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1861
PREVENTION OF STROKE IN ATRIAL FIBRILLATION: THE APPROACHES TO THE CHOICE OF ANTICOAGULANT, DEPENDING ON AGE
Published 2016-12-01“…The choice of anticoagulant should be based on a comprehensive assessment of a number of factors - the presence of significant valvular disease, kidney function, potential drug interactions, risk of complications of anticoagulant therapy. …”
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1862
Overview of Antifungal Drugs against Paracoccidioidomycosis: How Do We Start, Where Are We, and Where Are We Going?
Published 2020-11-01“…The limitations of antifungals, such as toxicity, drug interactions, restricted routes of administration, and the reduced bioavailability in target tissues, have become evident in clinical settings. …”
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1863
Role of the pharmacist in the management of postmenopausal breast cancer treatment with vasomotor symptoms: A case report
Published 2023-09-01“…Pharmacists can play an important role in the management of postmenopausal breast cancer and vasomotor symptoms by providing patient education and recommending medications based on treatment guidelines with consideration to side effects and drug interactions.…”
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1864
An unsupervised computational pipeline identifies potential repurposable drugs to treat Huntington's disease and multiple sclerosis
Published 2022-12-01“…Combined therapies are then prioritized on the basis of the drugs’ separation on the human interactome and the known drug-drug interactions. We eventually collected a number of molecules, and their plausible combinations, that could be proposed for the treatment of Huntington's disease and multiple sclerosis. …”
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1865
Magnesium Oxide in Constipation
Published 2021-01-01“…Despite these advantages, emerging clinical evidence indicates that the use of magnesium oxide should take account of the most appropriate dose, the serum concentration, drug–drug interactions, and the potential for side effects, especially in the elderly and in patients with renal impairment. …”
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1866
DEFINITION OF ZALEPLON, ZOLPIDEM AND ZOPICLON IN BIOLOGICAL OBJECTS
Published 2019-01-01“…To diagnose intoxications by these medicines and other purposes (for monitoring the concentration of these medicines in the blood, studying pharmacokinetics, evaluating drug interactions, optimizing treatment control), the development of methods for defining Z-preparations in biological objects becomes important, that is currently developed insufficient. …”
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1867
THE PROBLEM OF THE USE OF NEW ORAL ANTICOAGULANTS IN CANCER PATIENTS RECEIVING CHEMOTHERAPY
Published 2015-09-01“…New oral anticoagulants (NOAC) are promising drugs for use in oncology practice; however their use is complicated by the lack of data on efficacy and safety in these patients, potential drug interactions and the possibility of unpredictable changes in effect during chemotherapy. …”
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1868
Can Mesoporous Silica Speed Up Degradation of Benzodiazepines? Hints from Quantum Mechanical Investigations
Published 2022-02-01“…The adopted computational procedure has been chosen to investigate whether silica–drug interactions favor the drug degradation mechanism or not, hindering the beneficial pharmaceutical effect. …”
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1869
Severe hyponatremia due to trimethoprim-sulfamethoxazole-induced SIADH
Published 2022-10-01“…Simultaneous use of trimethoprim-sulfamethoxazole and spironolactone can cause serious drug interactions that increase the risk of hyponatremia, hyperkalemia, and overall mortality. …”
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1870
Augmented EHR: Enrichment of EHR with Contents from Semantic Web Sources
Published 2021-04-01“…Finally, to exemplify the approach, the work includes a practical use case in which the summarized EHR is augmented with drug–drug interactions and disease-related treatment information.…”
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1871
Treatment of dermatophytosis in elderly, children, and pregnant women
Published 2017-01-01“…Terbinafine is the preferred oral agent in elderly population for treatment of extensive cutaneous disease and onychomycosis due to its lack of cardiac complications and lower propensity for drug interactions. If required, additional physical/mechanical modalities can be employed for symptomatic onychomycosis. …”
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1872
Safety of chemotherapy of MDR/XDR-TB patients in high HIV prevalence settings
Published 2022-12-01“…In conditions of high prevalence of HIV, the pharmacovigilance of drug interactions in combination therapy is particularly relevant since HIV can indirectly increase the number of ADRs not only due to cross-toxicity but also severe immunosuppression, development of immune system recovery syndrome, opportunistic infections, a characteristic intoxication syndrome, a low index body weight and individual characteristics of patients in this category.…”
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1873
Privileged Scaffold Decoration for the Identification of the First Trisubstituted Triazine with Anti-SARS-CoV-2 Activity
Published 2022-12-01“…Unfortunately, these three drugs showed some limitations regarding potency and possible drug–drug interactions. A series of derivatives coming from a decoration approach of the privileged scaffold s-triazines were synthesized and evaluated against SAR-CoV-2. …”
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1874
Controversy about the Role of Rifampin in Biofilm Infections: Is It Justified?
Published 2021-02-01“…The risk for emergence of rifampin resistance and multiple drug interactions are emphasized. A recent randomized controlled trial (RCT) showing no beneficial effect of rifampin in patients with acute staphylococcal periprosthetic joint infection treated with prosthesis retention is critically reviewed and data interpreted. …”
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1875
Role of Direct Oral Anticoagulants for Post-operative Venous Thromboembolism Prophylaxis
Published 2022-05-01“…However, their use is limited by drawbacks including a narrow therapeutic range, numerous food and drug interactions, and the need for regular monitoring for dose adjustments. …”
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1876
Knowledge Graphs and Explainable AI in Healthcare
Published 2022-09-01“…Based on our review, knowledge graphs have been used for explainability to detect healthcare misinformation, adverse drug reactions, drug-drug interactions and to reduce the knowledge gap between healthcare experts and AI-based models. …”
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1877
The structure of mouse L1210 dihydrofolate reductase-drug complexes and the construction of a model of human enzyme.
Published 1987“…These structures reveal for the first time details of drug interactions with a mammalian DHFR, which are compared with those observed from previous X-ray investigations of DHFR/inhibitor complexes. …”
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1878
Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer
Published 2019“…Future research will need to focus on drug interactions to explore potential synergistic actions of diarylpentanoids and further establish the use of diverse animal models.…”
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1879
Collaborative Innovation: The Future of BioPharma
Published 2007-09-01“…During this process, researchers develop tests to screen libraries of chemical compounds against therapeutic targets, evaluate the amount of a drug required to effectively treat the disease, study the extent to which a drug interacts only with the target, assess the presence and significance of any harmful side effects and design the way the drug is going to be administered to patients.…”
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1880
Common Toxic Syndromes in Psychiatric Practice
Published 2010-12-01“…Entoxications which are confronted frequently include clinical scenarios ranging from known drug overdose or drug interactions, as well as, illicit drug use, suicide attempt, or accidental exposure. …”
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