Showing 21 - 40 results of 6,752 for search '"endoplasmic reticulum"', query time: 0.15s Refine Results
  1. 21

    Mechanisms of Endoplasmic Reticulum Protein Homeostasis in Plants by Zhihao Duan, Kai Chen, Tao Yang, Ronghui You, Binzhao Chen, Jianming Li, Linchuan Liu

    Published 2023-12-01
    “…Maintenance of proteome integrity is essential for cell function and survival in changing cellular and environmental conditions. The endoplasmic reticulum (ER) is the major site for the synthesis of secretory and membrane proteins. …”
    Get full text
    Article
  2. 22

    Endoplasmic reticulum-targeting nanomedicines for cancer therapy by Yi Liu, Hao-Ran Jia, Xiaofeng Han, Fu-Gen Wu

    Published 2021-01-01
    “…In drug development research, the specific affinity of drug delivery systems for particular pathological sites, cells, and even subcellular structures can largely reduce the side effects, systemic toxicity, and minimally required drug dose. Since endoplasmic reticulum (ER) plays an essential role in many important cellular activities and functions, including the synthesis and intracellular transport of secretory and membrane-associated proteins, the synthesis and transport of steroids and lipids, Ca2+ signaling, and stress response, the ER dysfunction is associated with many diseases. …”
    Get full text
    Article
  3. 23
  4. 24
  5. 25

    Endoplasmic reticulum stress in melanoma pathogenesis and resistance by Yi Kong, Jian Jiang, Yuqiong Huang, Li Li, Xin Liu, Zilin Jin, Fen Wei, Xinxin Liu, Song Zhang, Xiaoru Duan, Yonghui Zhang, Qingyi Tong, Hongxiang Chen

    Published 2022-11-01
    “…The genetic mutation and hypermetabolic environment of melanoma cells lead to increasing demands for protein synthesis and perturb proteostasis resulting in endoplasmic reticulum (ER) stress. Subsequently, three unfolded protein response (UPR) signaling branches, represented by IRE1α, PERK and ATF6, are activated to direct cell fate towards pro-survival or pro-apoptosis depending on the intensity and duration of ER stress. …”
    Get full text
    Article
  6. 26

    Endoplasmic Reticulum–Mitochondria Contacts Are Required for Pexophagy in by Xu Liu, Xin Wen, Daniel J. Klionsky

    Published 2019-01-01
    “…Here, we found that endoplasmic reticulum (ER)–mitochondria contact sites are necessary for efficient pexophagy. …”
    Get full text
    Article
  7. 27
  8. 28
  9. 29
  10. 30
  11. 31

    Endoplasmic reticulum stress response in yeast and humans by Wu, Haoxi, Ng, Benjamin S. H., Thibault, Guillaume

    Published 2014
    “…One of the best-characterized pathways, the unfolded protein response (UPR), is an intracellular signal transduction pathway that monitors endoplasmic reticulum (ER) homeostasis. Its activation is required to alleviate the effects of ER stress and is highly conserved from yeast to human. …”
    Get full text
    Get full text
    Journal Article
  12. 32

    Endoplasmic reticulum stress and lipids in health and diseases by Celik, Cenk, Lee, Stella Yue Ting, Yap, Wei Sheng, Thibault, Guillaume

    Published 2023
    “…The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many cellular pathways, including protein synthesis, protein quality control, and lipid synthesis. …”
    Get full text
    Journal Article
  13. 33

    Endoplasmic reticulum–plasma membrane contact sites by Saheki, Yasunori, De Camilli, Pietro

    Published 2019
    “…The endoplasmic reticulum (ER) has a broad localization throughout the cell and forms direct physical contacts with all other classes of membranous organelles, including the plasma membrane (PM). …”
    Get full text
    Get full text
    Journal Article
  14. 34
  15. 35

    The mammalian endoplasmic reticulum-associated degradation system. by Olzmann, J, Kopito, R, Christianson, J

    Published 2013
    “…The endoplasmic reticulum (ER) is the site of synthesis for nearly one-third of the eukaryotic proteome and is accordingly endowed with specialized machinery to ensure that proteins deployed to the distal secretory pathway are correctly folded and assembled into native oligomeric complexes. …”
    Journal article
  16. 36
  17. 37

    Cleaning up in the endoplasmic reticulum: ubiquitin in charge. by Christianson, J, Ye, Y

    Published 2014
    “…The eukaryotic endoplasmic reticulum (ER) maintains protein homeostasis by eliminating unwanted proteins through the evolutionarily conserved ER-associated degradation (ERAD) pathway. …”
    Journal article
  18. 38
  19. 39
  20. 40