Total ankle replacement versus ankle arthrodesis for patients aged 50–85 years with end-stage ankle osteoarthritis: the TARVA RCT by Goldberg Andrew J, Chowdhury Kashfia, Bordea Ekaterina, Blackstone James, Brooking Deirdre, Deane Elizabeth L, Hauptmannova Iva, Cooke Paul, Cumbers Marion, Skene Simon S, Doré Caroline J

“…Total ankle replacement appears to be cost-effective compared with ankle fusion at the National Institute for Health and Care Excellence’s cost-effectiveness threshold of £20,000 per quality-adjusted life-year gained over a patient’s lifetime based on long-term economic modelling. Future work We recommend long-term follow-up of this important cohort, in particular radiological and clinical progress. …”
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Adjunctive Medication Management and Contingency Management to enhance adherence to acamprosate for alcohol dependence: the ADAM trial RCT by Kim Donoghue, Sadie Boniface, Eileen Brobbin, Sarah Byford, Rachel Coleman, Simon Coulton, Edward Day, Ranjita Dhital, Anum Farid, Laura Hermann, Amy Jordan, Andreas Kimergård, Maria-Leoni Koutsou, Anne Lingford-Hughes, John Marsden, Joanne Neale, Aimee O’Neill, Thomas Phillips, James Shearer, Julia Sinclair, Joanna Smith, John Strang, John Weinman, Cate Whittlesea, Kideshini Widyaratna, Colin Drummond

“…For SS + MM + CM versus SS, the primary economic analysis at 6-month follow-up using QALYs, the secondary economic analysis at 6-month follow-up using medication adherence and the economic modelling over a 20-year time horizon using QALYs all found SS + MM + CM to dominate SS (better outcomes at lower cost). …”
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Individualised variable-interval risk-based screening in diabetic retinopathy: the ISDR research programme including RCT by Simon Harding, Ayesh Alshukri, Duncan Appelbe, Deborah Broadbent, Philip Burgess, Paula Byrne, Christopher Cheyne, Antonio Eleuteri, Anthony Fisher, Marta García-Fiñana, Mark Gabbay, Marilyn James, James Lathe, Tracy Moitt, Mehrdad Mobayen Rahni, John Roberts, Christopher Sampson, Daniel Seddon, Irene Stratton, Clare Thetford, Pilar Vazquez-Arango, Jiten Vora, Amu Wang, Paula Williamson

“…Future work Future work could include external validation with other programmes followed by scale-up of individualised screening outside a research setting and economic modelling beyond the 2-year time horizon. Trial registration This trial is registered as ISRCTN87561257. …”
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The Bioethics-CSR Divide by Caio Caesar Dib

“…The book influenced both the author responsible for the coining bioethics in the 1971[7] and early CSR literature.[8] By initiating a debate over the sustainability of economic models, the environmentalist discourse became a precursor to vigorous social movements for civil rights. …”
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The Bioethics-CSR Divide by Caio Caesar Dib

“…The book influenced both the author responsible for the coining bioethics in the 1971[7] and early CSR literature.[8] By initiating a debate over the sustainability of economic models, the environmentalist discourse became a precursor to vigorous social movements for civil rights. …”
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