Coupling metal and whole-cell catalysis to synthesize chiral alcohols by Hang Yin, Peng-Qian Luan, Yu-Fei Cao, Jun Ge, Wen-Yong Lou

“…Findings We report a chemoenzymatic cascade reaction involved Palladium (Pd) catalyzed Suzuki–Miyaura coupling and whole-cell catalyzed C = O asymmetric reduction for enantioselective synthesis of value-added chiral alcohol. The cell membrane serves as a natural barrier can protect intracellular enzymes from organic solvents. …”
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A direct approach to amines with remote stereocentres by enantioselective CuH-catalysed reductive relay hydroamination by Zhu, Shaolin, Niljianskul, Nootaree, Buchwald, Stephen Leffler

“…Here, we report a copper-hydride-catalysed, enantioselective synthesis of γ- or δ-chiral amines from readily available allylic alcohols, esters and ethers using a reductive relay hydroamination strategy (a net reductive process in which an amino group is installed at a site remote from the original carbon–carbon double bond). …”
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Asymmetric Hydroarylation of Vinylarenes Using a Synergistic Combination of CuH and Pd Catalysis by Friis, Stig During, Pirnot, Michael T, Buchwald, Stephen Leffler

“…Detailed in this Communication is the enantioselective synthesis of 1,1-diarylalkanes, a structure found in a range of pharmaceutical drug agents and natural products, through the employment of copper(I) hydride and palladium catalysis. …”
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Diastereo- and Enantioselective CuH-Catalyzed Hydroamination of Strained Trisubstituted Alkenes by Feng, Sheng, Hao, Hua, Liu, Peng, Buchwald, Stephen Leffler

“…Herein, we describe the diastereo- and enantioselective synthesis of various types of polysubstituted aminocyclobutanes and aminocyclopropanes through CuH-catalyzed hydroamination of 1-substituted cyclobutenes and cyclopropenes. …”
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Nickel-catalyzed asymmetric cross-couplings of secondary allylic chlorides and planar-chiral compounds in asymmetric synthesis by Son, Sunghee

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Total synthesis and study of myrmicarin alkaloids by Ondrus, Alison E., Movassaghi, Mohammad

“…Our concise enantioselective synthesis of the tricyclic myrmicarins enabled evaluation of a potentially biomimetic assembly of the complex members via direct dimerization of simpler structures. …”
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Sharpless Asymmetric Dihydroxylation: An Impressive Gadget for the Synthesis of Natural Products: A Review by Aqsa Mushtaq, Ameer Fawad Zahoor, Muhammad Bilal, Syed Makhdoom Hussain, Muhammad Irfan, Rabia Akhtar, Ali Irfan, Katarzyna Kotwica-Mojzych, Mariusz Mojzych

“…Sharpless asymmetric dihydroxylation is an important reaction in the enantioselective synthesis of chiral vicinal diols that involves the treatment of alkene with osmium tetroxide along with optically active quinine ligand. …”
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Novel palladium precatalysts and their application in cross- coupling reactions and copper-catalyzed enantioselective ring formation by Bruno, Nicholas C. (Nicholas Charles)

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Access to all-carbon spirocycles through a carbene and thiourea cocatalytic desymmetrization cascade reaction by Zhuo, Shitian, Zhu, Tingshun, Zhou, Liejin, Mou, Chengli, Chai, Huifang, Lu, Yunpeng, Pan, Lutai, Jin, Zhichao, Chi, Robin Yonggui

“…Our study constitutes the first success in the carbene-catalyzed enantioselective synthesis of all-carbon spirocycles. The reaction products can be readily transformed into sophisticated multicyclic molecules and chiral ligands.…”
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Phosphoramidite ligand design for the enantioselective conjugate addition of alkylzirconium reagents to enones by Roth, PMC

“…Chapter four describes the development of an enantioselective synthesis of quaternary centres with novel ligands used to optimise the new system. …”

Oxidative radical cyclisations for total synthesis by Ferrara, S

“…The methodology was then applied to a short catalytic and enantioselective synthesis of (+)-aphanamol I and related natural products.…”

The development of nitro-Mannich/hydroamination cascades for the synthesis of substituted N-heterocycles by Barber, D, David Barber

“…</p> <p>Chapter 3 describes the extension of this methodology to the diastereo- and enantioselective synthesis of 1,2,3,4-tetrahydropyridine derivatives using a nitroalkyne substrate with an extended carbon chain. …”

Ligand-induced chirality and optical activity in semiconductor nanocrystals: theory and applications by Kuznetsova Vera, Gromova Yulia, Martinez-Carmona Marina, Purcell-Milton Finn, Ushakova Elena, Cherevkov Sergei, Maslov Vladimir, Gun’ko Yurii K.

