Ciliary Dyneins and Dynein Related Ciliopathies por Dinu Antony, Han G. Brunner, Miriam Schmidts

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Conserved roles for the dynein intermediate chain and Ndel1 in assembly and activation of dynein por Kyoko Okada, Bharat R. Iyer, Lindsay G. Lammers, Pedro A. Gutierrez, Wenzhe Li, Steven M. Markus, Richard J. McKenney

“…Abstract Processive transport by the microtubule motor cytoplasmic dynein requires the regulated assembly of a dynein-dynactin-adapter complex. …”
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The Mechanical Components of the Dynein Motor por Peter Höök

“…Unlike our understanding of the other two classes of cytoskeletal motor proteins, the myosins and kinesins, we have only recently begun to comprehend the molecular mechanism for how dynein produces force and movement. The slow progress has been attributed, in part, to the enormous size of the dynein force-producing head, but also to the complex interplay between its structural components, each of which has a unique role in regulating dynein motor activity. …”
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Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation. por Dunsch, A, Hammond, D, Lloyd, J, Schermelleh, L, Gruneberg, U, Barr, F

“…The cytoplasmic dynein motor generates pulling forces to center and orient the mitotic spindle within the cell. …”

Molecular Cloning of Dynein Heavy Chain and the Effect of Dynein Inhibition on the Testicular Function of <i>Portunus trituberculatus</i> por Qiumeng Xiang, Chaoguang Wei, Xinming Gao, Yiner Chen, Daojun Tang, Junquan Zhu, Congcong Hou

Assuntos: “…dynein…”
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Structure and Function of Dynein’s Non-Catalytic Subunits por Lu Rao, Arne Gennerich

Assuntos: “…cytoplasmic dynein-1…”
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N-Terminal Processing and Modification of Ciliary Dyneins por Miho Sakato-Antoku, Jeremy L. Balsbaugh, Stephen M. King

Assuntos: Obter o texto integral

Cargo specificity, regulation, and therapeutic potential of cytoplasmic dynein por Jin-Gyeong Park, Hanul Jeon, Kwang Yeon Hwang, Sun-Shin Cha, Rafael T. Han, Hyesung Cho, In-Gyun Lee

“…Abstract Intracellular retrograde transport in eukaryotic cells relies exclusively on the molecular motor cytoplasmic dynein 1. Unlike its counterpart, kinesin, dynein has a single isoform, which raises questions about its cargo specificity and regulatory mechanisms. …”
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Dyneins across eukaryotes: a comparative genomic analysis. por Wickstead, B, Gull, K

“…Dyneins are large minus-end-directed microtubule motors. …”

Dynein‐Powered Cell Locomotion Guides Metastasis of Breast Cancer por Yerbol Tagay, Sina Kheirabadi, Zaman Ataie, Rakesh K. Singh, Olivia Prince, Ashley Nguyen, Alexander S. Zhovmer, Xuefei Ma, Amir Sheikhi, Denis Tsygankov, Erdem D. Tabdanov

Assuntos: Obter o texto integral

Dynein-Inspired Multilane Exclusion Process with Open Boundary Conditions por Riya Nandi, Uwe C. Täuber, Priyanka

Assuntos: “…dynein motors…”
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Nde1 promotes Lis1-mediated activation of dynein por Yuanchang Zhao, Sena Oten, Ahmet Yildiz

“…Abstract Cytoplasmic dynein drives the motility and force generation functions towards the microtubule minus end. …”
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Kinetochore dynein is sufficient to biorient chromosomes and remodel the outer kinetochore por Bram Prevo, Dhanya K. Cheerambathur, William C. Earnshaw, Arshad Desai

“…Our approach reveals that the kinetochore dynein module, comprised of cytoplasmic dynein and its kinetochore-specific adapters, is sufficient to biorient chromosomes; by contrast, this module is unable to support congression. …”
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Versatile properties of dynein molecules underlying regulation in flagellar oscillation por Takashi Fujiwara, Chikako Shingyoji, Hideo Higuchi

“…Abstract Dynein is a minus-end-directed motor that generates oscillatory motion in eukaryotic flagella. …”
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Expected and unexpected roles for dynein regulation of dendritic late endosomes por Chan Choo Yap, Bettina Winckler

Assuntos: Obter o texto integral

Roles for CEP170 in cilia function and dynein-2 assembly por Weijman, JF, Vuolo, L, Shak, C, Pugnetti, A, Mukhopadhyay, AG, Hodgson, LR, Heesom, KJ, Roberts, AJ, Stephens, DJ

“…Dynein-2 must be assembled and loaded onto IFT trains for entry into cilia for this process to occur, but how dynein-2 is assembled and how it is recycled back into a cilium remain poorly understood. …”

Control of the mitotic spindle by dynein light chain 1 complexes por Dunsch, A, Anja Dunsch

“…Different populations of the cytoplasmic dynein motor defined by specific dynein adaptor complexes are required for the formation of a stable bipolar mitotic spindle. …”

Vesicles driven by dynein and kinesin exhibit directional reversals without regulators por Ashwin I. D’Souza, Rahul Grover, Gina A. Monzon, Ludger Santen, Stefan Diez

“…Here, we demonstrate that a minimal system, comprising purified Dynein-Dynactin-BICD2 (DDB) and kinesin-3 (KIF16B) attached to large unilamellar vesicles, faithfully reproduces in vivo cargo motility, including runs, pauses, and reversals. …”
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Dynein catch bond as a mediator of codependent bidirectional cellular transport por Palka Puri, Nisha Gupta, Sameep Chandel, Supriyo Naskar, Anil Nair, Abhishek Chaudhuri, Mithun K. Mitra, Sudipto Muhuri

“…Unlike kinesin motors, dynein motors exhibit catch bonding, wherein the unbinding rates of these motors decrease with increasing force on them. …”
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Cortical Dynein and Asymmetric Membrane Elongation Coordinately Position the Spindle in Anaphase por Kiyomitsu, Tomomi, Cheeseman, Iain M

“…In asymmetrically elongating cells, dynein-dependent spindle anchoring at the stationary cell cortex ensures proper spindle positioning. …”
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