Drug-resistant monoarticular wrist joint tuberculosis in renal transplant recipient with literature review by Jasmine Sethi, Vignesh Subramani, Rajender Kumar, Shivakumar Patil, Ashish Sharma

“…Treatment of MDR-TB in a renal transplant recipient is a difficult task as the MDR-TB drugs are potentially toxic and some have drug interactions with immunosuppressive agents that can lead to difficulties in maintaining therapeutic trough levels.…”
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Importance of medication reconciliation in cancer patients by Ali Elbeddini, Anthony To, Yasamin Tayefehchamani, Cindy Xin Wen

“…Medication reconciliations provide the opportunity to identify and prevent drug–drug and herb–drug interactions. They also provide an opportunity to appropriately adjust chemotherapy dosing according to renal and hepatic function. …”
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Clinical Utility of Medication-Based Risk Scores to Reduce Polypharmacy and Potentially Avoidable Healthcare Utilization by Armando Silva-Almodóvar, Milap C. Nahata

“…However, exposure to polypharmacy has been associated with an increased risk for adverse effects, drug-drug interactions, inappropriate prescribing, medication nonadherence, increased healthcare utilization such as emergency department visits and hospitalizations, and costs. …”
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Research and development of drug delivery systems based on drug transporter and nano-formulation by Yi Peng, Lu Chen, Sheng Ye, Yu Kang, Junqing Liu, Su Zeng, Lushan Yu

“…Changes in the expression and activity of transporters can cause corresponding changes in drug pharmacokinetics and pharmacodynamics. The drug-drug interactions (DDI) caused by transporters can seriously affect drug effectiveness and toxicity. …”
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Investigation into in vitro anti-leishmanial combinations of calcium channel blockers and current anti-leishmanial drugs by Juliana Quero Reimão, André Gustavo Tempone

“…In this work, in vitro isobolograms of Leishmania (Leishmania) chagasi using promastigotes or intracellular amastigotes were utilised to identify the interactions between five CCBs and the standard drugs pentamidine, amphotericin B and glucantime. The drug interactions were assessed with a fixed ratio isobologram method and the fractional inhibitory concentrations (FICs), sum of FICs (ΣFICs) and the overall mean ΣFIC were calculated for each combination. …”
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Anti-diabetic drug binding site in a mammalian KATP channel revealed by Cryo-EM by Gregory M Martin, Balamurugan Kandasamy, Frank DiMaio, Craig Yoshioka, Show-Ling Shyng

“…The mechanism by which these drugs interact with and inhibit the channel has been extensively investigated, yet it remains unclear where the drug binding pocket resides. …”
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Novel oral anticoagulant induced upper limb haematoma: A case report by Nanda Kandamany, Heather Tan

“…These agents are gaining in popularity due to their more stable pharmacokinetic profile, fewer drug interactions, as well as eliminating the need for routine monitoring.NOAC induced haematomas of the upper limb are rare and there is no real consensus on management. …”
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Prevention and treatment of thrombosis in cancer and oncohematological patients by O. V. Somonova, A. L. Elizarova, T. V. Davydova

“…Direct oral anticoagulants are promising drugs for oral administration and are indicated as one of the treatment options for patients with tumor-associated thrombosis with a low risk of bleeding and no drug interactions with ongoing systemic chemotherapy.…”
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Prevention of gastrointestinal bleeding in patients receiving oral anticoagulants: focus on proton pump inhibitors by O. D. Ostroumova, E. A. Volkova, A. I. Kochetkov, A. P. Pereverzev, O. N. Tkacheva

“…The factors that increase the risk of bleeding associated with the use of anticoagulants are discussed, including the potential drug-drug interactions and patients’ dietary habits. A description of the scales that assess the bleeding risks during anticoagulant therapy is given. …”
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Pharmacokinetics and pharmacodynamics of rebamipide. New possibilities of therapy: A review by Natalia V. Bakulina, Sergey V. Tikhonov, Sergey V. Okovityi, Elena A. Lutaenko, Alexandеr O. Bolshakov, Veronika A. Prikhodko, Anna S. Nekrasova

“…A detailed understanding of pharmacodynamics and pharmacokinetics allows for individual selection of therapy based on the characteristics of the patient's body gender, age, comorbidities; choose the optimal route of administration and dosing regimen; predict adverse effects and drug interactions; be determined with new clinical indications.…”
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In Vitro Investigation of Binding Interactions between Albumin–Gliclazide Model and Typical Hypotensive Drugs by Ewa Zurawska-Plaksej, Rafal Wiglusz, Agnieszka Piwowar, Katarzyna Wiglusz

