by A. A. Rumyantsev, I. A. Pokataev, T. V. Kozlov, N. A. Rumyantsev

“…New oral anticoagulants (NOAC) are promising drugs for use in oncology practice; however their use is complicated by the lack of data on efficacy and safety in these patients, potential drug interactions and the possibility of unpredictable changes in effect during chemotherapy. …”
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Can Mesoporous Silica Speed Up Degradation of Benzodiazepines? Hints from Quantum Mechanical Investigations by Massimo Delle Piane, Marta Corno

“…The adopted computational procedure has been chosen to investigate whether silica–drug interactions favor the drug degradation mechanism or not, hindering the beneficial pharmaceutical effect. …”
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Severe hyponatremia due to trimethoprim-sulfamethoxazole-induced SIADH by Creticus Marak, Matthew Nunley, Achuta Kumar Guddati, Prashant Kaushik, Mark Bannon, Adrita Ashraf

“…Simultaneous use of trimethoprim-sulfamethoxazole and spironolactone can cause serious drug interactions that increase the risk of hyponatremia, hyperkalemia, and overall mortality. …”
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Augmented EHR: Enrichment of EHR with Contents from Semantic Web Sources by Alejandro Mañas-García, José Alberto Maldonado, Mar Marcos, Diego Boscá, Montserrat Robles

“…Finally, to exemplify the approach, the work includes a practical use case in which the summarized EHR is augmented with drug–drug interactions and disease-related treatment information.…”
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Treatment of dermatophytosis in elderly, children, and pregnant women by Subuhi Kaul, Savita Yadav, Sunil Dogra

“…Terbinafine is the preferred oral agent in elderly population for treatment of extensive cutaneous disease and onychomycosis due to its lack of cardiac complications and lower propensity for drug interactions. If required, additional physical/mechanical modalities can be employed for symptomatic onychomycosis. …”
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Safety of chemotherapy of MDR/XDR-TB patients in high HIV prevalence settings by A. V. Kukurika, E. I. Veselova, L. E. Parolina, O. V. Lovacheva

“…In conditions of high prevalence of HIV, the pharmacovigilance of drug interactions in combination therapy is particularly relevant since HIV can indirectly increase the number of ADRs not only due to cross-toxicity but also severe immunosuppression, development of immune system recovery syndrome, opportunistic infections, a characteristic intoxication syndrome, a low index body weight and individual characteristics of patients in this category.…”
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Privileged Scaffold Decoration for the Identification of the First Trisubstituted Triazine with Anti-SARS-CoV-2 Activity by Silvia Cesarini, Ilaria Vicenti, Federica Poggialini, Massimiliano Secchi, Federica Giammarino, Ilenia Varasi, Camilla Lodola, Maurizio Zazzi, Elena Dreassi, Giovanni Maga, Lorenzo Botta, Raffaele Saladino

“…Unfortunately, these three drugs showed some limitations regarding potency and possible drug–drug interactions. A series of derivatives coming from a decoration approach of the privileged scaffold s-triazines were synthesized and evaluated against SAR-CoV-2. …”
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Controversy about the Role of Rifampin in Biofilm Infections: Is It Justified? by Nora Renz, Andrej Trampuz, Werner Zimmerli

“…The risk for emergence of rifampin resistance and multiple drug interactions are emphasized. A recent randomized controlled trial (RCT) showing no beneficial effect of rifampin in patients with acute staphylococcal periprosthetic joint infection treated with prosthesis retention is critically reviewed and data interpreted. …”
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Role of Direct Oral Anticoagulants for Post-operative Venous Thromboembolism Prophylaxis by Han Naung Tun, May Thu Kyaw, Erik Rafflenbeul, Xiuhtlaulli López Suástegui

“…However, their use is limited by drawbacks including a narrow therapeutic range, numerous food and drug interactions, and the need for regular monitoring for dose adjustments. …”
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Knowledge Graphs and Explainable AI in Healthcare by Enayat Rajabi, Somayeh Kafaie

“…Based on our review, knowledge graphs have been used for explainability to detect healthcare misinformation, adverse drug reactions, drug-drug interactions and to reduce the knowledge gap between healthcare experts and AI-based models. …”
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The structure of mouse L1210 dihydrofolate reductase-drug complexes and the construction of a model of human enzyme. by Stammers, D, Champness, J, Beddell, C, Dann, J, Eliopoulos, E, Geddes, A, Ogg, D, North, A

“…These structures reveal for the first time details of drug interactions with a mammalian DHFR, which are compared with those observed from previous X-ray investigations of DHFR/inhibitor complexes. …”

Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer by Paulraj, Felicia Simone, Abas, Faridah, Lajis, Nordin, Othman, Iekhsan, Naidu, Rakesh

“…Future research will need to focus on drug interactions to explore potential synergistic actions of diarylpentanoids and further establish the use of diverse animal models.…”
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Collaborative Innovation: The Future of BioPharma by Cristián Hernández-Cuevas

“…During this process, researchers develop tests to screen libraries of chemical compounds against therapeutic targets, evaluate the amount of a drug required to effectively treat the disease, study the extent to which a drug interacts only with the target, assess the presence and significance of any harmful side effects and design the way the drug is going to be administered to patients.…”
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Common Toxic Syndromes in Psychiatric Practice by Vesile Altınyazar

“…Entoxications which are confronted frequently include clinical scenarios ranging from known drug overdose or drug interactions, as well as, illicit drug use, suicide attempt, or accidental exposure. …”
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