Endoplasmic reticulum stress, autophagy, neuroinflammation, and sigma 1 receptors as contributors to depression and its treatment by Chika Fujii, Charles F Zorumski, Yukitoshi Izumi

“…Initial inflammatory triggers induce endoplasmic reticulum stress, leading to neuroinflammatory responses. …”
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Endoplasmic reticulum stress-related gene expression causes the progression of dilated cardiomyopathy by inducing apoptosis by Jinhao Chen, Jinhao Chen, Xu Yang, Xu Yang, Weiwen Li, Weiwen Li, Ying Lin, Ying Lin, Run Lin, Run Lin, Xianzhen Cai, Xianzhen Cai, Baoxin Yan, Baoxin Yan, Bin Xie, Jilin Li

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Pharmacological inhibition of endoplasmic reticulum stress mitigates osteoporosis in a mouse model of hindlimb suspension by Hiba Al-Daghestani, Rizwan Qaisar, Sausan Al Kawas, Nurhafizah Ghani, K. G. Aghila Rani, Muhammad Azeem, Hijaz Kamal Hasnan, Nur Karyatee Kassim, A. R. Samsudin

“…We investigated the effects of inhibiting endoplasmic reticulum (ER) stress with 4-phenyl butyrate (4-PBA) on the morphology, physicochemical properties, and bone turnover markers of hindlimbs in HLS mice. …”
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Role of microRNA 690 in Mediating Angiotensin II Effects on Inflammation and Endoplasmic Reticulum Stress by Kalhara R. Menikdiwela, Latha Ramalingam, Mostafa M. Abbas, Halima Bensmail, Shane Scoggin, Nishan S. Kalupahana, Asha Palat, Preethi Gunaratne, Naima Moustaid-Moussa

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Identification and characterization of biomarkers associated with endoplasmic reticulum protein processing in cerebral ischemia-reperfusion injury by Liang-da Li, Yue Zhou, Shan-fen Shi

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Identification of immune-related endoplasmic reticulum stress genes in sepsis using bioinformatics and machine learning by Ting Gong, Ting Gong, Yongbin Liu, Zhiyuan Tian, Zhiyuan Tian, Min Zhang, Min Zhang, Hejun Gao, Hejun Gao, Zhiyong Peng, Zhiyong Peng, Shuang Yin, Shuang Yin, Chi Wai Cheung, Youtan Liu, Youtan Liu

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Editorial: Recent advances in mitochondria-associated endoplasmic reticulum membranes (MAMs) in heart-related diseases by Yang Yang, Yi Luan

Subjects: “…mitochondria-associated endoplasmic reticulum membranes…”
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Serum glycomarkers of endoplasmic reticulum and lysosomal-endosomal system stress in human healthy aging and diseases by I. U. Pismenetskaya, T. D. Butters

“…To verify the idea that extracellular free oligosaccharides might be able to reflect the functional status of the endoplasmic reticulum (ER) and lysosomal-endosomal system, HPLC-profiles of serum-derived free oligosaccharides (FOS) in human healthy aging, acute myeloproliferative neoplasms, and cardiovascular pathologies were compared with intracellular glycans. …”
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Identification of endoplasmic reticulum stress-related lncRNAs in lung adenocarcinoma by bioinformatics and experimental validation by Tong Xin, Yue Sun, Hongxue Meng, Ningzhi Zhang, Bo Peng, Xinxin Yang, Jing Hu, Mengru Cao

Subjects: “…Endoplasmic reticulum stress…”
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Endogenous Bok is stable at the endoplasmic reticulum membrane and does not mediate proteasome inhibitor-induced apoptosis by Caden G. Bonzerato, Katherine R. Keller, Jacqualyn J. Schulman, Xiaokong Gao, Laura M. Szczesniak, Richard J. H. Wojcikiewicz

“…Here we show that 1) endogenous Bok is expressed at readily-detectable levels in key cultured cells (e.g., mouse embryonic fibroblasts and HCT116 cells) and is not constitutively degraded by the proteasome, 2) proteasome inhibitor-induced apoptosis is not mediated by Bok, 3) endogenous Bok expression level is critically dependent on the presence of IP3Rs, 4) endogenous Bok is rapidly degraded by the ubiquitin-proteasome pathway in the absence of IP3Rs at the endoplasmic reticulum membrane, and 5) charged residues in the transmembrane region of Bok affect its stability, ability to interact with Mcl-1, and pro-apoptotic activity when over-expressed. …”
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The mitochondrial associated endoplasmic reticulum membranes: A platform for the pathogenesis of inflammation‐mediated metabolic diseases by Sisay T. Degechisa, Yosef T. Dabi, Solomon T. Gizaw