“…Type 2 diabetes management usually requires polytherapy, which increases the risk of drug-to-drug interactions. Among the multiple diabetes comorbidities, hypertension is the most prevalent. …”
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Management of Coronary Artery Disease in Older Adults: Recent Advances and Gaps in Evidence by Stefano Cacciatore, Luigi Spadafora, Marco Bernardi, Mattia Galli, Matteo Betti, Francesco Perone, Giulia Nicolaio, Emanuele Marzetti, Anna Maria Martone, Francesco Landi, Elad Asher, Maciej Banach, Olivier Hanon, Giuseppe Biondi-Zoccai, Pierre Sabouret

“…This narrative review aims to highlight the importance of assessing frailty as an aid to guide therapeutic decision-making and tailor CAD management to the specific needs of older adults, taking into account age-related pharmacokinetic and pharmacodynamic changes, polypharmacy, and potential drug interactions. We also discuss gaps in the evidence and offer perspectives on how best in the future to optimize the global strategy of CAD management in older adults.…”
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Pharmacogenomics and non-genetic factors affecting drug response in autism spectrum disorder in Thai and other populations: current evidence and future implications by Mohitosh Biswas, Mohitosh Biswas, Mohitosh Biswas, Natchaya Vanwong, Natchaya Vanwong, Chonlaphat Sukasem, Chonlaphat Sukasem, Chonlaphat Sukasem, Chonlaphat Sukasem, Chonlaphat Sukasem

“…In addition to pharmacogenomic (PGx) factors, drug–drug interactions (DDIs) and possibly cumulative effects of DDIs and PGx may affect the safety or effectiveness of risperidone/aripiprazole, which should be assessed in future clinical studies in children with ASD. …”
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Recent Advances of Resveratrol as Add on Therapy: Review article by Mona Adly, Reham A.M. Ellisy, Ahmed Noureldin Hassan

“…Also, the toxicity, side effects and drug interactions of RE is gathered and analyzed in this article. …”
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Neuroprotective activity of Hypericum perforatum and its major components by Ana Isabel Oliveira, Ana Isabel Oliveira, Cláudia Pinho, Cláudia Pinho, Bruno Sarmento, Bruno Sarmento, Bruno Sarmento, Alberto Dias

“…The present review aims to provide a comprehensive summary of the main biologically active compounds of H. perforatum, as for its chemistry, pharmacological activities, drug interactions and adverse reactions and gather scattered information about its neuroprotective abilities. …”
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Fragment merging approach for design, synthesis, and biological assessment of urea/acetyl hydrazide clubbed thienopyrimidine derivatives as GSK-3β inhibitors by Joseph S. Saleh, Soha R. Abd El Hadi, Hany S. Ibrahim, Eman Z. Elrazaz, Khaled A. M. Abouzid

“…CYP1D6 is predicted to be inhibited by compounds (5a, 5d, 6a, 9a and 9b), So drug-drug interactions are expected upon administration of these compounds. …”
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Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model by Magdalena Kasendra, Raymond Luc, Jianyi Yin, Dimitris V Manatakis, Gauri Kulkarni, Carolina Lucchesi, Josiah Sliz, Athanasia Apostolou, Laxmi Sunuwar, Jenifer Obrigewitch, Kyung-Jin Jang, Geraldine A Hamilton, Mark Donowitz, Katia Karalis

“…Induction of intestinal drug metabolizing enzymes can complicate the development of new drugs, owing to the potential to cause drug-drug interactions (DDIs) leading to changes in pharmacokinetics, safety and efficacy. …”
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ADVANTAGES OF BROAD SPECTRUM ANTIEPILEPTIC DRUGS IN TREATMENT OF EPILEPSY by K. V. Voronkova, G. S. Golosnaya, I. D. Lemeshko, A. S. Petrukhin

“…Pharmacotherapy of epilepsy requires deep knowledge  of anti-epileptic drugs (AEDs), including the following issues: spectrum of therapeutic efficacy and therapeutic strength, adverse effects (especially severe and life-threatening adverse reactions); specific features of pharmacokinetics,  pharmacodynamics, and drug interactions; titration rate, the need for laboratory tests  during treatment,  pharmacoeconomic components.  …”
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Impact of Obesity on Atrial Fibrillation Pathogenesis and Treatment Options by Rina Sha, Olivia Baines, Abbie Hayes, Katie Tompkins, Manish Kalla, Andrew P. Holmes, Christopher O'Shea, Davor Pavlovic

“…In this review, we discuss mechanisms by which obesity mediates AF and treatment outcomes, aiming to provide insight into obesity‐drug interactions and guide personalized treatment for this patient subgroup.…”
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Utilization of bilateral percutaneous microwave ablation of the adrenal glands in ectopic Cushing's syndrome by Lloyd Petty, MD, Karma Elliott, MD, Keith Quencer, MD, Matthew Wahl, MD, Anu Sharma, MD

“…Surgery and medical therapies were contraindicated due to comorbidities and drug interactions. Bilateral MWA of the adrenal glands was performed. …”
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