New insights into the mechanism of dynein motor regulation by lissencephaly-1 by Steven M Markus, Matthew G Marzo, Richard J McKenney

Subjects: “…dynein…”
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Versatile properties of dynein molecules underlying regulation in flagellar oscillation by Takashi Fujiwara, Chikako Shingyoji, Hideo Higuchi

“…Abstract Dynein is a minus-end-directed motor that generates oscillatory motion in eukaryotic flagella. …”
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Expected and unexpected roles for dynein regulation of dendritic late endosomes by Chan Choo Yap, Bettina Winckler

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In vivo characterization of dynein-driven nanovectors using Drosophila oocytes. by Nadège Parassol, Céline Bienvenu, Cécile Boglio, Sébastien Fiorucci, Delphine Cerezo, Xiao-Min Yu, Guilhem Godeau, Jacques Greiner, Pierre Vierling, Stéphane Noselli, Christophe Di Giorgio, Véronique Van De Bor

“…Here, we develop a fast and genetically tractable assay to test the efficiency and dynamics of fluospheres (FS) using microinjection into Drosophila oocytes coupled with time-lapse microscopy. We designed dynein motor driven FS using a collection of dynein light chain 8 (LC8) peptide binding motifs as molecular linkers and characterized in real time the efficiency of the FS movement according to its linker's sequence. …”
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Structural basis for two-way communication between dynein and microtubules by Noritaka Nishida, Yuta Komori, Osamu Takarada, Atsushi Watanabe, Satoko Tamura, Satoshi Kubo, Ichio Shimada, Masahide Kikkawa

“…The movement of cytoplasmic dynein on microtubule tracks is coordinated by the microtubule-binding domain (MTBD) and the ATPase domain via a coiled-coil stalk. …”
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Self-organization of dynein motors generates meiotic nuclear oscillations. by Sven K Vogel, Nenad Pavin, Nicola Maghelli, Frank Jülicher, Iva M Tolić-Nørrelykke

“…By combining quantitative live cell imaging and laser ablation with a theoretical description, we show that dynein dynamically redistributes in the cell in response to load forces, resulting in more dynein attached to the leading than to the trailing microtubules. …”
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SNX4 in complex with clathrin and dynein: implications for endosome movement. by Sigrid S Skånland, Sébastien Wälchli, Andreas Brech, Kirsten Sandvig

“…A short peptide containing this motif was sufficient to pull down both clathrin and dynein. Knockdown studies demonstrated that clathrin is not required for the SNX4/dynein interaction. …”
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Roles for CEP170 in cilia function and dynein-2 assembly by Weijman, JF, Vuolo, L, Shak, C, Pugnetti, A, Mukhopadhyay, AG, Hodgson, LR, Heesom, KJ, Roberts, AJ, Stephens, DJ

“…Dynein-2 must be assembled and loaded onto IFT trains for entry into cilia for this process to occur, but how dynein-2 is assembled and how it is recycled back into a cilium remain poorly understood. …”

Control of the mitotic spindle by dynein light chain 1 complexes by Dunsch, A, Anja Dunsch

“…Different populations of the cytoplasmic dynein motor defined by specific dynein adaptor complexes are required for the formation of a stable bipolar mitotic spindle. …”

Vesicles driven by dynein and kinesin exhibit directional reversals without regulators by Ashwin I. D’Souza, Rahul Grover, Gina A. Monzon, Ludger Santen, Stefan Diez

“…Here, we demonstrate that a minimal system, comprising purified Dynein-Dynactin-BICD2 (DDB) and kinesin-3 (KIF16B) attached to large unilamellar vesicles, faithfully reproduces in vivo cargo motility, including runs, pauses, and reversals. …”
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NuMA recruits dynein activity to microtubule minus-ends at mitosis by Christina L Hueschen, Samuel J Kenny, Ke Xu, Sophie Dumont

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Lis1 regulates dynein by sterically blocking its mechanochemical cycle by Katerina Toropova, Sirui Zou, Anthony J Roberts, William B Redwine, Brian S Goodman, Samara L Reck-Peterson, Andres E Leschziner

Subjects: “…dynein…”
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A single protofilament is sufficient to support unidirectional walking of dynein and kinesin. by Keitaro Shibata, Michi Miura, Yuta Watanabe, Kei Saito, Atsuko Nishimura, Ken'ya Furuta, Yoko Y Toyoshima

“…Cytoplasmic dynein and kinesin are two-headed microtubule motor proteins that move in opposite directions on microtubules. …”
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Lissencephaly-1 is a context-dependent regulator of the human dynein complex by Janina Baumbach, Andal Murthy, Mark A McClintock, Carly I Dix, Ruta Zalyte, Ha Thi Hoang, Simon L Bullock

Subjects: “…dynein…”
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Cytoplasmic Dynein Is Required for the Spatial Organization of Protein Aggregates in Filamentous Fungi by Martin J. Egan, Mark A. McClintock, Ian H.L. Hollyer, Hunter L. Elliott, Samara L. Reck-Peterson

“…We find that microtubules promote the formation of Hsp104-positive aggregates, which coalesce into discrete subcellular structures in a process dependent on the microtubule-based motor cytoplasmic dynein. Finally, we find that impaired clearance of these inclusions negatively impacts retrograde trafficking of endosomes, a conventional dynein cargo, indicating that microtubule-based transport can be overwhelmed by chronic cellular stress.…”
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Dynein Transmits Polarized Actomyosin Cortical Flows to Promote Centrosome Separation by Alessandro De Simone, François Nédélec, Pierre Gönczy

“…The minus-end-directed motor dynein plays a pivotal role in centrosome separation, but the underlying mechanisms remain elusive, particularly regarding how dynein coordinates this process in space and time. …”
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Structures of human dynein in complex with the lissencephaly 1 protein, LIS1 by Janice M Reimer, Morgan E DeSantis, Samara L Reck-Peterson, Andres E Leschziner

Subjects: “…dynein…”
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Dynein catch bond as a mediator of codependent bidirectional cellular transport by Palka Puri, Nisha Gupta, Sameep Chandel, Supriyo Naskar, Anil Nair, Abhishek Chaudhuri, Mithun K. Mitra, Sudipto Muhuri

“…Unlike kinesin motors, dynein motors exhibit catch bonding, wherein the unbinding rates of these motors decrease with increasing force on them. …”
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Ensemble and single-molecule dynamics of IFT dynein in Caenorhabditis elegans cilia by Jona Mijalkovic, Bram Prevo, Felix Oswald, Pierre Mangeol, Erwin J. G. Peterman

“…Cytoplasmic dynein 2 drives retrograde intraflagellar transport but little is known about its dynamics. …”
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TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport by John T. Canty, Andrew Hensley, Merve Aslan, Amanda Jack, Ahmet Yildiz

“…Here, the authors show that the mitochondrial TRAK adaptors activate the dynein-dynactin complex, enhance the motility of kinesin, and can scaffold both motors to control bidirectional transport.…”
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