“…Abstract Mitochondria‐associated endoplasmic reticulum membranes (MAM) are specialized subcellular compartments that are shaped by endoplasmic reticulum (ER) subdomains placed side by side to the outer membrane of mitochondria (OMM) being connected by tethering proteins in mammalian cells. …”
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Calnexin Depletion by Endoplasmic Reticulum Stress During Cholestasis Inhibits the Na+‐Taurocholate Cotransporting Polypeptide by Marion J.D. Robin, Monique D. Appelman, Harmjan R. Vos, Robert M. van Es, James C. Paton, Adrienne W. Paton, Boudewijn Burgering, Peter Fickert, Jarom Heijmans, Stan F.J. van de Graaf

“…Cholestasis‐induced accumulation of bile acids in the liver leads to farnesoid X receptor (FXR)‐mediated transcriptional down‐regulation of the bile acid importer Na+‐taurocholate cotransporting protein (NTCP) and to induction of endoplasmic reticulum (ER) stress. However, whether ER stress affects bile acid uptake is largely unknown. …”
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Attenuation of Olanzapine-Induced Endoplasmic Reticulum Stress Improves Insulin Secretion in Pancreatic Beta Cells by Diana Grajales, Patricia Vázquez, Rosa Alén, Ana B. Hitos, Ángela M. Valverde

“…Treatment of INS-1 beta cells with non-toxic concentrations of olanzapine (3–6 μM) during 4 h activated endoplasmic reticulum (ER) stress-mediated signaling by increasing PERK/eIF2α phosphorylation, IRE-1 phosphorylation and XBP-1 splicing. …”
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Curcumin Reduces Pathological Endoplasmic Reticulum Stress through Increasing Proteolysis of Mutant Matrilin-3 by Ella P. Dennis, Robyn N. Watson, Florence McPate, Michael D. Briggs

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LncRNAs and CircRNAs in Endoplasmic Reticulum Stress: A Promising Target for Cardiovascular Disease? by Francisco José Martinez-Amaro, Carlos Garcia-Padilla, Diego Franco, Houria Daimi

“…The endoplasmic reticulum (ER) is a principal subcellular organelle responsible for protein quality control in the secretory pathway, preventing protein misfolding and aggregation. …”
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Protein Misfolding and Aggregation: The Relatedness between Parkinson’s Disease and Hepatic Endoplasmic Reticulum Storage Disorders by Francisco J. Padilla-Godínez, Rodrigo Ramos-Acevedo, Hilda Angélica Martínez-Becerril, Luis D. Bernal-Conde, Jerónimo F. Garrido-Figueroa, Marcia Hiriart, Adriana Hernández-López, Rubén Argüero-Sánchez, Francesco Callea, Magdalena Guerra-Crespo

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Hydrogen Sulfide Plays an Important Role by Regulating Endoplasmic Reticulum Stress in Diabetes-Related Diseases by Huijie Zhao, Huiyang Liu, Yihan Yang, Tianyue Lan, Honggang Wang, Dongdong Wu

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The yeast p5 type ATPase, spf1, regulates manganese transport into the endoplasmic reticulum. by Yifat Cohen, Márton Megyeri, Oscar C W Chen, Giuseppe Condomitti, Isabelle Riezman, Ursula Loizides-Mangold, Alaa Abdul-Sada, Nitzan Rimon, Howard Riezman, Frances M Platt, Anthony H Futerman, Maya Schuldiner

“…The endoplasmic reticulum (ER) is a large, multifunctional and essential organelle. …”
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Development of Resistance to Endoplasmic Reticulum Stress-Inducing Agents in Mouse Leukemic L1210 Cells by Martin Cagala, Lucia Pavlikova, Mario Seres, Karolina Kadlecikova, Albert Breier, Zdena Sulova

Subjects: “…endoplasmic reticulum stress…”
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Disruption of the Golgi Apparatus and Contribution of the Endoplasmic Reticulum to the SARS-CoV-2 Replication Complex by Ted Hackstadt, Abhilash I. Chiramel, Forrest H. Hoyt, Brandi N. Williamson, Cheryl A. Dooley, Paul A. Beare, Emmie de Wit, Sonja M. Best, Elizabeth R. Fischer

“…A variety of immunolabeling procedures for both light and electron microscopy were used to examine the cellular origins of the host membranes supporting the SARS-CoV-2 replication complex. The endoplasmic reticulum has long been implicated as a source of membrane for the coronavirus replication organelle. …”
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