“…We also consider potential applications of these types of chiroptical QDs including sensing, bioimaging, enantioselective synthesis, circularly polarized light emitters, and spintronic devices. …”
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Engineering and Performance of Ruthenium Complexes Immobilized on Mesoporous Siliceous Materials as Racemization Catalysts by Monika Heba, Dominika Stradomska, Katarzyna Szymańska, Andrzej Jarzębski, Krzysztof Ambroziak, Monika Masternak, Anna Kolanowska, Wojciech Pudło, Nikodem Kuźnik

“…Dynamic kinetic resolution (DKR) is one of the most attractive routes to enantioselective synthesis, and ruthenium complexes are often applied as racemization catalysts. …”
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Lipase Immobilized on MCFs as Biocatalysts for Kinetic and Dynamic Kinetic Resolution of <i>sec</i>-Alcohols by Dominika Stradomska, Monika Heba, Aleksandra Czernek, Nikodem Kuźnik, Danuta Gillner, Katarzyna Maresz, Wojciech Pudło, Andrzej Jarzębski, Katarzyna Szymańska

“…Dynamic kinetic resolution (DKR) is one of the most attractive methods for enantioselective synthesis. In the reported studies, lipase B from <i>Candida antarctica</i> (CALB) immobilized on siliceous mesoporous cellular foams (MCF) functionalized with different hydrophobic groups, and two ruthenium complexes with substituted cyclopentadienyl ligands were investigated as catalysts for the chemoenzymatic DKR of (<i>rac</i>)-1-phenylethanol, using Novozym 435 as a benchmark biocatalyst. …”
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Synthetic Study of Natural Metabolites Containing a Benzo[<i>c</i>]oxepine Skeleton: Heterocornol C and D by Ján Gettler, Tomáš Čarný, Martin Markovič, Peter Koóš, Erika Samoľová, Ján Moncoľ, Tibor Gracza

“…A versatile strategy for the enantioselective synthesis of a benzo[<i>c</i>]oxepine structural core containing natural secondary metabolites was developed. …”
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Development and application of computational tools to analyse selectivity in organic chemistry by Jackson, K

“…</p> <p>The second chapter focusses on an asymmetric organocatalysed reaction for the diastereoselective and enantioselective synthesis of the morphan motif. We look at a range of primary amine organocatalysts in this section, and are able to account for the observed asymmetry that is imparted, both qualitatively and quantitatively. …”

Discovery of epigenetic probes against the bromodomain family of proteins by Clark, P

“…Optimisation of a lead compound against BRD9 resulted in the development of LP99, the first reported BRD7/9 probe, that was potent (BRD9 <em>K</em>_D 99 nM, BRD7 <em>K</em>_D 909 nM), selective amongst bromodomain proteins and active in cells. An enantioselective synthesis was performed using chiral organocatalyts and LP99 was used to identify a previously unknown role of BRD7/9 in the regulation of inflammatory processes. …”

Optimized enantioselective (S)-2-hydroxypropiophenone synthesis by free- and encapsulated-resting cells of Pseudomonas putida by Reihaneh Kordesedehi, Mohammad Ali Asadollahi, Azar Shahpiri, Davoud Biria, Pablo Iván Nikel

“…In the present study, enantioselective synthesis of 2-HPP was investigated by free and immobilized whole cells of Pseudomonas putida ATCC 12633 starting from readily-available aldehyde substrates. …”
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Development of new transition metal-catalyzed carbon-fluorine, carbon-nitrogen, and carbon-carbon bond forming processes by Ye, Yuxuan, Ph. D. Massachusetts Institute of Technology

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