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Mechanisms of Endoplasmic Reticulum Protein Homeostasis in Plants
Published 2023-12-01“…Maintenance of proteome integrity is essential for cell function and survival in changing cellular and environmental conditions. The endoplasmic reticulum (ER) is the major site for the synthesis of secretory and membrane proteins. …”
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Endoplasmic reticulum-targeting nanomedicines for cancer therapy
Published 2021-01-01“…In drug development research, the specific affinity of drug delivery systems for particular pathological sites, cells, and even subcellular structures can largely reduce the side effects, systemic toxicity, and minimally required drug dose. Since endoplasmic reticulum (ER) plays an essential role in many important cellular activities and functions, including the synthesis and intracellular transport of secretory and membrane-associated proteins, the synthesis and transport of steroids and lipids, Ca2+ signaling, and stress response, the ER dysfunction is associated with many diseases. …”
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Fidelity of Cotranslational Protein Targeting to the Endoplasmic Reticulum
Published 2021-12-01Subjects: Get full text
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Endoplasmic Reticulum Stress Signaling and the Pathogenesis of Hepatocarcinoma
Published 2021-02-01Subjects: Get full text
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Endoplasmic reticulum stress in melanoma pathogenesis and resistance
Published 2022-11-01“…The genetic mutation and hypermetabolic environment of melanoma cells lead to increasing demands for protein synthesis and perturb proteostasis resulting in endoplasmic reticulum (ER) stress. Subsequently, three unfolded protein response (UPR) signaling branches, represented by IRE1α, PERK and ATF6, are activated to direct cell fate towards pro-survival or pro-apoptosis depending on the intensity and duration of ER stress. …”
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Endoplasmic Reticulum–Mitochondria Contacts Are Required for Pexophagy in
Published 2019-01-01“…Here, we found that endoplasmic reticulum (ER)–mitochondria contact sites are necessary for efficient pexophagy. …”
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New insights into the role of the endoplasmic reticulum in microglia
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Endoplasmic reticulum stress response in yeast and humans
Published 2014“…One of the best-characterized pathways, the unfolded protein response (UPR), is an intracellular signal transduction pathway that monitors endoplasmic reticulum (ER) homeostasis. Its activation is required to alleviate the effects of ER stress and is highly conserved from yeast to human. …”
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Endoplasmic reticulum stress and lipids in health and diseases
Published 2023“…The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many cellular pathways, including protein synthesis, protein quality control, and lipid synthesis. …”
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Endoplasmic reticulum–plasma membrane contact sites
Published 2019“…The endoplasmic reticulum (ER) has a broad localization throughout the cell and forms direct physical contacts with all other classes of membranous organelles, including the plasma membrane (PM). …”
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Antigen processing and presentation. The role of the endoplasmic reticulum.
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The mammalian endoplasmic reticulum-associated degradation system.
Published 2013“…The endoplasmic reticulum (ER) is the site of synthesis for nearly one-third of the eukaryotic proteome and is accordingly endowed with specialized machinery to ensure that proteins deployed to the distal secretory pathway are correctly folded and assembled into native oligomeric complexes. …”
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Cleaning up in the endoplasmic reticulum: ubiquitin in charge.
Published 2014“…The eukaryotic endoplasmic reticulum (ER) maintains protein homeostasis by eliminating unwanted proteins through the evolutionarily conserved ER-associated degradation (ERAD) pathway. …”
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Endoplasmic Reticulum-Targeting Two-Photon Fluorescent Probe for CYP1A Activity and Its Imaging Application in Endoplasmic Reticulum Stress
Published 2023-04-01Subjects: Get full text
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Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma
Published 2022-02-01Subjects: Get full text
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